Annals of Internal Medicine




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سفارش

Population Genomic Screening for Three Common Hereditary Conditions

Gregory F. Guzauskas, MSPH, PhD, Shawn Garbett, MS, Zilu Zhou, MPH, Jonathan S. Schildcrout, PhD, John A. Graves, PhD, Marc S. Williams, MD, Jing Hao, PhD, MD, MS, MPH, Laney K. Jones, PharmD, MPH, Scott J. Spencer, MPA, MA, PhD, Shangqing Jiang, MPH, David L. Veenstra, PharmD, PhD*, and Josh F. Peterson, MD, MPH*

doi : 10.7326/M22-0846

May 2023Volume 176, Issue 5

The cost-effectiveness of screening the U.S. population for Centers for Disease Control and Prevention (CDC) Tier 1 genomic conditions is unknown.

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Long-Term Health Consequences After Ovarian Removal at Benign Hysterectomy

Mathilde Gottschau, MD, PhD,  Susanne Rosthøj, MSc, PhD,  Annette Settnes, MD, PhD,  Gitte Lerche Aalborg, MSc,  Jakob Hansen Viuff, MSc,  Christian Munk, MD, PhD,  Allan Jensen, MSc, PhD,  Susanne K. Kjær, MD, DMSc,  and Lene Mellemkjær, MSc, PhD

doi : 10.7326/M22-1628

More evidence is needed to substantiate current recommendations about removing ovaries during hysterectomy for benign conditions.

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Hypotension-Avoidance Versus Hypertension-Avoidance Strategies in Noncardiac Surgery

Maura Marcucci, MD, Thomas W. Painter, MBChB, David Conen, MD, Vladimir Lomivorotov, MD, Daniel I. Sessler, MD, Matthew T.V. Chan, MBBS, Flavia K. Borges, MD, Kate Leslie, MD, Emmanuelle Duceppe, MD, María José Martínez-Zapata, MD, Chew Yin Wang, MBChB, Denis Xavier, MD, Sandra N. Ofori, MBBS, Michael Ke Wang, MD, Sergey Efremov, MD, Giovanni Landoni, MD, Ydo V. Kleinlugtenbelt, MD, Wojciech Szczeklik, MD, Denis Schmartz, MD, Amit X. Garg, MD, Timothy G. Short, MD, Maria Wittmann, MD, Christian S. Meyhoff, MD, Mohammed Amir, MBBS, David Torres, MD, Ameen Patel, MD, Kurt Ruetzler, MD, Joel L. Parlow, MD, Vikas Tandon, MD, Edith Fleischmann, MD, Carisi A. Polanczyk, MD, Andre Lamy, MD, Raja Jayaram, MD, Sergey V. Astrakov, MD, William Ka Kei Wu, PhD, Chao Chia Cheong, MD, Sabry Ayad, MD, Mikhail Kirov, MD, Miriam de Nadal, MD, Valery V. Likhvantsev, MD, Pilar Paniagua, MD, Hector J. Aguado, MD, Kamal Maheshwari, MD, Richard P. Whitlock, MD, Michael H. McGillion, RN, Jessica Vincent, MSc, Ingrid Copland, Kumar Balasubramanian, MSc, Bruce M. Biccard, MBChB, Sadeesh Srinathan, MD, Samandar Ismoilov, MD, Shirley Pettit, RN, David Stillo, MASc, Andrea Kurz, MD, Emilie P. Belley-Côté, MD, Jessica Spence, MD, William F. McIntyre, MD, Shrikant I. Bangdiwala, PhD, Gordon Guyatt, MD, Salim Yusuf, MD, and P.J. Devereaux, MD, PhD

doi : 10.7326/M22-3157

Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively.

