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Inheritance in overactive bladder syndrome
Nicholas Raison, Sachin Malde & Arun SahaiÂ
doi : 10.1038/s41585-022-00667-1
Volume 20 Issue 2, February 2023
A vagina on a chip to model microbiome–host interactions
Louise StoneÂÂ
Can systematic biopsy be omitted from the prostate cancer diagnostic pathway?
Maria Chiara MasoneÂ
A CAF subcluster regulates bladder cancer stemness
Maria Chiara MasoneÂÂ
Irreversible electroporation in radio-recurrent prostate cancer
Maria Chiara MasoneÂ
ARBS heterogeneity in prostate cancer progression
Maria Chiara MasoneÂÂ
Microfluidics facilitating the use of small extracellular vesicles in innovative approaches to male infertility
Dale M. Goss, Steven A. Vasilescu, Gavin Sacks, David K. Gardner & Majid E. WarkianiÂ
doi : 10.1038/s41585-022-00660-8
Sperm are transcriptionally and translationally quiescent and, therefore, rely on the seminal plasma microenvironment for function, survival and fertilization of the oocyte in the oviduct. The male reproductive system influences sperm function via the binding and fusion of secreted epididymal (epididymosomes) and prostatic (prostasomes) small extracellular vesicles (S-EVs) that facilitate the transfer of proteins, lipids and nucleic acids to sperm. Seminal plasma S-EVs have important roles in sperm maturation, immune and oxidative stress protection, capacitation, fertilization and endometrial implantation and receptivity.
PBRM1, SETD2 and BAP1 � the trinity of 3p in clear cell renal cell carcinoma
Joseph Walton, Keith Lawson, Panagiotis Prinos, Antonio Finelli, Cheryl Arrowsmith & Laurie AillesÂ
doi : 10.1038/s41585-022-00659-1
Biallelic inactivation of the tumour suppressor gene Von Hippel–Lindau (VHL) occurs in the vast majority of clear cell renal cell carcinoma (ccRCC) instances, disrupting cellular oxygen-sensing mechanisms to yield a state of persistent pseudo-hypoxia, defined as a continued hypoxic response despite the presence of adequate oxygen levels.
Combination treatment in metastatic prostate cancer: is the bar too high or have we fallen short?
Kenneth Chen, Jonathan O’Brien, Aoife McVey, Pocharapong Jenjitranant, Brian D. Kelly, Veeru Kasivisvanathan, Nathan Lawrentschuk, Declan G. Murphy & Arun A. AzadÂ
doi : 10.1038/s41585-022-00669-z
Androgen deprivation therapy (ADT) alone has been the cornerstone of treatment for patients with newly diagnosed metastatic prostate cancer for the past century. Based on results from landmark trials in the past decade, combination approaches of ADT with chemotherapy or novel hormonal agents have established a new standard of care for these patients.
