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Pre-surgery optimization of patients’ expectations to improve outcome in heart surgery: Study protocol of the randomized controlled multi-center PSY-HEART-II trial
Stefan Salzmann, PhD a , Johannes A.C. Laferton, PhD b , Meike C. Shedden-Mora, PhD c,d , Nicole Horn a , Laura Gärtner a , Lara Schröder a , Jörn Rau e , Carmen Schade-Brittinger e , Kirsten Murmann, PhD e , Ardawan Rastan, MD f , Térezia B. Andrási, MD f , Andreas Böning, MD g , Miriam Salzmann-Djufri, MD g , Bernd Löwe, MD d , Jens Brickwedel, MD h , Christian Albus, MD i , Thorsten Wahlers, MD PhD j , Alfons Hamm, PhD k , Lutz Hilker, MD l , Wolfgang Albert, MD m , Volkmar Falk, MD n , Tanja Zimmermann, PhD o , Issam Ismail, MD p , Bernhard Strauß, PhD q , Torsten Doenst, MD r , Manfred Schedlowski, PhD s , Rainer Moosdorf, MD f , and Winfried Rief, PhD a Marburg; Potsdam; Hamburg; Marburg; Giessen; Cologne; Greifswald; Karlsburg; Berlin; Hannover; Jena; Essen; Stockholm
doi : 10.1016/j.ahj.2022.07.008
Volume 254, December 2022, Pages 1-11
The PSY-HEART-I trial indicated that a brief expectation-focused intervention prior to heart surgery improves disability and quality of life 6 months after coronary artery bypass graft surgery (CABG).
Transcatheter mitral valve repair for inotrope dependent cardiogenic shock – Design and rationale of the CAPITAL MINOS trial
Simon Parlow, MD a,b,∗, Pietro Di Santo, MD a,b,c,∗, Richard G. Jung, MD, PhD b,d,e , Neil Fam, MD, MSc f , Andrew Czarnecki, MD, MSc g , Eric Horlick, MDCM h , Omar Abdel-Razek, MD a,b , Vincent Chan, MD, MPH i , Mark Hynes, MD j , Donna Nicholson, MD, MSc j , Adam Dryden, MD j , Shannon M. Fernando, MD k,l , George A. Wells, PhD c,m , Jordan Bernick, MSc m , Marino Labinaz, MD a,b , Rebecca Mathew, MD a,b , Trevor Simard, MD n , and Benjamin Hibbert, MD, PhD a,b,d Ontario, Canada
doi : 10.1016/j.ahj.2022.08.008
Volume 254, December 2022, Pages 81-87
Rationale and design for the study of recombinant human hepatocyte growth factor plasmid in the treatment of patients with chronic limb-threatening ischemia (HOPE CLTI): Randomized, placebo-controlled, double-blind, phase III clinical trials
Xiao Di, M.D. a , Changwei Liu, M.D. a , Leng Ni, M.D. a , Wei Ye, M.D. a , Zhihua Rong, M.D. a , Rui Zhang, M.D. a , Shuai Niu, M.D. a , Fengshi Li, M.D. a , Yuehong Zheng, M.D. a , Chengquan Han, M.D. b , and Yue Liu, M.D. b Beijing, China
doi : 10.1016/j.ahj.2022.08.007
Volume 254, December 2022, Pages 88-101
Development and validation of an automated algorithm for end point adjudication for a large U.S. national registry
Daniel J. Friedman, MD a,b , Dominique Pierre, MPH c , Yongfei Wang, MS c,d , Louise Gambone, BA d , Christina Koutras, RN, BSN e , Claire Segawa, MPH e , Andrew Farb, MD f , Sreekanth Vemulapalli, MD b , Paul D. Varosy, MD g,h , Frederick A. Masoudi, MD, MSPH g,i , Alexandra Lansky, MD a,d , Jeptha P. Curtis, MD a,c , and James V. Freeman, MD, MPH, MS a,c New Haven,CT; Durham, NC; Washington D.C.; Silver Spring, MD; Aurora, CO; St. Louis, MO
doi : 10.1016/j.ahj.2022.08.006
Volume 254, December 2022, Pages 102-111
Primary left ventricular unloading with delayed reperfusion in patients with anterior ST-elevation myocardial infarction: Rationale and design of the STEMI-DTU randomized pivotal trial
Navin K. Kapur, MD a , Raymond J. Kim, MD b , Jeffrey W. Moses, MD c,e , Gregg W. Stone, MD d , James E. Udelson, MD a , Ori Ben-Yehuda, MD e , Bjorn Redfors, MD, PhD e , Melek Ozgu Issever, MS e , Noam Josephy, MD, MSc, MBA f,g , Samantha J. Polak, MD, PhD f , and William W. O’Neill, MD
doi : 10.1016/j.ahj.2022.08.011
Volume 254, December 2022, Pages 122-132
Despite successful primary percutaneous coronary intervention (PCI) in ST-elevation myocardial infarction (STEMI), myocardial salvage is often suboptimal, resulting in large infarct size and increased rates of heart failure and mortality.
Characterization of arrhythmia substrate to ablate persistent atrial fibrillation (COAST-AF): Randomized controlled trial design and rationale
Pablo B. Nery, MD a , George A. Wells, PhD a,b , Atul Verma, MD c , Jacqueline Joza, MD c , Girish M. Nair, MBBS, MSc a , George Veenhuyzen, MD d , Jason Andrade, MD e , Isabelle Nault, MD f , Jorge A. Wong, MD g , Markus Sikkel, MD h , Vidal Essebag, MD, PhD c,o , Laurent Macle, MD i , John Sapp, MD j , Jean-Francois Roux, MD k , Allan Skanes, MD l , Paul Angaran, MD m , Paul Novak, MD h , Damian Redfearn, MD n , Mehrdad Golian, MD a , Calum J. Redpath, MD a , Marcio Sturmer, MD o , and David Birnie, MD a Ottawa, Canada; Quebec, Canada; Nova Scotia, Canada
doi : 10.1016/j.ahj.2022.08.010
Volume 254, December 2022, Pages 133-140
CYP2C19 genotype-guided antithrombotic treatment versus conventional clopidogrel therapy in peripheral arterial disease: study design of a randomized controlled trial (GENPAD)
J Kranendonk, MD a,1 , LH Willems, MD a,1 , RJ. van der Vijver-Coppen, MD a , M. Coenen, PhD b , E. Adang, PhD c , R. Donders, PhD d , CJ Zeebregts, MD, PhD e , VHM Deneer, PharmD PhD f,g , MMPJ Reijnen, MD, PhD h,i , C Kramers, MD, PhD j,k , and MC Warlé, MD, PhD a Nijmegen, The Netherlands; Groningen, The Netherlands
doi : 10.1016/j.ahj.2022.08.001
Volume 254, December 2022, Pages 141-148
Personalized approach using wearable technology for early detection of atrial fibrillation in high-risk primary care patients (PATCH-AF): Study protocol for a cluster randomized controlled trial
Tessa Brik, MD, MSc, Wim A.M. Lucassen, PhD, Ralf E. Harskamp, PhD, Evert P.M. Karregat, MD, Jelle C.L. Himmelreich, MD, Wim B. Busschers, PhD, and Eric P. Moll van Charante, PhD Amsterdam, The Netherlands
doi : 10.1016/j.ahj.2022.09.002
Volume 254, December 2022, Pages 172-182
Atrial fibrillation (AF) is a common cardiac arrhythmia with a lifetime risk of one in 4. Unfortunately, AF often remains undetected, particularly when it is paroxysmal, for which single time-point evaluation is less effective. Recently, unobtrusive cardiac arrhythmia monitoring devices have become available, providing the opportunity to conduct prolonged electrocardiographic (ECG) monitoring in a patient-friendly manner.
