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Memantine: Drug information

Memantine: Drug information
(For additional information see "Memantine: Patient drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • Namenda;
  • Namenda Titration Pak;
  • Namenda XR;
  • Namenda XR Titration Pack [DSC]
Brand Names: Canada
  • ACT Memantine;
  • APO-Memantine;
  • Ebixa;
  • MED-Memantine;
  • PMS-Memantine;
  • RAN-Memantine [DSC];
  • RIVA-Memantine;
  • SANDOZ Memantine FCT
Pharmacologic Category
  • N-Methyl-D-Aspartate (NMDA) Receptor Antagonist
Dosing: Adult
Alzheimer disease, moderate to severe

Alzheimer disease, moderate to severe (monotherapy or in combination with a cholinesterase inhibitor):

Oral:

Immediate release: Initial: 5 mg once daily; increase daily dose by 5 mg every week as tolerated to a target maximum dose of 20 mg/day. Note: Dose may be administered once daily or in 2 divided doses (Ref).

Extended release: Initial: 7 mg once daily; increase daily dose by 7 mg every week as tolerated to a target maximum dose of 28 mg once daily (Ref).

Dementia

Dementia (ie, Parkinson disease dementia, dementia with Lewy bodies, comorbid vascular dementia) (monotherapy or in combination with a cholinesterase inhibitor) (off-label use):

Oral: Immediate release: Initial: 5 mg once daily; increase dose by 5 mg every week as tolerated to a target maximum dose of 20 mg/day. Note: Dose may be administered once daily or in 2 divided doses (Ref).

Neurocognitive toxicity of whole brain irradiation, prevention

Neurocognitive toxicity of whole brain irradiation, prevention (off-label use):

Oral:

Immediate release: Initial: 5 mg once daily with the initiation of radiation; increase dose by 5 mg weekly as tolerated to a target maximum dose of 20 mg/day. Doses >5 mg/day may be given in 2 divided doses. Continue for up to 6 months after completion of whole brain radiation therapy (WBRT) (Ref).

Extended release: Initial: 7 mg once daily with the initiation of radiation; increase dose by 7 mg weekly as tolerated to a target maximum dose of 28 mg once daily. Continue for up to 6 months after completion of WBRT (Ref).

Discontinuation of therapy: Discontinuation of therapy may result in worsening of cognitive function. Avoid abrupt discontinuation except in the case of severe adverse drug reaction to minimize withdrawal symptoms (eg, altered mental status, hallucinations, delusions, insomnia, increased anxiety and agitation). In general, memantine should be tapered using a 50% dose reduction or stepwise reduction via available dose formulations every 4 weeks to the lowest dose prior to discontinuation. Consider re-initiation if clear worsening of the condition occurs after withdrawal (Ref).

Conversion from immediate release to extended release: Begin the ER product the day after the last dose of the IR product.

If current IR dose is 10 mg/day: Convert to ER capsule 14 mg once daily.

If current IR dose is 20 mg/day: Convert to ER capsule 28 mg once daily.

Missed doses : If several days of dosing are missed with either formulation, dosing may need to be resumed at lower doses and retitrated.

Dosing: Kidney Impairment: Adult

The renal dosing recommendations are based upon the best available evidence and clinical expertise. Senior Editorial Team: Bruce Mueller, PharmD, FCCP, FASN, FNKF; Jason Roberts, PhD, BPharm (Hons), B App Sc, FSHP, FISAC; Michael Heung, MD, MS.

Altered kidney function: Note: Renal function may be estimated using the Cockcroft-Gault formula for dosage adjustment purposes.

Immediate release:

CrCl ≥50 mL/minute: No dosage adjustment necessary.

CrCl 30 to <50 mL/minute: Initial: 5 mg once daily; after at least 1 week of therapy and if tolerated, may increase in 5 mg increments no more frequently than weekly (Ref). However, predicted steady state exposures are 60% (Ref) to 100% (Ref) greater compared to those with normal kidney function; a reduced maximum dose may be necessary in some patients (Ref).

CrCl <30 mL/minute: Initial: 5 mg once daily; after at least 1 week of therapy and if tolerated, may increase to a target dose of 5 mg twice daily (Ref).

