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JCD Editorial September 2021
Michael H. Gold MD
doi : 10.1111/jocd.14366
Volume 20, Issue 9 p. 2683-2683
Hyaluronic acid soft tissue filler delayed inflammatory reaction following COVID-19 vaccination – A case report
Alain Michon MD
doi : 10.1111/jocd.14312
Volume 20, Issue 9 p. 2684-2690
The use of hyaluronic acid soft tissue fillers in aesthetic medicine exploded in recent years for many reasons, including being relatively safe. Incidence of delayed inflammatory reactions (DIRs) to hyaluronic acid soft tissue fillers range between 0.3% and 4.25%. These reactions are mediated by T-lymphocytes and can be triggered by flu-like illnesses, including SARS-CoV-2 infection. Vaccination may also induce hypersensitivity.
Evaluation of the evidence level for the use of radiofrequency in aesthetic treatments: A systematic review and meta-analysis
André Oliveira Paggiaro MD, PhD,Rafael Pinheiro MD,Kaolanna Soares,Viviane Fernandes Carvalho PhD,Rolf Gemperli MD,
doi : 10.1111/jocd.14353
Volume 20, Issue 9 p. 2691-2702
Radiofrequency (RF) is a non-invasive or minimally invasive procedure with a low risk of complications. It has been employed for several aesthetic purposes.
Cannabinoids for skin diseases and hair regrowth
Aditya K. Gupta MD, PhD,Mesbah Talukder PhD,
doi : 10.1111/jocd.14352
Volume 20, Issue 9 p. 2703-2711
The use of cannabis for skin diseases and hair regrowth is at the preliminary stage.
History of autologous platelet-rich plasma: A short review
Patrycja Mo?cicka MSc,Andrzej Przylipiak MD,
doi : 10.1111/jocd.14326
Volume 20, Issue 9 p. 2712-2714
Platelet-rich plasma (PRP) is a medical material with numerous applications. It produces particularly spectacular effects when applied in cosmetic dermatology.
Association between rosacea and cardiovascular disease: A systematic review and meta-analysis
Jiawen Zhang MD,Yang Yan MD,Peiyu Jiang MD,Zijing Liu MD,Yunyi Liu MD,Yixuan Liu MD,Xiaoyan Wang MD,Min Li MD,Yang Xu PhD,
doi : 10.1111/jocd.13884
Volume 20, Issue 9 p. 2715-2722
Rosacea and cardiovascular diseases (CVD) are chronic inflammatory disorders. While CVD is the leading cause of mortality globally, increasing evidence indicates that CVD prevalence could be higher among patients with rosacea.
Aesthetic and therapeutic outcome of fat grafting for localized Scleroderma treatment: From basic study to clinical application
Hayson Chenyu Wang,Ruijia Dong,Xiao Long,Xiaojun Wang,
doi : 10.1111/jocd.13941
Volume 20, Issue 9 p. 2723-2728
Localized scleroderma (LoS) is a rare autoimmune disease characterized by skin fibrosis and subcutaneous tissue atrophy, resulting in aesthetic impairment on patients. Fat grafting has been used to treat LoS patients, achieving aesthetic and therapeutic improvement.
Update on management of keloid and hypertrophic scars: A systemic review
Mohamed L. Elsaie MD
doi : 10.1111/jocd.14310
Volume 20, Issue 9 p. 2729-2738
Numerous therapeutic strategies have been described for prevention and reduction of hypertrophic scars and keloids, but none of the treatments is effective in all patients. No universal consensus in treatment regimen has been established, and there is limited evidence-based literature to guide the correct management. The process of scar development is complex and requires deeper understanding of the molecular mechanisms that cause their development and recurrences. Despite many available modes of targeting keloid and hypertrophic scars, yet they remain an ongoing challenge to patients and clinicians. To date, no one therapy has been universally accepted as the gold standard for the treatment of all excessive scars nor has the capability of complete scar resolution The search of literature included peer-reviewed articles including clinical trials and scientific reviews. Literature was identified from electronic databases (MEDLINE/PubMed) through May 2021 and references of respective articles and only the articles published in English language were included.