Efficacy and safety of a quadruple ultra-low-dose treatment for hypertension (QUARTET USA): Rationale and design for a randomized controlled trial
Abigail S. Baldridge, MS a , Mark D. Huffman, MD, MPH a,b,c , Danielle Lazar, AM d , Hiba Abbas, DNP, RN d , Fallon M. Flowers, MSN, RN d , Adriana Quintana, MPH d , Alema Jackson, MS, LPN a , Sadiya S. Khan, MD, MSc a , Aashima Chopra, MPH a , My Vu, MS a , Priya Tripathi, MS e , Tyler Jacobson, BBA a , Olutobi A. Sanuade, MPHIL, PhD a,f , Namratha R. Kandula, MD, MPH a , Stephen D. Persell, MD, MPH a , James J. Paparello, MD a , Linda L. Rosul, BA d , Jairo Mejia, MD, FACP d , Donald M. Lloyd-Jones, MD, SCM a , Clara K. Chow, MD, PhD c,g,h , and Jody D. Ciolino, PhD a Chicago, IL; St. Louis, MO; Sydney, Australia; Chicago, IL; Chicago, IL
doi : 10.1016/j.ahj.2022.09.004
Volume 254, December 2022, Pages 183-193
Over half of patients with elevated blood pressure require multi-drug treatment to achieve blood pressure control. However, multi-drug treatment may lead to lower adherence and more adverse drug effects compared with monotherapy.
The pediatric heart network's study on long-term outcomes of children with HLHS and the impact of Norwood Shunt type in the single ventricle reconstruction trial cohort (SVRIII): Design and adaptations
Caren S. Goldberg, MD a , J. William Gaynor, MD b , William T. Mahle, MD c , Chitra Ravishankar, MD d , Peter Frommelt, MD e , Dawn Ilardi, PhD f , David Bellinger, PhD g , Stephen Paridon, MD d , Michael Taylor, MD h , Kevin D. Hill, MD i , L. LuAnn Minich, MD j , Steven Schwartz, MD k , Katherine Afton l , Melissa Lamberti m , Felicia L. Trachtenberg, PhD m , Russell Gongwer m , Andrew Atz, MD n , Kristin M. Burns, MD n , Shahryar Chowdhury, MD n , James Cnota, MD o , Jon Detterich, MD p , Michele Frommelt, MD e , Jeffrey P. Jacobs, MD q , Thomas A. Miller, DO r , Richard G. Ohye, MD s , Christian Pizarro, MD t , Amee Shah, MD u , Patricia Walters, RN v , and Jane W. Newburger, MD w , for the Pediatric Heart Network Investigators Ann Arbor, MI; Philadelphia, PA; Atlanta, GE; Milwaukee, WI; Boston, MA; Cincinnati, OH; Durham, NC; Salt Lake City, UT; Toronto, ON; Ann Arbor, MI; Newton, MA; Charleston, SC; Cincinnati, OH; Los Angeles, CA; Gainseville, FL; PortlandSalt Lake City, MEUT; Wilmington, DE; New York, NY and Toronto, Ontario
doi : 10.1016/j.ahj.2022.09.005
Volume 254, December 2022, Pages 216-227
The Single Ventricle Reconstruction (SVR) Trial was the first randomized clinical trial of a surgical approach for treatment of congenital heart disease. Infants with hypoplastic left heart syndrome (HLHS) and other single right ventricle (RV) anomalies were randomized to a modified Blalock Taussig Thomas shunt (mBTTS) or a right-ventricular-to-pulmonary-artery shunt (RVPAS) at the time of the Norwood procedure.
ISCHEMIA-EXTEND studies: Rationale and design
Rebecca Anthopolos, DrPH a , David J. Maron, MD b , Sripal Bangalore, MD, MHA a , Harmony R. Reynolds, MD a , Yifan Xu, MPH a , Sean M. O’Brien, PhD c , Andrea B. Troxel, ScD a , Stavroula Mavromichalis, MS a , Michelle Chang, MPH a , Aira Contreras a , and Judith S. Hochman, MD a , on behalf of ISCHEMIA-EXTEND Research Group New York, NY; Stanford, CA; Durham, NC
doi : 10.1016/j.ahj.2022.09.009
Volume 254, December 2022, Pages 228-233
Black-White disparity in severe cardiovascular maternal morbidity: A systematic review and meta-analysis
Ugochinyere Vivian Ukah, MPH, PhD a,b , Xinting Li, MscPHc a,b , Shu Qin Wei, MD, PhD b,c , Jessica Healy-Profitós, MPH b,d , Natalie Dayan, MD, MSc, FRCPC a,e , and Nathalie Auger, MD, MSc, FRCPC a,b,d,f Quebec, Canada
doi : 10.1016/j.ahj.2022.07.009
Volume 254, December 2022, Pages 35-47
To synthesize existing evidence on Black-White disparities in the prevalence of severe cardiovascular maternal morbidity.
Integrating hemodynamics with ventricular and valvular remodeling in aortic stenosis. A paradigm shift in therapeutic decision making
Gregory S. Pavlides, MD, PhD, Yannis S. Chatzizisis, MD, PhD, and Thomas R. Porter, MD Omaha, Nebraska
doi : 10.1016/j.ahj.2022.08.004
Volume 254, December 2022, Pages 66-76
Aortic valve stenosis (AS) has traditionally been approached in hemodynamic terms. Although hemodynamics and symptoms have formed the basis of recommending interventional treatment in AS, other factors reflecting left ventricular and valvular and/or vascular remodeling are equally important for the prognosis and outcome of patients with AS.
Identifying quality of life outcome patterns to inform treatment choices in ischemic cardiomyopathy
Makoto Mori, MD, PhD a,b , Daniel B. Mark, MD, MPH c , Rohan Khera, MD, MS b,d , Haiqun Lin, PhD e , Philip Jones, MS f,g , Chenxi Huang, PhD b , Yuan Lu, ScD b,d , Arnar Geirsson, MD a , Eric J. Velazquez, MD d , John A. Spertus, MD, MPH f,g , and Harlan M. Krumholz, MD, SM b,h New Haven, CT; Durham, NC; Newark, NJ; Kansas City, MO
doi : 10.1016/j.ahj.2022.07.007
Volume 254, December 2022, Pages 12-22
The Surgical Treatment for Ischemic Heart Failure (STICH) trial found that routine use of coronary artery bypass surgery (CABG) improved mean quality of life (QoL) scores relative to guideline-directed medical therapy (GDMT) in patients with ischemic cardiomyopathy. However, mean differences in QoL scores do not provide what patients want to know when facing a high-risk/high-benefit treatment choice.
Early trends in cardiac allograft vasculopathy after implementation of the 2018 donor heart allocation policy in the United States
David M. Tehrani, MD, MS a , Juka S. Kim, BS a , Jeffrey J. Hsu, MD, PhD a , Ali Nsair, MD a , Kiran K. Khush, MD b , William F. Fearon, MD b , and Rushi V. Parikh, MD a Los Angeles; Stanford
doi : 10.1016/j.ahj.2022.08.002
Volume 254, December 2022, Pages 23-29
To evaluate the impact of the new donor heart allocation system implemented in the United States in October 2018 on development of early cardiac allograft vasculopathy (CAV).
Glycemic status and the association of change in blood pressure with incident cardiovascular disease
Yuta Suzuki, PhD, a,b , Hidehiro Kaneko, MD, a,c , Yuichiro Yano, MD, d,e , Akira Okada, MD, f , Hidetaka Itoh, MD, a , Satoshi Matsuoka, MD, a , Katsuhito Fujiu, MD, a,b , Nobuaki Michihata, MD, g , Taisuke Jo, MD, g , Norifumi Takeda, MD, a , Hiroyuki Morita, MD, a , Kentaro Kamiya, PhD, b , Atsuhiko Matsunaga, PhD, b , Junya Ako, MD, h , Koichi Node, MD, i , Hideo Yasunaga, MD, j , and Issei Komuro, MD, a Tokyo, Japan; Sagamihara, Japan; Tokyo, Japan; Shiga, Japan; Durham, NC; Tokyo, Japan; Tokyo, Japan; Sagamihara, Japan; Saga, Japan; Tokyo, Japan;
doi : 10.1016/j.ahj.2022.07.005
Volume 254, December 2022, Pages 48-56
The clinical benefit of blood pressure (BP) reduction in individuals with diabetes has not been fully elucidated. We sought to identify the clinical impact of BP reduction on incident cardiovascular disease in people having diabetes and hypertension.
