Gregory F. Guzauskas, MSPH, PhD, Shawn Garbett, MS, Zilu Zhou, MPH, Jonathan S. Schildcrout, PhD, John A. Graves, PhD, Marc S. Williams, MD, Jing Hao, PhD, MD, MS, MPH, Laney K. Jones, PharmD, MPH, Scott J. Spencer, MPA, MA, PhD, Shangqing Jiang, MPH, David L. Veenstra, PharmD, PhD*, and Josh F. Peterson, MD, MPH*
doi : 10.7326/M22-0846
May 2023Volume 176, Issue 5
The cost-effectiveness of screening the U.S. population for Centers for Disease Control and Prevention (CDC) Tier 1 genomic conditions is unknown.
Mathilde Gottschau, MD, PhD,  Susanne Rosthøj, MSc, PhD,  Annette Settnes, MD, PhD,  Gitte Lerche Aalborg, MSc,  Jakob Hansen Viuff, MSc,  Christian Munk, MD, PhD,  Allan Jensen, MSc, PhD,  Susanne K. Kjær, MD, DMSc,  and Lene Mellemkjær, MSc, PhD
doi : 10.7326/M22-1628
More evidence is needed to substantiate current recommendations about removing ovaries during hysterectomy for benign conditions.
Maura Marcucci, MD, Thomas W. Painter, MBChB, David Conen, MD, Vladimir Lomivorotov, MD, Daniel I. Sessler, MD, Matthew T.V. Chan, MBBS, Flavia K. Borges, MD, Kate Leslie, MD, Emmanuelle Duceppe, MD, MarÃÂa José MartÃÂnez-Zapata, MD, Chew Yin Wang, MBChB, Denis Xavier, MD, Sandra N. Ofori, MBBS, Michael Ke Wang, MD, Sergey Efremov, MD, Giovanni Landoni, MD, Ydo V. Kleinlugtenbelt, MD, Wojciech Szczeklik, MD, Denis Schmartz, MD, Amit X. Garg, MD, Timothy G. Short, MD, Maria Wittmann, MD, Christian S. Meyhoff, MD, Mohammed Amir, MBBS, David Torres, MD, Ameen Patel, MD, Kurt Ruetzler, MD, Joel L. Parlow, MD, Vikas Tandon, MD, Edith Fleischmann, MD, Carisi A. Polanczyk, MD, Andre Lamy, MD, Raja Jayaram, MD, Sergey V. Astrakov, MD, William Ka Kei Wu, PhD, Chao Chia Cheong, MD, Sabry Ayad, MD, Mikhail Kirov, MD, Miriam de Nadal, MD, Valery V. Likhvantsev, MD, Pilar Paniagua, MD, Hector J. Aguado, MD, Kamal Maheshwari, MD, Richard P. Whitlock, MD, Michael H. McGillion, RN, Jessica Vincent, MSc, Ingrid Copland, Kumar Balasubramanian, MSc, Bruce M. Biccard, MBChB, Sadeesh Srinathan, MD, Samandar Ismoilov, MD, Shirley Pettit, RN, David Stillo, MASc, Andrea Kurz, MD, Emilie P. Belley-Côté, MD, Jessica Spence, MD, William F. McIntyre, MD, Shrikant I. Bangdiwala, PhD, Gordon Guyatt, MD, Salim Yusuf, MD, and P.J. Devereaux, MD, PhD
doi : 10.7326/M22-3157
Among patients having noncardiac surgery, perioperative hemodynamic abnormalities are associated with vascular complications. Uncertainty remains about what intraoperative blood pressure to target and how to manage long-term antihypertensive medications perioperatively.
Kevin L. Thomas, MD, Sana M. Al-Khatib, MD, MHS, Andrzej S. Kosinski, PhD, Samuel F. Sears Jr., PhD, Nancy M. Allen LaPointe, PharmD, Larry R. Jackson II, MD, Daniel D. Matlock, MD, MPH, Daniel Haithcock, MD, B. Judson Colley III, MD, MPH, David S. Hirsh, MD, and Eric D. Peterson, MD, MPH
doi : 10.7326/M22-2934
Racial disparities in implantable cardioverter-defibrillator (ICD) implantation are multifactorial and are partly explained by higher refusal rates.
Carolyn D. Seib, MD, MAS, Calyani Ganesan, MD, MS, Adam Furst, MS, Alan C. Pao, MD, Glenn M. Chertow, MD, MPH, John T. Leppert, MD, MS, Insoo Suh, MD, Maria E. Montez-Rath, PhD, MS, Alex H.S. Harris, PhD, MS, Amber W. Trickey, PhD, MS, Electron Kebebew, MD, and Manjula Kurella Tamura, MD, MPH
doi : 10.7326/M22-2222
Multidisciplinary guidelines recommend parathyroidectomy to slow the progression of chronic kidney disease in patients with primary hyperparathyroidism (PHPT) and an estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2. Limited data address the effect of parathyroidectomy on long-term kidney function.
