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Should atopic dermatitis patients starting JAK inhibitors take prophylactic acyclovir?
Milaan A. Shah,Katherine G. Beuerlein,Joseph L. Jorizzo &Steven R. Feldman
doi : 10.1080/09546634.2021.1978665
Volume 32, 2021 - Issue 7 Pages 669-672
Old world cutaneous leishmaniasis in Iran: clinical variants and treatments
Alireza Firooz,Hossein Mortazavi,Ali Khamesipour,Maryam Ghiasi,Robabeh Abedini,Kamran Balighi,Nafiseh Esmaili,Mansour Nassiri-Kashani,S. Ebrahim Eskandari,Mehdi Mohebali,Akram Mir Amin Mohammadi &Yahya Dowlati
doi : 10.1080/09546634.2019.1704214
Volume 32, 2021 - Issue 7 Pages 673-683
Old World cutaneous leishmaniasis (OWCL) is endemic in Iran and most cases of cutaneous leishmaniasis (CL) are caused by Leishmania major, and then Leishmania tropica, and rarely by Leishmania infantum.
A systematic review of evidence based treatments for lichen simplex chronicus
Michelle C. Juarez &Shawn G. Kwatra
doi : 10.1080/09546634.2019.1708856
Volume 32, 2021 - Issue 7 Pages 684-692
Lichen simplex chronicus (LSC) is a disorder characterized by thickened areas of skin from repeated rubbing or scratching. The multifactorial nature of LSC makes management difficult and there are currently no evidence-based guidelines for treatment. We conducted a systematic review of the literature to evaluate treatments for LSC and provide an evidence-based summary of the current treatments as well as highlight novel therapies. A total of 21 studies were included which comprised 682 patients with LSC involving various areas. The most robust evidence was seen with the use of topical corticosteroids (n?=?7 RCTs) and limited data suggest benefit with other treatments such as topical immunomodulators, topical antipruritic agents, oral antihistamines, antiepileptics and antidepressants. We also discuss novel treatment approaches using transcutaneous electrical nerve stimulation, focused ultrasound, and phototherapy. Despite emerging evidence there remains a paucity of high-quality studies supporting treatments for LSC and larger controlled trials are needed.
Comparative cost-effectiveness of tildrakizumab and other commonly used treatments for moderate-to-severe psoriasis
Jashin J. Wu,Xiaoying Jia,Yang Zhao,Justin Carrico,Thor-Henrik Brodtkorb,Alan Mendelsohn,Simon Lowry,Steven R. Feldman &April Armstrong
doi : 10.1080/09546634.2019.1698700
Volume 32, 2021 - Issue 7 Pages 693-700
To compare the cost-effectiveness of tildrakizumab with other commonly used biologics and apremilast as the first-line treatment for moderate-to-severe plaque psoriasis from a US health plan’s perspective.
Cost per PASI-75 responder of calcipotriol plus betamethasone dipropionate cutaneous foam versus nonbiologic systemic therapies for the treatment of plaque psoriasis in seven European countries
Deepak M. W. Balak,Jose-Manuel CarrascosaORCID Icon,Stamatis Gregoriou,Piergiacomo Calzavara-Pinton,Anthony Bewley,Joana Antunes,Martin E. Nyeland,Marta G. Viola,Laura M. Sawyer &Lidia Becla
doi : 10.1080/09546634.2019.1707754
Volume 32, 2021 - Issue 7 Pages 701-708
To compare the short-term cost and effectiveness of calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam against nonbiologic systemics in psoriasis patients for whom oral systemic or topical therapy is considered appropriate in seven European countries.
Secukinumab rapidly improves EQ-5D health status in patients with psoriasis: Pooled analysis from four phase 3 trials
Steven R. Feldman,Braulio Gomez,Xiangyi Meng &Rebecca Germino
doi : 10.1080/09546634.2019.1708854
Volume 32, 2021 - Issue 7 Pages 709-715
Patients with psoriasis experience decreased health-related quality of life due to physical and psychological burdens.
