doi : 10.1097/MPG.0000000000003632
Volume 75(6) pgs. 685-774,e107-e119 December 2022
Cohran, Valeria C. *; Gold, Benjamin D. +; Spencer, Dennis J. ++; Cole, Conrad R. [S]
Krawczyk, Marcin MD, PhD *,+; Niewiadomska, Olga MD ++; Jankowska, Irena MD, PhD ++; Jankowski, Krzysztof MD, PhD [S],||; Swiderska, Jolanta MD [P]; Lebensztejn, Dariusz MD, PhD #; Wiecek, Sabina MD, PhD **; Gozdowska, Jolanta MD, PhD ++; Kulaga, Zbigniew MD, PhD ++++; Weber, Susanne N. PhD *; Lammert, Frank MD, PhD *,[S][S]; Socha, Piotr MD, PhD ++
doi : 10.1097/MPG.0000000000003609
AB Gallstones are increasingly frequent in children. In this candidate gene study, we genotyped 5 gene variants (ANO1, SPTLC3, TMEM147, TNRC6B, rs12532734) from a recent gallstone genome-wide association study (GWAS) in a cohort of 214 children with gallstones and 172 gallstone-free adult controls. In total, 138 genotyped children presented with symptomatic gallstone disease, 47 underwent cholecystectomy, and 126 received ursodeoxycholic acid (UDCA) as therapy for stones.
Valitutti, Francesco MD *,+; Lindley, Keith MD *; Saliakellis, Efstratios MD *; Chanpong, Atchariya MD *,++,[S]; Pesce, Marcella MD *,||; Rybak, Anna MD *; Thapar, Nikhil MD [P]; Borrelli, Osvaldo MD, PhD *,[S]
doi : 10.1097/MPG.0000000000003599
Studies in adults have suggested that high-resolution technology increases the diagnostic yield of antroduodenal manometry (ADM). However, there is no study comparing high-resolution with low-resolution ADM recordings as well as comparing the 2 types of high-resolution display [conventional line plot (CLP) and pressure topographic plots (PTP)].
Lazarus, Glen; Junaidi, Michelle Clarissa; Oswari, Hanifah
doi : 10.1097/MPG.0000000000003600
Functional constipation (FC) and malnutrition are 2 of the most common diseases affecting children worldwide with long-term consequences. We hereby performed a systematic review and meta-analysis to analyze the relationship between these 2 entities.
Begotka, Andrea PhD; Silverman, Alan PhD; Goday, Praveen MD
doi : 10.1097/MPG.0000000000003628
AB We aimed to prospectively evaluate the effectiveness of a protocolized shaping intervention in children with phagophobia, which occurs when an aversive oral experience causes fear of swallowing and can result in restricted oral intake and weight loss.
Singer, Andrew A. M. MD *; Rompca, Annemarie MD +; Gadepalli, Samir K. MD, MBA ++,[S]; Adler, Jeremy MD, MSc *,[S]
doi : 10.1097/MPG.0000000000003595
Perianal fistulas are among the most severe complications of Crohn disease, but limited data regarding their outcomes are available in children. Our objective was to determine predictors of perianal fistula healing among pediatric patients newly diagnosed with Crohn disease.
Yerushalmy-Feler, Anat MD *; Pujol-Muncunill, Gemma MD +; Martin-de-Carpi, Javier MD +; Kolho, Kaija-Leena MD ++; Levine, Arie MD [S]; Olbjorn, Christine MD ||; Granot, Maya MD [P],#; Bramuzzo, Matteo MD **; Rolandsdotter, Helena MD ++; Mouratidou, Natalia MD ++++; Hradsky, Ondrej MD [S][S]; Scarallo, Luca MD ||||; Matar, Manar MD [P][P]; Rimon, Ramit Magen MD ##; Rinawi, Firas MD ***; Shalem, Tzippi MD +++; Najajra, Hisham MD ++++++; de Meij, Tim MD [S][S][S]; Aloi, Marina MD ||||||; Rodriguez-Belvis, Marta Velasco MD [P][P][P]; Alvisi, Patrizia MD ###; Schneider, Anna-Maria MD ****; van Rheenen, Patrick MD ++++; Navas-Lopez, Victor Manuel MD ++++++++; Kiparissi, Fevronia MD [S][S][S][S]; Barrio, Josefa MD ||||||||; Turner, Dan MD [P][P][P][P]; Cohen, Shlomi MD *
doi : 10.1097/MPG.0000000000003608
Escalation of the ustekinumab (UST) maintenance dosage was effective in adults with Crohn disease (CD), but no data are available for children. We evaluated the effectiveness and safety of dose escalation of UST in pediatric CD.
