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doi : 10.1016/S0091-6749(22)00390-6

Volume 149, Issue 5, May 2022, Page OFC

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Brief Overview of This Month's JACI

doi : 10.1016/S0091-6749(22)00392-X

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Table of Contents

doi : 10.1016/S0091-6749(22)00393-1

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Editorial Board

doi : 10.1016/S0091-6749(22)00394-3

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Information for Readers

doi : 10.1016/S0091-6749(22)00396-7

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News & Notes

doi : 10.1016/S0091-6749(22)00397-9

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Continuing Medical Education Calendar

doi : 10.1016/S0091-6749(22)00398-0

خرید پکیج و مشاهده آنلاین مقاله

Mechanisms and pathogenesis of chronic rhinosinusitis

AtsushiKatoPhDabRobert P.SchleimerPhDabBenjamin S.BleierMDc

doi : 10.1016/j.jaci.2022.02.016

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Is there a role for antibiotics in the treatment of chronic rhinosinusitis?

Stephanie ShintaniSmithMD, MSabRaymondKimMBChB, PhDcRichardDouglasMD, MBChBc

doi : 10.1016/j.jaci.2022.02.004

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Unraveling the role of the microbiome in chronic rhinosinusitis

Alkis J.PsaltisMD, PhD, FRACSabBrett WagnerMackenziePhDcEmily K.CopePhDdVijay R.RamakrishnanMDe

doi : 10.1016/j.jaci.2022.02.022

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The climate change hypothesis for the allergy epidemic

Marc E.RothenbergMD, PhD

doi : 10.1016/j.jaci.2022.02.006

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Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees

Iris M.OtaniMDaHeather K.LehmanMDbArtemio M.JongcoMD, PhD, MPHcLulu R.TsaoMDaAntoine E.AzarMDdTeresa K.TarrantMDeElissaEngelMDfJolan E.WalterMD, PhDghiTho Q.TruongMDjDavid A.KhanMDkMarkBallowMDlCharlotteCunningham-RundlesMD, PhDmHuifangLuMD, PhDnMildredKwanMD, PhDoSaraBarmettlerMDp

doi : 10.1016/j.jaci.2022.01.025

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A Special Thank-You to Our Reviewers

doi : 10.1016/S0091-6749(22)00423-7

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The Editors’ Choice

doi : 10.1016/j.jaci.2022.03.011

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News Beyond Our Pages

Marc E.RothenbergMD, PhD∗JeanBousquetMD∗

doi : 10.1016/j.jaci.2022.03.009

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The 2022 AAAAI Foundation Faculty Development awardees

Zuhair K.BallasMD

doi : 10.1016/j.jaci.2022.03.012

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Weaving innate lymphoid cells (ILCs) into the fabric of asthma exacerbations

William W.BusseMDaJames E.GernMDb

doi : 10.1016/j.jaci.2022.01.021

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Tezepelumab administration in moderate-to-severe uncontrolled asthma: Is it all about eosinophils?

Pier GiorgioPuzzovioMScaRonEliasharMDbFrancescaLevi-SchafferPharmD, PhDa

doi : 10.1016/j.jaci.2022.01.019

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Understanding the highs and lows of socioeconomic status

Elizabeth A.ErwinMDaKelly J.KelleherMD, MPHb

doi : 10.1016/j.jaci.2022.03.007

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Fevipiprant in CRSwNP and comorbid asthma: Wrong target population or wrong PGD2 receptor?

Katherine N.CahillMD

doi : 10.1016/j.jaci.2022.03.001

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Atopic dermatitis and the atopic march: Considering racial and ethnic diversity in atopic disease progression

JunkoTakeshitaMD, PhD, MSCEabJayantaGuptaMD, PhDcYaqianZhuMSbRonaldBernaBAaZelma C.Chiesa FuxenchMD, MSCEabDavid J.MargolisMD, PhDab

doi : 10.1016/j.jaci.2022.03.008

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Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis (HLH)

DeepakKumarPhDaChristina A.RostadMDbPreetiJaggiMDbD. SofiaVillacis NunezMDcChengyuPrinceBSaAustinLuBSbLailaHussainiMPHbThinh H.NguyenMD, PhDaSakshiMalikPhDdeLori A.PonderBSfSreekala P.V.ShenoyMScEvan J.AndersonMDbgMichaelBrionesDOaIgnacioSanzMDhiSampathPrahaladMDcjShanmuganathanChandrakasanMDa

doi : 10.1016/j.jaci.2022.02.028

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Thunderstorm asthma in seasonal allergic rhinitis: The TAISAR study

Jo A.DouglassMDaCarolineLodgePhDbSamanthaChanFRACPcAliceDohertyMScbJu AnnTanFRACPcCelinaJinPhDcAlastairStewartPhDdAnne M.SouthcottFRACPeAndrewGillmanFRACPeJoyLeeFRACPfDannyCsutorosFAFPHMgLiamHannanPhDhLaurenceRuaneBSciiSaraBarnesFRACPjLouIrvingFRACPkNur-ShirinHarunFRACPkPhillipeLachapelleMDlKymbleSpriggsFRACPc…ShyamaliDharmagePhDb

doi : 10.1016/j.jaci.2021.10.028

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Socioeconomic disparities in asthma health care utilization, exacerbations, and mortality: A systematic review and meta-analysis