Concomitant atopic dermatitis and psoriasis – a retrospective review
Kelly Barry,Pedro Zancanaro,Rachel Casseres,Rana Abdat,Nicole Dumont &David Rosmarin
doi : 10.1080/09546634.2019.1702147
Volume 32, 2021 - Issue 7 Pages 716-720
At one time considered opposing diseases, it is now recognized that atopic dermatitis (AD) and psoriasis can coexist. There are limited data characterizing this population of patients. In this study, we characterize the population of patients diagnosed with both AD and psoriasis and summarize their response to therapy.
Comparing the effects of proactive treatment with tacrolimus ointment and mometasone furoate on the epidermal barrier structure and ceramide levels of patients with atopic dermatitis
Dorothee Dähnhardt,Mike Bastian,Stephan Dähnhardt-Pfeiffer,Matthias Buchner &Regina Fölster-Holst
doi : 10.1080/09546634.2019.1708240
Volume 32, 2021 - Issue 7 Pages 721-729
The epidermal skin barrier and lipids that are integral to its structure are impaired in atopic dermatitis (AD). Current treatment guidelines include proactive therapy.
Glycerol 85% efficacy on atopic skin and its microbiome: a randomized controlled trial with clinical and bacteriological evaluation
Randa Youssef,Vanessa Hafez,Yasmine Elkholy &Ahmed Mourad
doi : 10.1080/09546634.2019.1708246
Volume 32, 2021 - Issue 7 Pages 730-736
Treating atopic dermatitis (AD) is still a challenge. The staphylococcal skin load is known to aggravate AD. Narrow band ultraviolet B (NB-UVB) and glycerol in low concentration (20–40%) are established therapies for AD. NB-UVB has proven antimicrobial actions, while high concentration glycerol (85–100%) showed similar effects in vitro but has not been clinically tested.
Punctal stenosis associated with dupilumab therapy for atopic dermatitis
Debora H. Lee,Liza M. Cohen,Michael K. Yoon &Jeremiah P. Tao
doi : 10.1080/09546634.2019.1711010
Volume 32, 2021 - Issue 7 Pages 737-740
In this case series, the authors report three patients with severe atopic dermatitis who presented with epiphora and conjunctivitis while undergoing dupilumab therapy. On clinical examination, all patients were found to have punctal stenosis, with one case having progressed to punctal obstruction. An assortment of strategies was elected, including discontinuation of dupilumab, treatment of conjunctivitis, and surgical intervention with probing, punctoplasty, and silicone intubation. This report spotlights punctal stenosis as an important new side effect of dupilumab and suggests that additional cases of dupilumab-associated lacrimal drainage impairment will continue to emerge.
Emerging novel therapeutic agents for the treatment of patients with prurigo nodularis
Hasina Maredia &Shawn G. Kwatra
doi : 10.1080/09546634.2019.1707469
Volume 32, 2021 - Issue 7 Pages 741-744
Liraglutide improved inflammation via mediating IL-23/Th-17 pathway in obese diabetic mice with psoriasiform skin
Pin Chen,Lu Lin,Xiangjin Xu,Zhenting Zhang,Wei Cai,Zhulin Shao,Shengping Chen,Xiangqi Chen &Qiaoling Weng
doi : 10.1080/09546634.2019.1708853
Volume 32, 2021 - Issue 7 Pages 745-751
The purpose of this study was to investigate the effect of liraglutide on obesity diabetic mice with psoriasiform skin inflammation.
A prospective study examining isolated acne and acne with hyperandrogenic signs in adult females
Prekshi Bansal,Kabir Sardana,Lokesh Sharma,Umesh Chandra Garga &Gauri Vats
doi : 10.1080/09546634.2019.1708245
Volume 32, 2021 - Issue 7 Pages 752-755
Adult female acne (AFA) occurs beyond 25?years of age and can present either as isolated acne or with hyperandrogenic signs.
