دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial
Sima Vaez, Kazem Parivr, Fardin Amidi, Nasim Hayati Rudbari, Ashraf Moini, Naser Amini
doi : 10.1111/aji.13644
Women with PCOS have a reduced total antioxidant level in addition to higher oxidative stress. Quercetin is a flavonol-type antioxidant that may be found in many foods. Does quercetin affect inflammatory and hormonal factors and clinical outcomes in PCOS patients?
Expression and T cell regulatory action of the PD-1 immune checkpoint in the ovary and fallopian tube
Joshua Johnson, So-Youn Kim, Peter Ka Sam, Rengasamy Asokan, Evelyn Llerena Cari, Elise S. Bales, Thanh-Ha Luu, Lauren Perez, Amanda N. Kallen, Liesl Nel-Themaat, Alex J. Polotsky, Miriam D. Post, David J. Orlicky, Kimberly R. Jordan, Benjamin G. Bitler
doi : 10.1111/aji.13649
Immune cell trafficking and surveillance within the ovary and fallopian tube are thought to impact fertility and also tumorigenesis in those organs. However, little is known of how native cells of the ovary and fallopian tube interact with resident immune cells.
Microbiological composition of follicular fluid in patients undergoing IVF and its association with infertility
Yue-Rong Wu, Yong-Hong Dong, Chen-Jian Liu, Xiao-Dan Tang, Ning-Nan Zhang, Jie Shen, Ze Wu, Xiao-Ran Li, Jing-Yi Shao
doi : 10.1111/aji.13652
In recent years, the incidence of female infertility has risen sharply, which is affected by many factors. It was recognized that female reproductive tract microbes play a role in the process of female conception.
Maternal and cord blood BAFF and APRIL levels during pregnancy
Hindi E. Stohl, William Stohl
doi : 10.1111/aji.13654
Dysregulation of factors vital to the survival B cells and/or plasma cells, such as BAFF and APRIL, could be detrimental to a pregnancy.
NETs promote ROS production to induce human amniotic epithelial cell apoptosis via ERK1/2 signaling in spontaneous preterm birth
Min Hu, Hao Li, Guangzhen Li, Yuan Wang, Jing Liu, Meihua Zhang, Di Shen, Xietong Wang
doi : 10.1111/aji.13656
Premature birth is a common obstetric complication but its pathogenesis is unclear. Inflammation at the maternal-fetal interface in preterm labor leads to the infiltration of neutrophils, which promotes inflammatory responses and induces the degradation of extracellular matrix and cell apoptosis, thus contributing to preterm labor.Â
Circ_0111277 suppresses trophoblast cell proliferation, angiogenesis, migration, invasion and EMT via regulating miR-188-3p/GRHL2 axis
Meixi Zhou, Xiang Yu, Chenping Li, Lejing Lou, Song Yang, Jihao Cai, Chang Cai
doi : 10.1111/aji.13657
Preeclampsia (PE) is the main factor threatening the life of primipara. Defective migration and invasion of trophoblast cells was one of the causes of PE. Circ_0111277 had been reported to be related to the development of PE, but the mechanism of its effect on trophoblast cells needed further study.
Differences in Immune phenotype in decidual tissue from multigravid women compared to primigravid women
Anne Laskewitz, Tom. E. C. Kieffer, Karlijn L. van Benthem, Jan Jaap H. M. Erwich, Marijke M. Faas, Jelmer R. Prins
doi : 10.1111/aji.13658
Women with a previous uncomplicated pregnancy have lower risks of immune-associated pregnancy disorders in a subsequent pregnancy.
Lipoxin A4 depresses inflammation and promotes autophagy via AhR/mTOR/AKT pathway to suppress endometriosis
Zhi-Xiong Huang, Xiao-Rong He, Xin-Yu Ding, Jia-Hao Chen, Yi-Hong Lei, Jian-Bing Bai, Dian-Chao Lin, Yi-Huang Hong, Jian-Fa Lan, Qiong-Hua Chen
doi : 10.1111/aji.13659
Endometriosis is a benign gynecological disease with the feature of estrogen dependence and inflammation. The function of autophagy and the correlation with inflammation were not yet revealed.
