Alexander P. Cole, Mara Koelker, Jonathan Makanjuola & Caroline M. MooreÂ
doi : 10.1038/s41585-022-00682-2
Volume 20 Issue 3, March 2023
Wei Phin Tan, James S. Wysock & Herbert LeporÂ
Maria Chiara MasoneÂÂ
Maria Chiara MasoneÂÂ
Maria Chiara MasoneÂÂ
Maria Chiara MasoneÂÂ
Tim ThomasÂÂ
Matteo Rosellini, Andrea Marchetti, Veronica Mollica, Alessandro Rizzo, Matteo Santoni & Francesco MassariÂ
doi : 10.1038/s41585-022-00676-0
The therapeutic algorithm of renal cell carcinoma has been revolutionized by the approval of immunotherapy agents by regulatory agencies. However, objective and durable responses are still not observed in a large number of patients, and prognostic and predictive biomarkers for immunotherapy response are urgently needed.
Verena Sailer, Gunhild von Amsberg, Stefan Duensing, Jutta Kirfel, Verena Lieb, Eric Metzger, Anne Offermann, Klaus Pantel, Roland Schuele, Helge Taubert, Sven Wach, Sven Perner, Stefan Werner & Achim AignerÂ
doi : 10.1038/s41585-022-00677-z
Androgen deprivation therapy has a central role in the treatment of advanced prostate cancer, often causing initial tumour remission before increasing independence from signal transduction mechanisms of the androgen receptor and then eventual disease progression.
Kelly N. Fitzgerald, Robert J. Motzer & Chung-Han LeeÂ
doi : 10.1038/s41585-022-00666-2
Localized renal cell carcinoma (RCC) is primarily managed with nephrectomy, which is performed with curative intent. However, disease recurs in ~20% of patients. Treatment with adjuvant therapies is used after surgery with the intention of curing additional patients by disrupting the establishment, maturation or survival of micrometastases, processes collectively referred to as the metastatic cascade.
Alexander P. Cole, Mara Koelker, Jonathan Makanjuola & Caroline M. MooreÂ
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