Association between nitric oxide synthase 3 genetic variant and acute kidney injury following pediatric cardiac surgery
Sandra Kikano, MD, a , Joseph Breeyear, BS, b , Ida Aka, MPH, a , Todd L. Edwards, PhD, b , Sara L. Van Driest, MD, PhD, a,b , and Prince J. Kannankeril, MD, MSCI a Nashville, TN
doi : 10.1016/j.ahj.2022.08.003
Volume 254, December 2022, Pages 57-65
Machine learning to define phenotypes and outcomes of patients hospitalized for heart failure with preserved ejection fraction: Findings from ASCEND-HF
Evan M. Murray, MD a , Stephen J. Greene, MD b,c , Vishal N. Rao, MD, MPH b , Jie-Lena Sun, MS c , Brooke A. Alhanti, PhD c , Vanessa Blumer, MD f , Javed Butler, MD, MPH, MBA d , Tariq Ahmad, MD, MPH e , and Robert J. Mentz, MD b,c Durham, NC; Jackson, MS; New Haven, CT;
doi : 10.1016/j.ahj.2022.08.009
Volume 254, December 2022, Pages 112-121
Development of a unified national database of primary percutaneous coronary intervention centers with co-located emergency departments, 2020
Darya M. Herscovici, BS, Krislyn M. Boggs, MPH, Rebecca E. Cash, PhD, Janice A. Espinola, MPH, Ashley F. Sullivan, MS, MPH, Kohei Hasegawa, MD, MPH, John T. Nagurney, MD, MPH, and Carlos A. Camargo Jr., MD, DRPH Boston, MA
doi : 10.1016/j.ahj.2022.08.012
Volume 254, December 2022, Pages 149-155
Although primary percutaneous coronary intervention (pPCI) is the preferred intervention for ST-elevation myocardial infarction (STEMI), not all patients are admitted directly to an emergency department (ED) with 24/7/365 pPCI capabilities. This is partly due to a lack of a national system of known pPCI-capable EDs. Our objective was to create a unified, national database of confirmed 24/7/365 pPCI centers co-located in hospitals with EDs.
Rate versus rhythm control in patients with newly diagnosed atrial fibrillation: Effects of the treatment timing on health status outcomes
Ryo Nakamaru, MD, PhD a,b , Nobuhiro Ikemura a,c , John A. Spertus, MD, MPH c , Takehiro Kimura, MD, PhD a , Yoshinori Katsumata, MD, PhD a , Taishi Fujisawa, MD, PhD a , Koji Ueno, MD, PhD d , Soushin Inoue, MD, PhD e , Ikuko Ueda, PhD a , Keiichi Fukuda, MD, PhD a , Seiji Takatsuki, MD, PhD a , and Shun Kohsaka, MD a Tokyo, Japan; Kansas City, MO; Tochigi, Japan
doi : 10.1016/j.ahj.2022.09.001
Volume 254, December 2022, Pages 156-165
Comparative risk of dementia among patients with atrial fibrillation treated with catheter ablation versus anti-arrhythmic drugs
Emily P. Zeitler, MD, MHS a , T. Jared Bunch, MD b , Rahul Khanna, BPharm, MBA, PhD c , Xiaozhou Fan, MD, PhD c , Maximiliano Iglesias, MBA d , and Andrea M. Russo, MD e Lebanon, NH; Salt Lake City, UT; New Brunswick, NJ; Irvine, CA; Camden, NJ
doi : 10.1016/j.ahj.2022.09.007
Volume 254, December 2022, Pages 194-202
Comparative effectiveness of Empagliflozin in reducing the burden of recurrent cardiovascular hospitalizations among older adults with diabetes in routine clinical care
Rishi J. Desai, MS, PhD a , Robert J. Glynn, PhD a , Brendan M. Everett, MD, MPH b , Sebastian Schneeweiss, MD, ScD a , Deborah J. Wexler, MD, MSc c , Lily G. Bessette, BS a , Anouk Déruaz-Luyet, PhD, MPH d , Ola Vedin, MD, PhD d , Kimberly Brodovicz, DrPH d , and Elisabetta Patorno, MD, DrPH a Boston, MA
doi : 10.1016/j.ahj.2022.09.008
Volume 254, December 2022, Pages 203-215
The effect of sodium glucose cotransporter 2 inhibitors (SGLT2i) on the total (first and recurrent) burden of cardiovascular (CV) hospitalizations, including hospitalization for heart failure, myocardial infarction, and stroke, is poorly understood.
Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial
Stephen Y. Wang, MD, MPH a , Jonathan M. Hanna, MD a , Prajesh Gongal, MD b , Oyere K. Onuma, MD, MSc c , and Michael G. Nanna, MD, MHS c New Haven, CT; Lebanon, NH; New Haven, CT;
doi : 10.1016/j.ahj.2022.07.006
Volume 254, December 2022, Pages 30-34
Despite broad treatment recommendations, there are limited published reports comparing the efficacy of different antihypertensive agents in patients with isolated systolic hypertension or isolated diastolic hypertension. This study was a secondary analysis of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial.
Association of change in QRS duration with chronic heart failure outcomes
Andrew S. Perry, MD, and Song Li, MD Seattle, WAAndrew S. Perry, MD, and Song Li, MD Seattle, WA
doi : 10.1016/j.ahj.2022.08.005
Volume 254, December 2022, Pages 77-80
QRS duration is an established risk factor among patients with heart failure. How change in QRS duration relates to heart failure outcomes has had limited study. In this post-hoc analysis of the Beta-Blocker Evaluation of Survival Trial, we demonstrated that QRS duration change from baseline to 3 months is independently associated with long-term survival and left ventricle ejection fraction.
Insights into the genetic architecture underlying complex, critical congenital heart disease.
Gillian M. Blue, PhD a,b , Eddie K.K. Ip, PhD c , Michael Troup, BCST(adv)(hons) c , Russell C. Dale, PhD b , Gary F. Sholler, MBBS, FRACP a,b , Richard P. Harvey, PhD c,d,e , Sally L. Dunwoodie, PhD c,d , Eleni Giannoulatou, DPhil c,d , and David S. Winlaw, MBBS, MD, FRACS a,b,f Sydney, Australia
doi : 10.1016/j.ahj.2022.09.006
Volume 254, December 2022, Pages 166-171
Congenital heart disease (CHD) has a multifactorial aetiology, raising the possibility of an underlying genetic burden, predisposing to disease but also variable expression, including variation in disease severity, and incomplete penetrance.
End-Stage Renal Disease is Associated with Increased Inpatient Mortality in Patients Admitted for Atrial Fibrillation: Analysis of the National Inpatient Sample
Richard Orji, MD 1,2, Michael Fatuyi, MD 3, Jashan Gill, MD 1,2, Adedoyin Olawoye, MD 4, Aman Dutta, MD 1,2, Komal Malik, MD 1,2, Kevin Nab- han 5, Ebehireme Ukpokolo
doi : 10.1016/j.ahj.2022.10.011
Volume 254, December 2022, Page 234
End-stage renal disease (ESRD) has been shown to affect different heart pathologies through its underlying pathogenesis of unabating chronic inflammation. Our study sought to estimate the impact of ESRD on clinical outcomes of hospitalizations for atrial fibrillation (AF) using a national database.
Impact of Diabetes Mellitus on Early Clinical Outcome and Stent Restenosis after Carotid Artery Stenting
Alexandru Achim, Dávid Lackó, Artúr Hüttl, Csaba Csobay-Novák, �dám Csavajda, Péter Sótonyi, Béla Merkely, Balázs Nemes, Zoltán Ruzsa Department of Internal Medicine, Division of Invasive Cardiology, University of Szeged, Szeged, Hungary
doi : 10.1016/j.ahj.2022.10.012
Volume 254, December 2022, Page 234
Diabetes mellitus is closely related to both the severity of carotid disease and its outcome after revascularization. Carotid artery stenting (CAS) has emerged as a viable alternative to surgical endarterectomy but little is known about the impact of diabetes after CAS.
Prevalence of Dyslipidaemia, Obesity and Vitamin d Insufficiency Among Patients Attending the Diabetic Clinic at Queen Elizabeth Central Hospital in Malawi
Kondwani Katundu 1,2, Victoria Mukhula 2, Johnstone Kumwenda 3, Mwapatsa Mipando 1, Adamson Muula 5, Tamara Phiri 3,4, Chimota Phiri 4, Fanuel Lampiao 1, Henry Mwandumba
doi : 10.1016/j.ahj.2022.10.013
Volume 254, December 2022, Page 235
Dyslipidaemia, obesity and vitamin D insufficiency are important risk factors for cardiovascular disease and may increase the risk for severe COVID-19 among individuals with Diabetes mellitus.
