European Heart Journal

Javier Escaned, Davide Cao, Usman Baber, Johny Nicolas, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J Angiolillo, Carlo Briguori, David J Cohen, Timothy Collier, Dariusz Dudek, Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W Krucoff, Vijay Kunadian, Shamir Mehta, David J Moliterno, E Magnus Ohman, Keith G Oldroyd, Gennaro Sardella, Samin K Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran

doi : 10.1093/eurheartj/ehab702

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4624–4634

Patients at high bleeding risk (HBR) represent a prevalent subgroup among those undergoing percutaneous coronary intervention (PCI). Early aspirin discontinuation after a short course of dual antiplatelet therapy (DAPT) has emerged as a bleeding avoidance strategy. The aim of this study was to assess the effects of ticagrelor monotherapy after 3-month DAPT in a contemporary HBR population.

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The Cornelian dilemma† of quitting DAPT

Zuzana Motovska, Gilles Montalescot

doi : 10.1093/eurheartj/ehab658

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4635–4637

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Cardiac mortality in patients randomised to elective coronary revascularisation plus medical therapy or medical therapy alone: a systematic review and meta-analysis

Eliano P Navarese, Alexandra J Lansky, Dean J Kereiakes, Jacek Kubica, Paul A Gurbel, Diana A Gorog, Marco Valgimigli, Nick Curzen, David E Kandzari, Marc P Bonaca, Marc Brouwer, Julia Umi?ska, Milosz J Jaguszewski, Paolo Raggi, Ron Waksman, Martin B Leon, William Wijns, Felicita Andreotti

doi : 10.1093/eurheartj/ehab246

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4638–4651

The value of elective coronary revascularisation plus medical therapy over medical therapy alone in managing stable patients with coronary artery disease is debated. We reviewed all trials comparing the two strategies in this population.

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Impact of revascularisation on outcomes in chronic coronary syndromes: a new meta-analysis with the same old biases?

David L Brown, William E Boden

doi : 10.1093/eurheartj/ehab330

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4652–4655

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Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR)

Damien Collison, Matthaios Didagelos, Muhammad Aetesam-ur-Rahman, Samuel Copt, Robert McDade, Peter McCartney, Thomas J Ford, John McClure, Mitchell Lindsay, Aadil Shaukat, Paul Rocchiccioli, Richard Brogan, Stuart Watkins, Margaret McEntegart, Richard Good, Keith Robertson, Patrick O’Boyle, Andrew Davie, Adnan Khan, Stuart Hood, Hany Eteiba, Colin Berry, Keith G Oldroyd

doi : 10.1093/eurheartj/ehab449

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4656–4668

A fractional flow reserve (FFR) value ?0.90 after percutaneous coronary intervention (PCI) is associated with a reduced risk of adverse cardiovascular events. TARGET-FFR is an investigator-initiated, single-centre, randomized controlled trial to determine the feasibility and efficacy of a post-PCI FFR-guided optimization strategy vs. standard coronary angiography in achieving final post-PCI FFR values ?0.90.

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We need intracoronary physiology guidance before percutaneous coronary intervention, but do we need it post-stenting?

David Erlinge, Matthias Götberg

doi : 10.1093/eurheartj/ehab525

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4669–4670

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Thin-cap fibroatheroma predicts clinical events in diabetic?patients with normal fractional flow reserve: the COMBINE OCT–FFR trial

Elvin Kedhi, Balazs Berta, Tomasz Roleder, Renicus S Hermanides, Enrico Fabris, Alexander J J IJsselmuiden, Floris Kauer, Fernando Alfonso, Clemens von Birgelen, Javier Escaned, Cyril Camaro, Mark W Kennedy, Bruno Pereira, Michael Magro, Holger Nef, Sebastian Reith, Arif Al Nooryani, Fernando Rivero, Krzysztof Malinowski, Giuseppe De Luca, Hector Garcia Garcia, Juan F Granada, Wojciech Wojakowski

doi : 10.1093/eurheartj/ehab433

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4671–4679

The aim of this study was to understand the impact of optical coherence tomography (OCT)-detected thin-cap fibroatheroma (TCFA) on clinical outcomes of diabetes mellitus (DM) patients with fractional flow reserve (FFR)-negative lesions.

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What are the PROSPECTs and clinical implications of vulnerable plaque?

Rasha Al-Lamee, Gary S Mintz

doi : 10.1093/eurheartj/ehab521

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4680–4682

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Ticagrelor monotherapy in patients with chronic kidney disease undergoing percutaneous coronary intervention: TWILIGHT-CKD

Giulio G Stefanini, Carlo Briguori, Davide Cao, Usman Baber, Samantha Sartori, Zhongjie Zhang, George Dangas, Dominick J Angiolillo, Shamir Mehta, David J Cohen, Timothy Collier, Dariusz Dudek, Javier Escaned, C Michael Gibson, Robert Gil, Kurt Huber, Upendra Kaul, Ran Kornowski, Mitchell W Krucoff, Vijay Kunadian, David J Moliterno, E Magnus Ohman, Keith G Oldroyd, Gennaro Sardella, Samin K Sharma, Richard Shlofmitz, Giora Weisz, Bernhard Witzenbichler, Stuart Pocock, Roxana Mehran

doi : 10.1093/eurheartj/ehab533

European Heart Journal, Volume 42, Issue 45, 1 December 2021, Pages 4683–4693

The aim of this study was to assess the impact of chronic kidney disease (CKD) on the safety and efficacy of ticagrelor monotherapy among patients undergoing percutaneous coronary intervention (PCI).

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