Scar tissue I wish you saw: Patient expectations regarding scar treatment
Tamar Gomolin BS,Abigail Cline PhD, MD,David Ginsberg MD,Bijan Safai MD,
doi : 10.1111/jocd.13945
Volume 20, Issue 9 p. 2739-2742
Although many invasive and noninvasive approaches exist, management of keloids and hypertrophic scars remains challenging. By better understanding patient expectations regarding scar treatments, dermatologists can provide higher quality and more satisfying care. Survey patients age 18 to 80 years with a history of hypertrophic, keloid, or disfiguring scars. Overall, 187 participants completed the 25-question survey. Expectations and willingness were measured on a 1-5 Likert scale. Results were analyzed overall and by patient demographics. Older respondents more often expected scar reduction, while younger patients expected scar removal. Compared with Caucasians, Asian respondents were more symptomatic, more likely to have seen a physician, and more willing to undergo invasive therapies. Respondent willingness for treatment and their perceived efficacy significantly differed across gender, age, and race. This study explores a gap in the literature of what role patient expectations play in electing specific treatments. Although patient expectations are complex and context dependent, gaining more understanding of what therapies patients are willing to attempt, and their expectations from those therapies could help guide counseling with the goal setting realistic expectations to improve patient compliance and satisfaction.
Efficacy study of the new polycaprolactone thread compared with other commercialized threads in a murine model
Seung Woo Cho MD,Byung Ho Shin PhD,Chan Yeong Heo MD, PhD,Jung Hee Shim PhD,
doi : 10.1111/jocd.13883
Volume 20, Issue 9 p. 2743-2749
Polydioxanone (PDO) threads, poly-L-lactic acid (PLLA) threads, and polycaprolactone (PCL) threads have been used for lifting and antiaging purposes. The new PCL threads that have less residual monomer compared to the previous PCL are developed.
Xanthelasma palpebrarum after hyaluronic acid injection in the lower eyelid: A case report and review of the literature
Vivian Simões Pires MD,Isabella Osorio Wender MS,Manoella Freitas Santos MD,Gabriela Lorentz Sartori MD,Analú Vivian MD,Gabriela Dallagnese MD,
doi : 10.1111/jocd.13930
Volume 20, Issue 9 p. 2750-2752
Hyaluronic acid filler treatments are a very popular nonsurgical procedure worldwide, most wanted to create a more attractive profile and correct facial aging. Since its usage has expanded, more complications have been seen.
Use of allograft dermal matrix for repairing large oral epithelial defects: Outcomes of patients with lingual and buccal leukoplakia
Bin Zhou DDS, PhD,Kai-fang Yuan DDS,Wei-liang Chen DDS, MD, MBA,
doi : 10.1111/jocd.13973
Volume 20, Issue 9 p. 2753-2757
The best treatment approach for wide oral leukoplakia (OL) remains to be determined.
Upper eyelid blepharoplasty using plasma exeresis: Evaluation of outcomes, satisfaction, and symptoms after procedure
Flávio Calice Ferreira MD,Célia Simões Cardoso de Oliveira Sathler MD,Ilana Yamakami Hida MD,Suzana Crispin Leite MD,Alessandra Akemi Kusabara MD,Ana Clara Vieira de Castro MD,Mariana Zaíra Moraes Lima Ribeiro MD,Tatiana Rizkallah Nahas MD
doi : 10.1111/jocd.13868
Volume 20, Issue 9 p. 2758-2764
Facial care treatments have grown a remarkable demand for effective and minimally invasive techniques with fast recovery time. Plasma technology is a nonsurgical alternative technique for skin rejuvenation.
A clinical evaluation of noninvasive and contactless radiofrequency technique in the treatment of abdominal fat
Jie Qin MD,Meng-er Guo MM,Xue-gang Xu MD,Chao Zhang MD,Cheng-qian Yu MM,Yuan-hong Li MD,Hong-duo Chen MD,
doi : 10.1111/jocd.13892
Volume 20, Issue 9 p. 2765-2768
There is an increasing demand for fat reduction and body contouring procedures. Noninvasive radiofrequency devices have been used to tighten skin and treat cellulite, but there are few studies confirming their efficacy for abdominal fat reduction.