Benefits of Fiber-Rich Snacks on Waist Circumference and Atergenic Index of Plasma in Obese
Fatma Syukrina, Sunarti, Ika Ratna Palupi
doi : 10.1016/j.ahj.2022.10.014
Volume 254, December 2022, Page 235
Dyslipidaemia Patterns and Risk Factors Among Patients with Diabetes, Hypertension, and Both Diabetes and Hypertension at a Tertiary Hospital in Malawi
Kondwani Katundu 1,2, Victoria Mukhula 2, Johnstone Kumwenda 3, Mwapatsa Mipando 1, Adamson Muula 5, Tamara Phiri 3,4, Chimota Phiri 4, Fanuel Lampiao 1, Henry Mwandumba 1,2
doi : 10.1016/j.ahj.2022.10.015
Volume 254, December 2022, Page 236
Dyslipidaemia is a significant risk factor for cardiovascular events but is often neglected in most resource-poor settings.
Efficacy of Liraglutide Versus Gliclazide in Treatment of Patients with Type II Diabetes Mellitus: Systematic Review and Meta-Analysis
Manar Ahmed Kamal 1, Raneem Mahmoud Al- Arawi 2, Mohamed Ahmed Kamal
doi : 10.1016/j.ahj.2022.10.016
Volume 254, December 2022, Page 236
Type 2 diabetes mellitus (T2DM) triggers long-lasting and progressive metabolic disorders, causing a severe health issue resulting in several high predominance and dangerous complications. Liraglutide is a glucagon-like peptide-1 (GLP-1), while gliclazide is an oral antihyperglycemic agent.
Weight Status and Cardiovascular Diseases in Newly Diagnosed Diabetes
Andreea Morosanu 1,2, Magdalena Morosanu
doi : 10.1016/j.ahj.2022.10.017
Volume 254, December 2022, Page 237
Prevalence of diabetes is increasing exponentially and obesity is usually associated with the appearance of diabetes. Cardiovascular diseases can be present since diagnosis of the disease or can be consequences of diabetes. The aim was to evaluate weight status and cardiovascular diseases in newly diagnosed diabetes.
Association of Plaque Burden with Insulin Resistance Represented by Triglyceride - High Density Protein Ratio
Luay Alalawi, April Kinninger, Venkat Sanjay Manubolu, Dhiran Verghese, Ahmed Shafter, Ahmed K. Ghanem, Omar Al Taweel, Khadije Ahmad, Ilana Golub, Zahra Al- chokhachi, George Boll, Orly Termeie, Lucia Schroeder, Stephanie Kristo, Sion Roy, Matthew J. Budoff
doi : 10.1016/j.ahj.2022.10.018
Volume 254, December 2022, Page 237
Multiple population-based studies has demonstrated that insulin resistance (IR) is strongly associated with coronary artery disease (CAD), plaque development, progression, and burden. Several surrogate biomarkers were used to assess for IR, such as hyperinsulinemic-euglycemic clamp, which still remains impractical in a clinical setting. We used simpler biomarkers as a surrogate for IR.
Trends, Predictors and Outcomes of Cardiovascular Complications at Delivery Associated with Gestational Diabetes Mellitus-a National Inpatient Sample Analysis (2004-2019)
Salman Zahid, MD, Anas Hashem, MD, Anum S. Min- has, MD, MHS, Wendy L. Bennett, MD, MPH, Michael C. Honigberg, MD, MPP, Jennifer Lewey, MD, Melinda B. Davis, MD, Erin D. Michos, MD, MHS
doi : 10.1016/j.ahj.2022.10.019
Volume 254, December 2022, Page 238
Women with gestational diabetes mellitus (GDM) have an increased risk of pregnancy-associated complications and long-term risk of cardiovascular (CV) disease. However, data on in-hospital peripartum CV complications remain limited.
Estimate Patient's 10-Years Cardiovascular Risk using Arteriosclerotic Cardiovascular Disease Tool a Cross-Sectional Study in Al-Harja, Asser, Saudi Arabia, 2021
Abdulrahman Saeed, Abdullah Saeed, Bahaa Abaalkhail
doi : 10.1016/j.ahj.2022.10.020
Volume 254, December 2022, Page 238
Coagulation and cognitive function - science behind the scenes
Edin Begic 1,2, Slobodan Jankovic 3,4, Mirsada Cause- vic
doi : 10.1016/j.ahj.2022.10.021
Volume 254, December 2022, Page 239
Cardiovascular risk factors and proteins that regulate endothelial cell function have been suggested to contribute to the development of Alzheimer's disease (AD)-related dementia.
Investigating the Micrornas as Key Regulator in Diabetic Cardiomyopathy
Iqra Azhar, Ayesha Ishtiaq, Iram Murtaza
doi : 10.1016/j.ahj.2022.10.022
Volume 254, December 2022, Page 239
Diabetic Cardiomyopathy (DCM) is a state in which cardiomyopathy occurs in patients due to diabetes mellitus without valvular and coronary artery disease. The DCM prevalence is about 50% in patients diagnosed with diabetes at either clinical or preclinical stages.
Mirnas as Potential Diagnostic Tool for Diabetes-Linked Myocardial Infarction
Sana Karim, Ayesha Ishtiaq, Iram Murtaza
doi : 10.1016/j.ahj.2022.10.023
Volume 254, December 2022, Pages 239-240
Cardiovascular diseases affect millions of people worldwide with a prevalence of 17.9 deaths in 2019. Myocardial infarction (MI) is the initial indicator of heart failure associated with reduced blood flow causing cardiac cell apoptosis.
Influence of Body Mass Index and Glucose Metabolism on Results of Cabg for High Risk Patients
Olena Gogayeva, Anatolii Rudenko, Vasyl Lazo- ryshynets
doi : 10.1016/j.ahj.2022.10.024
Volume 254, December 2022, Page 240
to study influence of BMI and glucose metabolism on results of CABG for high-risk patients.
Side Effect Synergism Between Metformin and GLP-1 Receptor Agonists
E Cristiano, JM Miles
doi : 10.1016/j.ahj.2022.10.025
Volume 254, December 2022, Pages 240-241
Metformin and GLP-1 receptor agonists (GLP-1RAs) are both widely used in the treatment of type 2 diabetes (T2DM) in part because of their potential for cardiovascular risk reduction.
Predictors of Major Adverse Limb Events After Infrainguinal Bypass in Patients with Diabetes
Dana Alameddine, Keyuree Satam, Martin Slade, He Wang, Carlos Mena-Hurtado, Jeffrey Turner, Silvio E Inzucchi, Cassius Iyad Ochoa Chaar
doi : 10.1016/j.ahj.2022.10.026
Volume 254, December 2022, Page 241
Diabetes mellitus is a major risk factor for peripheral artery disease (PAD). The association of diabetes with major adverse limb events (MALE) after lower extremity revascularization (LER) remains controversial as patients with diabetes are often analyzed as a homogenous group.
“Ogtt-Plus� – A Novel Web-App for Model Assessment of Cardio-Vascular Risk in Obesity, Dysmetabolism & Dysglycemia
Suresh N. Shinde 1,2, Rituparna S. Shinde 1,2, Ashwini S. Joshi
doi : 10.1016/j.ahj.2022.10.027
Volume 254, December 2022, Page 241
We developed this web based ‘Dysmetabolism-Risk Calculator’ after analysing 1800 individuals, who underwent ‘standard two hour 75 gram OGTT’ along with insulin levels.
Efficacy and Safety of Tirzepatide in Type 2 Diabetes: The Surpass Clinical Trial Program
Mike Barros, Joshua A. Levine Eli Lilly and Company, Indianapolis, IN, USA
doi : 10.1016/j.ahj.2022.10.028
Volume 254, December 2022, Pages 241-242
Tirzepatide is a novel, once-weekly, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist that is approved for the treatment of type 2 diabetes (T2D).
Micro Rnas as Potential Biomarkers for Early-Stage Diagnosis of Hyperglycemia Induced Cardiac Autoimmunity
Rafia Gul, Iram Mushtaq, Iram Murtaza
doi : 10.1016/j.ahj.2022.10.029
Volume 254, December 2022, Page 242
In autoimmune disorder of Type 1 diabetes mellitus (T1DM), T cells mediated destruction of pancreatic beta cells results in insulin deficiency leads to hyperglycemia.
