دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Adenocarcinoma of the oesophagus: is it gastric cancer?
Michael Quante1, Timothy C Wang2, Adam J Bass3
doi : 10.1136/gutjnl-2022-327096
June 2023 - Volume 72 - 6
Picking up microbial clues in early-onset colorectal cancer
Neelendu Dey
Prophylactic vaccination against hepatitis D virus superinfection: from fiction to reality?
Julia Lang-Meli, Christoph Neumann-Haefelin
Ten reasons gastroenterologists and hepatologists should be treating obesity
Michael Camilleri, Emad M El-Omar
Australian inflammatory bowel disease consensus statements for preconception, pregnancy and breast feeding
Robyn Laube, Christian P Selinger, Cynthia H Seow, Britt Christensen, Emma Flanagan, Debra Kennedy, Reme Mountifield, Sean Seeho, Antonia Shand, Astrid-Jane Williams, Rupert W Leong
doi : 10.1136/gutjnl-2022-329304
Objective Because pregnancy outcomes tend to be worse in women with inflammatory bowel disease (IBD) than in those without, we aimed to update consensus statements that guide the clinical management of pregnancy in patients with IBD.
Empirical rescue treatment of Helicobacter pylori infection in third and subsequent lines: 8-year experience in 2144 patients from the European Registry on H. pylori management (Hp-EuReg)
Diego Burgos-SantamarÃa, Olga P Nyssen, Antonio Gasbarrini, Dino Vaira, Ã�ngeles Pérez-Aisa, LuÃs Rodrigo, Rinaldo Pellicano, Alma Keco-Huerga, Manuel Pabón-Carrasco, Manuel Castro-Fernandez, Doron Boltin, Jesus Barrio, Perminder Phull, Juozas Kupcinskas, Laimas Jonaitis, Inmaculada Ortiz-Polo, Bojan Tepes, Alfredo J Lucendo, José MarÃa Huguet, Miguel Areia, Natasa Brglez Jurecic, Maja Denkovski, LuÃs Bujanda, June Ramos-San Román, Antonio Cuadrado-LavÃn, Judith Gomez-Camarero, Manuel Alfonso Jiménez Moreno, Angel Lanas, Samuel Jesús Martinez-Dominguez, Enrique Alfaro, Ricardo Marcos-Pinto, Vladimir Milivojevic, Theodore Rokkas, Marcis Leja, Sinead Smith, Ante Tonkić, György Miklós Buzás, Michael Doulberis, Marino Venerito, Frode Lerang, Dmitry S Bordin, Vincent Lamy, Lisette G Capelle, Wojciech Marlicz, Daniela Dobru, Oleksiy Gridnyev, Ignasi Puig, Francis Mégraud, Colm O'Morain, Javier P Gisbert
doi : 10.1136/gutjnl-2022-328232
Objective To evaluate the use, effectiveness and safety of Helicobacter pylori empirical rescue therapy in third and subsequent treatment lines in Europe.
Effect of endoscopic sleeve gastroplasty on gastric emptying, motility and hormones: a comparative prospective study
Eric J Vargas, Monika Rizk, Jacky Gomez-Villa, Phillip K Edwards, Veeravich Jaruvongvanich, Andrew C Storm, Andres Acosta, David Lake, Jeff Fidler, Adil E Bharucha, Michael Camilleri, Barham K Abu Dayyeh
doi : 10.1136/gutjnl-2022-327816
Objective Endoscopic sleeve gastroplasty (ESG) has gained global adoption but our understanding of its mechanism(s) of action and durability of efficacy is limited. We sought to determine changes in gastric emptying (GE), gastric motility (GM), hormones and eating behaviours after ESG.
CARD9 in neutrophils protects from colitis and controls mitochondrial metabolism and cell survival
Camille Danne, Chloé Michaudel, Jurate Skerniskyte, Julien Planchais, Aurélie Magniez, Allison Agus, Marie-Laure Michel, Bruno Lamas, Gregory Da Costa, Madeleine Spatz, Cyriane Oeuvray, Chloé Galbert, Maxime Poirier, Yazhou Wang, Alexia Lapière, Nathalie Rolhion, Tatiana Ledent, Cédric Pionneau, Solenne Chardonnet, Floriant Bellvert, Edern Cahoreau, Amandine Rocher, Rafael Rose Arguello, Carole Peyssonnaux, Sabine Louis, Mathias L Richard, Philippe Langella, Jamel El-Benna, Benoit Marteyn, Harry Sokol
doi : 10.1136/gutjnl-2022-326917
Objectives Inflammatory bowel disease (IBD) results from a combination of genetic predisposition, dysbiosis of the gut microbiota and environmental factors, leading to alterations in the gastrointestinal immune response and chronic inflammation. Caspase recruitment domain 9 (Card9), one of the IBD susceptibility genes, has been shown to protect against intestinal inflammation and fungal infection. However, the cell types and mechanisms involved in the CARD9 protective role against inflammation remain unknown.
