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Pediatric Neurogastroenterology and Motility: Moving Rapidly Into the Future.
Chanpong, Atchariya MD, MRes, PhD *,+,++; Thapar, Nikhil MRCP, FRCPCH, FRACP, PhD +,++,[S],||
doi : 10.1097/MPG.0000000000003721
Volume 76(5) pgs. 547-695,e82-e82 May 2023
AB The field of pediatric neurogastroenterology and motility encompasses some of the most common and severe gastrointestinal (GI) disorders that affect children. GI motility disorders remain, in general, poorly understood, variably diagnosed, and inadequately treated.
Long-Term Outcomes After Autologous Intestinal Reconstructive Surgery in Children With Short Bowel Syndrome.
Pajunen, Sanni MD *; Mutanen, Annika MD, PhD +; Kivisaari, Reeta MD ++; Merras-Salmio, Laura MD, PhD [S]; Pakarinen, Mikko P. MD, PhD +,||
doi : 10.1097/MPG.0000000000003729
Autologous intestinal reconstructive (AIR) surgery is frequently utilized in the management of pediatric short bowel syndrome (SBS). However, little is known about the long-term sequela of these procedures.
Pneumatosis Intestinalis in Children With Intestinal Failure: The Result of Intestinal Stress From Enteral Feeding?.
Reppucci, Marina L. MD *; Nolan, Margo M. BA +; Cooper, Emily MS ++; Gallagher, Lauren T. MD +,[S]; Diaz-Miron, Jose MD +,[S]; Somme, Stig MD +,[S]; Soden, Jason MD ||,[P]; Gumer, Lindsey MD ||,[P]; Acker, Shannon N. MD +,[S]
doi : 10.1097/MPG.0000000000003737
The incidence and significance of pneumatosis intestinalis (PI) in children with a diagnosis of intestinal failure is not well understood. The aim of this study was to identify clinical and anatomical factors associated with the imaging findings of PI in patients with intestinal failure.
Use, Durability, and Risks for Discontinuation of Initial and Subsequent Biologics in a Large Pediatric-Onset IBD Cohort.
Kaplan, Jess L. MD *; Liu, Chunyan MS +; King, Eileen C. PhD +,++; Bass, Julie A. DO [S]; Patel, Ashish S. MD ||; Tung, Jeanne MD [P]; Chen, Shiran MS +; Lissoos, Trevor MD #; Candela, Ninfa MD #; Saeed, Shehzad MD **; Colletti, Richard B. MD ++; for the ImproveCareNow Network; Adler, Jeremy; Baron, Howard I.; Cabrera, Jose M.; Dorsey, Jill M.; Dykes, Dana M.H.; Ebach, Dawn R.; Garin-Laflam, Monica P.; Gold, Benjamin D.; Grunow, John; Higuchi, Leslie M.; Jester, Traci W.; Lapsia, Sameer P.; Leibowitz, Ian; Linvlle, Tiffany M.; Morhardt, Tina L.; Moses, Jonathan; Moulton, Dedrick; Nasiri-Blomgren, Shaida; Niklinska-Schirtz, B. Joanna; Ogunmola, Nicholas A.; Palomo, Pablo J.; Park, K.T.; Pashankar, Dinesh S.; Pasternak, Brad A.; Radano, Marcella C.; Samson, Charles M.; Sandberg, Kelly C.; Schaefer, Marc E.; Shashidhar, Harohalli; Steiner, Steven J.; Sullivan, Jillian S.; Tomer, Gitit; Verstraete, Sophia G.
doi : 10.1097/MPG.0000000000003734
Biologic medications are recommended for treatment of moderately-to-severely active Crohn disease (CD) or ulcerative colitis (UC) in children. However, many patients require sequential biologic treatment because of nonresponse or loss of response to the initial biologic.
Trough Concentration Response in Infliximab and Adalimumab Treated Children With Inflammatory Bowel Disease Following Treatment Adjustment: A Pharmacokinetic Model.
Levy, Rachel MD *; Matar, Manar MD +,++; Zvuloni, Maya MD +; Shamir, Raanan MD +,++; Assa, Amit ++,[S]
doi : 10.1097/MPG.0000000000003726
In patients with inflammatory bowel diseases (IBD), data on trough concentration (TC) response to adjustments of anti-tumor necrosis factor (TNF[alpha]) are scarce.