Extended release:

CrCl ≥50 mL/minute: No dosage adjustment necessary.

CrCl 30 to <50 mL/minute: Initial: 7 mg once daily; after at least 1 week of therapy and if tolerated, may increase in 7 mg increments no more frequently than weekly (Ref). However, predicted steady state exposures are 60% (Ref) to 100% (Ref) greater compared to those with normal kidney function; a reduced maximum dose may be necessary in some patients (Ref).

CrCl <30 mL/minute: Initial: 7 mg once daily; after at least 1 week of therapy and if tolerated, may increase to a target dose of 14 mg once daily (Ref).

Hemodialysis, intermittent (thrice weekly): Not likely to be significantly dialyzable (large Vd) (Ref):

Immediate release: Dose as if the patient has a CrCl <30 mL/minute (Ref).

Extended release: Avoid use (Ref).

Peritoneal dialysis: Not likely to be significantly dialyzable (large Vd) (Ref):

Immediate release: Dose as if the patient has a CrCl <30 mL/minute (Ref).

Extended release: Avoid use (Ref).

CRRT or PIRRT (eg, sustained, low-efficiency diafiltration) : Not likely to be significantly dialyzed (large Vd) (Ref):

Immediate release: Dose as if the patient has a CrCl <30 mL/minute (Ref).

Extended release: Avoid use (Ref).

Dosing: Hepatic Impairment: Adult

Mild-to-moderate impairment: No dosage adjustment necessary.

Severe impairment:

US labeling: There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied); use with caution.

Canadian labeling: There are no dosage adjustments provided in the manufacturer’s labeling (has not been studied); use is not recommended.

Dosing: Older Adult

Refer to adult dosing.

Adverse Reactions (Significant): Considerations
Neuropsychiatric effects

Neuropsychiatric effects, including confusion, dizziness, drowsiness, and headache, are the most commonly reported adverse reactions with memantine (Ref). Ataxia, impaired consciousness, loss of consciousness, sleep disturbance, falling, and seizures are among other CNS effects that have also been reported (Ref). Agitation, delusion, and hallucination have also occurred (Ref).

Mechanism: Not clearly established; binds with low affinity to the phencyclidine (PCP) site at the N-methyl-D-aspartate (NMDA) receptor. PCP has a high affinity to the NMDA receptor and may cause psychotomimetic effects, such as agitation, delusions, and hallucinations. Patients with a concomitant dopamine/glutamate imbalance may be more susceptible to these effects (Ref).

Risk factors:

• Dose titration may be a risk factor for transient confusion, especially in patients with severe dementia (Ref).

• Lewy body dementia, preexisting hallucinations, or concurrent use of a selective serotonin reuptake inhibitor may be risk factors for developing new-onset or worsening agitation, delusions, and hallucinations (Ref).

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified. Adverse reactions similar in immediate and extended release formulations except as noted.

1% to 10%:

Cardiovascular: Hypertension (4%), hypotension (ER: 2%)

Endocrine & metabolic: Weight gain (ER: 3%)

Gastrointestinal: Abdominal pain (ER: 2%), constipation (3% to 5%), diarrhea (ER: 5%), vomiting (2% to 3%)

Genitourinary: Urinary incontinence (ER: 2%)

Nervous system: Aggressive behavior (ER: 2%) (table 1), anxiety (ER: 4%) (table 2), confusion (IR: 6%) (table 3), depression (ER: 3%) (table 4), dizziness (5% to 7%) (table 5), drowsiness (3%) (table 6), fatigue (IR: 2%) (table 7), hallucination (IR: 3%) (table 8), headache (6%) (table 9), pain (IR: 3%) (table 10)

Memantine: Adverse Reaction: Aggressive Behavior

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

2%

1%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Anxiety

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

4%

3%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Confusion

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

6%

5%

Adults

IR tablets

Dementia

940

922

Memantine: Adverse Reaction: Depression

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

3%

1%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Dizziness

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

7%

5%

Adults

IR tablets

Dementia

940

922

5%

1%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Drowsiness

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

3%

1%

Adults

IR tablets

Dementia

940

922

3%

1%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Fatigue

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

2%

1%

Adults

IR tablets

Dementia

940

922

Memantine: Adverse Reaction: Hallucination

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

3%

2%

Adults

IR tablets

Dementia

940

922

Memantine: Adverse Reaction: Headache

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

6%

3%

Adults

IR tablets

Dementia

940

922

6%

5%

Adults

ER tablets

Moderate to severe dementia of the Alzheimer's type

341

335

Memantine: Adverse Reaction: Pain

Drug (Memantine)