Biomarkers in Determining the Risk of Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease and Hypertension
Anastasiia Rozhdestvenska, MD, PhD student, Natalia Zhelezniakova, MD, Doctor of Medicine, professor
doi : 10.1016/j.ahj.2022.10.030
Volume 254, December 2022, Pages 242-243
Non-alcoholic steatohepatitis (NASH) affects up to 50% of patients with arterial hypertension (HT). Laboratory biomarkers are believed to help in liver fibrosis (LF) risk determination in patients with NASH and HT.
Telomere, Telomerase and The Aging Heart
Ahmed Saad Elsaeidy, Manar Ahmed Kamal, Mostafa Sameh, Ahmed Fady Fouad
doi : 10.1016/j.ahj.2022.10.031
Volume 254, December 2022, Page 243
Aging is a physiological process in all populations with time and finally leads to cellular senescence and organ dysfunction. Telomere's primary function is the protection of DNA with the help of the telomerase enzyme. Telomerase activity declines with time, and with each cell division, telomere length decreases.
Potential Cyp3a4-Mediated Drug-Drug Interactions with Ritonavir-Containing Medications in U.S. Patients with Diabetes or Cardiovascular Diseases: An Analysis of Nhanes Data
Ebuwa Igho-Osagie, Kaylen Brzozowski, Harry Jin, Jeff Brown, Amy Puenpatom
doi : 10.1016/j.ahj.2022.10.032
Volume 254, December 2022, Page 243
This cross-sectional study examined the 2015-2019 National Health and Nutrition Examination Surveys (NHANES), which has been used in previous COVID-19 research, to estimate the proportion of adults with diabetes and serious heart conditions (SHCs) at risk of potential drug-drug interactions (pDDIs) arising from concomitant use of ritonavir and medications used to treat their comorbid conditions.
Major Adverse Cardiovascular Events Across the Sotagliflozin Clinical Development Program
Michael J. Davies 1, Franklin Sun 1, Phillip Banks 1, Deepak L. Bhatt 2, Bertram Pitt
doi : 10.1016/j.ahj.2022.10.033
Volume 254, December 2022, Pages 243-244
SGLT inhibitors, including sotagliflozin, have been shown to consistently reduce the risk of heart failure (HF) and renal-related events. Their effects on major adverse cardiovascular events (MACE: myocardial infarction [MI] and stroke) have been variable.
Comorbidity Burden in Patients with Covid-19 Treated with Molnupiravir in the United States
Girish Prajapati, Amar Das, Yezhou Sun, Eileen Fon- seca
doi : 10.1016/j.ahj.2022.10.034
Volume 254, December 2022, Page 244
Individuals with certain medical conditions, e.g., diabetes, heart, and/or lung disease, are at higher risk of severe COVID-19. Molnupiravir, an oral antiviral drug for treatment of mild-to-moderate COVID-19 in certain adults, was granted US FDA emergency use authorization.
In-Silico Profiling of Mirnas Against Type 2 Diabetes Mellitus and Myocardial Infarction Associated Genes
Khadam Hussain, Muhammad Yousaf, Iram Mur- taza
doi : 10.1016/j.ahj.2022.10.035
Volume 254, December 2022, Pages 244-245
In-silico profiling of miRNAs against type 2 diabetes mellitus and myocardial infarction associated genes Khadam Hussain, Muhammad Yousaf, Iram Murtaza Signal Transduction Laboratory, Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan Abstract Type 2 diabetes mellitus (T2DM) and myocardial infarction (MI) are among top ten leading cause of death, worldwide.
Change in Galectin-3 (Marker of Fibrosis) During Empagliflozin Therapy
K. Tchaava, N. Gegeshidze, M. Shavdia, N. Ninashvili, T. Shervashidze
doi : 10.1016/j.ahj.2022.10.036
Volume 254, December 2022, Page 245
Change in Galectin-3 (marker of fibrosis) during Empagliflozin therapy. K.Tchaava1, N.Gegeshidze1, M.Shavdia1, N.Ninashvili1, T.Shervashidze2 1Tbilisi State Medical University, 2 Ilia State University, Tbilisi, Georgia Goal: To study Empagliflozin therapy effect on fibrosis marker- Galectin-3.
Results from a Randomized, Open-Label, Crossover Study Evaluating Pharmacokinetic Interaction Between the Aldosterone Synthase Inhibitor Baxdrostat and Metformin in Healthy Human Subjects
Mason W. Freeman 1, Mary Bond 2, Brian Murphy 2, James Hui 1, Jonathan Isaacsohn
doi : 10.1016/j.ahj.2022.10.037
Volume 254, December 2022, Page 245
Due to the high prevalence of diabetes in patients with hypertension, co-administration of metformin with anti-hypertensive drugs is likely. The aldosterone synthase inhibitor baxdrostat (CIN 107) was developed to treat hypertension.
Association of QT Markers of Arrhythmia and Familial Mediterranean Fever: A Meta-Analysis
Karam R. Motawea 1, Joseph Varney 2, Omneya A. Kandil 1, Nancy Ibrahim 1, Merna Aboelenein 1, Bishoy Zaki 3, Sarya Swed 4, Mohamed A. Shebl 5, Zakria Helmy 6, Ahmed Helmy 7, Ahmed Khalifa 8, Mohamed A. Elbahaie 9, Areeg A. El- bahaie 9, Arwa A. Elbahaie 9, Hani Aiash
doi : 10.1016/j.ahj.2022.10.038
Volume 254, December 2022, Pages 245-246
Some studies found no association between Familial Mediterranean fever (FMF) patients and abnormal QT markers of arrhythmia, others found prolongation of these markers in FMF patients. The aim of this study is to perform a met-analysis to find whether there is an actual association between FMF and abnormal QT markers.
Coronary Embolism After Infection with Covid-19 in Non-Diabetic Non-Hypertensive Patient. A Case Report
Karam R. Motawea, Sarraa M. Reyad, Pensée Chébl
doi : 10.1016/j.ahj.2022.10.039
Volume 254, December 2022, Page 246
A 72-year-old female patient presented to the emergency department with one week history of dry cough, sore throat, and dyspnea grade 3, and 9 hours history of retrosternal chest pain. The patient had normal pulse, temperature and blood pressure.
Lactate Dehydrogenase can be Considered a Predictive Marker of Severity and Mortality of Covid-19 in Diabetic and Non-Diabetic Patients. A Case Series
Karam R. Motawea 1, Joseph Varney 2, Nesreen E. Talat 1, Samah S. Rozan 1, Pensée Chébl 1, Sarraa M. Reyad
doi : 10.1016/j.ahj.2022.10.040
Volume 254, December 2022, Pages 246-247
Eight elderly confirmed SARS-CoV-2 patients who had severe course of COVID-19 and admitted to ICU expressed high lactate dehydrogenase (LDH) above normal level.
Statin Therapy is Associated with Higher Risk of Diabetic Complications: A Population-Based Cohort Study
Danish Iltaf Satti, Teddy Tai Loy Lee, Oscar Hou In Chou, Chengsheng Ju, Evbayekha Endurance Osas, Gary Tse, Sharen Lee
doi : 10.1016/j.ahj.2022.10.041
Volume 254, December 2022, Page 247
Data regarding diabetic complications with chronic statin use among Asian population is very limited. Hence, we investigated diabetic progression in diabetic patients receiving statin therapy by evaluating the association with acute and chronic diabetic complications.
Periodontal Disease in Association with Myocardial Infarction with Non-Obstructive Coronary Arteries and Microvascular Coronary Artery Disease
Danish Iltaf Satti 1, Jahanzeb Malik 2, Syed Muhammad Jawad Zaidi 3, Farwa Jaffar 4, Kanwal Latif 5, Ali Tahir Rana 6, Mamoona Zahoor 7, Waheed Akhtar
doi : 10.1016/j.ahj.2022.10.042
Volume 254, December 2022, Pages 247-248
The relationship between periodontitis and myocardial infarction with non-obstructive coronary arteries (MINOCA) and microvascular angina has not been previously investigated.
Intranasal Co-Administration of Insulin and C-Peptide Restores Metabolic and Hormonal Indices in Rats with Normoinsulinemic, but not with Hyperinsulinemic, Type 2 Diabetes
A.M. Stepochkina 1,2, K.V. Derkach 1, V.M. Bondareva 1, A.A. Bakhtyukov 1, A.O. Shpakov
doi : 10.1016/j.ahj.2022.10.043
Volume 254, December 2022, Page 248
In type 2 diabetes mellitus (T2DM), the functions of the brain insulin system are impaired, which is associated with a decrease in insulin transport across the blood-brain barrier due to insulin resistance.