Comparison of microfocused ultrasound with visualization for skin laxity among vegan and omnivore patients
Marta Fusano MD,Michela Gianna Galimberti MD,Matelda Bencini MD,Isabella Fusano Dr.,Pier Luca Bencini MD,
doi : 10.1111/jocd.13961
Volume 20, Issue 9 p. 2769-2774
The aging of facial structures depends on genetic, anatomic, chronologic, and environmental factors that affect the skin and underlying tissues. Microfocused ultrasound with visualization (MFU-V) has emerged as a safe and effective treatment for skin laxity. As the nutritional status may contribute to skin aging, it would be interesting to evaluate whether different dietary patterns can also influence the response to MFU-V treatment for skin laxity.
Intense pulsed light versus cryotherapy in the treatment of hypertrophic scars: A clinical and histopathological study
Samar A.M. Salem MD,Sharief M. Abdel Hameed MS,Azza E. Mostafa MD,
doi : 10.1111/jocd.13971
Volume 20, Issue 9 p. 2775-2784
Different therapeutic modalities have been tried for hypertrophic scar treatment. To our knowledge, intense pulsed light (IPL) has not been previously evaluated in comparison with cryotherapy as a stand-alone treatment for hypertrophic scars.
Comparison between the use of intense pulsed light and Q-switched neodymium-doped yttrium aluminum garnet laser for the treatment of axillary hyperpigmentation
Watinee Amornpetkul MD,Silada Kanokrungsee MD,Nanticha Kamanamool MD, PhD,Montree Udompataikul MD,Salinee Rojhirunsakool MD, MSc,
doi : 10.1111/jocd.13981
Volume 20, Issue 9 p. 2785-2793
Axillary hyperpigmentation (AH) is a condition in which axillary skin is darker than the adjacent areas. To date, there is no standard treatment for AH. The Q-switched neodymium-doped yttrium aluminum garnet 1064-nm(QS) laser and intense pulsed light (IPL) are two effective modalities for the treatment of pigmentary disorders; however, the efficacy and safety levels of both treatments for AH have not yet been compared in a controlled study.
Analgesic effect of topical lidocaine is enhanced by cold atmospheric plasma pretreatment in facial CO2 laser treatments
Yue Xin MD,Xiang Wen MD, PhD,Xian Jiang MD, PhD,
doi : 10.1111/jocd.13983
Volume 20, Issue 9 p. 2794-2799
Topical anesthesia is widely used in many dermatological and cosmetic procedures. Nevertheless, the stratum corneum serves as the skin barrier, impedes the transdermal drug delivery greatly, and results in insufficient analgesia. Cold atmospheric plasma (CAP) has been researched as a transdermal drug delivery promoter with ex vivo experiments for a few years, while clinical trials are scarce.
Treatment of periorbital and perioral wrinkles with fractional Er:YAG laser: What are the effects of age, smoking, and Glogau stage?
Defne Özkoca MD,Özge A?k?n MD,Burhan Engin MD,
doi : 10.1111/jocd.13984
Volume 20, Issue 9 p. 2800-2804
Dynamic and static wrinkling are observed on the facial skin as a result of aging. Previously, it was showed that fractional Er:YAG laser was effective in the treatment of facial wrinkles.
A pilot study of minimal invasion combined PDL/Nd:YAG laser in treating facial epidermoid cyst
Hongyi Fu MD,Fuling Luo MD,Hengguang Zhao PhD,
doi : 10.1111/jocd.13994
Volume 20, Issue 9 p. 2805-2809
To compare the efficacy and complication of minimal invasion and combined pulsed dye laser/Nd:YAG laser and traditional surgical excision in the treatment of facial epidermoid cyst.
Analysis of the effectiveness of chemical peelings in the treatment of acne vulgaris assessed using high-frequency ultrasound—A comparative study
Julita Zdrada MSc,Wiktoria Odrzywo?ek MSc,Anna Deda PhD,S?awomir Wilczy?ski PhD,Barbara B?o?ska-Fajfrowska MD, PhD,
doi : 10.1111/jocd.13934
Volume 20, Issue 9 p. 2810-2815
The use of high-frequency ultrasound for noninvasive assessment of skin during chemical peeling therapies may be a useful tool.