Placebo

Population

Dosage Form

Indication

Number of Patients (Memantine)

Number of Patients (Placebo)

3%

1%

Adults

IR tablets

Dementia

940

922

Neuromuscular & skeletal: Back pain (3%)

Respiratory: Cough (IR: 4%), dyspnea (IR: 2%)

Postmarketing:

Cardiovascular: Bradycardia (Gallini 2008), heart failure (Gallini 2008), prolonged QT interval on ECG (Kajitani 2016), syncope (Curcio 2020)

Dermatologic: Fixed drug eruption (Saito 2017), Stevens-Johnson syndrome

Gastrointestinal: Anorexia (Kose 2023), pancreatitis

Hematologic & oncologic: Agranulocytosis, leukopenia (including neutropenia), pancytopenia, thrombocytopenia, thrombotic thrombocytopenic purpura

Hepatic: Cholestatic hepatitis (Ferrara 2008)

Nervous system: Agitation (Monastero 2007), ataxia (Ferreira 2020), delirium (Kose 2023), delusion (Ridha 2005), falling (Kose 2023), impaired consciousness (Kose 2023), loss of consciousness (Savić 2013), mania (Duan 2018), seizure (Ferreira 2020), sleep disturbance (Isaac 2022), suicidal ideation

Neuromuscular & skeletal: Rhabdomyolysis (Kose 2023)

Ophthalmic: Epithelial keratopathy (Feng 2015)

Renal: Acute kidney injury (Horikawa 2013)

Contraindications

Hypersensitivity to memantine or any component of the formulation

Warnings/Precautions

Concerns related to adverse effects:

• Hypersensitivity: Rare skin hypersensitivity reactions (eg, Stevens-Johnson syndrome) have been reported; advise patients to report skin reactions immediately.

Disease-related concerns:

• Cardiovascular disease: Use with caution in patients with cardiovascular disease; although adverse cardiac events were infrequent in clinical trials, an increased incidence of cardiac failure, bradycardia, and hypertension/hypotension was observed.

• Hepatic impairment: Use with caution in patients with severe hepatic impairment. The Canadian labeling recommends avoiding use in severe impairment due to a lack of data in this population.

• Ophthalmic disease: Worsening of corneal condition has been observed in a clinical trial. Reversible corneal endothelial dysfunction may occur; case report where noted around keratoplasty (Feng 2015).

• Renal impairment: Use with caution in patients with renal impairment; dose adjustments may be required.

• Seizure disorder: Use with caution in patients with a history of seizure disorder; may increase risk of seizures.

Other warnings/precautions:

• Urine pH: Clearance is significantly reduced by alkaline urine; use caution with alkalinizing medications, dietary changes, or patient conditions that may increase urine pH.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule Extended Release 24 Hour, Oral, as hydrochloride:

Namenda XR: 7 mg [DSC], 14 mg, 21 mg, 28 mg

Namenda XR Titration Pack: 7 mg (7s) and 14 mg (7s) and 21 mg (7s) and 28 mg (7s) [DSC]

Generic: 7 mg, 14 mg, 21 mg, 28 mg

Solution, Oral, as hydrochloride:

Generic: 2 mg/mL (240 mL, 360 mL); 10 mg/5 mL (5 mL [DSC])

Tablet, Oral, as hydrochloride:

Namenda: 5 mg [contains fd&c blue #2 (indigotine,indigo carmine), fd&c yellow #6 (sunset yellow)]

Namenda: 10 mg

Namenda Titration Pak: 5 mg (28s) and 10 mg (21s) [contains fd&c blue #2 (indigotine,indigo carmine), fd&c yellow #6 (sunset yellow)]

Generic: 5 mg, 10 mg, 5 mg (28s) and 10 mg (21s)