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Facilitating Shared Decision Making Among Black Patients at Risk for Sudden Cardiac Arrest

Kevin L. Thomas, MD, Sana M. Al-Khatib, MD, MHS, Andrzej S. Kosinski, PhD, Samuel F. Sears Jr., PhD, Nancy M. Allen LaPointe, PharmD, Larry R. Jackson II, MD, Daniel D. Matlock, MD, MPH, Daniel Haithcock, MD, B. Judson Colley III, MD, MPH, David S. Hirsh, MD, and Eric D. Peterson, MD, MPH

doi : 10.7326/M22-2934

Racial disparities in implantable cardioverter-defibrillator (ICD) implantation are multifactorial and are partly explained by higher refusal rates.

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Estimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism

Carolyn D. Seib, MD, MAS, Calyani Ganesan, MD, MS, Adam Furst, MS, Alan C. Pao, MD, Glenn M. Chertow, MD, MPH, John T. Leppert, MD, MS, Insoo Suh, MD, Maria E. Montez-Rath, PhD, MS, Alex H.S. Harris, PhD, MS, Amber W. Trickey, PhD, MS, Electron Kebebew, MD, and Manjula Kurella Tamura, MD, MPH

doi : 10.7326/M22-2222

Multidisciplinary guidelines recommend parathyroidectomy to slow the progression of chronic kidney disease in patients with primary hyperparathyroidism (PHPT) and an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. Limited data address the effect of parathyroidectomy on long-term kidney function.

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Effects of Cognitive Behavioral Therapy and Cash Transfers on Older Persons Living Alone in India

Madeline McKelway, PhD, Abhijit Banerjee, PhD, Erin Grela, BS, Frank Schilbach, PhD, Miriam Sequeira, MA, Garima Sharma, BA, Girija Vaidyanathan, MSc, PhD, and Esther Duflo, PhD

doi : 10.7326/M22-2496

A growing number of older persons in developing countries live entirely alone and are physically, mentally, and financially vulnerable.

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Tecovirimat Treatment of People With HIV During the 2022 Mpox Outbreak

Jacob McLean, DO*, Kate Stoeckle, MD*, Simian Huang, MPH, Jonathan Berardi, FNP, Brett Gray, ANP, MPH, Marshall J. Glesby, MD, PhD†, and Jason Zucker, MD†

doi : 10.7326/M22-3132

The recent mpox outbreak has disproportionately affected people with HIV (PWH) and resulted in the first widespread use of the novel antiviral tecovirimat. Whether treatment outcomes differ between PWH and those without HIV is unknown.

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Prioritizing Quality Measures in Acute Stroke Care

Jinyi Zhu, PhD, Hooman Kamel, MD, Ajay Gupta, MD, Alvin I. Mushlin, MD, ScM, Nicolas A. Menzies, PhD, Thomas A. Gaziano, MD, MSc, Meredith B. Rosenthal, PhD, and Ankur Pandya, PhD

doi : 10.7326/M22-3186

The American Heart Association and American Stroke Association (AHA/ASA) endorsed 15 process measures for acute ischemic stroke (AIS) to improve the quality of care. Identifying the highest-value measures could reduce the administrative burden of quality measure adoption while retaining much of the value of quality improvement.

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Safety and Efficacy of Combination SARS-CoV-2 Neutralizing Monoclonal Antibodies Amubarvimab Plus Romlusevimab in Nonhospitalized Patients With COVID-19

Teresa H. Evering, MD, MS*, Kara W. Chew, MD, MS*, Mark J. Giganti, PhD, Carlee Moser, PhD, Mauricio Pinilla, MS, David Alain Wohl, MD, Judith S. Currier, MD, MSc, Joseph J. Eron, MD, Arzhang Cyrus Javan, MD, MPH, DTM&H, Rachel Bender Ignacio, MD, MPH, David Margolis, MD, MPH, Qing Zhu, PhD, Ji Ma, PhD, Lijie Zhong, PhD, MBA, Li Yan, MD, PhD, Ulises D’Andrea Nores, MD, Keila Hoover, MD, Bharat Mocherla, MD, Manish C. Choudhary, PhD, Rinki Deo, PhD, Justin Ritz, MS, William A. Fischer, MD, Courtney V. Fletcher, PharmD, Jonathan Z. Li, MD, MMSc, Michael D. Hughes, PhD, Davey Smith, MD*, and Eric S. Daar, MD*

doi : 10.7326/M22-3428

Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti–SARS-CoV-2 monoclonal antibodies with an extended half-life.