A pilot study evaluating the efficacy and tolerability of a comprehensive, hydrating topical antioxidant developed specifically for men
Brooke C. Sikora MD,Mitchell Wortzman PhD,Diane B. Nelson RN, MPH,Jeffrey S. Dover MD, FRCPC,
doi : 10.1111/jocd.14314
Volume 20, Issue 9 p. 2816-2823
There is growing interest in skincare products designed for men. This pilot study evaluated the efficacy and tolerability of a comprehensive antioxidant product in men.
Beneficial effects of an alkaline topical treatment in patients with mild atopic dermatitis
Ludovit Jurecek MD, PhD,Tana Rajcigelova MD, PhD,Andrea Kozarova MD, PhD,Tanja Werner PhD,Juergen Vormann PhD,Martin Kolisek PhD,
doi : 10.1111/jocd.13936
Volume 20, Issue 9 p. 2824-2831
Atopic dermatitis (AD) is the most common cause of eczema. The skin condition affects millions of people worldwide. Severe cases of AD demand systemic treatment, but most AD cases rely on local therapy with topical corticosteroids, emollients, and moisturizing agents to alleviate eczema. Commonly, derma-cosmetics with a pH around 5.5 are used to treat eczematous lesions (EL). However, evidence is currently amassing that the use of mildly alkaline topical creams is beneficial for AD-related eczema treatment because of its effect on the inflammation in the skin.
Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration
Antonino Araco MD,Araco Francesco MD, PhD,
doi : 10.1111/jocd.13937
Volume 20, Issue 9 p. 2832-2840
A new topical formulation (TF) based on 3 main lifting components has been developed to reduce superficial facial wrinkles.
Synbiotics supplement is effective for Melasma improvement
Piyanat Piyavatin MD,Sirinthip Chaichalotornkul MD, PhD,Thamthiwat Nararatwanchai MD, PhD,Akkarach Bumrungpert PhD,Tawee Saiwichai PhD,
doi : 10.1111/jocd.13955
Volume 20, Issue 9 p. 2841-2850
Melasma is a disorder of melanogenesis among humans causing localized, chronic acquired hypermelanosis of the skin requiring a combination of treatments. Related studies have shown probiotics contribute distinct advantages for skin disorders possibly including melasma because of its anti-inflammatory activities, anti-oxidation properties, ultraviolet protection, and tyrosinase activity inhibition.
Clinical brightening efficacy and safety of Melasolv™ (3,4,5-trimethoxy cinnamate thymol ester, TCTE) in Southeast Asian women
Seung Hun Kim PhD,Byung Ryol Paik MS,Sung Hoon Lee PhD,So Mi Lee MS,Mi Jin Kim MS,Eun Joo Kim PhD,Chin Yong Leow BE,Changhui Cho BS,Won-Seok Park PhD,Byung-Fhy Suh MS,
doi : 10.1111/jocd.13969
Volume 20, Issue 9 p. 2851-2859
Skin darkening because of increased and irregular synthesis of melanin causes melasma, solar lentigo, and freckles. Melasolv™, produced in the early 2000s, shows potent depigmenting effect and has low cytotoxicity. It has been used as a brightening agent in cosmetics for decades.
Evaluation of the efficacy and tolerance of a cosmetic mask containing 89% of vichy volcanic mineralizing water and hyaluronic acid after facial laser procedures
Paulo Torreao MD,Edmond Phua MD,Raphael Clark MPharm,Erika Fernandes MPharm,Thais Pontes PhD,Ana P. Fonseca MBiom,Nadia Singh MSc,Bandana Seesurn MPharm,Marion Nielsen PharmD,Audrey Valois MPharm,Delphine Kerob MD,
doi : 10.1111/jocd.13972
Volume 20, Issue 9 p. 2860-2866
M89 M (Mineral 89 mask, Laboratoires Vichy, France), containing 89% Vichy volcanic mineralizing water and hyaluronic acid, aims to strengthen and repair skin barrier.
Pumpkin seed oil vs. minoxidil 5% topical foam for the treatment of female pattern hair loss: A randomized comparative trial
Ibrahim M. Ibrahim MD,Mohamed S. Hasan MD,Khaled I. Elsabaa MSc,Mohamed L. Elsaie MD,
doi : 10.1111/jocd.13976
Volume 20, Issue 9 p. 2867-2873
Pumpkin (Cucurbita pepo L.) is an annual climber plant, and its seeds have considerable amount of oil with nutritional and medicinal importance.