Generic Equivalent Available: US

Yes

Pricing: US

Capsule ER 24 Hour Therapy Pack (Memantine HCl ER Oral)

7 mg (per each): $15.26 - $15.28

14 mg (per each): $15.26 - $15.28

21 mg (per each): $15.26 - $15.28

28 mg (per each): $15.26 - $15.28

Capsule ER 24 Hour Therapy Pack (Namenda XR Oral)

14 mg (per each): $18.59

21 mg (per each): $18.59

28 mg (per each): $18.59

Solution (Memantine HCl Oral)

2 mg/mL (per mL): $2.05 - $2.67

Tablets (Memantine HCl Oral)

5 mg (per each): $6.04 - $8.00

10 mg (per each): $6.04 - $8.00

28 x 5 MG &21 x 10 MG (per each): $6.10

Tablets (Namenda Oral)

5 mg (per each): $8.90

10 mg (per each): $8.90

Tablets (Namenda Titration Pak Oral)

28 x 5 MG &21 x 10 MG (per each): $8.89

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Tablet, Oral, as hydrochloride:

Ebixa: 10 mg [contains polysorbate 80]

Generic: 5 mg, 10 mg

Administration: Adult

Administer without regard to meals. Extended release capsules may be swallowed whole or entire contents of capsule may be sprinkled on applesauce and swallowed immediately; do not chew, crush, or divide. Withdraw and administer oral solution with provided dosing device; dose should be slowly squirted into the corner of the patient’s mouth. Do not mix oral solution with any other liquid. The Canadian labeling recommends tablets to be swallowed whole with water.

Use: Labeled Indications

Alzheimer disease, moderate to severe: Treatment of moderate to severe dementia of the Alzheimer type.

Use: Off-Label: Adult

Dementia (ie, Parkinson disease dementia, dementia with Lewy bodies, comorbid vascular dementia); Neurocognitive toxicity of whole brain irradiation, prevention

Medication Safety Issues
Sound-alike/look-alike issues:

Memantine may be confused with mesalamine, methadone

Metabolism/Transport Effects

Substrate of OCT2

Drug Interactions

Note: Interacting drugs may not be individually listed below if they are part of a group interaction (eg, individual drugs within “CYP3A4 Inducers [Strong]” are NOT listed). For a complete list of drug interactions by individual drug name and detailed management recommendations, use the Lexicomp drug interactions program by clicking on the “Launch drug interactions program” link above.

Alkalinizing Agents: May increase the serum concentration of Memantine. Risk C: Monitor therapy

Benperidol: Memantine may diminish the therapeutic effect of Benperidol. Risk C: Monitor therapy

Carbonic Anhydrase Inhibitors: May increase the serum concentration of Memantine. Risk C: Monitor therapy

NMDA Receptor Antagonists: May enhance the adverse/toxic effect of Memantine. Risk C: Monitor therapy

Trimethoprim: May enhance the adverse/toxic effect of Memantine. Specifically, the risk of myoclonus and/or delirium may be increased. Trimethoprim may increase the serum concentration of Memantine. Risk C: Monitor therapy

Pregnancy Considerations

Adverse events have been observed in animal reproduction studies.

Breastfeeding Considerations

It is not known if memantine is present in breast milk.

According to the manufacturer, the decision to breastfeed during therapy should consider the risk of infant exposure, the benefits of breastfeeding to the infant, and benefits of treatment to the mother.

Monitoring Parameters

Cognitive function; functional outcomes (eg, Activities of Daily Living [ADLs], Instrumental Activities of Daily Living [IADLs]); periodic ophthalmic exam (Canadian labeling)

Mechanism of Action

Glutamate, the primary excitatory amino acid in the CNS, may contribute to the pathogenesis of Alzheimer's disease (AD) by overstimulating various glutamate receptors leading to excitotoxicity and neuronal cell death. Memantine is an uncompetitive antagonist of the N-methyl-D-aspartate (NMDA) type of glutamate receptors, located ubiquitously throughout the brain. Under normal physiologic conditions, the (unstimulated) NMDA receptor ion channel is blocked by magnesium ions, which are displaced after agonist-induced depolarization. Pathologic or excessive receptor activation, as postulated to occur during AD, prevents magnesium from reentering and blocking the channel pore resulting in a chronically open state and excessive calcium influx. Memantine binds to the intra-pore magnesium site, but with longer dwell time, and thus functions as an effective receptor blocker only under conditions of excessive stimulation; memantine does not affect normal neurotransmission.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Well absorbed