The impact of active vitamin D administration on the clinical outcomes of acne vulgaris
Amal Ahmed Mohamed,Eman Mohamed Salah Ahmed,Rasha T.A. Abdel-Aziz,Halaa H. Eldeeb Abdallah,Hadeel El-Hanafi,Ghada Hussein,Maggie M. Abbassi &Radwa El Borolossy
doi : 10.1080/09546634.2019.1708852
Volume 32, 2021 - Issue 7 Pages 756-761
Acne vulgaris is one of the most common chronic inflammatory skin disorder affecting millions of people worldwide. Vitamin D deficiency has a role in various inflammatory skin diseases as acne. This study aimed to investigate the serum level of 25 hydroxy vitamin D in acne patients and to assess the efficacy and safety of active vitamin D in management of acne. This study was conducted on 100 patients with acne and 100 healthy controls, then the 100 acne patients were randomized to either the study group that received 0.25ug alfacalcidol daily or the placebo group that received oral placebo during the 3?months study period. Serum levels of 25-hydroxy-vitamin D were significantly lower in acne patients than in healthy control and were inversely correlated to the severity of acne. After alfacalcidol administration, the study group showed significant higher level of 25(OH) D levels (p?<?.05) compared to placebo group. In addition, median serum level of IL6 and TNF? significantly decreased (p?<?.05) in the study group in comparison to placebo group and as compared to their baseline results. Acne patients are more commonly to have vitamin D deficiency as compared to healthy people and hence, alfacalcidol might have a beneficial role in the acne management with no reported side effects.
Efficacy and safety of artemether emulsion for the treatment of mild-to-moderate acne vulgaris: a randomized pilot study
Wen-tong Shen,Yun Wu,Hui-qiong He,Yue Yu,Hai-hong Qin,Jian-biao Fei &Guo-jiang Wang
doi : 10.1080/09546634.2019.1710447
Volume 32, 2021 - Issue 7 Pages 762-765
To evaluate the efficacy and safety of artemether emulsion treating patients with mild-to-moderate acne vulgaris.
A split-face randomized controlled trial of treatment with broadband light for enlarged facial pores
Wenxin Yu,Yue Han,Xianglei Wu,Ying Shang,Hnaru Ying,Gang Ma,Ying Liu &Xiaoxi Lin
doi : 10.1080/09546634.2019.1698701
Volume 32, 2021 - Issue 7 Pages 766-770
Broadband light (BBL) is one of the intense pulsed light. BBL treatment for nonablative, noninvasive skin tightening and rejuvenation reportedly elicits satisfactory clinical outcomes. Up until now, self-controlled case series with objective evaluation of efficacy of facial pores in response to BBL treatment have not been reported. We aimed to assess its safety and efficacy on enlarged facial pores by objective measuring technique.
The efficacy of intradermal injections of botulinum toxin in the management of enlarged facial pores and seborrhea: a split face-controlled study
Khadiga S. Sayed,Rehab Hegazy,Heba I. Gawdat,Rania M. Abdel Hay,Mona M. Ahmed,Faisal Nouredin Mohammed,Riham Allam &Aya Fahim
doi : 10.1080/09546634.2019.1708241
Volume 32, 2021 - Issue 7 Pages 771-777
Enlarged facial pores are becoming a matter of cosmetic concern. Injections of (botulinum toxin type A) have an increasing popularity among cosmetic procedures.
Prevalence and treatment outcomes of skin infections among elderly population: a retrospective cross-sectional study
Ali Akhtar,Mohamed Azmi Ahmad Hassali,Hadzliana Zainal &Amer Hayat Khan
doi : 10.1080/09546634.2020.1714539
Volume 32, 2021 - Issue 7 Pages 778-782
Geriatric population is increasing day by day throughout the world and there is a critical need to provide them the best health services including dermatological care due to their weakened immune system. The main objective of this study is to determine the prevalence and factors affecting the treatment outcomes of skin infections among elderly population.