The efficacy and safety of multilamellar vesicle containing retinaldehyde: A double-blinded, randomized, split-face controlled study
Jemin Kim MD,Jihee Kim MD, PhD,Tunyaporn Jongudomsombat MD,Eunbin Kim BS,Jangmi Suk MS,Dongwon Lee MD, PhD,Ju Hee Lee MD, PhD,
doi : 10.1111/jocd.13993
Volume 20, Issue 9 p. 2874-2879
Retinaldehyde is one of the major members of the retinoid family, which has potential skin rejuvenating effects on photoaged skin and has a good safety profile.
Superficial X-ray-induced hyperpigmentation in postoperative keloid radiotherapy: A study of 70 keloids to identify clinical features and risk factors
Li Li MD,Chen Yuan MD,Xiaofeng Zhang MD,Baoxi Wang MD,Yan Yan MD,
doi : 10.1111/jocd.14308
Volume 20, Issue 9 p. 2880-2886
Postoperative radiation is one of the most effective treatments for keloid. Radiation-induced hyperpigmentation is, however, a concern for both patients and dermatologists.
The use of biostatic human amnion and platelet-rich plasma in topical treatment of toxic epidermal necrolysis—A case report
Agnieszka Klama-Bary?a PhD,Przemys?aw Strzelec MD,Danuta Pawlik-Knapik MD,Zbigniew Cholewa MD,Micha? Szapski MSc,Diana Kitala PhD,Wojciech ?abu? PhD,Ma?gorzata Kraut MSc,Wojciech Sm?tek MSc,Marek Kucharzewski MD, PhD,
doi : 10.1111/jocd.13864
Volume 20, Issue 9 p. 2887-2893
Toxic epidermal necrolysis (TEN) (also known as Lyell syndrome) and Stevens-Johnson syndrome (SJS) are life-threatening mucocutaneous blistering diseases. They are characterized by generalized blisters and epidermal inflammation, most likely resulting from the administration or interaction of medicines.
Efficacy of topical calcipotriol betamethasone dipropionate as a new adjuvant therapy to follicular unit extraction technique in treatment of stable vitiligo: clinical, dermoscopic and immunohistological study
Nagwa E. Abd Elazim MD,Ahmed Kamal MD,Reham M. Abdel Gaber MD,Eman Fathy MS,Heba E. M. EL-Deek MD,
doi : 10.1111/jocd.13922
Volume 20, Issue 9 p. 2894-2905
Follicular unit extraction (FUE) grafting is a surgical procedure which provides the vitiliginous patches with undifferentiated stem cells of the hair follicles. It has been postulated that adjuvant therapy enhances the results. This is the first study to assess two different adjuvant therapies vs FUE alone.
Effect of a new cryotherapy device on an itchy sensation in patients with mild atopic dermatitis
Eun Hye Lee MD,Hyun Ji Lee MD,Kyung Duck Park MD, PhD,Weon Ju Lee MD, PhD,
doi : 10.1111/jocd.13975
Volume 20, Issue 9 p. 2906-2910
The existence of an itchy sensation is a common complaint in patients with atopic dermatitis. More therapeutic modalities to address the itchy sensation in atopic dermatitis are still required.
Transconjunctival lower eyelid blepharoplasty with fat transposition above the orbicularis muscle for improvement of the tear trough deformity
Mandy Majidian BA,Hiren Kolli BS,Ronald L. Moy MD,
doi : 10.1111/jocd.13978
Volume 20, Issue 9 p. 2911-2916
The tear trough is the hollow concavity of the medial lower eyelid. Surgery can address tear trough deformities and reverse visible signs of periorbital aging. The previous methods of transconjunctival blepharoplasty with fat transposition were first described with subperiosteal placement of fat (Plast Reconstr Surg, 125, 2010,699, Aesthetic Surg J, 32, 2012, 426). This was followed by techniques with submuscular transposition of fat, which overcame certain difficulties associated with the subperiosteal methods (Clin Plast Surg, 20, 1993, 393, Arch Facial Plast Surg, 2, 2000, 16).
