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Systemic Delivery of Extracellular Vesicles Attenuates Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction
Rui Zhang, MD, a,b, * Thassio Mesquita, P HD, a, * Jae Hyung Cho, MD, P HD, a Chang Li, BS, a Lizbeth Sanchez, BS, a Kevin Holm, BS, a Akbarshakh Akhmerov, MD, a Weixin Liu, BS,a Yigang Li, MD, b Ahmed G. Ibrahim, PHD, a Eugenio Cingolani, MD
doi : 10.1016/j.jacep.2022.09.012
Volume 9, Issue 2, February 2023, Pages 147-158
Atrial fibrillation (AF) is a common comorbidity in heart failure with preserved ejection fraction (HFpEF) patients. To date, treatments for HFpEF-related AF have been limited to anti-arrhythmic drugs and ablation. Here we examined the effects of immortalized cardiosphere-derived extracellular vesicles (imCDCevs) in rats with HFpEF.
Extracellular Vesicles for the Treatment of Atrial Fibrillation∗
Kensuke Ihara, MD, PHD, a,b Tetsuo Sasano, MD, P HD b
doi : 10.1016/j.jacep.2023.01.007
Volume 9, Issue 2, February 2023, Pages 159-160
Neuromodulation for the Treatment of Refractory Ventricular Arrhythmias
Timothy M. Markman, MD, a Douglas Gugger, MD,b Jeffrey Arkles, MD, a Michael P. Riley, MD, PHD, a Sanjay Dixit, MD,a Gustavo S. Guandalini, MD,a David S. Frankel, MD, a Andrew E. Epstein, MD,a David J. Callans, MD, a Sunil Singhal, MD,c Francis E. Marchlinski, MD,a Saman Nazarian, MD, P HD
doi : 10.1016/j.jacep.2022.08.031
Volume 9, Issue 2, February 2023, Pages 161-169
Neuromodulation is increasingly recognized as a therapeutic strategy for patients with refractory ventricular arrhythmias (VAs). Percutaneous stellate ganglion blockade (SGB), transcutaneous magnetic stimulation (TcMS), and surgical cardiac sympathetic denervation (CSD) have all been utilized in this setting.
Neuromodulation Strategies for Refractory Ventricular Arrhythmias: Time to “Tune� the Volume?∗
Filippo Maria Cauti, MD, Pietro Rossi, MD, PHD, Stefano Bianchi, MD
doi : 10.1016/j.jacep.2022.11.002
Volume 9, Issue 2, February 2023, Pages 170-172
Temporal and Spatial Changes of Proarrhythmic Substrate in Premature Ventricular Contraction–Induced Cardiomyopathy
Mu Qin, MD,a, * Zi-Liang Song, MD, a,b, * Xi-Yao Zhu, MD,c, * Yu Zhang, MD, a Wei-Feng Jiang, MD,a Shao-Hui Wu, MD,a Xiao-Yu Shen, MD, a Tao Liu, MD, d Xu Liu, MD, P HD
doi : 10.1016/j.jacep.2022.09.026
Volume 9, Issue 2, February 2023, Pages 173-188
The changes in proarrhythmic substrates and malignant ventricular arrhythmia mechanisms caused by premature ventricular contraction–induced cardiomyopathy (PVCCM) remain unclear.
PVC-Induced Cardiomyopathy: Closer Still to a Mechanistic Understanding?∗
David Spragg, MD
doi : 10.1016/j.jacep.2022.10.034
Volume 9, Issue 2, February 2023, Pages 189-191
Left and Right PVC-Induced Ventricular Dysfunction
Anurut Huntrakul, MD,a,b Adam Helms, MD,a Anil Attili, MD, c Prachi P. Agarwal, MD, c Michael Ghannam, MD,a Jackson J. Liang, DO, a Rakesh Latchamsetty, MD, a Krit Jongnarangsin, MD,a Fred Morady, MD,a Frank Bogun, MD
doi : 10.1016/j.jacep.2022.09.016
Volume 9, Issue 2, February 2023, Pages 192-199
Frequent premature ventricular complexes (PVCs) can result in a reversible form of cardiomyopathy that usually affects the left ventricle (LV).
Impact of Low Body Mass Index on Cardiac Tamponade During Catheter Ablation for Atrial Fibrillation
Reina Tonegawa-Kuji, MD, P HD, a Michikazu Nakai, PH D, a Koshiro Kanaoka, MD, PHD, a Yoko Sumita,a Yoshihiro Miyamoto, MD, PHD, b Kengo Kusano, MD, P HD, c Yoshitaka Iwanaga, MD, P HD, a Teiichi Yamane, MD, PHD
doi : 10.1016/j.jacep.2022.08.025
Volume 9, Issue 2, February 2023, Pages 200-208
Cardiac tamponade is a potentially fatal complication of catheter ablation for atrial fibrillation (AF).