Retrospective analysis of adverse events with systemic onychomycosis medications reported to the United States Food and Drug Administration
Yu Wang &Shari R. Lipner
doi : 10.1080/09546634.2019.1708242
Volume 32, 2021 - Issue 7 Pages 783-787
Onychomycosis is the most common nail condition and when left untreated, has esthetic, physical and emotional-social sequelae.
An exploratory pilot analysis of the optimal pellet number in 100?mg of itraconazole capsule to maximize the surface area to satisfy the Noyes–Whitney equation
Kabir Sardana,Ananta Khurana,Sanjeet Panesar &Ajeet Singh
doi : 10.1080/09546634.2019.1708848
Volume 32, 2021 - Issue 7 Pages 788-794
Recalcitrant dermatophytoses is on the rise. With increasing microbiological resistance and clinical failures reported to terbinafine, itraconazole (ITR) is being increasingly used for the condition. ITR has an unpredictable bioavailability and quality variation among brands is known to affect clinical outcome. Bioequivalence to innovator brand is often not established and many spurious brands have flooded the market. Morphometric characteristics of the pellets, especially their count, size, and surface area impact dissolution of drug in the gastrointestinal tract, as per the Noyes–Whitney equation. It would be of value to clinicians to be able to differentiate good quality from poorly manufactured brands to achieve optimum clinical results, especially when rigorously done bioequivalence studies are not available.
308-nm excimer laser: a hopeful and optional therapy for pityriasis versicolor
Fathia M. Khattab & Farida H. Omran
doi : 10.1080/09546634.2020.1713972
Volume 32, 2021 - Issue 7
Pityriasis Versicolor (PV) is known as a superficial fungal infection. It is suggested that resistant strains to azoles may be developed and hence, the treatment would be difficult. This study aimed to evaluate the efficacy of excimer laser (308?nm) as an alternative therapy for PV.
Photodynamic therapy following fractional CO2 laser for treatment of primary vulvar Paget’s disease: does it really work?
Francesca Ferrara,Federico Bardazzi,Stefano Messori,Diego Abbenante,Alessia Barisani &Sabina Vaccari
doi : 10.1080/09546634.2019.1707755
Volume 32, 2021 - Issue 7 Pages 800-802
Extra-mammary Paget’s disease is a rare form of intraepithelial adenocarcinoma with a variable pattern of invasion. Vulvar Paget’s disease represents 1% of all vulvar cancers. Standard treatment is surgical excision, however, the recurrence rate is high and surgery leads to anatomical, functional and sexual morbidity. Some studies suggest the efficacy of photodynamic therapy following CO2 Laser irradiation as treatment for this disease.
The therapeutic effects of blocking IGF-R1 on mice model of skin cancer
Abdullah Alyoussef
doi : 10.1080/09546634.2019.1708243
Volume 32, 2021 - Issue 7 Pages 803-811
The incidence of skin cancer has raised in the last few years. One of the important growth factors found in the skin layers is insulin-like growth factor (IGF)-1. It is directly linked with many cancers in different organs. Therefore, we aimed to explore the therapeutic effects of blocking IGF-1 receptor (IGF-R1) pathway by PQ401 in skin cancer as well as studying its effect on tumor invasion markers.
Anti-TNF agent etanercept augments UV-induced skin cancer development in SKH-1 mice
Ercan Cal?skan,Mehmet Gams?zkan,Aslan Yurekli,Aysenur Botsali,Mehmet Esref Kabalar,Murat Demiriz &Mustafa Tunca
doi : 10.1080/09546634.2019.1708851
Volume 32, 2021 - Issue 7 Pages 812-818
Despite being employed in the treatment of inflammatory disorders for more than 20?years all over the world, data regarding photocarcinogenic risks of anti-TNF agents is scarce.
