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Safety and Effectiveness of the SVELTE Fixed-Wire and Rapid Exchange Bioresorbable-Polymer Sirolimus-Eluting Coronary Stent Systems for the Treatment of Atherosclerotic Lesions: Results of the OPTIMIZE Randomized Study
Kereiakes, Dean J. MD; Feldman, Robert L. MD; Ijsselmuiden, A.J.J. MD, PhD; Saito, Shigeru MD; Amoroso, Giovanni MD, PhD; Zidar, James P. MD; Wong, S. Chiu MD; Stella, Pieter MD, PhD; Yakubov, Steven MD; Lasala, John MD, PhD; Cohen, David J. MD, MSc; Doros, Gheorghe PhD; Cutlip, Donald E. MD; Rao, Sunil V. MD
doi : 10.1161/CIRCINTERVENTIONS.121.010609
Volume 14(9), September 2021, p e010609
The SVELTE fixed-wire and rapid exchange bioresorbable-polymer sirolimus-eluting coronary stent systems (SVELTE sirolimus-eluting stent [SES]) are novel, low-profile devices designed to facilitate direct stenting, transradial access, and enhance procedural efficiencies.
Sex-Related Differences in the Prevalence and Prognostic Value of the Academic Research Consortium for High Bleeding Risk Criteria
Nardin, Matteo MD,,,*; Cao, Davide MD,*; Mehran, Roxana MD; Chandiramani, Rishi MD; Chiarito, Mauro MD; Sartori, Samantha PhD; Qiu, Hanbo PhD; Zhang, Zhongjie MPH; Golani, Ekta MD; Nicolas, Johny MD; Baber, Usman MD, MS; Dangas, George MD, PhD; De Luca, Giuseppe MD, PhD; Stefanini, Giulio G. MD, PhD; Sweeny, Joseph MD; Sharma, Samin K. MD; Kini, Annapoorna MD
doi : 10.1161/CIRCINTERVENTIONS.120.010392
Volume 14(9), September 2021, p e010392
Bleeding events after percutaneous coronary intervention are associated with substantial morbidity and mortality. Female patients undergoing percutaneous coronary intervention are often older and present with a higher burden of comorbidities, which in turn increases their risk of adverse events, including bleeding complications. The Academic Research Consortium (ARC) have proposed a list of clinical criteria to define high bleeding risk (HBR). Our aim was to evaluate the prevalence and predictive value of the ARC-HBR criteria according to sex in a contemporary cohort of patients undergoing percutaneous coronary intervention.
Sex-Related Differences in the Bleeding Trade-Off for Patients Undergoing Percutaneous Coronary Intervention
Sutton, Nadia R. MD, MPH; Hughes, Erinn K. MD
doi : 10.1161/CIRCINTERVENTIONS.121.011299
Volume 14(9), September 2021, p e011299
Long-Term Outcomes Following Drug-Eluting Balloons Versus Thin-Strut Drug-Eluting Stents for Treatment of In-Stent Restenosis (DEB-Dragon-Registry)
Wanha, Wojciech MD, PhD; Bil, Jacek MD, PhD; Januszek, Rafal MD, PhD; Gilis-Malinowska, Natasza MD; Figatowski, Tomasz MD; Milewski, Marek MD; Pawlik, Artur MD; Staszczak, Bartlomiej MD; Wybraniec, Maciej MD, PhD; Tomasiewicz, Brunon MD; Kubler, Piotr MD, PhD; Kuliczkowski, Wiktor MD, PhD; Walczak, Tomasz MD; Hrymniak, Bruno MD; Desperak, Piotr MD; Mielczarek, Maksymilian MD; Ciecwierz, Dariusz MD; Niezgoda, Piotr MD; Wolny, Rafal MD; Chudzik, Magdalena MD; Kuzma, Lukasz MD; Kralisz, Pawel MD; Kedhi, Elvin MD; D'Ascenzo, Fabrizio MD; Hudziak, Damian MD; Kowalowka, Adam MD; Smolka, Grzegorz MD, PhD; Reczuch, Krzysztof MD, PhD; Gruchala, Marcin MD, PhD; Kubica, Jacek MD, PhD; Gil, Robert J. MD, PhD; Dobrzycki, Slawomir MD, PhD; Dudek, Dariusz MD, PhD; Bartus, Stanislaw MD, PhD; Gasior, Mariusz MD, PhD; Ochala, Andrzej MD, PhD; Witkowski, Adam MD, PhD; Jaguszewski, Milosz MD, PhD; Wojakowski, Wojciech MD, PhD
doi : 10.1161/CIRCINTERVENTIONS.121.010868
Volume 14(9), September 2021, p e010868
Data regarding the use of percutaneous coronary intervention with drug-eluting balloons (DEB) versus thin-strut drug-eluting stents (thin-DES) for treating DES in-stent restenosis in everyday clinical practice is scarce. Our goal was to evaluate the efficacy and safety profile of DEB versus thin-DES in DES in-stent restenosis.
Burden of In-Stent Restenosis: Shall We Overcome?
