European Heart Journal

Michal Cohen-Shelly, Zachi I Attia, Paul A Friedman, Saki Ito, Benjamin A Essayagh, Wei-Yin Ko, Dennis H Murphree, Hector I Michelena, Maurice Enriquez-Sarano, Rickey E Carter, Patrick W Johnson, Peter A Noseworthy, Francisco Lopez-Jimenez, Jae K Oh

doi : 10.1093/eurheartj/ehab153

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2885–2896

Early detection of aortic stenosis (AS) is becoming increasingly important with a better outcome after aortic valve replacement in asymptomatic severe AS patients and a poor outcome in moderate AS. We aimed to develop artificial intelligence-enabled electrocardiogram (AI-ECG) using a convolutional neural network to identify patients with moderate to severe AS.

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Artificial intelligence using electrocardiography: strengths and pitfalls

Joon-myoung Kwon, Yong-Yeon Jo, Soo Youn Lee, Kyung-Hee Kim

doi : 10.1093/eurheartj/ehab090

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2896–2898

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Oral fluoroquinolones and risk of aortic or mitral regurgitation: a nationwide nested case-control study

Jarl Emanuel Strange, Anders Holt, Paul Blanche, Gunnar Gislason, Christian- Torp-Pedersen, Daniel M?lager Christensen, Morten Lock Hansen, Morten Lamberts, Morten Schou, Jonas Bjerring Olesen, Emil Loldrup Fosb?l, Lars K?ber, Peter Vibe Rasmussen

doi : 10.1093/eurheartj/ehab374

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2899–2908

Reports have suggested an increased risk of aortic and mitral regurgitation associated with oral fluoroquinolones (FQs) resulting in a safety warning published by the European Medicines Agency (EMA). However, these findings have not yet been replicated.

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Fluoroquinolone use and valvular heart disease: is the jury still out?

Juan Tamargo, Stefan Agewall

doi : 10.1093/eurheartj/ehab426

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2909–2911

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Eight-year outcomes for patients with aortic valve stenosis at low surgical risk randomized to transcatheter vs. surgical aortic valve replacement

Troels H?jsgaard J?rgensen, Hans Gustav H?rsted Thyregod, Nikolaj Ihlemann, Henrik Nissen, Petur Petursson, Bo Juel Kjeldsen, Daniel Andreas Steinbrüchel, Peter Skov Olsen, Lars S?ndergaard

doi : 10.1093/eurheartj/ehab375

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2912–2919

The aims of the study were to compare clinical outcomes and valve durability after 8 years of follow-up in patients with symptomatic severe aortic valve stenosis at low surgical risk treated with either transcatheter aortic valve implantation (TAVI) or surgical aortic valve replacement (SAVR).

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Transcatheter aortic valve implantation or replacement? Valve durability in the context of patient life expectancy

Shakirat O Oyetunji, Catherine M Otto

doi : 10.1093/eurheartj/ehab393

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2920–2923

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HIV infection is associated with thoracic and abdominal aortic aneurysms: a prospective matched cohort study

Julie H?gh, Michael Huy Cuong Pham, Andreas Dehlb?k Knudsen, Rebekka Faber Thudium, Marco Gelpi, Per Ejlstrup Sigvardsen, Andreas Fuchs, , J?rgen Tobias Kühl, Shoaib Afzal, B?rge Gr?nne Nordestgaard, Thomas Benfield, Lars K?ber, Jan Gerstoft, Klaus Fuglsang Kofoed, Susanne Dam Nielsen

doi : 10.1093/eurheartj/ehab348

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2924–2931

Little is known about the prevalence of aortic aneurysms among people living with HIV (PLWH). We investigated whether HIV status is independently associated with having aortic aneurysms. Furthermore, we determined risk factors associated with aortic aneurysms in PLWH.

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HIV infection and aortic aneurysms: a similar story but in a new vascular bed

Priscilla Y Hsue

doi : 10.1093/eurheartj/ehab429

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2932–2934

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DUSP26 induces aortic valve calcification by antagonizing MDM2-mediated ubiquitination of DPP4 in human valvular interstitial cells

Yongjun Wang, Dong Han, Tingwen Zhou, Cheng Chen, Hong Cao, Joe Z Zhang, Ning Ma, Chun Liu, Moshi Song, Jiawei Shi, Xin Jin, Feng Cao, Nianguo Dong

doi : 10.1093/eurheartj/ehab316

European Heart Journal, Volume 42, Issue 30, 7 August 2021, Pages 2935–2951

The morbidity and mortality rates of calcific aortic valve disease (CAVD) remain high while treatment options are limited. Here, we evaluated the role and therapeutic value of dual-specificity phosphatase 26 (DUSP26) in CAVD.

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