CharleneRedmondBScaAbdul QadrAkinoso-ImranPhDaLiam G.HeaneyMDbAzizSheikhMDcFrankKeeMDaJohnBusbyPhDa

doi : 10.1016/j.jaci.2021.10.007

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Cannabinoid receptor 2 engagement promotes group 2 innate lymphoid cell expansion and enhances airway hyperreactivity

Benjamin P.HurrellPhDDoumet GeorgesHelouPhDPedramShafiei-JahaniMSEmilyHowardBSJacob D.PainterMSChristineQuachMSOmidAkbariPhD

doi : 10.1016/j.jaci.2021.09.037

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CD38 plays an age-related role in cholinergic deregulation of airway smooth muscle contractility

YanBaiMDabAlonso G.P.GuedesDVM, MS, PhDcRamaswamyKrishnanPhDdXingbinAiPhDb

doi : 10.1016/j.jaci.2021.10.033

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Granulocyte-colony stimulating factor: Missing link for stratification of type 2–high and type 2–low chronic rhinosinusitis patients

SharonVan NevelMScaJozefienDeclercqMDbcGabrieleHoltappelsBScaBart N.LambrechtMD, PhDbcClausBachertMD, PhDa

doi : 10.1016/j.jaci.2022.02.019

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Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps

Julie A.PoposkiMSaAiko I.KlinglerPhDaWhitney W.StevensMD, PhDaLydia A.SuhMSaBruce K.TanMD, MSbAnju T.PetersMDaHiamAbdala-ValenciaPhDcLeslie C.GrammerMDaKevin C.WelchMDbStephanie S.SmithMDbDavid B.ConleyMDbRobert C.KernMDabRobert P.SchleimerPhDabAtsushiKatoPhDab

doi : 10.1016/j.jaci.2021.11.023

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Phase 3b randomized controlled trial of fevipiprant in patients with nasal polyposis with asthma (THUNDER)

PhilippeGevaertMD, PhDaClausBachertMD, PhDabJorge FernandoMasperoMDcMandyCuevasMDdDavidSteeleBSceSandipAcharyaMScfPabloAltmanMDg

doi : 10.1016/j.jaci.2021.12.759

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An open-label, proof-of-concept study of lirentelimab for antihistamine-resistant chronic spontaneous and inducible urticaria

SabineAltrichterMDabcPetraStaubachMDdMalikaPashaMBAeBhupinderSinghMDeAlan T.ChangBSeJonathan A.BernsteinMDfHenrik S.RasmussenMD, PhDeFrankSiebenhaarMDabcMarcusMaurerMDabc

doi : 10.1016/j.jaci.2021.12.772

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CD38+ B cells affect immunotherapy for allergic rhinitis

Gui-XiangTianMD, PhDabKe-PingPengMDcMing-HuiLiuMDabDao-FaTianMD, PhDcHai-QingXieMDaLi-WenWangMDaYu-YangGuoMDaShanZhouMDaLi-HuaMoPhDdePing-ChangYangMD, PhDdef

doi : 10.1016/j.jaci.2022.01.012

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Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children

Jocelyn M.BiaginiPhDacJohn W.KronerMSaAselBaatyrbek kyzyBSaAlexandraGonzalesMPHaHuaHeMSbMarianaStevensPhDaBrittanyGrashelBSaDanielSpagnaBSaSamuelPaulBSaRahulPatelBSaAngeloBucciBSaMichael G.SherenianMDacLiza BronnerMurrisonPhD, MPHacLisa J.MartinPhDbcGurjit K.Khurana HersheyMD, PhDac

doi : 10.1016/j.jaci.2021.09.036

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Mepolizumab for chronic rhinosinusitis with nasal polyps: Treatment efficacy by comorbidity and blood eosinophil count

ClausBachertMD, PhDabcAna R.SousaPhDdJoseph K.HanMDeRodney J.SchlosserMDfLeigh J.SowerbyMDgClaireHopkinsDM (Oxon)hJorge F.MasperoMD, FCCPiSteven G.SmithPhDjOliverKanteMSckDespina E.Karidi-AndriotiMSclBhabitaMayerMScmRobert H.ChanMDdSteve W.YanceyMScmAdam M.ChakerMDn

doi : 10.1016/j.jaci.2021.10.040

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Metabolomic profiling revealed altered lipid metabolite levels in childhood food allergy

HaerinJangMSaEun GyulKimMSaMinaKimPhDaSoo YeonKimMD, PhDaYoon HeeKimMD, PhDbMyung HyunSohnMD, PhDaKyung WonKimMD, PhDa

doi : 10.1016/j.jaci.2021.10.034

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Single-cell characterization of dog allergen–specific T cells reveals TH2 heterogeneity in allergic individuals