Distribution: 9 to 11 L/kg

Protein binding: 45%

Metabolism: Partially hepatic, primarily independent of the CYP enzyme system; forms 3 metabolites (minimal activity)

Half-life elimination: Terminal: ~60 to 80 hours

Time to peak, serum: Immediate release: 3 to 7 hours; Extended release: 9 to 12 hours

Excretion: Urine (74%; ~48% of the total dose as unchanged drug; undergoes active tubular secretion moderated by pH-dependent tubular reabsorption; excretion reduced by alkaline urine pH)

Pharmacokinetics: Additional Considerations (Adult Data Unless Noted)

Altered kidney function: Mean AUC0-∞ increased by 4%, 60%, and 115% in patients with mild, moderate, and severe renal impairment, respectively. The terminal elimination half-life increased by 18%, 41%, and 95% in patients with mild, moderate, and severe renal impairment, respectively.

Hepatic function impairment: Terminal elimination half-life increased by ~16% in patients with moderate hepatic impairment.

Sex: Women had ~45% greater exposure than men; however, there was no difference in exposure when body weight was taken into account.

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Ebimenta | Ebixa | Zementa;
  • (AR) Argentina: Akatinol | Carrier | Carrier xr | Conexine | Ebixa | Exem | Fentina | Lucidex | Lucidex xr | Memantina richet | Memantina teva | Merital | Neuroplus | Neuroplus xr 7/14/21/28 | Precel | Prilben | Recorine | Tonibral | Tonibral xr;
  • (AT) Austria: Axura | Ebixa | Memantin 1a pharma | Memantin accord | Memantin easypharm | Memantin g.l. | Memantin genericon | Memantin HCS | Memantin ratiopharm | Memantin sandoz | Memantin stada | Memantine merz;
  • (AU) Australia: Apo memantine | Ebixa | Memantine generichealth | Memantine rbx | Memanxa;
  • (BD) Bangladesh: Abixa | Dementa | Memogen | Remtin;
  • (BE) Belgium: Ebixa | Memantine | Memantine abdi | Memantine apotex | Memantine eg | Memantine lek | Memantine sandoz | Memantine Teva;
  • (BG) Bulgaria: Axura | Memantine | Memigmin | Mexia | Nemdatine | Polmatine | Ymana;
  • (BR) Brazil: Alois | Alz | Clomenac | Cloridarto de memantina | Cloridrato de memantina | Desiree | Ebix | Heimer | Kamppi | Maizher | Mealz | Memorall | Vie | Zider;
  • (CH) Switzerland: Axura | Ebixa | Memantin mepha | Memantin sandoz | Memantin zentiva;
  • (CL) Chile: Dantex | Ebixa | Mebral | Memanvitae | Memax | Memikare | Merital | Mimetix | Vivimex;
  • (CN) China: Ebixa | Memantine hydrochloride tablets;
  • (CO) Colombia: Admenta 10 | Airzat | Akatinol | Alzantina | Biogaran | Cordure | Dinive | Ebixa | Esmirtal | Eutebrol | Lucidex | Memantina | Memanvitae | Memdrive | Memorex | Memoxil | Modualz | Normokin | Timantil | Valcox | Vigentia | Zeimer;
  • (CZ) Czech Republic: Akatinol memantine | Cognomem | Ebixa | Mantomed | Marixino | Memantin apotex | Memantin mylan | Memantin sandoz | Memantin stada | Memantin zentiva | Memantine accord | Memantine aurovitas | Memantine Glenmark | Memantine ratiopharm | Memantine vipharm | Memigmin | Memixa | Memolan | Mirvedol | Morysa | Nemdatine | Polmatine | Tormoro;