Assessing Disease Activity in Pediatric Crohn's Disease Using Ultrasound: The Pediatric Crohn Disease Intestinal Ultrasound Score.
van Wassenaer, Elsa A. MD, PhD *,+,++; van Rijn, Rick R. MD, PhD [S]; de Voogd, Floris A.E. MD, PhD ||; van Schuppen, Joost MD [S]; Kindermann, Angelika MD, PhD *; de Meij, Tim G.J. MD, PhD [P]; van Limbergen, Johan E. MD, PhD *,++; Gecse, K.B. MD, PhD ||; D'Haens, Geert R. MD, PhD ||; Benninga, Marc A. MD, PhD *; Koot, Bart G.P. MD, PhD *; on behalf of the RAINBOW group
doi : 10.1097/MPG.0000000000003727
Currently, there is no consensus on how to score Crohn disease (CD) activity assessed by intestinal ultrasound (IUS) in children. This study aimed to design an easy-to-use IUS score for disease activity in pediatric CD.
Clinical Course of Very Early-Onset Inflammatory Bowel Disease.
Cucinotta, Ugo MD *; Arrigo, Serena MD +; Dipasquale, Valeria MD *; Gramaglia, Simone Maria Calogero MD *; Lagana, Francesca MD *; Romano, Claudio MD, PhD *; Gandullia, Paolo MD +
doi : 10.1097/MPG.0000000000003730
Data on the phenotypes and disease outcomes of very early-onset inflammatory bowel disease (VEO-IBD) are limited. The aims of this study were to describe the clinical features, outcomes, and treatment response of VEO-IBD patients and to compare them with later-onset pediatric inflammatory bowel disease (P-IBD) patients.
The Effectiveness and Safety of Methotrexate as the First-Line Immunomodulator of Maintenance Therapy in Pediatric Crohn Disease.
Choi, Young Min MD *; Kim, Jeong Min MD *; Moon, Jin Soo MD, PhD +; Ko, Jae Sung MD, PhD +; Yang, Hye Ran MD, PhD *,+
doi : 10.1097/MPG.0000000000003731
Methotrexate (MTX) has been used as maintenance therapy for Crohn disease (CD) in adults and children. However, there are only a few studies on the MTX's effectiveness in thiopurine-naive CD adult patients and children.
Mucosal Atrophy Predicts Poorer Outcomes in Pediatric Ulcerative Colitis-A National Inception Cohort Study.
Stenke, Emily MB, PhD, MRCPI *; Stallard, Lorraine MB, MRCPI *; Cooper, Sarah PhD +,++; Dominik, Anna MSc +,++; Pilkington, Abigail BSc *,[S]; Sugrue, Sheila MSc [S]; O'Sullivan, Maureen MD, FRCPath +,++,||,[P]; McDermott, Michael FRCPath ++[P]; Quinn, Shoana MD, FRCPI *++; Broderick, Annemarie MB, FRCPI *,+,++,#; Bourke, Billy MD, FRCPI *,+,++,#; Hussey, Seamus FRCPI *,+,++,#,**
doi : 10.1097/MPG.0000000000003746
Outcomes in pediatric ulcerative colitis (UC) are heterogeneous and predictors of disease course eagerly sought. Mucosal atrophy (MA) is characterized by histological abnormalities of colonic intestinal glands.
Venous Thromboembolism Prophylaxis in Pediatric Inflammatory Bowel Disease Patients Hospitalized With a Central Line.
Hamant, Laura G. MD *; Gonzalez-llanos, Lucia MD *; Patel, Ashish S. MD *,+; McMahon, Lisa MD *,++; Knoll, Christine MD *,[S]; Swing, Ted PhD *; Pasternak, Brad MD *,+
doi : 10.1097/MPG.0000000000003747
Patients hospitalized with inflammatory bowel disease (IBD) have increased risk of venous thromboembolism (VTE). The aim of this study was to determine whether the adoption of a VTE protocol would change rates of medical VTE prophylaxis (low molecular weight heparin) in patients with IBD and a central venous catheter (CVC), while subsequently decreasing the incidence of VTE in this population.
