European Heart Journal

Theresa A McDonagh, Marco Metra, Marianna Adamo, Roy S Gardner, Andreas Baumbach, Michael B?hm, Haran Burri, Javed Butler, Jelena ?elutkien?, Ovidiu Chioncel, John G F Cleland, Andrew J S Coats, Maria G Crespo-Leiro, Dimitrios Farmakis, Martine Gilard, Stephane Heymans, Arno W Hoes, Tiny Jaarsma, Ewa A Jankowska, Mitja Lainscak, Carolyn S P Lam, Alexander R Lyon, John J V McMurray, Alexandre Mebazaa, Richard Mindham, Claudio Muneretto, Massimo Francesco Piepoli, Susanna Price, Giuseppe M C Rosano, Frank Ruschitzka, Anne Kathrine Skibelund, ESC Scientific Document Group

doi : 10.1093/eurheartj/ehab368

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3599–3726

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Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF

James P Curtain, Kieran F Docherty, Pardeep S Jhund, Mark C Petrie, Silvio E Inzucchi, Lars K?ber, Mikhail N Kosiborod, Felipe A Martinez, Piotr Ponikowski, Marc S Sabatine, Olof Bengtsson, Anna Maria Langkilde, Mikaela Sj?strand, Scott D Solomon, John J V McMurray

doi : 10.1093/eurheartj/ehab560

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3727–3738

The aim of this study was to examine the effect of dapagliflozin on the incidence of ventricular arrhythmias and sudden death in patients with heart failure and reduced ejection fraction (HFrEF).

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Decoding the effects of SGLT2 inhibitors on cardiac arrhythmias in heart failure

Peter E Light

doi : 10.1093/eurheartj/ehab563

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3739–3740

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Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction

Alice M Jackson, Pardeep S Jhund, Inder S Anand, Hans-Dirk Düngen, Carolyn S P Lam, Marty P Lefkowitz, Gerard Linssen, Lars H Lund, Aldo P Maggioni, Marc A Pfeffer, Jean L Rouleau, Jose F K Saraiva, Michele Senni, Orly Vardeny, Magnus O Wijkman, Mehmet B Yilmaz, Yoshihiko Saito, Michael R Zile, Scott D Solomon, John J V McMurray

doi : 10.1093/eurheartj/ehab499

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3741–3752

Patients with heart failure and preserved ejection fraction (HFpEF) frequently have difficult-to-control hypertension. We examined the effect of neprilysin inhibition on ‘apparent resistant hypertension’ in patients with HFpEF in the PARAGON-HF trial, which compared the effect of sacubitril–valsartan with valsartan.

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Sacubitril/valsartan for heart failure with preserved ejection fraction and resistant hypertension: one shot for a double strike?

Massimo Volpe, Giovanna Gallo

doi : 10.1093/eurheartj/ehab489

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3753–3755

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Early invasive coronary angiography and acute ischaemic heart failure outcomes

Leah B Kosyakovsky, Peter C Austin, Heather J Ross, Xuesong Wang, Husam Abdel-Qadir, Shaun G Goodman, Michael E Farkouh, Ruth Croxford, Patrick R Lawler, John A Spertus, Douglas S Lee

doi : 10.1093/eurheartj/ehab423

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3756–3766

While myocardial ischaemia plays a major role in the pathogenesis of heart failure (HF), the indications for coronary angiography during acute HF are not established. We determined the association of early coronary angiography during acute HF hospitalization with 2-year mortality, cardiovascular death, HF readmissions, and coronary revascularization.

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Does early angiography pave the way for improved outcomes in patients with acute heart failure?

Mehmet Birhan Yilmaz

doi : 10.1093/eurheartj/ehab513

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3767–3769

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Neuraminidase 1 is a driver of experimental cardiac hypertrophy

Qian-Qian Chen, Gaoxiang Ma, Jin-Feng Liu, Yuan-Yuan Cai, Jun-Yuan Zhang, Ting-Ting Wei, An Pan, Shujun Jiang, Yibei Xiao, Pingxi Xiao, Jiangping Song, Ping Li, Lei Zhang, Lian-Wen Qi

doi : 10.1093/eurheartj/ehab347

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3770–3782

Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants of cardiac hypertrophy that culminate in heart failure. Neuraminidases are a family of enzymes that catalyze the cleavage of terminal sialic acids from glycoproteins or glycolipids. This study sought to characterize the role of neuraminidases in pathological cardiac hypertrophy and identify pharmacological inhibitors targeting mammalian neuraminidases.

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Drug repurposing to prevent pressure overload-induced cardiac hypertrophy and heart failure

Simon Tual-Chalot, Konstantinos Stellos

doi : 10.1093/eurheartj/ehab427

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3783–3785

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3? untranslated region of Ckip-1 inhibits cardiac hypertrophy independently of its cognate protein

Yinlong Zhao, Shukuan Ling, Jianwei Li, Guohui Zhong, Ruikai Du, Youyou Li, Yanqing Wang, Caizhi Liu, Xiaoyan Jin, Wei Liu, Tong Liu, Yuheng Li, Dingsheng Zhao, Weijia Sun, Zizhong Liu, Zifan Liu, Junjie Pan, Xinxin Yuan, Xingcheng Gao, Wenjuan Xing, Yan-Zhong Chang, Yingxian Li

doi : 10.1093/eurheartj/ehab503

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3786–3799

3? untranslated region (3? UTR) of mRNA is more conserved than other non-coding sequences in vertebrate genomes, and its sequence space has substantially expanded during the evolution of higher organisms, which substantiates their significance in biological regulation. However, the independent role of 3? UTR in cardiovascular disease was largely unknown.

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A ‘decoy’ function of the 3'-untranslated region adds a new dimension to gene regulation in cardiac disease

Riccardo Bernasconi, Gabriela M Kuster

doi : 10.1093/eurheartj/ehab515

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Pages 3800–3802

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Cardiac amyloidosis secondary to multiple myeloma: successful sequential cardiac and autologous stem cell transplantations with excellent outcome

Jaros?aw Bili?ski, El?bieta Katarzyna Biernacka, Andrzej Januszewicz

doi : 10.1093/eurheartj/ehab386

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Page 3803

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Microvascular thrombi in recurrent myocardial injury after coronavirus disease 2019 infection

Tadao Aikawa, Jiro Ogino, Aina Hirofuji, Noriko Oyama-Manabe

doi : 10.1093/eurheartj/ehab539

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Page 3804

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‘Strange quadruple rhythm’: listen to the writing on the heart wall

Makiko Suto, Kensuke Matsumoto, Ken-Ichi Hirata

doi : 10.1093/eurheartj/ehab149

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Page 3805

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Corrigendum to: The World Stroke Organization Brain & Heart Task Force: collaborations between stroke physicians and cardiologists

doi : 10.1093/eurheartj/ehab278

European Heart Journal, Volume 42, Issue 36, 21 September 2021, Page 3802

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