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Oral Fluvoxamine With Inhaled Budesonide for Treatment of Early-Onset COVID-19

Gilmar Reis, MD, PhD, Eduardo Augusto dos Santos Moreira Silva, MD, PhD, Daniela Carla Medeiros Silva, MD, PhD, Lehana Thabane, PhD, Vitoria Helena de Souza Campos, Thiago Santiago Ferreira, MD, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, MD, Ana Paula Figueiredo Guimaraes Almeida, MD, Leonardo Cançado Monteiro Savassi, MD, PhD, Adhemar Dias de Figueiredo Neto, MD, PhD, Carina Bitarães, RN, Aline Cruz Milagres, RN, Eduardo Diniz Callegari, MD, Maria Izabel Campos Simplicio, BScPharm, Luciene Barra Ribeiro, RN, MPH, Rosemary Oliveira, Ofir Harari, PhD, Lindsay A. Wilson, MSc, Jamie I. Forrest, PhD, MPH, Hinda Ruton, MSc, Sheila Sprague, PhD, Paula McKay, MSc, Christina M. Guo, BCom, Gordon H. Guyatt, MD, Craig R. Rayner, PharmD, David R. Boulware, MD, MPH, Nicole Ezer, MDCM, MPH, Todd C. Lee, MD, MPH, Emily Gibson McDonald, MD, MSc, Mona Bafadhel, MBChB, PhD, Christopher Butler, MD, Josue Rodrigues Silva, MD, MSc, Mark Dybul, MD, and Edward J. Mills, PhD

doi : 10.7326/M22-3305

Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.

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Comparative Efficacy and Safety of Wakefulness-Promoting Agents for Excessive Daytime Sleepiness in Patients With Obstructive Sleep Apnea

Tyler Pitre, MD, MA, Jasmine Mah, MD, MSc, Sarah Roberts, BHSc, Kairavi Desai, BMSc, Yusing Gu, MD, Clodagh Ryan, MD, PhD, Jason W. Busse, DC, PhD, and Dena Zeraatkar, PhD

doi : 10.7326/M22-3473

Excessive daytime sleepiness (EDS) is common among patients with obstructive sleep apnea (OSA). The comparative effectiveness of pharmacologic agents is unknown.

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Challenges in Estimating the Effectiveness of COVID-19 Vaccination Using Observational Data

William J. Hulme, PhD, Elizabeth Williamson, PhD, Elsie M.F. Horne, PhD, Amelia Green, PhD, Helen I. McDonald, PhD, Alex J. Walker, PhD, Helen J. Curtis, DPhil, Caroline E. Morton, MRCGP, Brian MacKenna, MPharm, Richard Croker, MSc, Amir Mehrkar, MRCGP, Seb Bacon, BA, David Evans, MPhil, Peter Inglesby, MPhil, Simon Davy, PhD, Krishnan Bhaskaran, PhD, Anna Schultze, PhD, Christopher T. Rentsch, PhD, Laurie Tomlinson, PhD, Ian J. Douglas, PhD, Stephen J.W. Evans, MSc, Liam Smeeth, PhD, Tom Palmer, PhD, Ben Goldacre, MRCPsych, Miguel A. Hernán, MD, DrPH, and Jonathan A.C. Sterne, PhD

doi : 10.7326/M21-4269

The COVID-19 vaccines were developed and rigorously evaluated in randomized trials during 2020. However, important questions, such as the magnitude and duration of protection, their effectiveness against new virus variants, and the effectiveness of booster vaccination, could not be answered by randomized trials and have therefore been addressed in observational studies.