Exploring the Role of Micro Rnas as Key Regulators of Diabetic Nephropathy Induced Cardiovascular Diseases
Javaria Nawaz, Iram Mushtaq, Iram Murtaza
doi : 10.1016/j.ahj.2022.10.044
Volume 254, December 2022, Page 248
Diabetic nephropathy (DN) refers to the impairment of kidney function that occurs in patients with type 1 and type 2 diabetes mellitus. Diabetic Patients with kidney disease have an exceptionally high risk of developing cardiovascular complications.
Single Nucleotide Variants of the MCM6 Gene as a Risk Factor for Metabolically Unhealthy Obesity in Children
Aleksandr Abaturov, Anna Nikulina, Dmytro Nikulin
doi : 10.1016/j.ahj.2022.10.045
Volume 254, December 2022, Page 249
Lactose maldigestion associated with lactase non-persistence is a trigger for persistent meta-inflammation in metabolically unhealthy obesity (MUO), including arterial hypertension, atherogenic-type dyslipidemia, and insulin resistance.
Relationship Between Vaccines Against Coronavirus Disease 2019 (Covid-19) and Myocarditis
Lorena Araujo Silva Dias, Nathalia Monerat Pinto Blazuti Barreto
doi : 10.1016/j.ahj.2022.10.046
Volume 254, December 2022, Page 249
Relationship between vaccines against coronavirus disease 2019 (COVID-19) and myocarditis Lorena Araujo Silva Dias1, Nathalia Monerat Pinto Blazuti Barreto1 1Faculty of Medicine, Centro Universitario de Volta Redonda, Volta Redonda-Brazil.
Zofenopril Treatment Efficacy on Survival, Endostatin and Insulin-Like Growth Factor-1 in Patients with Diabetes Mellitus Type 2 After Acute Myocardial Infarction
Valeriy Kapustnyk, Borys Shelest, Dmytro Martovyt- skyi, Yuliia Kovalova
doi : 10.1016/j.ahj.2022.10.047
Volume 254, December 2022, Pages 249-250
to study zofenopril treatment effect on survival and endostatin and insulin-like growth factor-1 levels in patients with acute myocardial infarction with ST elevation (STEMI) with concomitant diabetes mellitus type 2(T2DM) in 6-month follow up.
Efficacy of Anterior Lateral Electrode Compared with Anterior Posterior Electrode in External Cardioversion of Atrial Fibrillation. A Meta-Analysis of Clinical Trials
Karam R. Motawea 1,12, Mostafa Reda Mostafa 2, Mohamed Magdi 2, Sarya Swed 3, Hager Fathy 4, Merna Aboelenein 1, Mohamed Mohamed Be- lal 1, Dina M. Awad 1, Nesreen Elsayed Ta- lat 1, Samah S. Rozan 1, Sana Afreen Ansari 5,12, Rameen Shahid 6,12, Taher Sbitli 7,12, Ramy Eweis 8,12, Bdoor Bamousa 7,12, Muaaz Aslam 9,12, Yousef Tanas 1,12, Yomna E. Dean 1,12, Walaa Hasan 10,12, Hani Aiash
doi : 10.1016/j.ahj.2022.10.048
Volume 254, December 2022, Page 250
Some clinical trials reported conflicting results about the efficacy of anterior lateral electrode compared with anterior posterior electrode in electrical cardioversion of atrial fibrillation, and some studies reported no difference in the efficacy between the two procedures.
Effect of Early Metoprolol Before PCI in St-Segment Elevation Myocardial Infarction on Infarct Size and Left Ventricular Ejection Fraction. A Systematic Review and Meta-Analysis
Karam R. Motawea 1,15, Hamed Gaber 1, Ravi B Singh 2, Sarya Swed 3, Salem Elshenawy 1, Nesreen Elsayed Talat 1, Nawal Elgabrty 1, Sheikh Shoib 4, Engy A. Wahsh 5, Sara Gebril 6,15, Mohamed Kishk 7,15, Omar A. Elkoumi 8,15, Mazen At- tia 9,15, Ahmed Khalifa 10,15, Omar Khaled Habib 11,15, Ahmed Foad 12,15, Yousef Tanas 1,15, Yomna E. Dean 1,15, Walaa Hasan 13,15, Hani Aiash
doi : 10.1016/j.ahj.2022.10.049
Volume 254, December 2022, Pages 250-251
ST-segment elevation myocardial infarction (STEMI) is the most life threatening condition for people with coronary artery disease. Metoprolol has been reported to reduce the size of myocardial infarctions (MIS) while maintaining LV function.
Association of Increased Fructose Consumption with Atrial Fibrillation Symptoms
Sebahat Ulusan 1, Mevlut Serdar Kuyumcu 2, Aliye Kuyumcu 3, Ahmet Peynirci
doi : 10.1016/j.ahj.2022.10.050
Volume 254, December 2022, Page 251
Atrial fibrillation (AF) is the most common and increasingly common rhythm disorder .
Echocardiography Findings in a Cohort of Older Diabetic Patients with Diastolic Dysfunction: Do They Fall Under the Diabetic Cardiomyopathy Diagnosis?
Adrian Valverde, MD 1, Richard G. Vaca, MD 2, Silvia Caceres Vinueza, MD, PhD 1, Yan Carlos Duarte Vera, MD, PhD 1
doi : 10.1016/j.ahj.2022.10.051
Volume 254, December 2022, Page 252
Our main goal is to describe the echocardiography findings in older type 2 diabetic patients with diastolic dysfunction (DD) and contrast them with the diabetic cardiomyopathy criteria (1).
Selenium Metabolism and Systemic Inflammation in Hypertensive Patients with Nonalcoholic Fatty Liver Disease
Iryna Tverezovska, Natalia Zhelezniakova
doi : 10.1016/j.ahj.2022.10.052
Volume 254, December 2022, Page 252
Nonalcoholic fatty liver disease (NAFLD) and hypertension (HNT) are major risk factors of development of diabetes and its complications. Selenium (SE) takes part in antioxidant protection, which also determines insulinoresistance.
Relationship Between Vaccines Against Coronavirus Disease 2019 (Covid-19) and Myocarditis
Lorena Araujo Silva Dias, Nathalia Monerat Pinto Blazuti Barreto
doi : 10.1016/j.ahj.2022.10.053
Volume 254, December 2022, Page 253
Due to 2019 coronavirus disease (COVID-19) pandemic, it was necessary to develop a vaccine able to reduce the severity of the disease, decreasing hospitalization and death.
Finerenone and Cardiorenal Outcomes by History of Cardiovascular Disease in Patients with Type 2 Diabetes: Fidelity Analyses
Gerasimos Filippatos 1, Stefan D. Anker 2, Bertram Pitt 3, Peter Rossing 4,5, Luis M. Rui- lope 6,7,8, Darren K. McGuire 9, Ewa A. Jankowska 10,11, Erin D. Michos 12, Javed Butler 13, Alfredo E. Farjat 14, Peter Kolkhof 15, Andrea Scalise 16, Amer Joseph 17, Marco A.L. Viaud 18, George L. Bakris 19, Rajiv Agar- wal
doi : 10.1016/j.ahj.2022.10.054
Volume 254, December 2022, Pages 253-254
Patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) are at risk of cardiovascular complications.
Finerenone in Mild to Severe Chronic Kidney Disease and Type 2 Diabetes: A Fidelity Subgroup Analysis in Patients with Heart Failure
Gerasimos Filippatos 1, Rajiv Agarwal 2, Stefan D. Anker 3, Peter Rossing 4,5, Amer Joseph 6, Peter Kolkhof 7, Marc Lambelet 8, Marco A.L. Vi- aud 9, Luis M. Ruilope 10,11,12, George L. Bakris 13, Bertram Pitt
doi : 10.1016/j.ahj.2022.10.055
Volume 254, December 2022, Page 254
Patients with chronic kidney disease (CKD), type 2 diabetes (T2D), and heart failure (HF) have a very high risk of adverse cardiorenal events.
Prevalence of Infection and Effect of Diabetes on Clinical Presentations of Patients Diagnosed with Ischemic Heart Disease Admitted to Coronary Angiography
Elfatih A. Hasabo 1, Ghassan E. Mustafa 1, Alaa S. Ahmed 1, Walaa Elnaiem 1, Ahmed A A Suli- man, FACP, FESC
doi : 10.1016/j.ahj.2022.10.056
Volume 254, December 2022, Pages 254-255
Patients with Ischemic heart disease (IHD) have multiple risk factors and present to the hospital with different symptoms and some of these symptoms were a typical. We aimed to investigate the clinical presentation and prevalence of infection among patients with IHD admitted to a coronary catheterization.