Biosimilars for Pediatric Patients With Inflammatory Bowel Disease: Pediatric Gastroenterology Clinical Practice Survey.
Maltz, Ross M. MD *,+; McClinchie, Madeline G. BS *; Boyle, Brendan M. MD *,+; McNicol, Megan PharmD, BCACP ++; Morris, Grant A. MD [S]; Crawford, Erin C. MD ||; Moses, Jonathan MD [P]; Kim, Sandra C. MD ||
doi : 10.1097/MPG.0000000000003750
Biosimilars are biological agents that have been demonstrated to have similar safety and efficacy profiles as the originator. The objective of this study was to evaluate the perspectives of pediatric gastroenterologists in the United States (U.S.) toward biosimilar use and to explore factors that impact their comfort level with prescribing infliximab biosimilars.
Epidemiologic Assessment of Pediatric Inflammatory Bowel Disease Presentation in NYC During COVID-19.
Rosenbaum, Janet E. PhD *; Ochoa, Kenny Castro MD +; Hasan, Faria MD ++; Goldfarb, Alexa DO [S]; Tang, Vivian MD ||; Tomer, Gitit MD ++; Wallach, Thomas MD +
doi : 10.1097/MPG.0000000000003740
AB Inflammatory bowel disease (IBD) pathogenesis is thought to be induced by a mix of genetic susceptibility, microbial populations, and immune triggers such as infections.
Protocol Biopsies in Pediatric Liver Transplantation Recipients Improve Graft Histology and Personalize Immunosuppression.
Karbaum, Eva MD *; Weidemann, Soren MD +; Grabhorn, Enke MD *; Fischer, Lutz MD ++; Herden, Uta MD ++; Oh, Jun MD *; Briem-Richter, Andrea MD *; Krebs-Schmitt, Dorothee MD *
doi : 10.1097/MPG.0000000000003707
Protocol liver biopsies (PLBs) are part of the follow-up program at many pediatric liver transplant centers, but the impact on clinical decision-making and allograft histology following adjustments of immunosuppression (IS) after PLB has not been thoroughly analyzed.
Association Between Perioperative Costs and Induction Immunosuppression in Pediatric Liver Transplant Recipients.
Ewing, Caroline B. MD, MS *; Farnan, Sheila MBChB, MSc +; Squires, James E. MD, MS ++; Raghu, Vikram K. MD, MS ++
doi : 10.1097/MPG.0000000000003728
The objectives of this study was to describe variation in induction regimen, identify predictors of induction immunosuppression (IS) choice, and examine the impact of induction IS regimen on length of stay (LOS) and total perioperative costs in pediatric liver transplant recipients.
A Better Understanding of Pediatric Autoimmune Pancreatitis: Over 13 Years of Experience.
Garcia Tirado, Diana MD *; Molera Busoms, Cristina MD *; Alvarez Beltran, Marina MD +; Mercadal-Hally, Maria MD ++; Vaquero Raya, Eva Cristina MD [S]; Meavilla Oliva, Silvia Maria MD *; Martinez Osorio, Johanna MD *; Barber Martinez, Ignasi MD, PhD ||; Cardenas Vasquez, Andres MD, PhD [S]; Segarra Canton, Oscar MD, PhD +; Martin-de-Carpi, Javier MD, PhD *
doi : 10.1097/MPG.0000000000003732
Pediatric autoimmune pancreatitis (P-AIP) is an uncommon disease whose diagnosis requires strong clinical suspicion. Late diagnosis increases morbidity.
Magnetic-Assisted Capsule Endoscopy in Children With Crohn Disease: Feasibility and Impact on Gastric Transit Time.
Di Nardo, Giovanni MD, PhD *; Micheli, Federica MD +; Cozzi, Denis A. MD ++; Mercantini, Paolo MD +; Parisi, Pasquale MD *; Baccini, Flavia MD +; Mennini, Maurizio MD, PhD [S]; Raucci, Umberto MD ||; Marasco, Giovanni MD [P],#
doi : 10.1097/MPG.0000000000003733
Standard capsule endoscopy (CE) is ineffective for upper gastrointestinal (GI) tract examination because it does not allow operator-controlled navigation of the capsule.