A comparative study between oral tranexamic acid versus oral tranexamic acid and Q-switched Nd-YAG laser in melasma treatment: a clinical and dermoscopic evaluation
Naglaa Agamia,Zoe Apalla,Walaa Salem &Wafaa Abdallah
doi : 10.1080/09546634.2019.1708847
Volume 32, 2021 - Issue 7 Pages 819-826
Melasma is a common acquired disorder of pigmentation.
Clinical, trichoscopic, and folliscopic identification of the impact of metabolic syndrome on the response to intradermal dutasteride 0.02% injection in patients with female pattern hair loss: a prospective cohort study
Nayera Moftah,Rana Mubarak &Rania Abdelghani
doi : 10.1080/09546634.2019.1708849
Volume 32, 2021 - Issue 7 Pages 827-836
No studies investigating the impact of metabolic syndrome (MetS) in treatment response of female pattern hair loss (FPHL).
The randomized trials of 10% urea cream and 0.025% tretinoin cream in the treatment of acanthosis nigricans
Arucha Treesirichod,Suthida Chaithirayanon,Thitiwat Chaikul &Somboon Chansakulporn
doi : 10.1080/09546634.2019.1708855
Volume 32, 2021 - Issue 7 Pages 837-842
Acanthosis nigricans is characterized as hyperpigmented skin and velvety surface on posterior and lateral folds of the neck and the intertriginous areas. This study aimed to assess the efficacy of topical 10% urea cream compared to 0.025% tretinoin cream in the treatment of acanthosis nigricans.
Vitamin D deficiency and hidradenitis suppurativa: the impact on clinical severity and therapeutic responsivity
Gabriella Fabbrocini,Claudio Marasca,Maria Antonietta Luciano,Maria Guarino,Serena Poggi,Giuseppina Fontanella &Sara Cacciapuoti
doi : 10.1080/09546634.2020.1714538
Volume 32, 2021 - Issue 7 Pages 843-844
Efficacy of fractional carbon dioxide laser therapy for burn scars: a meta-analysis
Cong Zhang,Kai Yin &Yu-ming Shen
doi : 10.1080/09546634.2019.1704679
Volume 32, 2021 - Issue 7 Pages 845-850
The present study evaluates the effectiveness of fractional carbon dioxide (CO2) laser for the treatment of burn scars.
Randomized, controlled trial testing the effectiveness and safety of 2.5% and 5% benzoyl peroxide for the treatment of pitted keratolysis
Charussri Leeyaphan,Pichaya Limphoka,Rungsima Kiratiwongwan,Punyawee Ongsri &Sumanas Bunyaratavej
doi : 10.1080/09546634.2019.1708244
Volume 32, 2021 - Issue 7 Pages 851-854
The appropriate dosage and duration of topical benzoyl peroxide gel (BP) treatment of pitted keratolysis (PK) is controversial.
Cardiac function in pemphigus vulgaris patients before and after steroid pulse therapy
Mohammad Shahidi-Dadras,Mehdi Pishgahi,Mohammadreza Tabary,Zohreh Kheradmand,Farnaz Araghi,Sahar Dadkhahfar &Reza M. Robati
doi : 10.1080/09546634.2019.1708850
Volume 32, 2021 - Issue 7 Pages 855-859
Pemphigus vulgaris which is an autoimmune dermatological disorder characterized by vesiculobullous lesions over the skin and mucosae may also give rise to cardiac disease. Global Longitudinal Strain (GLS) measurement may help to predict cardiac dysfunction in these patients.
Clinical recommendations made in dermatology publications are frequently not supported by adequate evidence
Kathleen M. Coerdt,Wasim Haidari,William W. Huang &Steven R. Feldman
doi : 10.1080/09546634.2019.1708247
Volume 32, 2021 - Issue 7 Pages 860-861
Absolute risk and cost-benefit analyses are necessary to guide clinical decision making. The purpose of this study was to evaluate whether clinical recommendations in dermatology publications were supported by adequate evidence. We also assessed whether dermatology residents report sufficient evidence when they author publications.