  • (DE) Germany: Akatinol memantine | Axura | Ebixa | Memando | Memangeneri initial | Memantigamma | Memantin 1a pharma | Memantin Aaa Pharma | Memantin abdi | Memantin abz | Memantin accord | Memantin aristo | Memantin Aurobindo | Memantin basics | Memantin hcl Zentiva | Memantin Heumann | Memantin Hexal | Memantin mylan | Memantin puren | Memantin ratiopharm | Memantin winthrop | Memantine merz | Memantinhydrochlorid al | Memantinhydrochlorid axcount | Memantinhydrochlorid hormosan | Memantinhydrochlorid Macleods | Memantinhydrochlorid neuraxpharm | Memantinhydrochlorid puren | Memantinhydrochlorid stada | Memdub | Memolan | Memutz;
  • (DO) Dominican Republic: Akatinol | Akatinol Memantina | Carrier | Cordure | Demantin | Esmirtal | Eurodementina | Eutebrol | Memantin | Memantina mk | Memanvitae | Mimetix | Neuroplus | Pilsol | Proconex | Rebrain | Tonibral;
  • (EC) Ecuador: Acepter | Admenta | Carrier xr | Cognum | Esmirtal | Eutebrol | Lindex | Lucidex | Memantina | Memantina hcl | Mimetix | Neuroplus;
  • (EE) Estonia: Akatinol memantine | Axura | Cognomem | Mantomed | Marixino | Memantine accord | Memantine grindeks | Memantine ratiopharm | Nemdatine | Xapimant;
  • (EG) Egypt: Alzixa | Alzmenda | Condomania | Delmenda | Dementexa | Ebixa | Lurvntel | Mantine | Memantcare | Memexa | Ravemantine | Zalhinapex;
  • (ES) Spain: Axura | Ebixa | Lonrela | Mantinex | Marixino | Memabix | Memantina accord | Memantina alter | Memantina apotex | Memantina Aristo | Memantina aurobindo | Memantina cinfa | Memantina kern pharma | Memantina mabo | Memantina mylan | Memantina normon | Memantina pensa | Memantina pharma combix | Memantina pharmagenus | Memantina qualigen | Memantina ranbaxy | Memantina ratiopharm | Memantina sandoz | Memantina stada | Memantina tarbis | Memantina tecnigen | Memantina teva | Memantina vir | Memantina zentiva | Nabila | Nemdatine | Protalon | Uxamax;
  • (FI) Finland: Adaxor | Ebixa | Marbodin | Memantin orion | Memantine accord | Memantine lek | Memantine merz | Memantine ratiopharm | Memantine sandoz | Mentixa | Nemdatine;
  • (FR) France: Ebixa | Memantine actavis | Memantine almus | Memantine biogaran | Memantine cristers | Memantine eg | Memantine evolugen | Memantine hcs | Memantine lek | Memantine mylan | Memantine Ohre pharma | Memantine ranbaxy | Memantine sandoz | Memantine Teva | Memantine zentiva | Memantine zydus france;
  • (GB) United Kingdom: Ebixa | Maruxa | Memantine | Memantine accord | Memantine Glenmark | Memantine hydrochloride Zentiva | Memantine sandoz | Nemdatine;
  • (GR) Greece: Cognomem | Ebimem | Ebixa | Mantomed | Marixino | Memantine merz | Memantine mylan | Memantine/ariti | Memantine/sandoz | Memantine/teva | Memasolv | Memini | Mentifar | Mobius | Nemdatine | Zolmemin;
  • (HK) Hong Kong: Albix | Apo memantine | Ebixa | Marixino | Memantine actavis | Memantine sandoz | Pms memantine;
  • (HR) Croatia: Ebixa | Memando | Memantin PharmaS | Memantin Pliva | Ymana;
  • (HU) Hungary: Akatinol memantine | Ebixa | Memantin stada | Memantine orion | Memantine ranbaxy | Memantine vipharm | Mirvedol | Morysa | Nemdatine;
  • (ID) Indonesia: Abixa | Nemdatine | Pertam;