Phase III Randomized Non-Inferiority Study of OSS Versus PEG + Electrolyte Colonoscopy Preparation in Adolescents.
Socha, Piotr MD, PhD *; Posovszky, Carsten MD +,++; Szychta, Monika MD, PhD *; Viscogliosi, Federica MD [S]; Martemucci, Luigi MD [S]; Grzybowska-Chlebowczyk, Urszula MD [//],[P]; Perrot, Valerie MD #; Kornowski, Anne MD **; Benninga, Marc A. MD, PhD ++; on behalf of the EASYKID Study Group
doi : 10.1097/MPG.0000000000003745
Many protocols and preparations are used for bowel cleansing before pediatric colonoscopy but few are based on scientific evidence. We evaluated efficacy, safety, tolerability, and patient preference of oral sulfate solution (OSS) at 75% of the adult dose versus polyethylene glycol (PEG)-electrolyte solution in adolescents presenting for diagnostic colonoscopy.
Elevations in End-Tidal CO2 With CO2 Use During Pediatric Endoscopy With Airway Protection: Is This Physiologically Significant?.
Dike, Chinenye R. MD, MS *,+; Huang Pacheco, Andrew MD *; Lyden, Elizabeth MS ++; Freestone, David DO *; Choudhry, Ojasvini MD *; Bishop, Warren P. MD [S]; Shukry, Mohanad MD, PhD [//]
doi : 10.1097/MPG.0000000000003748
Inflation of the gastrointestinal lumen is vital for proper visualization during endoscopy. Air, insufflated via the endoscope, is gradually being replaced with carbon dioxide (CO2) in many centers, with the intention of minimizing post-procedural discomfort due to retained gas.
Topical Pharyngeal Anesthesia in Sedated Pediatric Patients Undergoing Esophagogastroduodenoscopy.
Aljabari, Salim MD *; Ohler, Adrienne PhD +; Waheed, Shahzad MD +; El-Halabi, Issam MD +; Tryon, Christina MD +; Friedman, Samantha MD +
doi : 10.1097/MPG.0000000000003749
Pediatric patients undergoing esophagogastroduodenoscopy (EGD) commonly receive procedural sedation for comfort and to facilitate the procedure.
Evaluation and Management of Iron Deficiency in Children Undergoing Intestinal Rehabilitation-A Position Paper From the NASPGHAN Intestinal Rehabilitation Special Interest Group.
Talathi, Saurabh MD, MPH *; Namjoshi, Shweta MD, MPH +; Raghu, Vikram MD, MS ++; Wendel, Danielle MD [S]; Oliveira, Stephanie B MD ||; Reed, Kerry RN, MS, CPNP-PC [P]; Yanchis, Dianna RD #; Mezoff, Ethan A. MD **
doi : 10.1097/MPG.0000000000003736
AB Iron deficiency (ID) is the most common nutritional deficiency affecting children undergoing intestinal rehabilitation (IR). Patients may be asymptomatic or present with nonspecific symptoms including fatigue, irritability, and dizziness.
North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Statement for Telehealth.
Franciosi, James P. MD *,+; Berg, Elizabeth A. MD ++; Rosen, John M. MD [S],||; Lee, Jennifer A. MD [P],#,**; Sandberg, Kelly C. MD, MSc ++,++++; Srinath, Arvind MD, MSc [S][S],||||; Setty, Mala MD [P][P]; Li, B U.K. MD ##
doi : 10.1097/MPG.0000000000003754
AB Telehealth (TH) broadly encompasses remote activities of clinical care (telemedicine), provider and patient education, and general health services. The use of synchronous video for TH first occurred in 1964 and then catapulted to the forefront in 2020 during the coronavirus disease 2019 public health emergency.
Gate-Crashers Are Not Always Welcome! A Case of Hepatobiliary Ascariasis in a 3-Year-Old Child.
Poddar, Ujjal DM *; Vadlapudi, Srinivas Srinidhi DM *; Mohindra, Samir DM +
Extravasation of Intravenous Iron Causing Skin Staining in a Child With Crohn Disease.
Paglinco, Samantha R. DO *; Ciciora, Steven L. MD *
Functional Gastrointestinal Disorders in Mediterranean Countries According to Rome IV Criteria: Erratum.
