Multiple Sclerosis Journal




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سفارش

Strengthening the link: Diet quality and disability in MS

J Nicholas Brenton and Laura Piccio

doi : 10.1177/13524585221127413

Volume 29 Issue 2, February 2023

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Corpus callosum damage to account for cognitive, affective, and social-cognitive dysfunctions in multiple sclerosis: A model of callosal disconnection syndrome?

Béatrice Degraeve , Henrique Sequeira, Halima Mecheri and Bruno Lenne

doi : 10.1177/13524585221091067

The corpus callosum (CC) is the major commissure interconnecting the two hemispheres and is particularly affected in multiple sclerosis (MS). In the present review, we aimed to investigate the role played by callosal damages in the pathogenesis of MS-related dysfunctions and examine whether a model of callosal disconnection syndrome is a valid model for MS.

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Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A systematic review and meta-analysis

Harald Hegen, Janette Walde , Klaus Berek , Georgina Arrambide , Sharmilee Gnanapavan , Batia Kaplan, Michael Khalil , Ruba Saadeh, Charlotte Teunissen , Hayrettin Tumani, Luisa M Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer

doi : 10.1177/13524585221134213

Intrathecal immunoglobulin-G synthesis is a hallmark of multiple sclerosis (MS), which can be detected by oligoclonal IgG bands (OCB) or by κ-free light chains (κ-FLC) in cerebrospinal fluid.

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Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: A consensus statement

Harald Hegen, Georgina Arrambide , Sharmilee Gnanapavan , Batia Kaplan, Michael Khalil , Ruba Saadeh, Charlotte Teunissen , Hayrettin Tumani, Luisa Maria Villar, Maria Alice V Willrich, Henrik Zetterberg and Florian Deisenhammer

doi : 10.1177/13524585221134217

Cerebrospinal fluid (CSF) analysis is of utmost importance for diagnosis and differential diagnosis of patients with suspected multiple sclerosis (MS). Evidence of intrathecal immunoglobulin G (IgG) synthesis proves the inflammatory nature of the disease, increases diagnostic certainty and substitutes for dissemination in time according to current diagnostic criteria.

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Serum neurofilament light levels in natalizumab-treated patients with multiple sclerosis who switch to extended interval dosing from every-4-week dosing in real-world clinical practice

John Foley, Kuangnan Xiong, Tammy Hoyt, Carol M Singh, Evan Riddle, Carl de Moor, Tatiana Plavina and Nolan Campbell

doi : 10.1177/13524585221130949

Serum levels of neurofilament light chain (sNfL) are a potentially useful biomarker for assessing the efficacy of multiple sclerosis (MS) treatments.

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Serum NfL but not GFAP predicts cognitive decline in active progressive multiple sclerosis patients

Christian Barro , Brian C Healy, Shrishti Saxena, Bonnie I Glanz, Anu Paul, Mariann Polgar-Turcsanyi, Charles RG Guttmann, Rohit Bakshi , Howard L Weiner and Tanuja Chitnis

doi : 10.1177/13524585221137697

Cognitive decline is inadequately captured by the standard neurological examination. Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (sGFAP) are biomarkers of neuronal damage and astrocytic reactivity that may offer an accessible measure of the multiple sclerosis (MS) pathology linked to cognitive decline.

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Magnetization transfer saturation reveals subclinical optic nerve injury in pediatric-onset multiple sclerosis

Giulia Longoni, Edgar Martinez Chavez, Kimberly Young, Robert A Brown, Sonya Bells , Dumitru Fetco , Laura Kim, Stephanie A Grover, Fiona Costello , Arun Reginald, Amit Bar-Or, Ruth Ann Marrie , Douglas L Arnold , Sridar Narayanan, Helen M Branson, Brenda L. Banwell, John G Sled, Donald J. Mabbott and E Ann Yeh

doi : 10.1177/13524585221137500

The presence of subclinical optic nerve (ON) injury in youth living with pediatric-onset MS has not been fully elucidated. Magnetization transfer saturation (MTsat) is an advanced magnetic resonance imaging (MRI) parameter sensitive to myelin density and microstructural integrity, which can be applied to the study of the ON.

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Comparative effectiveness of cladribine tablets versus other oral disease-modifying treatments for multiple sclerosis: Results from MSBase registry

Tim Spelman , Serkan Ozakbas, Raed Alroughani , Murat Terzi, Suzanne Hodgkinson, Guy Laureys, Tomas Kalincik , Anneke Van Der Walt , Bassem Yamout, Jeannette Lechner-Scott , Aysun Soysal, Jens Kuhle, Jose Luis Sanchez-Menoyo, Yolanda Blanco Morgado, Daniele LA Spitaleri, Vincent van Pesch, Dana Horakova , Radek Ampapa, Francesco Patti , Richard Macdonell, Abdullah Al-Asmi, Oliver Gerlach, Jiwon Oh , Ayse Altintas, Namita Tundia, Schiffon L Wong and Helmut Butzkueven; MSBase Study Group

doi : 10.1177/13524585221137502

Effectiveness of cladribine tablets, an oral disease-modifying treatment (DMT) for multiple sclerosis (MS), was established in clinical trials and confirmed with real-world experience.