Madeline McKelway, PhD, Abhijit Banerjee, PhD, Erin Grela, BS, Frank Schilbach, PhD, Miriam Sequeira, MA, Garima Sharma, BA, Girija Vaidyanathan, MSc, PhD, and Esther Duflo, PhD
doi : 10.7326/M22-2496
A growing number of older persons in developing countries live entirely alone and are physically, mentally, and financially vulnerable.
Jacob McLean, DO*, Kate Stoeckle, MD*, Simian Huang, MPH, Jonathan Berardi, FNP, Brett Gray, ANP, MPH, Marshall J. Glesby, MD, PhD†, and Jason Zucker, MDâ€
doi : 10.7326/M22-3132
The recent mpox outbreak has disproportionately affected people with HIV (PWH) and resulted in the first widespread use of the novel antiviral tecovirimat. Whether treatment outcomes differ between PWH and those without HIV is unknown.
Jinyi Zhu, PhD, Hooman Kamel, MD, Ajay Gupta, MD, Alvin I. Mushlin, MD, ScM, Nicolas A. Menzies, PhD, Thomas A. Gaziano, MD, MSc, Meredith B. Rosenthal, PhD, and Ankur Pandya, PhD
doi : 10.7326/M22-3186
The American Heart Association and American Stroke Association (AHA/ASA) endorsed 15 process measures for acute ischemic stroke (AIS) to improve the quality of care. Identifying the highest-value measures could reduce the administrative burden of quality measure adoption while retaining much of the value of quality improvement.
Teresa H. Evering, MD, MS*, Kara W. Chew, MD, MS*, Mark J. Giganti, PhD, Carlee Moser, PhD, Mauricio Pinilla, MS, David Alain Wohl, MD, Judith S. Currier, MD, MSc, Joseph J. Eron, MD, Arzhang Cyrus Javan, MD, MPH, DTM&H, Rachel Bender Ignacio, MD, MPH, David Margolis, MD, MPH, Qing Zhu, PhD, Ji Ma, PhD, Lijie Zhong, PhD, MBA, Li Yan, MD, PhD, Ulises D’Andrea Nores, MD, Keila Hoover, MD, Bharat Mocherla, MD, Manish C. Choudhary, PhD, Rinki Deo, PhD, Justin Ritz, MS, William A. Fischer, MD, Courtney V. Fletcher, PharmD, Jonathan Z. Li, MD, MMSc, Michael D. Hughes, PhD, Davey Smith, MD*, and Eric S. Daar, MD*
doi : 10.7326/M22-3428
Development of safe and effective SARS-CoV-2 therapeutics is a high priority. Amubarvimab and romlusevimab are noncompeting anti–SARS-CoV-2 monoclonal antibodies with an extended half-life.
Gilmar Reis, MD, PhD, Eduardo Augusto dos Santos Moreira Silva, MD, PhD, Daniela Carla Medeiros Silva, MD, PhD, Lehana Thabane, PhD, Vitoria Helena de Souza Campos, Thiago Santiago Ferreira, MD, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, MD, Ana Paula Figueiredo Guimaraes Almeida, MD, Leonardo Cançado Monteiro Savassi, MD, PhD, Adhemar Dias de Figueiredo Neto, MD, PhD, Carina Bitarães, RN, Aline Cruz Milagres, RN, Eduardo Diniz Callegari, MD, Maria Izabel Campos Simplicio, BScPharm, Luciene Barra Ribeiro, RN, MPH, Rosemary Oliveira, Ofir Harari, PhD, Lindsay A. Wilson, MSc, Jamie I. Forrest, PhD, MPH, Hinda Ruton, MSc, Sheila Sprague, PhD, Paula McKay, MSc, Christina M. Guo, BCom, Gordon H. Guyatt, MD, Craig R. Rayner, PharmD, David R. Boulware, MD, MPH, Nicole Ezer, MDCM, MPH, Todd C. Lee, MD, MPH, Emily Gibson McDonald, MD, MSc, Mona Bafadhel, MBChB, PhD, Christopher Butler, MD, Josue Rodrigues Silva, MD, MSc, Mark Dybul, MD, and Edward J. Mills, PhD
doi : 10.7326/M22-3305
Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19.
Tyler Pitre, MD, MA, Jasmine Mah, MD, MSc, Sarah Roberts, BHSc, Kairavi Desai, BMSc, Yusing Gu, MD, Clodagh Ryan, MD, PhD, Jason W. Busse, DC, PhD, and Dena Zeraatkar, PhD
doi : 10.7326/M22-3473
Excessive daytime sleepiness (EDS) is common among patients with obstructive sleep apnea (OSA). The comparative effectiveness of pharmacologic agents is unknown.