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Performance Measures for Physicians Providing Clinical Care Using Telemedicine: A Position Paper From the American College of Physicians

Amir Qaseem, MD, PhD, MHA, Catherine H. MacLean, MD, PhD, Samantha Tierney, MPH, J. Thomas Cross Jr., MD, Scott T. MacDonald, MD, Caroline L. Goldzweig, MD, and Nick Fitterman, MD

doi : 10.7326/M23-0140

There has been an exponential growth in the use of telemedicine services to provide clinical care, accelerated by the COVID-19 pandemic. Clinical care delivered via telemedicine has become a major and accepted method of health care delivery for many patients. There is an urgent need to understand quality of care in the telemedicine environment.

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Overweight and Obesity: Current Clinical Challenges

Christine Laine, MD, MPH and Christina C. Wee, MD, MPH

doi : 10.7326/M23-0628

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Infectious Diseases: What You May Have Missed in 2022

Rand Al Ohaly, MBBS*, Marie-Eve Benoit, MD*, and Mindy G. Schuster, MD, MSCE

doi : 10.7326/M23-0757

In 2022, COVID-19 remained the infectious disease at the top of most internal medicine physicians' minds. However, it was not the only infectious disease that was the topic of clinically relevant research that year. This article highlights some important infectious disease evidence unrelated to COVID-19 that was published in 2022.

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Multi-cancer Early Detection Tests, Primary Care, and Shared Decision Making

Kevin Selby, MD, MAS, Glyn Elwyn, MD, PhD, MSc, and Robert J. Volk, PhD

doi : 10.7326/M23-0067

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The Credibility Conundrum: Can Social Media Companies Define Credibility for Users?

Hussain S. Lalani, MD, MPH and Christine Laine, MD, MPH

doi : 10.7326/M23-0490

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Oophorectomy at the Time of Hysterectomy: The Debate Continues

Elizabeth Casiano Evans, MD, Deslyn T.G. Hobson, MD

doi : 10.7326/M23-0756

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Perioperative Management of Antihypertensive Agents: More Answers or More Questions?

Jason F. Shiffermiller, MD, MPH, Christopher M. Whinney, MD

doi : 10.7326/M23-0745

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In Memoriam: Dr. Frank Davidoff: Leading Annals as It Entered the 21st Century

Christine Laine, MD, MPH

doi : 10.7326/M23-0946

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Erythema Gyratum Repens Secondary to Pulmonary Tuberculosis

Caitlin A. Contag, MD, Nolan Maloney, MD, Ralph Tayyar, MD, Maria Alexandrova Aleshin, MD, Roberto Andres Novoa, MD, Dora Yukwai Ho, MD, PhD

doi : 10.7326/L22-0453

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Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients

Mei Qiu, MS, Lixin Du, MD

doi : 10.7326/L22-0501

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Early Rhythm Control Therapy for Atrial Fibrillation in Low-Risk Patients

Boyoung Joung, MD, PhD, Daehoon Kim, MD, Pil-Sung Yang, MD, Jung-Hoon Sung, MD

doi : 10.7326/L22-0502

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Detection of Monkeypox Virus in Anorectal Swabs From Asymptomatic Men Who Have Sex With Men in a Sexually Transmitted Infection Screening Program in Paris, France

Aaron Shengting Mai, MBBS and Eng-King Tan, MD

doi : 10.7326/L23-0022

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Detection of Monkeypox Virus in Anorectal Swabs From Asymptomatic Men Who Have Sex With Men in a Sexually Transmitted Infection Screening Program in Paris, France

Shu Yuan, PhD, Si-Cong Jiang, PhD, Zi-Lin Li, MD

doi : 10.7326/L23-0023

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Outpatient Treatment of Confirmed COVID-19