Constant, Brad D. MD, MSCS *; Baldassano, Robert MD *; Kirsch, Jacqueline *; Mitchel, Elana B. MD, MSCE *; Stein, Ronen MD *; Albenberg, Lindsey DO *
doi : 10.1097/MPG.0000000000003616
Colectomy rates following acute severe ulcerative colitis have plateaued around 20% despite intravenous corticosteroid and intensified anti-tumor necrosis factor (TNF) biologic dosing. Recent studies have shown tofacitinib to provide additional benefit in further decreasing colectomy rates among hospitalized adult patients with corticosteroid- and anti-TNF-nonresponsive ulcerative colitis. Pediatric data describing the effectiveness of tofacitinib for this indication does not yet exist. We aimed to describe the treatment courses and colectomy-free survival among pediatric patients treated with tofacitinib while hospitalized for refractory ulcerative colitis.
Bayoumy, Ahmed B. MD *; Jagt, Jasmijn Z. MD +,++; van Wering, Herbert M. MD, PhD [S]; de Ridder, Lissy MD, PhD ||; Hummel, Thalia MD, PhD [P]; Wolters, Victorien M. MD, PhD #; Stapelbroek, Janneke MD, PhD **; Benninga, Marc A. MD, PhD ++; Mulder, Chris J.J. MD, PhD ++++; de Boer, Nanne K.H. MD, PhD ++++; de Meij, Tim G.J. MD, PhD +,++; on behalf of the Kids with Crohn's, Colitis (KiCC) Working Group for Collaborative Paediatric IBD Research in the Netherlands
doi : 10.1097/MPG.0000000000003621
Thioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]. However, data in pediatric IBD are scarce. Therefore, we aimed to assess the safety of TG as maintenance therapy.
Salzmann, Medea MD *; von Graffenried, Thea MD +; Righini-Grunder, Franziska MD ++; Braegger, Christian MD [S]; Spalinger, Johannes MD *,++; Schibli, Susanne MD *; Schoepfer, Alain MD ||; Nydegger, Andreas MD +; Pittet, Valerie PHD [P]; Sokollik, Christiane MD *; the Swiss IBD Cohort Study Group
doi : 10.1097/MPG.0000000000003630
Inflammatory bowel disease (IBD) requires long-term drug therapy in most patients, posing a risk for adverse drug events with the need for discontinuation. In this study, we investigated adverse events (AE) necessitating drug discontinuation in pediatric and adolescent IBD patients.
Cheung, Telly MD *; de Zoeten, Edwin F. MD, PhD *; Hoffenberg, Edward J. MD *; Liu, Edwin MD *; Pan, Zhaoxing PhD +; Walker, Thomas MD *; Stahl, Marisa MD, MSCS *
doi : 10.1097/MPG.0000000000003613
Celiac disease (CeD) autoimmunity and coexisting inflammatory bowel disease (IBD) present a diagnostic dilemma. Our aims were to describe the phenotype of children with IBD and CeD seropositivity and evaluate provider confidence for diagnosing CeD in this population.
Donat, Ester MD, PhD *,+; Roca, Maria PhD *; Castillejo, Gemma MD ++; Sanchez-Valverde, Felix MD, PhD [S]; Garcia-Burriel, Jose Ignacio MD ||; Martinez-Ojinaga, Eva MD, PhD [P]; Eizaguirre, Francisco Javier MD, PhD #; Barrio, Josefa MD, PhD **; Cilleruelo, M[feminine ordinal indicator] Luz MD, PhD ++; Perez-Solis, David MD, PhD ++++; Ochoa-Sangrador, Carlos MD, PhD [S][S]; Vecino-Lopez, Raquel MD, PhD ||||; Miranda-Cid, M[feminine ordinal indicator] del Carmen MD, PhD [P][P]; Garcia-Calatayud, Salvador MD, PhD ##; Torres-Peral, Ricardo MD, PhD ***; Juste, Mercedes MD, PhD +++; Armas, Honorio MD, PhD ++++++; Barros-Garcia, Patricia MD, PhD [S][S][S]; Leis, Rosaura MD, PhD ||||||; Solaguren, Rosa MD, PhD [P][P][P]; Salazar, Jose Carlos MD ###; Garcia-Romero, Ruth MD, PhD ****; Ortigosa, Luis MD, PhD ++++; Pena-Quintana, Luis MD, PhD ++++++++; Urruzuno, Pedro MD, PhD [S][S][S][S]; Codoner-Franch, Pilar MD, PhD ||||||||; Garcia-Casales, Zurine MD, PhD [P][P][P][P]; Masiques, Maria Lluisa MD ####; Galicia-Poblet, Gonzalo MD, PhD *****; Crehua-Gaudiza, Elena MD, PhD +++++; Balmaseda, Elena MD ++++++++++; Rubio-Santiago, Javier MD [S][S][S][S][S]; Polanco-Allue, Isabel MD, PhD [P],||||||||; Roman-Riechmann, Enriqueta MD, PhD ++; Ribes-Koninckx, Carmen MD, PhD *+; Coeliac Disease Working Group of the Spanish Gastroenterology, Hepatology, Paediatric Nutrition Society (SEGHNP)
doi : 10.1097/MPG.0000000000003620
The objective of this study was to assess the association between serological markers and changes of the intestinal mucosa in children with celiac disease (CD).