Esposito, Giuseppe MD; Barbato, Emanuele MD, PhD; Bartunek, Jozef MD, PhD
doi : 10.1161/CIRCINTERVENTIONS.121.011292
Volume 14(9), September 2021, p e011292
Long-Term Results up to 12 Months After Catheter-Based Alcohol-Mediated Renal Denervation for Treatment of Resistant Hypertension
Mahfoud, Felix MD; Sievert, Horst MD; Bertog, Stefan MD; Lauder, Lucas MD; Ewen, Sebastian MD; Lengele, Jean-Philippe MD; Wojakowski, Wojciech MD; Schmieder, Roland MD; van der Giet, Markus MD; Weber, Michael A. MD; Kandzari, David E. MD; Parise, Helen ScD; Fischell, Tim A. MD; Pathak, Atul MD; Persu, Alexandre MD
doi : 10.1161/CIRCINTERVENTIONS.120.010075
Volume 14(9), September 2021, p e010075
Primary results of this prospective, open-label, multicenter trial suggested that alcohol-mediated renal denervation with perivascular injection of dehydrated alcohol using the Peregrine System Infusion Catheter safely reduces blood pressure (BP) in patients with resistant hypertension. To date, maintenance of the BP-lowering effect beyond 6 months using this novel technology has not been reported. This article describes the final, 12-month follow-up data on the safety and efficacy of alcohol-mediated renal denervation in these patients.
Catheter-Based Alcohol-Mediated Renal Denervation for Treating Resistant Hypertension: Is the Peregrine Predator or Prey?
Flood, Shane P. MB, BCh, BAO; Aronow, Herbert D. MD, MPH
doi : 10.1161/CIRCINTERVENTIONS.121.011293
Volume 14(9), September 2021, p e011293
Initial Experience With the PASCAL Ace Implant System for Treatment of Severe Tricuspid Regurgitation
Aurich, Matthias MD,*; Volz, Martin J. MD,*; Mereles, Derliz MD; Geis, Nicolas A. MD; Frey, Norbert MD; Konstandin, Mathias H. MD,,*; Raake, Philip W. MD,,*
doi : 10.1161/CIRCINTERVENTIONS.121.010770
Volume 14(9), September 2021, p e010770
Percutaneous tricuspid valve leaflet repair is an emerging treatment option for severe tricuspid regurgitation (TR). Recent studies demonstrated the usefulness and feasibility of the lately introduced TriClip and PASCAL Transcatheter Valve Repair System. However, initial experiences regarding safety and efficacy of the novel transcatheter PASCAL Ace implant system have not yet been reported.
Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair
Rieth, Andreas J. MD,,*; Kriechbaum, Steffen D. MD,,*; Richter, Manuel J. MD; Wenninger, Elena MD; Fischer-Rasokat, Ulrich MD; Tello, Khodr MD; Gall, Henning MD; Ghofrani, Hossein A. MD; Guth, Stefan MD; Wiedenroth, Christoph B. MD; Mitrovic, Veselin MD; Hamm, Christian W. MD; Liebetrau, Christoph MD; Walther, Claudia MD
doi : 10.1161/CIRCINTERVENTIONS.120.010453
Volume 14(9), September 2021, p e010453
Percutaneous mitral valve repair (PMVR) in high-risk patients is currently controversial, especially in those with secondary mitral regurgitation (MR). Exercise pulmonary hemodynamics may help to unmask cardiac dysfunction as well as the dynamic impact of MR. The present study sought to explore the clinical impact of preprocedural exercise right heart catheterization (RHC) for the selection of patients who could most benefit from PMVR.
Real-World Experience With the SAPIEN 3 Ultra Transcatheter Heart Valve: A Propensity-Matched Analysis From the United States
Nazif, Tamim M. MD; Cahill, Thomas J. MBBS, DPhil; Daniels, David MD; McCabe, James M. MD; Reisman, Mark MD; Chakravarty, Tarun MD; Makkar, Raj MD; Krishnaswamy, Amar MD; Kapadia, Samir MD; Chehab, Bassem M. MD; Wang, John MD; Spies, Christian MD; Rodriguez, Evelio MD; Kaneko, Tsuyoshi MD; Hahn, Rebecca T. MD; Leon, Martin B. MD; George, Isaac MD
doi : 10.1161/CIRCINTERVENTIONS.121.010543
Volume 14(9), September 2021, p e010543
Paravalvular regurgitation (PVR) after transcatheter aortic valve replacement is associated with adverse clinical outcomes. The SAPIEN 3 Ultra (Ultra) is a new generation balloon-expandable transcatheter heart valve with a modified external skirt that is designed to reduce PVR, but reports of clinical and echocardiographic outcomes are limited. The aim of this study was to compare short-term outcomes of patients undergoing transcatheter aortic valve replacement with the Ultra and the original SAPIEN 3 (S3) transcatheter heart valve in a large national registry.