Estrogen receptor 1 appears essential for fetal viability in a murine model of premature birth
Stacey S. Schmiedecke, Andrew S. Thagard, Sarah M. Edwards, Rebecca L. Talley, Elisabeth M. Dornisch, Jennifer R. Damicis, Michael McLane, Irina Burd, Peter G. Napolitano, Nicholas Ieronimakis
doi : 10.1111/aji.13662
Protective effects for adult neurological disorders have been attributed to sex hormones. Using a murine model of prematurity, we evaluated the role of estrogen signaling in the process of perinatal brain injury following exposure to intrauterine inflammation.
The overexpression of neurokinin B–neurokinin 3 receptor system exerts direct effects on the ovary under PCOS-like conditions to interfere with mitochondrial function
Fei Guo, Taniya Fernando, Xiaoyong Zhu, Yingli Shi
doi : 10.1111/aji.13663
The increased hypothalamic neurokinin B (NKB) level may contribute to the hyperactive LH pulse secretion in Polycystic ovary syndrome (PCOS).
Chlamydia trachomatis antigen induces TLR4-TAB1-mediated inflammation, but not cell death, in maternal decidua cells
Briana Ortiz, Ashley Driscoll, Ramkumar Menon, Brandie D. Taylor, Lauren S. Richardson
doi : 10.1111/aji.13664
During gestation, the decidua is an essential layer of the maternal-fetal interface, providing immune support and maintaining inflammatory homeostasis. Although Chlamydia (C.) trachomatis is associated with adverse pregnancy outcomes the pathogenic effects on maternal decidua contributing to adverse events are not understood.
Sex-specific differences in T-cell immune dysregulation and aberrant response to inflammatory stimuli in offspring exposed to maternal chronic inflammation
Jin Liu, Yang Liu, Gregory Kirschen, Anguo Liu, Jun Lei, Irina Burd
doi : 10.1111/aji.13665
Maternal chronic inflammation (MI) can adversely affect offspring's immune development resulting in dysregulation of splenic T cells. Interleukin 1 beta (IL-1β) contributes to mediating inflammation in the placenta to induce fetal toxicity and cause long-term postnatal sequelae.
Increased fetal microchimerism in immune and stem cell subsets in preeclampsia
Stephen A. McCartney, Teodora Kolarova, Sami B. Kanaan, Angel Chae, Caitlin I. Laughney, J. Lee Nelson, Hilary S. Gammill, Raj Shree
doi : 10.1111/aji.13666
Preeclampsia (PE) is associated with an increased risk of maternal cardiovascular disease (CVD), however, it is unclear whether this is due to shared underlying physiology or changes which occur during the disease process.
Primary oral vaccination followed by a vaginal pull protects mice against genital HSV-2 infection
Peter B. M. Mulvey, Logan K. Trim, John G. Aaskov, Emily R. Bryan, Emma L. Sweeney, Avinash Kollipara, Mark B. Plenderleith, Frank E. Aldwell, Kenneth W. Beagley
doi : 10.1111/aji.13668
HSV-2 infected more than 491 million people aged 15–49 world-wide in 2016. The morbidity associated with recurrent infections and the increased risk of HIV infection make this a major health problem.
Effect of different antibiotic therapies on the reproductive outcomes of fresh embryo transfer for chronic endometritis: A retrospective cohort study
Jingjing Liu, Sheling Wu, Zhong-Kai Wang, Xiaoqiang Liu, Wen Liu, Yanbo Du, Lei Yan
doi : 10.1111/aji.13669
To investigate the reproductive outcomes by comparing two kinds of antibiotic schemes for chronic endometritis (CE) in infertile women's fresh embryo transfer (FET) cycles and identify subgroups of patients with CE who need long-term antibiotics treatment.