  • (IE) Ireland: Ebixa | Marixino | Maruxa | Memantine | Memantine accord | Memantine clonmel | Memantine Hydrochloride Niche | Memantine hydrochloride pinewood | Memantine lek | Memantine ratiopharm | Nemdatine;
  • (IL) Israel: Ebixa | Memox;
  • (IN) India: Admenta | Almantin | Alzitin | Axura | Demenzil | Ebixa | Larentine | Mentadem | Mentra | Nemdaa;
  • (IS) Iceland: Nemdatine | Zalatine;
  • (IT) Italy: Ebixa | Ezemantis | Marixino | Memantina accord | Memantina aurobindo | Memantina doc generici | Memantina lek | Memantina mylan | Memantina sandoz | Memantina tecnigen | Solemantis;
  • (JO) Jordan: Demax | Ebixa | Gladius | Mirale | Tabixa;
  • (JP) Japan: Memary;
  • (KE) Kenya: Foliant | Stir Up;
  • (KR) Korea, Republic of: Admed | Akatinol | Albix | Almantin | Almix | Altsumetin | Amentin | Bl memantine | Dementine | Dimantine | Diments | Dimenza | Dongkoo memantine hcl | Dongwha memantine | Easymantine | Ebixa | Ebixia | Eisatine | Emantin | Fello | Glivixa | Mabigs | Mamantin | Mamobixa | Mantini | Mavis | Mebix | Memanten | Memanti | Memantia | Memantigen | Memantil | Memantine | Memanto | Memanzen | Memanzin | Memixa | Memoratine | Memotin | Menobixa | Mevitan | Momentine | Neuro K | Neuronal | Newmantine | Pms memantine | Prometine | Romantin | Samantine | Samsung memantine | Unex | Wi memantine | Zenbixa | Zymer;
  • (KW) Kuwait: Ebixa | Tabixa;
  • (LB) Lebanon: Alzema | Ebimenta | Ebixa | Memantine Arrow Lab | Memantine biogaran | Memora | Pms memantine;
  • (LT) Lithuania: Akatinol memantine | Axura | Cognomem | Mantomed | Marixino | Maryzola | Memantine accord | Memantine grindeks | Memantine orion | Memantine ratiopharm | Nemdatine | Polmatine | Xapimant;
  • (LU) Luxembourg: Akatinol | Axura | Ebixa | Memantine eg | Memantine merz | Memantine ratiopharm | Memantine sandoz;
  • (LV) Latvia: Akatinol memantine | Axura | Ebixa | Marixino | Memantine accord | Memantine grindeks | Memantine orion | Memantine ratiopharm | Nemdatine | Polmatine;
  • (MA) Morocco: Almantin | Memantine gt | Phipixa;
  • (MX) Mexico: Acepter | Akatinol | Alzeti | Cediav In | Cediavin | Ebixa | Eutebrol | Ezagun | Keptic | Linybindo | Matinev | Mechanun | Memantina | Menural | Mimetice | Muvixden | Nemet | Perduquan | Sytine | Tejaswi | Ziyol;
  • (MY) Malaysia: Ebixa | Macmenta | Marixino | Mementor | Memxa;
  • (NL) Netherlands: Ebixa | Memantine | Memantine abdi | Memantine accord | Memantine cf | Memantine mylan | Memantine sandoz | Memantine Teva | Nemdatine;
  • (NO) Norway: Ebixa | Memantin accord | Memantine ratiopharm | Nemdatine;
  • (NZ) New Zealand: Ebixa;
  • (PE) Peru: Admenta | Akatinol | Clauss | Depsert | Esmirtal | Eutebrol | Lemix | Mardewel | Meanti | Memantina | Memanvitae | Merital | Mimetix | Talentum;
  • (PH) Philippines: Abixa | Amint | Cognitine | Denigma | Memadem | Memry | Mentra | Xapimant | Zimerz;
  • (PK) Pakistan: Afdol | Akatinol | Alzagon | Alzamantine | Alzentine | Contine | Demantin | Ebixa | Foliant | Mamgit | Mantex | Mantin | Mantine | Memlip | Memril | Namentec | Rement | Rementia | Stir Up | Synaptin | Xantol | Zexa | Zilment;