William J. Hulme, PhD, Elizabeth Williamson, PhD, Elsie M.F. Horne, PhD, Amelia Green, PhD, Helen I. McDonald, PhD, Alex J. Walker, PhD, Helen J. Curtis, DPhil, Caroline E. Morton, MRCGP, Brian MacKenna, MPharm, Richard Croker, MSc, Amir Mehrkar, MRCGP, Seb Bacon, BA, David Evans, MPhil, Peter Inglesby, MPhil, Simon Davy, PhD, Krishnan Bhaskaran, PhD, Anna Schultze, PhD, Christopher T. Rentsch, PhD, Laurie Tomlinson, PhD, Ian J. Douglas, PhD, Stephen J.W. Evans, MSc, Liam Smeeth, PhD, Tom Palmer, PhD, Ben Goldacre, MRCPsych, Miguel A. Hernán, MD, DrPH, and Jonathan A.C. Sterne, PhD
doi : 10.7326/M21-4269
The COVID-19 vaccines were developed and rigorously evaluated in randomized trials during 2020. However, important questions, such as the magnitude and duration of protection, their effectiveness against new virus variants, and the effectiveness of booster vaccination, could not be answered by randomized trials and have therefore been addressed in observational studies.
Amir Qaseem, MD, PhD, MHA, Catherine H. MacLean, MD, PhD, Samantha Tierney, MPH, J. Thomas Cross Jr., MD, Scott T. MacDonald, MD, Caroline L. Goldzweig, MD, and Nick Fitterman, MD
doi : 10.7326/M23-0140
There has been an exponential growth in the use of telemedicine services to provide clinical care, accelerated by the COVID-19 pandemic. Clinical care delivered via telemedicine has become a major and accepted method of health care delivery for many patients. There is an urgent need to understand quality of care in the telemedicine environment.
Christine Laine, MD, MPH and Christina C. Wee, MD, MPH
doi : 10.7326/M23-0628
Rand Al Ohaly, MBBS*, Marie-Eve Benoit, MD*, and Mindy G. Schuster, MD, MSCE
doi : 10.7326/M23-0757
In 2022, COVID-19 remained the infectious disease at the top of most internal medicine physicians' minds. However, it was not the only infectious disease that was the topic of clinically relevant research that year. This article highlights some important infectious disease evidence unrelated to COVID-19 that was published in 2022.
Kevin Selby, MD, MAS, Glyn Elwyn, MD, PhD, MSc, and Robert J. Volk, PhD
doi : 10.7326/M23-0067
Hussain S. Lalani, MD, MPH and Christine Laine, MD, MPH
doi : 10.7326/M23-0490
Elizabeth Casiano Evans, MD, Deslyn T.G. Hobson, MD
doi : 10.7326/M23-0756
Jason F. Shiffermiller, MD, MPH, Christopher M. Whinney, MD
doi : 10.7326/M23-0745
Christine Laine, MD, MPH
doi : 10.7326/M23-0946
Caitlin A. Contag, MD, Nolan Maloney, MD, Ralph Tayyar, MD, Maria Alexandrova Aleshin, MD, Roberto Andres Novoa, MD, Dora Yukwai Ho, MD, PhD
doi : 10.7326/L22-0453
Mei Qiu, MS, Lixin Du, MD
doi : 10.7326/L22-0501
Boyoung Joung, MD, PhD, Daehoon Kim, MD, Pil-Sung Yang, MD, Jung-Hoon Sung, MD
doi : 10.7326/L22-0502
Aaron Shengting Mai, MBBS and Eng-King Tan, MD
doi : 10.7326/L23-0022
Shu Yuan, PhD, Si-Cong Jiang, PhD, Zi-Lin Li, MD
doi : 10.7326/L23-0023
David J. Sullivan, MD, Massimo Franchini, MD, Jonathon W. Senefeld, PhD, Michael J. Joyner, MD, Arturo Casadevall, MD, PhD, Daniele Focosi, MD
doi : 10.7326/L23-0099
Katherine Mackey, MD, MPP, Devan Kansagara, MD, MCR, Kathryn Vela, MLIS, AHIP
doi : 10.7326/L23-0049
doi : 10.7326/L23-0096
Delphine S. Tuot, MDCM, Neil R. Powe, MD
doi : 10.7326/AITC202305160
Blood and urine tests are commonly performed by clinicians in both ambulatory and hospital settings that detect chronic and acute kidney disease.
Matthew van Norman, DO, Donald A. Molony, MD
doi : 10.7326/J23-0023
Rahul Nanchal, MD, MS
doi : 10.7326/J23-0029
Jeremy Clark, MBBS (Hons), Steven Y.C. Tong, MBBS (Hons), PhD
doi : 10.7326/J23-0025
Blake J. Purtle, MD, Brooks D. Cash, MD
doi : 10.7326/J23-0022
Duncan J. Flynn, MD, Joseph D. Feuerstein, MD
doi : 10.7326/J23-0028
Darren Lau, MD, PhD
doi : 10.7326/J23-0030
Michael Griffin, MB, Gregory Y.H. Lip, MD
doi : 10.7326/J23-0024
James Kim, MD, MBA
doi : 10.7326/J23-0026
Dominic L. Raco, MD
doi : 10.7326/J23-0027
Richard H. White, MD
doi : 10.7326/J23-0021
LucÃÂa Guilabert, MD, and Enrique de-Madaria, MD, PhD
doi : 10.7326/M23-0792
doi : 10.7326/P23-0001
doi : 10.7326/P23-0002
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