The combination of CD138/MUM1 dual-staining and artificial intelligence for plasma cell counting in the diagnosis of chronic endometritis
Zhongtang Xiong, Wei Zhang, Shaoyan Liu, Kai Liu, Jin Wang, Ping Qin, Yuping Liu, Qingping Jiang
doi : 10.1111/aji.13671
To investigate the utility of combination of CD138/MUM1 dual-staining (DS) and artificial intelligence (AI) for plasma cell (PC) counting in the diagnosis of chronic endometritis (CE).
Transcriptomic analysis of mid-secretory endometrium reveals essential immune factors associated with pregnancy after single euploid blastocyst transfer
Yanfei Cheng, Hui Wang, Jin Shang, Jue Wang, Jingwen Yin, Jinning Zhang, Xinmeng Guo, Sidong Wang, Yong-Gang Duan, Cheuk-Lun Lee, Philip C. N. Chiu, Jian Zhang, William S. B. Yeung, Dandan Cao, Yuanqing Yao
doi : 10.1111/aji.13672
Implantation is a limiting factor for treatment success in assisted reproduction. Both embryonic and endometrial factors contribute to implantation.
Altered profile of plasma phospholipids in woman with recurrent pregnancy loss and recurrent implantation failure treated with lipid emulsion therapy
Paula Renata Bueno Campos Canella, Salvador Sánchez Vinces, Ã�lex Aparecido Rosini Silva, Pedro Henrique Godoy Sanches, Ricardo Barini, Andréia de Melo Porcari, Daniela Soares Razolli, PatrÃcia de Oliveira Carvalho
doi : 10.1111/aji.13673
Recurrent Pregnancy Loss (RPL) and Recurrent Implantation Failure (RIF) are highly heterogeneous condition and many of the mechanisms involved still require elucidation. The aim was to analyze the lipidomic profile in plasma of women with RPL and RIF before and after receiving the Lipid Emulsion Therapy (LET) containing 10% fish oil (SMOFlipid® 20%).
Soluble E-cadherin: A marker of genital epithelial disruption
Rachel Liu, Eric Armstrong, Shirley Constable, Lane B Buchanan, Avid Mohammadi, Ronald M Galiwango, Sanja Huibner, Marie C Perry, Jessica L Prodger, Bryan Coburn, Rupert Kaul
doi : 10.1111/aji.13674
The genital epithelial barrier is a crucial first line of defence against HIV, and epithelial disruption may enhance HIV susceptibility. Assessment of genital epithelial integrity requires biopsies, but their collection is not practical in many research settings.
Peripheral blood subpopulations of Bregs producing IL-35 in women with endometriosis
Anna Slawek, Daria Lorek, Anna Ewa Kedzierska, Paulina Kubik, Jaroslaw Pajak, Agnieszka Chrobak, Anna Chelmonska-Soyta
doi : 10.1111/aji.13675
Interleukin 35 (IL-35) is involved in the pathogenesis of endometriosis by suppressing immunoreaction and promoting endometrial cell proliferation.
Overexpression of lipocalin 2 in PBX1-deficient decidual NK cells promotes inflammation at the maternal-fetal interface
Xue An, Jingkun Qin, Xinyu Hu, Yonggang Zhou, Binqing Fu, Haiming Wei
doi : 10.1111/aji.13676
Impairment of PBX1 expression in decidual natural killer (dNK) cells is associated with the pathogenesis of unexplained recurrent spontaneous abortion, which results in fetal growth restriction (FGR) by affecting the secretion of downstream growth factors.
Rheumatoid arthritis and the risk of preterm birth
Robbi Miguel G. Falcon, Renne Margaret U. Alcazar, Alric V. Mondragon, Ester G. Penserga, Ourlad Alzeus G. Tantengco
doi : 10.1111/aji.13661
During pregnancy, many diseases are correlated with different adverse outcomes. In turn, pregnancy affects the body, leading to increased disease susceptibility.