A cross-sectional study on clinico-dermoscopic features of periorbital melanosis in a tertiary care hospital
Smera Ramakrishnan MBBS,Spandana P. Hegde MD,Manjunath M. Shenoy MD, DNB,Malcolm Pinto MD,Amina A. M Iqbal MD,Vishal B. Amin MD,
doi : 10.1111/jocd.13979
Volume 20, Issue 9 p. 2917-2923
Periorbital melanosis (POM) is an esthetic facial concern on increasing trend and has a severe emotional impact on patients. We aimed to study the clinical and dermoscopic patterns of periorbital melanosis to aid in the classification and strategize therapy.
Modeling lipid layers of atopic skin and observation of changes in lipid layer properties with changes in ceramide content
In-Keun Jung PhD,Joonho Choi PhD,Jin Nam PhD,Kyoung Tai No PhD,
doi : 10.1111/jocd.13861
Volume 20, Issue 9 p. 2924-2931
Studies have shown that there is a high correlation between atopic dermatitis and decrease in ceramide content in the lipid bilayer of skin. Moreover, it has been shown that the reduction in ceramide content in the stratum corneum is unique to atopic dermatitis, indicating that there are particular structural differences between the lipid bilayers of normal and atopic skin.
Isolated isoquercitrin from Green ball apple peel inhibits photoaging in CCD-986Sk fibroblasts cells via modulation of the MMPs signaling
Eun-Ho Lee PhD,Hye-Jin Park MD,Han-Hyuk Kim PhD,Hee-Young Jung PhD,In-Kyu Kang PhD,Young-Je Cho PhD,
doi : 10.1111/jocd.13903
Volume 20, Issue 9 p. 2932-2939
Ultraviolet B (UVB) irradiation is viewed as the main factor of skin aging, associated with acceleration of elastin, collagen degradation and expression of matrix metalloproteinases (MMPs). Apples are one of the most commonly eaten fruits in the world, and isoquercitrin is the main active ingredient in new bred varieties “Green ball” apple. Therefore, we are studying the functionality of the active ingredient of apple, a natural raw material that does not have toxicity or sensitivity problems.
Serum angiopoietin-2 level as a novel potential biomarker in oral lichen planus
Hagar Bessar MD,Noha M. Hammad MD,Tawhed Ismail MSc,Mohamed AbdElkader Teama MD,Ayman Youssef MD,
doi : 10.1111/jocd.13926
Volume 20, Issue 9 p. 2940-2944
Lichen planus is a common chronic cutaneous inflammatory disease. Recent advances evidenced that angiogenesis is tightly connected to it. More recently, the endothelial specific growth factor angiopoietin-2 has been clarified to interact with vascular endothelial growth factor. Angiopoietin-2 level has not been investigated in lichen planus.
Increases in uric acid and monocyte-high-density lipoprotein ratio as possible atherosclerotic indicators in acne patients using isotretinoin
Nurcan Metin MD,Ça?r? Turan MD,
doi : 10.1111/jocd.13931
Volume 20, Issue 9 p. 2945-2949
We aimed to reveal the relationship of serum uric acid (SUA) with monocyte-high-density lipoprotein ratio (MHR) and other inflammatory markers in acne patients before and after isotretinoin treatment. In this way, we can try to shed light on the relationship between isotretinoin treatment and atherosclerosis.
Dynamic evaluation of an in vivo postinflammatory hyperpigmentation model using reflectance confocal microscopy and spectrophotometry
Juemin Zhao MD,Ziqi Liu MD,Chengfeng Zhang MD, PhD,Jiaqiang Wu MD,Nan Huang PhD,Yaping Du MD,Leihong Xiang MD, PhD,
doi : 10.1111/jocd.13932
Volume 20, Issue 9 p. 2950-2962
Postinflammatory hyperpigmentation (PIH) reflects a dynamic process from primary injury and cutaneous inflammation to subsequent melanogenesis and hyperpigmentation, of which pathogenesis remains unclear, hindering the development of targeted therapies.