Horizontal Aorta in Transcatheter Self-Expanding Valves: Insights From the HORSE International Multicentre Registry
Gallo, Francesco MD; Gallone, Guglielmo MD; Kim, Won-Keun MD; Reifart, Jorg MD; Veulemans, Verena MD; Zeus, Tobias MD; Toggweiler, Stefan MD; De Backer, Ole MD; Sondergaard, Lars MD; Mangieri, Antonio MD; Khokhar, Arif BM BCh; De Marco, Federico MD; Regazzoli, Damiano MD; Reimers, Bernhard MD; Muntane-Carol, Guillem MD; Estevez-Loureiro, Rodrigo MD; Espino, Antonio MD; Moscarelli, Marco MD; Armario, Xavier MD; Mylotte, Darren MD; Gorla, Riccardo MD; Bhadra, Oliver Daniel MD; Conradi, Lenard MD; Marroquin Donday, Luis Alfonso MD; Nombela-Franco, Luis MD; Barbanti, Marco MD; Reddavid, Claudia MD; Criscione, Enrico MD; Brugaletta, Salvatore MD; Regueiro, Ander MD; Perez-Fuentes, Pedro MD; Nicolini, Elisa MD; Piva, Tommaso MD; Tzanis, Giorgos MD; Rodes-Cabau, Josep MD; Colombo, Antonio MD; Giannini, Francesco MD
doi : 10.1161/CIRCINTERVENTIONS.121.010641
Volume 14(9), September 2021, p e010641
An increased degree of aortic angulation (AA) represents a challenging feature for bioprosthesis positioning. Whether AA has an impact on procedural outcomes of contemporary self-expanding valves remains unsettled. The aim of this study was to evaluate the impact of AA on procedural outcomes of transcatheter aortic valve replacement with contemporary self-expanding valves.
Transcatheter Mitral Valve Implantation: Current Status and Future Perspectives
Russo, Giulio MD, PhD; Gennari, Marco MD; Gavazzoni, Mara MD; Pedicino, Daniela MD, PhD, MSc; Pozzoli, Alberto MD; Taramasso, Maurizio MD, PhD; Maisano, Francesco MD
doi : 10.1161/CIRCINTERVENTIONS.121.010628
Volume 14(9), September 2021, p e010628
Mitral transcatheter therapies represent the treatment of choice for all patients deemed unsuitable for cardiac surgery. So far, the largest clinical experience has been limited to percutaneous repair techniques. However, given the complexity and heterogeneity of mitral valve anatomy and pathology, transcatheter mitral valve implantation will widen the mitral valve therapies horizon, toward a patient-tailored approach. Current data about transcatheter mitral valve implantation is still limited and, although some data are promising, there are still some issues to be addressed. This review provides a comprehensive insight into the available devices and describes potential advantages and limitations of transcatheter mitral valve implantation.
Effect of Percutaneous Left Ventricular Unloading on Coronary Flow and Cardiac Coronary Coupling in Patients Undergoing High-Risk Percutaneous Coronary Intervention
Briceno, Natalia MDRes; Ryan, Matthew MBChB; O'Gallagher, Kevin MBBS; Patterson, Tiffany PhD; Rivolo, Simone PhD; Lee, Jack DPhil; O'Kane, Peter MD; Redwood, Simon R. MD; Shah, Ajay M. MD; Perera, Divaka MD
doi : 10.1161/CIRCINTERVENTIONS.120.010454
Volume 14(9), September 2021, p e010454
Evaluation of Cerebral Thromboembolism After Transcatheter Aortic Valve Replacement (EARTH TAVR): A Serial Magnetic Resonance Imaging Evaluation as Substudy of the GALILEO Trial
Frohlich, Georg Marcus MD; Endres, Matthias MD; Falk, Volkmar MD; Steinbeck, Lisa MD; Erbay, Aslihan MD; Stangl, Verena MD; Wohrle, Jochen MD; Rudolph, Tanja K. MD; Geisler, Tobias MD; Dreger, Henryk MD; Leistner, David Manuel MD; Nolte, Christian H. MD; Unbehaun, Axel MD; Linke, Axel MD; Fiebach, Jochen B. MD; Majoie, Charles MD; PhD; Knapp, Guido MSc; Georg Haeusler, Karl MD; Mehran, Roxana MD; Windecker, Stephan MD; Dangas, George D. MD, PhD; Landmesser, Ulf MD
doi : 10.1161/CIRCINTERVENTIONS.121.011074
Volume 14(9), September 2021, p e011074
Letter by Moroni et al Regarding Article, "Feasibility and Safety of High-Risk Percutaneous Coronary Intervention Without Mechanical Circulatory Support"
Moroni, Francesco MD; Kaki, Amir MD; Azzalini, Lorenzo MD, PhD, MSc
doi : 10.1161/CIRCINTERVENTIONS.121.011244
Volume 14(9), September 2021, p e011244
Response by Khalid et al to Letter Regarding Article, "Feasibility and Safety of High-Risk Percutaneous Coronary Intervention Without Mechanical Circulatory Support"
Khalid, Nauman MD; Rogers, Toby MD, PhD; Waksman, Ron MD
doi : 10.1161/CIRCINTERVENTIONS.121.011275
Volume 14(9), September 2021, p e011275