CélineVandammePhDa∗MarjaRytkönen-NissinenPhDaTapioLönnbergPhDbcJukkaRandellMD, PhDdRauno J.HarvimaMD, PhD, DSceTuureKinnunenMD, PhDafTuomasVirtanenMD, PhDa

doi : 10.1016/j.jaci.2021.11.018

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Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort

Arjan C.LankesterMD, PhDaBenedicteNevenMD, PhDbcdNizarMahlaouiMD, PhDeErik G.J.von AsmuthMDaVirginieCourteilleeMikaelAlligoneMichael H.AlbertMD, PhDfIsabelle BadellSerraMDgPeterBaderMD, PhDhDmitryBalashovMDiRitaBeierMDjYvesBertrandMD, PhDkStephaneBlancheMD, PhDbVictoriaBordonMD, PhDlRobbert G.BrediusMD, PhDaAndrewCantMDmMarinaCavazzanaMD, PhDcnopCristinaDiaz-de-HerediaMDq…Andrew R.GenneryMD, PhDm

doi : 10.1016/j.jaci.2021.10.017

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Human stem cell-derived thymic epithelial cells enhance human T-cell development in a xenogeneic thymus

RafaelGras-PeñaPhDabNichole M.DanzlPhDb∗MohsenKhosravi-MaharlooeiMDb∗Sean R.CampbellMD, PhDbAmanda E.RuizBAbChristopher A.ParksPhDbWilliam MengSuen SavageBAbMarkus A.HolzlPhDbDebanjanaChatterjeePhDbMeganSykesMDbc

doi : 10.1016/j.jaci.2021.09.038

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Glucocorticoids inhibit human hematopoietic stem cell differentiation toward a common ILC precursor

LindaQuatriniPhDaNicolaTuminoPhDaFrancescaBesiMScaCeciliaCiancagliniMScaFedericaGalavernaMD, PhDbAntonio GiacomoGrassoMDbPietroMerliMDbFrancoLocatelliMD, PhDbcPaolaVaccaPhDaLorenzoMorettaMDa

doi : 10.1016/j.jaci.2021.10.012

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Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1

StefanieSchmalzMScaVanessaMayrMScaAlexandraShosherovaBScaBarbaraGeppPhDabDanielaAckerbauerMScaGunterSturmMDcdBarbaraBohlePhDaHeimoBreitenederPhDaChristianRadauerPhDa

doi : 10.1016/j.jaci.2021.10.026

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Targeting IgE polyadenylation signal with antisense oligonucleotides decreases IgE secretion and plasma cell viability

AnneMarchalotPhD, PharmDaCatherineHoriotMScaJean-MarieLambertPhDaClaireCarrionMScaChristelleObletMScaJustinePolletMScbMichelCognéMD, PhDacJeanneMoreauPhDaBriceLaffleurPhDcLaurentDelpyPhDa

doi : 10.1016/j.jaci.2021.09.039

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Cellular and systemic energy metabolic dysregulation in asthma development—a hypothesis-generating approach

SergejsBerdnikovsPhDaDawn C.NewcombPhDbcTebebGebretsadikMPHdBrittney M.SnyderPhDbDerek A.WigginsMSbKadijah S.PoleonBSbTina V.HartertMD, MPHb

doi : 10.1016/j.jaci.2021.10.024

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Discovering metabolite quantitative trait loci in asthma using an isolated population

Randi K.JohnsonPhDaTonyaBrunettiPhDaKevinQuinnPhDbKatrinaDoengesMSbMonicaCampbellMSaChristopherArehartBSaMargaret A.TaubPhDcRasika A.MathiasPhDdNicholeReisdorphPhDbKathleen C.BarnesPhDaMichelleDayaPhDa

doi : 10.1016/j.jaci.2021.11.002

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TNF inhibition in vasculitis management in adenosine deaminase 2 deficiency (DADA2)

Natalie T.DeuitchMS, CGCaDanYangPhDbPui Y.LeeMD, PhDcXiaominYuPhDdNatalia SampaioMouraBSaOskarSchnappaufPhDaAmanda K.OmbrelloMDaDeborahStoneMDaHye SunKuehnPhDeSergio D.RosenzweigMD, PhDePatrycjaHoffmannNPaCorneliaCudriciMDbDeborah M.LevyMDfElizabethKesslerMDgJennifer B.SoepMDhArielle D.HayMDiAustinDalrympleDOjYuZhangPhDk…QingZhouPhDads

doi : 10.1016/j.jaci.2021.10.030

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Mepolizumab response in severe chronic rhinosinusitis with nasal polyps is dissociated from blood eosinophil levels

BrianLipworthMDRoryChanMBChBRasadsMisirovsMBBSKirstenStewartMBChB

doi : 10.1016/j.jaci.2022.02.017

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Corrigendum

doi : 10.1016/j.jaci.2022.03.005

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