Development of the facial glycation imaging system for in situ human face skin glycation index measurement
Jinyong Lee PhD,Eui Taek Jeong MS,Jun-Man Lim MS,Sun Gyoo Park MS,
doi : 10.1111/jocd.13943
Volume 20, Issue 9 p. 2963-2968
The accumulation of advanced glycation end products has been proposed as a causative agent of skin aging, but there are no conventional devices for quantifying advanced glycation end-product accumulation in facial skin.
Dermatological signs in liver transplant recipients
Gulbahar Sarac MD,Kubra Nur Ozcan MD,Adil Baskiran MD,Hulya Cenk MD,Mehmet Sarac MD,Serpil Sener MD,Sezai Yilmaz MD,
doi : 10.1111/jocd.13944
Volume 20, Issue 9 p. 2969-2974
In recent years, the number of liver transplantations for advanced-stage liver diseases has considerably increased and the patients have a wide range of dermatologic manifestations.
Almond consumption increased UVB resistance in healthy Asian women
Jason N. Li BS,Susanne M. Henning PhD, RD,Gail Thames BA,Omar Bari MD,Patrick T. Tran BA,Chi-Hong Tseng PhD,David Heber MD, PhD,Jenny Kim MD, PhD,Zhaoping Li MD, PhD,
doi : 10.1111/jocd.13946
Volume 20, Issue 9 p. 2975-2980
Almonds are a rich source of phenolic and polyphenolic compounds, which have antioxidant activity. In vitro and in vivo studies have demonstrated that topical application of almond oil and almond skin extract reduces UVB-induced photoaging. Ultraviolet-B (UVB) protection by oral almond consumption has not been previously studied in humans.
Role of CYR61 in psoriatic lesional and perilesional skin: A clinical and immunohistochemical study
Wafaa Ahmed Shehata MD,Alaa Hassan Maraee MD,Eman Essam Abdo MBBCh,Aiat Shaban Hemida MD,
doi : 10.1111/jocd.13947
Volume 20, Issue 9 p. 2981-2988
Psoriasis is considered as an immune-mediated disorder with significant epidermal hyperplasia and inflammation. Cysteine-rich angiogenic inducer 61 (CYR61), known as CCN family member 1 (CCN1), plays an important role in cell proliferation and neovascularization which may trigger psoriasis development.
Topical cream containing live lactobacilli decreases malodor-producing bacteria and downregulates genes encoding PLP-dependent enzymes on the axillary skin microbiome of healthy adult Nigerians
Victoria Onwuliri MSc,Nneka R. Agbakoba PhD,Kingsley C. Anukam PhD,
doi : 10.1111/jocd.13949
Volume 20, Issue 9 p. 2989-2998
Clinical data exist that support the utility of topical probiotics for certain dermatological diseases such as atopic dermatitis, acne, and psoriasis. However, there is paucity of data on the use of live lactobacilli to control axillary malodor. The objective of this study was to determine whether application of topical oil-based cream containing live Lactobacilli could decrease malodor-producing bacteria in the axilla of healthy subjects.
Bioenergetic analysis of aged-phenotype skin in a rare syndromic cutis laxa
Nasrinsadat Nabavizadeh PhD Candidate,Mohammad Shboul PhD,Zohreh Hojati PhD,
doi : 10.1111/jocd.13951
Volume 20, Issue 9 p. 2999-3006
Skin aging is an inevitable phenomenon characterized by wrinkled skin and loss of elasticity. To date, several studies have been performed on skin aging to discover the underlying mechanisms and improve efficient preventive strategies and anti-aging therapeutics.
Serum folate and vitamin B12 levels in cutaneous melanoma
Faruk Tas,Kayhan Erturk,Hilal Oguz Soydinc,
doi : 10.1111/jocd.13953
Volume 20, Issue 9 p. 3007-3010
Vitamin B12 and folate are the major micronutrients that play significant roles in DNA synthesis. Epidemiological studies and clinical evidences displayed alterations in serum concentrations folate and of vitamin B12 in various human malignancies, yet their roles in patients with melanoma have yet to be understood.