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Improving the decision to switch from first- to second-line therapy in multiple sclerosis: A dynamic scoring system

Camille Sabathé, Romain Casey, Sandra Vukusic , Emmanuelle Leray, Guillaume Mathey, Jérôme De Sèze, Jonathan Ciron , Sandrine Wiertlewski, Aurélie Ruet , Jean Pelletier, Hélène Zéphir, Laure Michel, Christine Lebrun-Frenay , Xavier Moisset , Eric Thouvenot , Jean-Philippe Camdessanché, Serge Bakchine, Bruno Stankoff, Abdullatif Al Khedr, Philippe Cabre, Elisabeth Maillart , Eric Berger, Olivier Heinzlef, Karolina Hankiewicz, Thibault Moreau, Olivier Gout, Bertrand Bourre, Abir Wahab, Pierre Labauge, Alexis Montcuquet, Gilles Defer, Aude Maurousset, Nicolas Maubeuge, Dalia Dimitri Boulos , Haïfa Ben Nasr, Chantal Nifle, Olivier Casez, David-Axel Laplaud * and Yohann Foucher* , On behalf of OFSEP investigators

doi : 10.1177/13524585221139156

In relapsing-remitting multiple sclerosis (RRMS), early identification of suboptimal responders can prevent disability progression.

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Mediterranean diet is linked to less objective disability in multiple sclerosis

Ilana Katz Sand, Sarah Levy , Kathryn Fitzgerald , Tali Sorets and James F Sumowski

doi : 10.1177/13524585221127414

The multiple sclerosis (MS) community is highly interested in diet as a potential protective factor against disability, but empirical evidence remains limited.

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External validation of a clinical prediction model in multiple sclerosis

Nahid Moradi , Sifat Sharmin, Charles B Malpas, Vahid Shaygannejad, Murat Terzi, Cavit Boz, Bassem Yamout, Samia J Khoury, Recai Turkoglu, Rana Karabudak, Nevin Shalaby, Aysun Soysal, Ayşe Altıntaş, Jihad Inshasi , Talal Al-Harbi, Raed Alroughani and Tomas Kalincik ; On behalf of MSBase Study Group

doi : 10.1177/13524585221136036

Timely initiation of disease modifying therapy is crucial for managing multiple sclerosis (MS).

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Pregnancy and post-partum in patients with myelin-oligodendrocyte glycoprotein antibody-associated disease

Clarisse Carra-Dallière , Fabien Rollot, Romain Deschamps, Jonathan Ciron , Sandra Vukusic , Bertrand Audoin , Aurélie Ruet , Elisabeth Maillart , Caroline Papeix , Hélène Zephir, David Laplaud, Mikael Cohen , Bertrand Bourre, Illiasse El-Bahi, Pierre Labauge, Romain Casey, Xavier Ayrignac* and Romain Marignier* on behalf of the NOMADMUS and OFSEP group

doi : 10.1177/13524585221134214

Myelin-oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) frequently initiates during childbearing years. This study investigated the impact of pregnancy and post-partum on MOGAD activity.

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Frequency of NMOSD misdiagnosis in a cohort from Latin America: Impact and evaluation of different contributors

Edgar Carnero Contentti , Pablo A López, Juan Criniti, Ricardo Alonso , Berenice Silva , Geraldine Luetic , Edgar Patricio Correa-Díaz , Lorna Galleguillos , Carlos Navas, Ibis Soto de Castillo , Fernando Hamuy Diaz de Bedoya, Fernando Gracia, Verónica Tkachuk, Brian G Weinshenker and Juan Ignacio Rojas

doi : 10.1177/13524585221136259

Neuromyelitis optica spectrum disorder (NMOSD) misdiagnosis (i.e. the incorrect diagnosis of patients who truly have NMOSD) remains an issue in clinical practice. We determined the frequency and factors associated with NMOSD misdiagnosis in patients evaluated in a cohort from Latin America.

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MeTooMS: Sexual, physical, and emotional abuse experience among women with multiple sclerosis

Jeta Pol-Patil, Bonnie Glanz, Laura Safar , Elizabeth Misasi, Maria Claudia Manieri, Rachel Shanahan, Brian Healy and Maria Houtchens

doi : 10.1177/13524585221122169

Sexual and physical violence against disabled individuals is widespread and linked to negative public health and social outcomes. The real-world prevalence of abuse in women with multiple sclerosis (MS) has not been well studied.

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Differential vulnerability of thalamic nuclei in multiple sclerosis

Simon Blyau*, Ismail Koubiyr*, Manojkumar Saranathan, Pierrick Coupé, Mathilde Deloire, Julie Charré-Morin, Aurore Saubusse, Bei Zhang , Brian Rutt, Vincent Dousset, Bruno Brochet , Aurélie Ruet and Thomas Tourdias

doi : 10.1177/13524585221114247

Investigating differential vulnerability of thalamic nuclei in multiple sclerosis (MS).

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Management approach including pembrolizumab for fingolimod-associated progressive multifocal leukoencephalopathy in a patient with relapsing-remitting multiple sclerosis

Andrew W Barritt , Esther Das, Nadine Morley, Matthew Seymour, Romi Saha, Jaime Vera, Sriram Vundavalli, Sabina Dizdarevic, Richard Nicholas, Joseph R Berger and Leonora K Fisniku

doi : 10.1177/13524585221137279

A 62-year-old man with relapsing-remitting multiple sclerosis developed progressive multifocal leukencephalopathy (PML) after 6 years on fingolimod. The fingolimod was immediately discontinued and preexisting mirtazepine increased.

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Immune checkpoint inhibitors: A potential bright spot in the treatment of progressive multifocal leukoencephalopathy in multiple sclerosis

Jeremias Motte and Ralf Gold

doi : 10.1177/13524585221137275

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Should anti-CD20 be used as an immune reconstitution therapy?

Ide Smets Beatrijs Wokke Joost Smolders

doi : 10.1177/13524585221109386

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