Clinical Data and Diagnostic findings in Patients with Ischemic Heart Disease undergoing Coronary Angiography: a Cross-sectional study from a Tertiary Hospital in Sudan, Africa
Elfatih A. Hasabo 1, Ghassan E. Mustafa 1, Anab M. Jabir 1, Mohammed H. Omer 1, Mohammed A. Abdalla 1, Wefag Hussein Mohammed 2, Ahmed A A Suliman, FACP, FESC
doi : 10.1016/j.ahj.2022.10.057
Volume 254, December 2022, Page 255
Coronary angiography is done for the evaluation of patients with coronary disease. It helps physicians to know the place of lesions for management. Clinical findings about coronary angiography were unknown in Sudan.
Clinical Characteristics and Treatment of Patients with Ischemic Heart Disease Underwent Percutaneous Coronary Intervention (PCI): An African Experience from a Tertiary Hospital
Elfatih A. Hasabo 1, Ghassan E. Mustafa 1, Anab M. Jabir 1, Mohammed H. Omer 1, Mohammed A. Abdalla 1, Wefag Hussein Mohammed 2, Ahmed A A Suliman, FACP, FESC
doi : 10.1016/j.ahj.2022.10.058
Volume 254, December 2022, Pages 255-256
Coronary artery disease is the leading cause of death in the world. Percutaneous coronary intervention (PCI) is needed to manage patients with ischemic heart disease. No data about the status of PCI in Sudan.
Dna-Methylation Signature of Microrna Coding Genes Associated with Chronological Age in a High-Cardiovascular Risk Mediterranean Population. Sex-Specific Analysis
Rebeca Fernández Carrión 1,2, José V. Sorlà Guerola 1,2, Eva C. Pascual Castelló 1, Carolina Ortega-AzorÃn 1,2, RocÃo Barragán Ar- nal 1,2, Eva M. Asensio Márquez 1,2, Laura Viviana Villamil Penagos 3, Dolores Corella Pi- quer 1,2, Oscar Coltell Simón
doi : 10.1016/j.ahj.2022.10.059
Volume 254, December 2022, Page 256
DNA-methylation has been associated with biological age and several epigenetic clocks have been reported (Hovarth) MicroRNA (miRNA) are short single-stranded RNA molecules implicated in the regulation of gene expression.
Self-Medication Practices from the Perspective of Tunisian Cardiovascular Patients – A Community Pharmacy-Based Survey
Maria Suciu 1, Lavinia Vlaia 1, Eya Boujneh 2, Liana Suciu 1, Valentina Oana Buda 1, Vicențiu Vlaia 1, Carmen Cristescu
doi : 10.1016/j.ahj.2022.10.060
Volume 254, December 2022, Pages 256-257
Tunisia, a developing country, is facing in recent years a growing burden of chronic diseases, mainly cardiovascular diseases (CVDs).
IL-6 as a Surrogate Biomarker: The IL-6 Clinical Value for the Diagnosis of Insulin Resistance and Type 2 Diabetes
R Rafik, RR Andrew, RR Mark, Alaa I
doi : 10.1016/j.ahj.2022.10.061
Volume 254, December 2022, Page 257
Insulin Resistance is the leading cause of Type 2 diabetes mellitus (T2D). It occurs as a result of lipid disorders and increased levels of circulating free fatty acids (FFAs).
Kidney Dysfunction in Central Obesity Associated Metabolic Disorders
Katalin Csép 1, �gnes Bálint
doi : 10.1016/j.ahj.2022.10.062
Volume 254, December 2022, Page 257
Epidemiological data confirm the association of the metabolic syndrome (MS) with CKD, causality, however, is still debated.
Prognostic Value of Triglyceride-Glucose Index for the Prediction of Cardiovascular Events: Results from the Multi-Ethnic Study of Atherosclerosis (MESA)
Dhiran Verghese, MD, Venkat S Manubolu, MD, MPH, April Kinninger, MPH, Luay Hussein, MD, Michael P Bancks, MD, PhD, Matthew J Budoff, MD Harbor UCLA Medical Center
doi : 10.1016/j.ahj.2022.10.063
Volume 254, December 2022, Page 258
Myocardial infarction (MI) and coronary heart disease (CHD) remain the leading cause of cardiovascular disease (CVD) associated morbidity and mortality.
Breastfeeding Impact on Kidney Functions: A Systematic Review
. Boutrid 1,2, H. Rahmoune 1,2, B. Bioud 1,2, D. Abdel- malek 1, M. Amrane
doi : 10.1016/j.ahj.2022.10.064
Volume 254, December 2022, Page 258
Breast milk depict a huge maternal and pediatric benefits, including a long-term impact on cardiovascular and metabolic health. We conducted a systematic review to explore the relevant sudies exploring the link between breastfeeding and future renal outcome
Risk Factors and Evidence Based Interventions for Cardiometabolic Disease in the South Asian Diaspora
BS Pranav Mellacheruvu 1, Suhaas Bonkur 2, Neha J Pagidipati
doi : 10.1016/j.ahj.2022.10.065
Volume 254, December 2022, Page 259
South Asians (SAs) have higher rates of mortality from cardiometabolic disease (CMD) compared to non-Hispanic whites (NHWs) and other ethnic groups. We review the risk factors for and the relative efficacies of CMD prevention and treatment strategies in this high-risk population.
Central Venous Access: Conventional Seldinger Versus Ultrasound-Guided Technique to Reduce Associated Complications in A School Hospital
Velasquez Jose, Pinto Jimena
doi : 10.1016/j.ahj.2022.10.066
Volume 254, December 2022, Page 259
Hypertension and diabetes are the main comorbidities and risk factors for complications related to the placement of central venous accesses,these complications are extremely frequent when performed by the conventional Seldinger technique.
Nox5 in Human Peripheral Blood Mononuclear Cells: A Promising Biomarker for Unstable Diabetic Vascular Disease
Tomasz J Block, Karly Sourris, Abdul Khan, Phillip Kantharidis, Jay Jha, Mark Cooper, James Shaw, Karin Jandeleit-Dahm
doi : 10.1016/j.ahj.2022.10.067
Volume 254, December 2022, Page 260
Human NADPH oxidase 5 (NOX5) is expressed and functionally active in peripheral blood mononuclear cells (PBMCs). Increased NOX5 expression has been demonstrated in atherosclerotic plaques of diabetic patients with associated coronary artery disease (CAD) and within diabetic kidney biopsies.
Incorporating Ensembled Stacked Approach into Automated Machine Learning in an Attempt to Predict Acute Ischemic Heart Disease in Patients with Atypical Chest Pain: Secondary Analysis of a Single-Center Retrospective Cohort Study
Hashir Fahim Khawaja 1,§ , Aliya Ali 1,§ , Saleha Yurf Asghar 1,§ , Rabia Mohsin 1,§ , Ali Danish Khan Yousafzai 1,§ , Ali Haider Bangash 1,§ , Arshiya Fatima 1,§ , Saiqa Zehra 1,§ , Ali Haider Shah 1,§ , Syed Mohammad Mehmood Ab- bas 1,§ , Syed Muhammad Qasim Shah 1,§ , Ain ul Badar 1,¶ , Adil Baloch 1,¶ , Ambar Sattar Khan 1,¶ , Asjad Ullah Khan 1,¶ , Ayesha Khalid Khan 1,¶ , Aymen Yunus 1,¶ , Farhan Faisal 1,¶ , Gulfam Jameel 1,¶ , Kashaf Mushtaq 1,¶ , Muhammad Awais Bilal 1,¶ , Maryam Naveed Abbasi 1,¶ , Mehwish Nawaz 1,¶ , Mishal Bilal 1,¶ , Muhammad Ashraf 2,¶ , Musa Kamil 1,¶ , Noor Ayesha 1,¶ , Oneeza Tariq 1,¶ , Sadaf Khalid 1,¶ , Shafquat Rasool
doi : 10.1016/j.ahj.2022.10.068
Volume 254, December 2022, Pages 260-261
Considerable research has been carried out to explore the adoption of novel methodologies in a bid to optimize the management protocols for acute ischemic heart disease (AIHD) that is prevalent worldwide and has significant morbidity and mortality associated with it.