Increase adapalene delivery using chemical and herbal enhancers
Anayatollah Salimi PhD,Monasadat Emam PharmD,Saeed Mohammad Soleymani PharmD,
doi : 10.1111/jocd.13960
Volume 20, Issue 9 p. 3011-3017
Acne is one of the skin diseases that include abnormalities in the production of sebum, changes in the microbial flora, abnormal keratinization, and inflammation. Adapalene is a good choice in the treatment of acne with fewer side effects and high effectiveness. However, the absorption of adapalene through human skin is low. We investigated the effect of several enhancers on the skin absorption of adapalene.
Mechanisms of skin moisturization with hyperharmonized hydroxyl modified fullerene substance
Suzana Miljkovic PhD,Branislava Jeftic PhD,Ivana Stankovic MSc,Nikola Stojiljkovic PhD,Djuro Koruga PhD,
doi : 10.1111/jocd.13965
Volume 20, Issue 9 p. 3018-3025
Hyper Harmonized Hydroxyl Modified Fullerene Substance (3HFWC+) establishes hydrogen bonds with the surrounding water molecules and organizes them in clusters with the liquid crystalline state, similar to the properties of water surrounding the biomolecules.
Experience with oral tofacitinib in severe alopecia areata with different clinical responses
Didem Dincer Rota MD,Mehmet Ali Can Emeksiz MD, PhD,Fatma Gulru Erdogan MD,Dilsun Yildirim MD,
doi : 10.1111/jocd.13966
Volume 20, Issue 9 p. 3026-3033
Alopecia areata (AA) and generalized form, universalis (AU) are common causes of noncicatricial alopecia, targeting anagen hair follicles. A dominant interferon-gamma transcriptional signaling and cytotoxic T lymphocytes were accused as the main drivers of disease pathogenesis. Tofacitinib is a Janus kinase inhibitor that has been proven to interfere with the positive feedback loop between the follicular cell and the cytotoxic T lymphocytes in AA. There is an increasing number of studies reporting success with tofacitinib in AA.
Assessment of serum interleukin-19 in acne vulgaris patients of different clinical severities
Hanan M. Saleh MD,Moustafa A. Deif MSc,Rania M. El-Husseiny MD,
doi : 10.1111/jocd.13977
Volume 20, Issue 9 p. 3034-3040
Acne vulgaris (AV) is a common chronic inflammatory disorder of the pilosebaceous unit among adolescents and young adults. Inflammation does have a central role in formation of both inflammatory and noninflammatory acne lesions with production of proinflammatory cytokines.
Evaluation of epicardial fat thickness and the ankle-brachial index in patients with rosacea: A case-control study
Asl? Aksu Çerman MD,Arzu Er Kara MD,Ezgi Akta? Karabay MD,Hazel Ezgi Kaya MD,?lknur K?vanç Altunay MD,
doi : 10.1111/jocd.13997
Volume 20, Issue 9 p. 3041-3045
Recent data suggest that rosacea is related to cardiovascular diseases (CVD) due to its inflammatory nature and immune dysregulation.
Prevalence, clinical, and biochemical characteristics of the female acne patients with insulin resistance
Duyi Guo,Hua Zhang,Shiyuan Yang,Shi Yan,Xiangbo Wei,Jiangang Hu,Xiulian Zhang,Xueyan Lu,Chunlei Zhang,Wei Jiang,
doi : 10.1111/jocd.13939
Volume 20, Issue 9 p. 3046-3048
Upward trend in number of injectable treatments in the Netherlands 2016–2019
Tom S. Decates MD,Peter Velthuis MD, PhD,Danial Zarringam MD,Luca Bruin MD,Rutger H. Schepers MD, DMD, PhD,Berend van der Lei MD, PhD,
doi : 10.1111/jocd.14339
Volume 20, Issue 9 p. 3049-3051
A case of frontal fibrosing alopecia in a 19th century portrait?
Nicolas Kluger MD, PhD
doi : 10.1111/jocd.13948
Volume 20, Issue 9 p. 3052-3053
Pigmented disseminated superficial actinic porokeratosis in dark-skinned patients: Clinical, dermoscopic, and histopathologic features
Irving Llibrán Reyna-Rodríguez MD,José Alberto García-Lozano MD,Jorge Ocampo-Candiani MD, PhD,
doi : 10.1111/jocd.13998
Volume 20, Issue 9 p. 3054-3056
