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Hypomagnesemia and Cardiovascular Risk in Type 2 Diabetes
Lynette J Oost, Cees J Tack, Jeroen H F de Baaij
doi : 10.1210/endrev/bnac028
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 357–378
Hypomagnesemia is 10-fold more common in individuals with type 2 diabetes (T2D) than in the healthy population. Factors that are involved in this high prevalence are low Mg2+ intake, gut microbiome composition, medication use, and presumably genetics. Hypomagnesemia is associated with insulin resistance, which subsequently increases the risk to develop T2D or deteriorates glycemic control in existing diabetes.
A State of Natriuretic Peptide Deficiency
Michael Nyberg, Dijana Terzic, Trine P Ludvigsen, Peter D Mark, Natasha B Michaelsen, Steen Z Abildstrøm, Mads Engelmann, A Mark Richards, Jens P Goetze
doi : 10.1210/endrev/bnac029
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 379–392
Measurement of natriuretic peptides (NPs) has proven its clinical value as biomarker, especially in the context of heart failure (HF). In contrast, a state of partial NP deficiency appears integral to several conditions in which lower NP concentrations in plasma presage overt cardiometabolic disease.
Levothyroxine: Conventional and Novel Drug Delivery Formulations
Hanqing Liu, Wei Li, Wen Zhang, Shengrong Sun, Chuang Chen
doi : 10.1210/endrev/bnac030
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 393–416
Although levothyroxine is one of the most prescribed medications in the world, its bioavailability has been reported to be impaired by many factors, including interfering drugs or foods and concomitant diseases, and persistent hypothyroidism with a high dose of levothyroxine is thus elicited.
Bone Turnover Markers: Basic Biology to Clinical Applications
Marian Schini, Tatiane Vilaca, Fatma Gossiel, Syazrah Salam, Richard Eastell
doi : 10.1210/endrev/bnac031
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 417–473
Bone turnover markers (BTMs) are used widely, in both research and clinical practice. In the last 20 years, much experience has been gained in measurement and interpretation of these markers, which include commonly used bone formation markers (bone alkaline phosphatase, osteocalcin, and procollagen I N-propeptide); and commonly used resorption markers (serum C-telopeptides of type I collagen, urinary N-telopeptides of type I collagen, and tartrate-resistant acid phosphatase type 5b).
Molecular Mechanisms of PTH/PTHrP Class B GPCR Signaling and Pharmacological Implications
Jean-Pierre Vilardaga, Lisa J Clark, Alex D White, Ieva Sutkeviciute, Ji Young Lee, Ivet Bahar
doi : 10.1210/endrev/bnac032
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 474–491
The classical paradigm of G protein-coupled receptor (GPCR) signaling via G proteins is grounded in a view that downstream responses are relatively transient and confined to the cell surface, but this notion has been revised in recent years following the identification of several receptors that engage in sustained signaling responses from subcellular compartments following internalization of the ligand–receptor complex.
New Insights into the Structure and Function of Class B1 GPCRs
Brian P Cary, Xin Zhang, Jianjun Cao, Rachel M Johnson, Sarah J Piper, Elliot J Gerrard, Denise Wootten, Patrick M Sexton
doi : 10.1210/endrev/bnac033
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 492–517
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide hormones.
Contemporary Biological Insights and Clinical Management of Craniopharyngioma
John Richard Apps, Hermann Lothar Muller, Todd Cameron Hankinson, Torunn Ingrid Yock, Juan Pedro Martinez-Barbera
doi : 10.1210/endrev/bnac035
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 518–538
Craniopharyngiomas (CPs) are clinically aggressive tumors because of their invasive behavior and recalcitrant tendency to recur after therapy. There are 2 types based on their distinct histology and molecular features: the papillary craniopharyngioma (PCP), which is associated with BRAF-V600E mutations and the adamantinomatous craniopharyngioma (ACP), characterized by mutations in CTNNB1 (encoding β-catenin).
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
Anita C S Hokken-Koelega, Manouk van der Steen, Margaret C S Boguszewski, Stefano Cianfarani, Jovanna Dahlgren, Reiko Horikawa, Veronica Mericq, Robert Rapaport, Abdullah Alherbish, Debora Braslavsky, Evangelia Charmandari, Steven D Chernausek, Wayne S Cutfield, Andrew Dauber, Asma Deeb, Wesley J Goedegebuure, Paul L Hofman, Elvira Isganatis, Alexander A Jorge, Christina Kanaka-Gantenbein, Kenichi Kashimada, Vaman Khadilkar, Xiao-Ping Luo, Sarah Mathai, Yuya Nakano, Mabel Yau
doi : 10.1210/endrev/bnad002
Endocrine Reviews, Volume 44, Issue 3, June 2023, Pages 539–565
This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations.