Effect of Direct Slow Pathway Capture Mapping–Guided Ablation on Typical Atrioventricular Nodal Re-Entrant Tachycardia
Ryu Tsushima, MD,a Keisuke Okawa, MD, PH D, a Takeshi Morimoto, MD, P HD, MPH,b Yuya Sudo, MD,a Masahiro Sogo, MD, a Masatomo Ozaki, MD, a Masahiko Takahashi, MD,a Takeshi Tobiume, MD, PHD
doi : 10.1016/j.jacep.2022.08.029
Volume 9, Issue 2, February 2023, Pages 209-218
Direct slow pathway capture (DSPC) mapping is a novel electrophysiological technique for detecting antegrade slow pathway input sites. However, the effect of DSPC mapping–guided ablation on atrioventricular nodal re-entrant tachycardia (AVNRT) is unknown.
The Value of Programmed Ventricular Extrastimuli From the Right Ventricular Basal Septum During Supraventricular Tachycardia
Satoshi Higuchi, MD, a Hiroyuki Ito, MD, b Edward P. Gerstenfeld, MD, a Adam C. Lee, MBBS,a Byron K. Lee, MD,a Gregory M. Marcus, MD,a Henry H. Hsia, MD, a Joshua D. Moss, MD,a Randall J. Lee, MD, a Thomas A. Dewland, MD,a Vasanth Vedantham, MD, a Zian H. Tseng, MD,a Akash R. Patel, MD, c Ronn E. Tanel, MD,c Nitish Badhwar, MBSS,d Cara N. Pellegrini, MD,a,e Mitsuharu Kawamura, MD, b Morio Shoda, MD, f Chun Hwang, MD, g Marwan M. Refaat, MD,h Melvin M. Scheinman, MD
doi : 10.1016/j.jacep.2022.09.005
Volume 9, Issue 2, February 2023, Pages 219-228
The difference between the right ventricular (RV) apical stimulus–atrial electrogram (SA) interval during resetting of supraventricular tachycardia (SVT) versus the ventriculoatrial (VA) interval during SVT (ΔSA-VAapex) is an established technique for discerning SVT mechanisms but is limited by a significant diagnostic overlap.
The Best Ventricular Pacing Site During Electrophysiology Study: Are We All Creatures of Habit?∗
Patrick Tchou, MD, Hiroshi Nakagawa, MD, PHD
doi : 10.1016/j.jacep.2022.10.015
Volume 9, Issue 2, February 2023, Pages 229-231
Clinical Validation of 5Â Direct-to-Consumer Wearable Smart Devices to Detect Atrial Fibrillation: BASEL Wearable Study
Diego Mannhart, MD, a,b Mirko Lischer, MD,a,b Sven Knecht, DS C, P HD, a,b Jeanne du Fay de Lavallaz, MD, P HD, a,b Ivo Strebel, DS C, PH D, a,b Teodor Serban, MD,a,b David Vögeli, MS,a,b Beat Schaer, MD,a,b Stefan Osswald, MD, a,b Christian Mueller, MD, a,b Michael Kühne, MD,a,b Christian Sticherling, MD, a,b Patrick Badertscher, MDa,
doi : 10.1016/j.jacep.2022.09.011
Volume 9, Issue 2, February 2023, Pages 232-242
Multiple smart devices capable to detect atrial fibrillation (AF) are presently available. Sensitivity and specificity for the detection of AF may differ between available smart devices, and this has not yet been adequately investigated.
Smart Devices in Detecting AF: Excellent Signal Quality, But AI Can Still Learn From Clinicians∗
Andrew W. Teh, MBBS, PH D, a,b Marcus Dörr, MD
doi : 10.1016/j.jacep.2022.10.036
Volume 9, Issue 2, February 2023, Pages 243-245
Development of an AI-Driven QT Correction Algorithm for Patients in Atrial Fibrillation
Constantine Tarabanis, MD,* Robert Ronan, MA,* Mohamed Shokr, MD, Larry Chinitz, MD, Lior Jankelson, MD, P HD
doi : 10.1016/j.jacep.2022.09.021
Volume 9, Issue 2, February 2023, Pages 246-254
Prolongation of the QTc interval is associated with the risk of torsades de pointes. Determination of the QTc interval is therefore of critical importance. There is no reliable method for measuring or correcting the QT interval in atrial fibrillation (AF).