David J. Sullivan, MD, Massimo Franchini, MD, Jonathon W. Senefeld, PhD, Michael J. Joyner, MD, Arturo Casadevall, MD, PhD, Daniele Focosi, MD

doi : 10.7326/L23-0099

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Update Alert 10: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults

Katherine Mackey, MD, MPP, Devan Kansagara, MD, MCR, Kathryn Vela, MLIS, AHIP

doi : 10.7326/L23-0049

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Correction: 15-Year Benefits of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality

doi : 10.7326/L23-0096

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Correction: Outpatient Treatment of Confirmed COVID-19

doi : 10.7326/L23-0098

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Waiting for the Ambulance

Maryella Desak Sirmon, MD

doi : 10.7326/M22-3067

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Fifty in the Sock Drawer

Maryella Desak Sirmon, MD

doi : 10.7326/M22-3068

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Care of the Patient With Abnormal Kidney Test Results

Delphine S. Tuot, MDCM, Neil R. Powe, MD

doi : 10.7326/AITC202305160

Blood and urine tests are commonly performed by clinicians in both ambulatory and hospital settings that detect chronic and acute kidney disease.

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KDIGO provided recommendations on SGLT2 inhibitors and nonsteroidal MRAs in patients with diabetes and CKD

Matthew van Norman, DO, Donald A. Molony, MD

doi : 10.7326/J23-0023

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In mechanically ventilated patients at nutritional risk, high protein did not reduce time to discharge alive

Rahul Nanchal, MD, MS

doi : 10.7326/J23-0029

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In outpatients with mild to moderate COVID-19, low-dose fluvoxamine did not reduce time to sustained recovery

Jeremy Clark, MBBS (Hons), Steven Y.C. Tong, MBBS (Hons), PhD

doi : 10.7326/J23-0025

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In persons with constipation or IBS-C, kiwifruit vs. psyllium increased spontaneous bowel movements

Blake J. Purtle, MD, Brooks D. Cash, MD

doi : 10.7326/J23-0022

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In H pylori infection, vonoprazan plus high-dose amoxicillin was noninferior to B-quadruple therapy for eradication

Duncan J. Flynn, MD, Joseph D. Feuerstein, MD

doi : 10.7326/J23-0028

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In prediabetes, oral vitamin D reduces progression to new-onset diabetes

Darren Lau, MD, PhD

doi : 10.7326/J23-0030

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In limb or pelvic fracture, aspirin was noninferior to enoxaparin for reducing all-cause death

Michael Griffin, MB, Gregory Y.H. Lip, MD

doi : 10.7326/J23-0024

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In patients with chronic neuropathic pain, cannabinoids improve sleep and reduce pain vs. placebo

James Kim, MD, MBA

doi : 10.7326/J23-0026

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In type 2 MI, the T2-risk score predicted death or MI at 1 y

Dominic L. Raco, MD

doi : 10.7326/J23-0027

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In adults with VTE who received anticoagulants for ≥3 mo, VTE-PREDICT predicted recurrence and bleeding at up to 5 y

Richard H. White, MD

doi : 10.7326/J23-0021

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Annals Graphic Medicine - Pre Scrub

George M. Anderson

doi : 10.7326/G22-0043

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Annals Graphic Medicine - Dr. Mom: Stethoscope Stories

Grace E. Farris, MD

doi : 10.7326/G23-0015

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Annals for Educators - May 2023

Christine Laine, MD, MPH

doi : 10.7326/AWED202305160

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Annals for Hospitalists Inpatient Notes - Fluid Resuscitation for Noncritically Ill Patients With Acute Pancreatitis

Lucía Guilabert, MD, and Enrique de-Madaria, MD, PhD

doi : 10.7326/M23-0792

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Summary for Patients: Long-Term Health Consequences After Ovarian Removal at Benign Hysterectomy

doi : 10.7326/P23-0001

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Summary for Patients: Population Genomic Screening for Three Common Hereditary Conditions

doi : 10.7326/P23-0002

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