  • (PL) Poland: Akatinol memantine | Auromemo | Axura | Biomentin | Cognomem | Ebixa | Marbodin | Marixino | Memabix | Memantin NeuroPharma | Memantine accord | Memantine Glenmark | Memantine mylan | Memantine orion | Memantine Teva | Memantine vipharm | Memigmin | Memolek | Merandex | Mirvedol | Morysa | Nemdatine | Nemedan | Polmatine | Tormoro;
  • (PR) Puerto Rico: Memantine HCL | Namenda | Namenda xr;
  • (PT) Portugal: Axura | Ebixa | Memantina alter | Memantina Aluzime | Memantina Aristo | Memantina aurobindo | Memantina aurovitas | Memantina Bluepharma | Memantina ciclum | Memantina Farmoz | Memantina Generis | Memantina Jaba | Memantina krka | Memantina Labesfal | Memantina lek | Memantina mylan | Memantina pentafarma | Memantina pharmacons | Memantina pharmakern | Memantina ratiopharm | Memantina tecnigen | Memantina Tecnilor | Memantina teva | Memantina toLife | Memantina zentiva | Memantine Teva | Nemdatine;
  • (PY) Paraguay: Akatinol | Carrier | Eutebrol | Fulplex | Lucidex | Megavital | Memantil | Memantina promepar | Memax | Memoral | Mimetix;
  • (QA) Qatar: Demax | Ebixa | Gladius | Memoria | Tabixa;
  • (RO) Romania: Cognomen | Ebixa | Mantomed | Marixino | Maruxa | Memantina aurobindo | Memantina torrent | Memantine accord | Xapimant;
  • (RU) Russian Federation: Akatinol memantine | Alzeim | Auranex | Maruxa | Marvedol | Memantal | Memantin | Memantin Kanon | Memantin tl | Memantine | Memantine akrikhin | Memantine avexima | Memantine canon | Memantine richter | Memantine sandoz | Memantine tl | Memantinol | Memicar | Memorel | Noojerone | Noojerone teva | Tingreks | Zemotine;
  • (SA) Saudi Arabia: Apo memantine | Ebixa | Espada | Marlon | Memaxia | Mementa | Tabixa | Zementa;
  • (SE) Sweden: Ebixa | Marbodin | Memantin Ebb | Memantin orion | Memantin stada | Memantine accord | Memantine lek | Memantine merz | Memantine mylan | Memantine ratiopharm | Memantine sandoz | Mentixa | Nemdatine;
  • (SG) Singapore: Ebixa | Marixino | Nemdatine;
  • (SI) Slovenia: Ebixa | Marbodin | Maruxa | Memantin | Memantin accord | Memantine merz | Memantine mylan | Memaxa | Xapimant | Ymana;
  • (SK) Slovakia: Ebixa | Mantomed | Marixino | Memamed | Memantin stada | Memantine accord | Memantine Glenmark | Memantine mylan | Memantine ratiopharm | Memantine vipharm | Memigmin | Memolan | Morysa | Nemdatine | Polmatine | Xapimant;
  • (TH) Thailand: Ebixa | Memxa | Neumantine | Remem;
  • (TN) Tunisia: Appelom | Ebixa | Memixa;
  • (TR) Turkey: Alceba | Almenta | Alzant | Alzer | Alzia | Alzmex | Angetin | Ceramin | Cogito | Demax | Ebitex | Ebixa | Korint | Maxiram | Melanda | Memanzaks | Memorix | Mentax | Mexia | Mexia xr | Xeimer;
  • (TW) Taiwan: Ebixa | Exmem | Manotin | Memary | Witgen;
  • (UA) Ukraine: Abixa | Admenta | Cognimet | Denigma | Mema | Memamed | Memantine Teva | Mematon ic | Membral | Memox | Mexia | Mirvedol | Neurontin | Tingrex;
  • (UY) Uruguay: Akatinol | Eutebrol | Glutamod | Neuroplus | Tonibral;
  • (VE) Venezuela, Bolivarian Republic of: Cognimet | Esmirtal | Eutebrol | Meligen | Memantina | Memantina Bluepharma | Memantine | Mezhitin | Mimetix | Timantil;
  • (ZA) South Africa: Cognimet 10 | Ebitine | Memantine unichem | Meminist | Memor | Noalzh;
  • (ZW) Zimbabwe: Mementor
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