Prediction of In-Hospital Mortality Among Heart Failure Patients: An Automated Machine Learning Analysis of Mimic-III Database
Aliya Ali 1,§ , Saleha Yurf Asghar 1,§ , Ali Danish Khan Yousafzai 1,§ , Ali Haider Ban- gash 1,§ , Rabia Mohsin 1,§ , Arshiya Fatima 1,§ , Saiqa Zehra 1,§ , Ayesha Khalid Khan 1,§ , Ali Haider Shah 1,§ , Syed Mohammad Mehmood Ab- bas 1,§ , Syed Muhammad Qasim Shah 1,§ , Hashir Fahim Khawaja 1,§ , Ain ul Badar 1,¶ , Adil Baloch 1,¶ , Ambar Sattar Khan 1,¶ , Asjad Ullah Khan 1,¶ , Aymen Yunus 1,¶ , Farhan Faisal 1,¶ , Gulfam Jameel 1,¶ , Kashaf Mushtaq 1,¶ , Muhammad Awais Bilal 1,¶ , Maryam Naveed Ab- basi 1,¶ , Mehwish Nawaz 1,¶ , Mishal Bi- lal 1,¶ , Muhammad Ashraf 2,¶ , Musa Kamil 1,¶ , Namira Khan Khakwani 1,¶ , Noor Ayesha 1,¶ , Oneeza Tariq 1,¶ , Sadaf Khalid 1,¶ , Shafquat Rasool
doi : 10.1016/j.ahj.2022.10.069
Volume 254, December 2022, Page 261
MIMIC-III database has been explored to develop predictive risk models for heart failure outcome.1 With Artificial intelligence in general and machine learning in particular exhibiting superior predictive and prognositicative capabilities, when compared with conventional statistical techniques, we explored the current state-of-the-art for automated Machine Learning to develop mortality prediction risk models among those heart failure patients who are being managed in ICU with the aim to optimise risk stratification.
The Effect of Avocado Drink (Persea Americana Mill) on the Incidence of Ballooning Hepatocyte in the Liver Organs of Rats (Rattus Novergicus) Induced by Hypercholesterolemia
Helga Febrina Kinayahnty, Miranti Dewi Praman- ingtyas, Rokhima Lusiantari, Hanggoro Tri Rinonce
doi : 10.1016/j.ahj.2022.10.070
Volume 254, December 2022, Pages 261-262
Hypercholesterolemia is one of the risk factors for Non Alcoholic Fatty Liver Disease (NAFLD) which is characterized by the formation of ballooning hepatocytes. Avocados are one of the fruits that are easily available and contain high antioxidants and various active compounds.
Q-Wave Myocardial Infarction & Stroke in Patients Managed Interventionally for Left Main Coronary Artery Disease: Prediction by Incorporation of Ensemble Approach into Automated Machine Learning
Ali Danish Khan Yousafzai 1,§ , Saleha Yurf As- ghar 1,§ , Hashir Fahim Khawaja 1,§ , Syed Mohammad Mehmood Abbas 1,§ , Ali Haider Ban- gash 1,§ , Ain ul Badar 1,¶ , Adil Baloch 1,¶ , Ali Haider Shah 1,¶ , Aliya Ali 1,¶ , Ambar Sattar Khan 1,¶ , Arshiya Fatima 1,¶ , Ayesha Khalid Khan 1,¶ , Asjad Ullah Khan 1,¶ , Aymen Yunus 1,¶ , Farhan Faisal 1,¶ , Gulfam Jameel 1,¶ , Kashaf Mushtaq 1,¶ , Muhammad Awais Bilal 1,¶ , Maryam Naveed Ab- basi 1,¶ , Mehwish Nawaz 1,¶ , Mishal Bi- lal 1,¶ , Muhammad Ashraf 2,¶ , Musa Kamil 1,¶ , Namira Khan Khakwani 1,¶ , Noor Ayesha 1,¶ , Oneeza Tariq 1,¶ , Osama Ahmed 1,¶ , Rabia Mohsin 1,¶ , Sadaf Khalid 1,¶ , Saiqa Zehra 1,¶ , Shafquat Rasool 1,¶ , Syed Muhammad Qasim Shah 1,
doi : 10.1016/j.ahj.2022.10.071
Volume 254, December 2022, Page 262
Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) are recognised as a couple of time-tested interventions to manage left main coronary artery (LMCA) disease.
Yurf-Bangash-Yousafzai Augur: Proposal of Carotid Plaque Formation Predictor Among General Population by Exploration of State-Of-The-Art for Automated Machine Learning
Saleha Yurf Asghar 1,§ , Ali Haider Ban- gash 1,§ , Ali Danish Khan Yousafzai 1,§ , Syed Mohammad Mehmood Abbas 1,§ , Hashir Fahim Khawaja 1,§ , Ain ul Badar 1,¶ , Adil Baloch 1,¶ , Ali Haider Shah 1,¶ , Aliya Ali 1,¶ , Ambar Sattar Khan 1,¶ , Arshiya Fatima 1,¶ , Ayesha Khalid Khan 1,¶ , Asjad Ullah Khan 1,¶ , Aymen Yunus 1,¶ , Farhan Faisal 1,¶ , Gulfam Jameel 1,¶ , Kashaf Mushtaq 1,¶ , Muhammad Awais Bilal 1,¶ , Maryam Naveed Abbasi 1,¶ , Mehwish Nawaz 1,¶ , Mishal Bilal 1,¶ , Muhammad Ashraf 2,¶ , Musa Kamil 1,¶ , Namira Khan Khakwani 1,¶ , Noor Ayesha 1,¶ , Oneeza Tariq 1,¶ , Osama Ahmed 1,¶ , Rabia Mohsin 1,¶ , Sadaf Khalid 1,¶ , Saiqa Zehra 1,¶ , Shafquat Rasool 1,¶ , Syed Muhammad Qasim Shah
doi : 10.1016/j.ahj.2022.10.072
Volume 254, December 2022, Page 263
Carotid plaque, recognized as a predictor of adverse cardiovascular and cerebrovascular complications, has been explored via machine learning.
Atherosclerosis in Diabetes: Celiac Disease as a Cherry on the Cake
Nada Boutrid 1,2, Dhia Errahmane Abdelmelek 1, Mounira Amrane 1, Hakim Rahmoune
doi : 10.1016/j.ahj.2022.10.073
Volume 254, December 2022, Pages 263-264
Few study has been conducted to unmask the potential role of celiac disease (CD) as a supplementary cardio-vascular risk factor in diabetes mellitus (DM) patients developing atherosclerosis.
Bempedoic Acid for Management of Dyslipidemia from an Indian Perspective: An Expert Consensus Report
Srinivasa Rao Maddury 1, Jps Sawh- ney 2, Prafulla G Kerkar 3, Piyush Jain 4, Praveen Chandra 5, T. Sashikant 6, Jay Shah 7, Jitendra Singh Makkar 8, Bino Benjamin 9, Rachel Daniel 10, Dharmesh Solanki 11, A.B. Chan- dorkar 12, B Yugandhar 13, Kamal Sharma
doi : 10.1016/j.ahj.2022.10.074
Volume 254, December 2022, Page 264
Bempedoic acid has recently been made available for Indian patients. To formulate a consensus statement to utilize Bempedoic acid in the Indian context based on the contemporary evidence
Longitudinal Study of New Diabetes Cases at Seven Years in a Risk-Sample of Peruvian Subjects with Elevated 1-Hour Ogtt
Juan Carlos Lizarzaburu-Robles, Alonso Garro- Mendiola, Flor Vento
doi : 10.1016/j.ahj.2022.10.075
Volume 254, December 2022, Pages 264-265
Several studies have recommended the evaluation of the first hour during the OGTT(1hr-OGTT) as a criterion for prediabetes, as it is an earlier biomarker of dysglycemia and is associated with a worse cardiometabolic profile.
Retraction notice to ``Association Between Post-Operative Infection and Blood Transfusion in Diabetic Patients Who Underwent Cardiac Surgery� [American Heart Journal 242(2021) 150]
Abdulmalek Alzahrani, Ziad Bukhari, Mohammed Alqarni, Abdulkarim Abukhodair
doi : 10.1016/j.ahj.2022.09.010
Volume 254, December 2022, Page 266
