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Pharmacological profile of once-weekly injectable semaglutide for chronic weight management
David C. W. Lau, Rachel L Batterham & Carel W. le Roux
doi : 10.1080/17512433.2022.2070473
Expert Review of Clinical Pharmacology, Volume 15, Issue 3 (2022)
The recent approval in the USA (Food and Drug Administration), Canada (Health Canada), UK (Medicines and Healthcare products Regulatory Agency), and EU (European Medicines Agency) of once-weekly injectable semaglutide 2.4 mg, as an adjunct to a calorie-controlled diet and increased physical activity, for chronic weight management provides health-care practitioners with an additional option when prescribing weight-loss medication.
A single inhaler triple therapy fluticasone furoate/umeclidinium/vilanterol for the treatment of COPD
Mario Cazzola, Paola Rogliani, Luigino Calzetta, Josuel Ora & Maria Gabriella Matera
doi : 10.1080/17512433.2022.2071700
Single inhaler triple therapy (SITT) with an inhaled corticosteroid, a long-acting β2-agonist, and a long-acting muscarinic antagonist is an effective and attractive therapeutic option codified in the recommendations of guidelines and treatment strategies for the management of COPD.
Anticholinergics and falls in older adults
Xiang Jiang Xu & Maw Pin Tan
doi : 10.1080/17512433.2022.2070474
The use of medications with anticholinergic (ACh) properties is associated with numerous adverse effects especially in older adults. Emerging evidence suggests the presence of long-term effects with ACh use.
Peroxisome proliferator-activated receptor-gamma (PPARγ) and its immunomodulation function: current understanding and future therapeutic implications
Carlos Antonio Trindade da Silva, Juliana Trindade Clemente-Napimoga, Henrique Ballassini Abdalla, Rosanna Tarkany Basting & Marcelo Henrique Napimoga
doi : 10.1080/17512433.2022.2071697
Pain is a multidimensional experience involving the biological, psychological, and social dimensions of each individual. Particularly, the biological aspects of pain conditions are a response of the neuroimmunology system and the control of painful conditions is a worldwide challenge for researchers. Although years of investigation on pain experience and treatment exist, the high prevalence of chronic pain is still a fact.
Splicing deregulation, microRNA and notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma
Dario P. Anobile, Giulia Montenovo, Camilla Pecoraro, Marika Franczak, Widad Ait Iddouch, Godefridus J Peters, Chiara Riganti & Elisa Giovannetti
doi : 10.1080/17512433.2022.2074835
Malignant mesothelioma (MMe) is an aggressive rare cancer of the mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at all stages mainly due to resistance to treatments. It is therefore necessary to elucidate key mechanisms underlying chemoresistance, in an effort to exploit them as novel therapeutic targets.
Gender differences in new hypoglycemic drug effects on renal outcomes: a systematic review
Guido Gembillo, Valeria Cernaro, Alfio Edoardo Giuffrida, Giuseppina Russo, Annalisa Giandalia, Rossella Siligato, Elisa Longhitano & Domenico Santoro
doi : 10.1080/17512433.2022.2055546
Lifetime diabetes risk is greater in women than in men. Women with diabetes mellitus (DM) have a greater prevalence of diabetic kidney disease (DKD) risk factors. The diagnosis of DM is often delayed in women, with poorer outcomes and with expected therapeutic goals missed.
Efficacy of local prostaglandin analogues for vitiligo treatment: a systematic review and meta-analysis
Hua-Ching Chang & Siao-Pei Guo
doi : 10.1080/17512433.2022.2071699
Vitiligo is a common cutaneous depigmentation disorder. Although multiple treatment options are available, no single modality is satisfactory for all patients. Several studies have demonstrated that prostaglandin analogues can potentially treat cutaneous depigmentation, but the evidence is limited to their inconsistent study design.
Switching of oral anticoagulants in atrial fibrillation: a cohort study using Australian general practice data
Adane Teshome Kefale, Gregory M. Peterson, Woldesellassie M. Bezabhe & Luke R. Bereznicki
doi : 10.1080/17512433.2022.2044793
We assessed switching patterns of oral anticoagulants (OACs) in patients with atrial fibrillation (AF) in the period following widespread availability of the direct-acting oral anticoagulants (DOACs).
Comparing the renal outcomes in patients with atrial fibrillation receiving different oral anticoagulants
Woldesellassie M. Bezabhe, Luke R. Bereznicki, Jan Radford, Barbara C. Wimmer, Mohammed S. Salahudeen, Ivan Bindoff & Gregory M. Peterson
doi : 10.1080/17512433.2022.2070151
We aimed to compare renal function changes in patients with atrial fibrillation (AF) prescribed different oral anticoagulants (OACs).
Effect of Wuzhi capsules on cyclosporine A concentration in children with aplastic anemia immunotherapy: a single-center observational study
Xiaoling Cheng, Jie Ma, Xiaolin Xu, Liqiang Zhang, Xiaoling Wang & Runhui Wu
doi : 10.1080/17512433.2022.2045193
This research aimed to assess the effect of Wuzhi capsules (WZC) on the blood concentration of cyclosporine A (CsA) in renal aplastic anemia recipients.