Catheter Ablation of Ventricular Tachycardia in Patients With Structural Heart Disease: A Meta-Analysis
Sohaib A. Virk, BMed/MD *Saurabh Kumar, BSc (Med)/MBBS, PhD
doi : 10.1016/j.jacep.2022.09.002
Volume 9, Issue 2, February 2023, Pages 255-257
Electromagnetic Field–Induced Interactions Among Electric Vehicles, New-Generation Electronic Devices, and Cardiovascular Implantable Electronic Devices
Jakrin Kewcharoen, MD Kuldeep Shah, MD Rahul Bhardwaj, MD Tahmeed Contractor, MD Mohit K. Turagam, MD Ravi Mandapati, MD Dhanunjaya Lakkireddy, MD *Jalaj Garg, MD
doi : 10.1016/j.jacep.2022.09.027
Volume 9, Issue 2, February 2023, Pages 257-259
Clinical Worsening of Tuberculous Myocarditis After Antituberculous Therapy: The Phenomenon of Paradoxical Worsening
Muthiah Subramanian, DM Sachin Yalagudri, DMDaljeet Saggu, DM Debabrata Bera, DM Ajit Thachil, DM *Calambur Narasimhan, DM
doi : 10.1016/j.jacep.2022.09.018
Volume 9, Issue 2, February 2023, Pages 259-261
Pulmonary Ridge Coverage as a Potential Modifiable Risk Factor of Device-Related Thrombosis
Pedro Luis Cepas-Guillen, PhDy Eduardo Flores-Umanzor, PhDy Laura Sanchis, PhD Ander Regueiro, PhD *Xavier Freixa, PhD
doi : 10.1016/j.jacep.2022.10.041
Volume 9, Issue 2, February 2023, Page 261
The Clinical Outcomes and Success of Posterior Wall Isolation Using a “Box� Approach
Arash Aryana, MD, PhD Eduardo B. Saad, MD, PhD André d’Avila, MD, PhD Luigi DiBiase, MD, PhD Andrea Natale, MD
doi : 10.1016/j.jacep.2022.11.035
Volume 9, Issue 2, February 2023, Pages 261-262
Reply: The Clinical Outcomes and Success of Posterior Wall Isolation Using a “Box� Approach
Daehoon Kim, MD *Hui-Nam Pak, MD, PhD
doi : 10.1016/j.jacep.2022.12.019
Volume 9, Issue 2, February 2023, Pages 262-263
Should SGLT2 Inhibitors Be Part of the Standard Treatment for Atrial Fibrillation in Type 2 Diabetes?
*Rodolfo San Antonio, MD, PhD
doi : 10.1016/j.jacep.2022.11.036
Volume 9, Issue 2, February 2023, Pages 263-264
Reply: Should SGLT2 Inhibitors Be Part of the Standard Treatment for Atrial Fibrillation in Type 2 Diabetes?
*Hideyuki Kishima, MD
doi : 10.1016/j.jacep.2023.01.008
Volume 9, Issue 2, February 2023, Pages 264-265
Alcohol and Arrhythmias
Christopher X. Wong, MBBS, MS, P HD, a,b Samuel J. Tu, MBBS (HONS), b Gregory M. Marcus, MD, MAS
doi : 10.1016/j.jacep.2022.10.023
Volume 9, Issue 2, February 2023, Pages 266-279
The association between alcohol consumption and abnormalities of heart rate and rhythm has long been recognized. Significant attention has focused on the risk of atrial fibrillation (AF) and sudden cardiac death (SCD) with excessive alcohol intake.
Late, Slow, or Decremental: Elucidating the Ideal Surrogate for Ventricular Tachycardia Isthmus
Andres Enriquez, MD, a Adam Korogyi, MS C, b David Bakker, CVT, a Sanoj Chacko, MD,a Victor Neira, MD,a Christopher Simpson, MD,a Hoshiar Abdollah, MD,a Adrian Baranchuk, MD, a Damian Redfearn, MD
doi : 10.1016/j.jacep.2022.09.023
Volume 9, Issue 2, February 2023, Pages 280-282
Response to Para-Hisian Pacing in the Setting of Presence of a Concealed Nodoventricular/Nodofascicular Pathway
Koichi Nagashima, MD, PHD, a Mitsunori Maruyama, MD, PH D, b Yoshiaki Kaneko, MD, PH D, c Akihiko Nogami, MD, PHD, d Hitoshi Mori, MD, PHD, e Naokata Sumitomo, MD, P HD, e Kojiro Tanimoto, MD, P HD, f Satoshi Hayashida, MD, a Yuji Wakamatsu, MD, PHD, a Shu Hirata, MD, a Moyuru Hirata, MD, a Yasuo Okumura, MD, P HD
doi : 10.1016/j.jacep.2022.10.022
Volume 9, Issue 2, February 2023, Pages 283-296
Cardioneuroablation in a Pregnant Woman With Malignant Vasovagal Syncope
Tolga Aksu, MD,a Sibel Temur, MD,b Henry D. Huang, MD,c Andre d’Avila, MDd
doi : 10.1016/j.jacep.2022.10.021
Volume 9, Issue 2, February 2023, Pages 297-299