Hawa, Kathryn DO *; Corker, Lisa MD +; Hornung, Lindsey MS ++; Noritz, Garey MD [S]; Gariepy, Cheryl MD *; Shaikhkhalil, Ala MD *; Abu-El-Haija, Maisam MD, MS ||,[P]
doi : 10.1097/MPG.0000000000003610
To describe the incidence and presentation of pancreatitis in Children with Medical Complexity (CMC) while evaluating severity of disease and outlining risk factors.
Troendle, David M. MD *; Ruan, Wenly MD +; Fishman, Douglas S. MD +; Barth, Bradley A. MD, MPH *; Liu, Quin Y. MD ++; Giefer, Matthew MD [S]; Kim, Kyung Mo MD ||; Martinez, Mercedes MD [P]; Dall'oglio, Luigi MD #; Torroni, Filippo MD #; De Angelis, Paola MD #; Faraci, Simona MD #; Bitton, Sam MD, MS **; Wilsey, Michael MD ++; Khalaf, Racha MD ++++; Werlin, Steven MD [S][S]; Dua, Kulwinder MD [S][S]; Gugig, Roberto MD ||||; Huang, Clifton MD [P][P]; Mamula, Petar MD ##; Quiros, J. Antonio MD ***; Zheng, Yuhua MD, MS +++; Grover, Amit MD ++++++; Fox, Victor L. MD ++++++
doi : 10.1097/MPG.0000000000003612
Endoscopic retrograde cholangiopancreatography (ERCP) in adults has been extensively studied through multicenter prospective studies. Similar pediatric studies are lacking. The Pediatric ERCP Database Initiative (PEDI) is a multicenter collaborative aiming to evaluate the indications and technical outcomes in pediatric ERCPs.
Berg, Elizabeth A. MD *; Huang, Zixing MS *; Wang, Youya MS +; Baidal, Jennifer Woo MD, MPH *; Fennoy, Ilene MD ++; Lavine, Joel E. MD, PhD +; Zitsman, Jeffrey MD [S]; Shen, Wei MD, MPH, MS *,+,||
doi : 10.1097/MPG.0000000000003607
Metabolic and bariatric surgery is the most effective weight loss treatment for severe obesity. The number of adolescents undergoing sleeve gastrectomy is increasing. We investigated changes in body composition in adolescents undergoing sleeve gastrectomy 12-26 weeks post-operatively using whole-body magnetic resonance imaging (WB-MRI).
Tickell, Kirkby D. MBBS, PhD *,+; Denno, Donna M. MD, MPH *,+,++; Saleem, Ali MBBS, MSc +,[S]; Ali, Asad MBBS, MPH +,[S]; Kazi, Zaubina BSc +,[S]; Singa, Benson O. MBChB, MPH +,||; Otieno, Catherine Ba +,||; Mutinda, Charles BSc +,||; Ochuodho, Victor Ba +,||; Richardson, Barbra A. PhD *,[P]; Asbjornsdottir, Kristjana H. PhD #,**; Hawes, Stephen E. PhD *,#; Berkley, James A. MD, PhD +,++,++++; Walson, Judd L. MD, MPH *,+,++,#,[S][S]
doi : 10.1097/MPG.0000000000003619
To determine whether gut permeability is associated with post-discharge growth and systemic inflammation among hospitalized children in low- and middle-income countries.
Granot, Maya *,+; Haberman, Yael *,+; Schiby, Ginette +,++; Weiss, Batia *,+
Bashir, Anam *; Suchi, Mariko +; Martinez, Alfonso M. *
Cheung, Donna MD *,+,++,[S]; Katz, Daphna T. MD +,++,[S]; Webster-Carrion, Andrea MD ++,[S],||; Saad, Ali G. MD [S],[P]; Fifi, Amanda MD +,++,[S]; Llanos-Chea, Alejandro MD +,++,[S]; Pillai, Asha B. MD ++,[S],#
Vernon-Roberts, Angharad *; Lopez, Robert N. +; Day, Andrew S. *
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