Lifestyle factors for the prevention of inflammatory bowel disease
Emily W Lopes, Simon S M Chan, Mingyang Song, Jonas F Ludvigsson, Niclas Håkansson, Paul Lochhead, Allan Clark, Kristin E Burke, Ashwin N Ananthakrishnan, Amanda J Cross, Domenico Palli, Manuela M Bergmann, James M Richter, Andrew T Chan, Ola Olén, Alicja Wolk, Hamed Khalili
doi : 10.1136/gutjnl-2022-328174
Objective To estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.
TiO2 nanoparticles abrogate the protective effect of the Crohn’s disease-associated variation within the PTPN22 gene locus
Marlene Schwarzfischer, Anna Niechcial, Kristina Handler, Yasser Morsy, Marcin Wawrzyniak, Andrea S Laimbacher, Kirstin Atrott, Roberto Manzini, Katharina Baebler, Larissa Hering, Egle Katkeviciutė, Janine Häfliger, Silvia Lang, Maja E Keller, Jérôme Woodtli, Lisa Eisenbeiss, Thomas Kraemer, Elisabeth M Schraner, Mahesa Wiesendanger, Sebastian Zeissig, Gerhard Rogler, Andreas E Moor, Michael Scharl, Marianne R Spalinger
doi : 10.1136/gutjnl-2021-325911
Objective Inflammatory bowel disease (IBD) is a multifactorial condition driven by genetic and environmental risk factors. A genetic variation in the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene has been associated with autoimmune disorders while protecting from the IBD subtype Crohn’s disease. Mice expressing the murine orthologous PTPN22-R619W variant are protected from intestinal inflammation in the model of acute dextran sodium sulfate (DSS)-induced colitis. We previously identified food-grade titanium dioxide (TiO2, E171) as a neglected IBD risk factor. Here, we investigate the interplay of the PTPN22 variant and TiO2-mediated effects during IBD pathogenesis.
Harnessing the Vnn1 pantetheinase pathway boosts short chain fatty acids production and mucosal protection in colitis
Virginie Millet, Thomas Gensollen, Michael Maltese, Melanie Serrero, Nathalie Lesavre, Christophe Bourges, Christophe Pitaval, Sophie Cadra, Lionel Chasson, Thien Phong Vu Man, Marion Masse, Juan Jose Martinez-Garcia, Fabrice Tranchida, Laetitia Shintu, Konrad Mostert, Erick Strauss, Patricia Lepage, Mathias Chamaillard, Achille Broggi, Laurent Peyrin-Biroulet, Jean-Charles Grimaud, Philippe Naquet, Franck Galland
doi : 10.1136/gutjnl-2021-325792
Objective In the management of patients with IBD, there is a need to identify prognostic markers and druggable biological pathways to improve mucosal repair and probe the efficacy of tumour necrosis factor alpha biologics. Vnn1 is a pantetheinase that degrades pantetheine to pantothenate (vitamin B5, a precursor of coenzyme A (CoA) biosynthesis) and cysteamine. Vnn1 is overexpressed by inflamed colonocytes. We investigated its contribution to the tolerance of the intestinal mucosa to colitis-induced injury.
Integrated metagenomic and metabolomic analysis reveals distinct gut-microbiome-derived phenotypes in early-onset colorectal cancer
Cheng Kong, Lei Liang, Guang Liu, Lutao Du, Yongzhi Yang, Jianqiang Liu, Debing Shi, Xinxiang Li, Yanlei Ma
doi : 10.1136/gutjnl-2022-327156
Objective The incidence of early-onset colorectal cancer (EO-CRC) is steadily increasing. Here, we aimed to characterise the interactions between gut microbiome, metabolites and microbial enzymes in EO-CRC patients and evaluate their potential as non-invasive biomarkers for EO-CRC.
Gut microbiota influence anastomotic healing in colorectal cancer surgery through modulation of mucosal proinflammatory cytokines
Roy Hajjar, Emmanuel Gonzalez, Gabriela Fragoso, Manon Oliero, Ahmed Amine Alaoui, Annie Calvé, Hervé Vennin Rendos, Souad Djediai, Thibault Cuisiniere, Patrick Laplante, Claire Gerkins, Ayodeji Samuel Ajayi, Khoudia Diop, Nassima Taleb, Sophie Thérien, Frédéricke Schampaert, Hefzi Alratrout, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric Debroux, Jean-François Cailhier, Bertrand Routy, Borhane Annabi, Nicholas J B Brereton, Carole Richard, Manuela M Santos
doi : 10.1136/gutjnl-2022-328389
Objective Colorectal cancer (CRC) is the third most diagnosed cancer, and requires surgical resection and reconnection, or anastomosis, of the remaining bowel to re-establish intestinal continuity. Anastomotic leak (AL) is a major complication that increases mortality and cancer recurrence. Our objective is to assess the causal role of gut microbiota in anastomotic healing.
Epithelial presenilin-1 drives colorectal tumour growth by controlling EGFR-COX2 signalling
Reyes Gamez-Belmonte, Mousumi Mahapatro, Lena Erkert, Miguel Gonzalez-Acera, Elisabeth Naschberger, Yuqiang Yu, Mireia Tena-Garitaonaindia, Jay V Patankar, Yara Wagner, Eva Podstawa, Lena Schödel, Marvin Bubeck, Markus F Neurath, Michael Stürzl, Christoph Becker
doi : 10.1136/gutjnl-2022-327323
Objective Psen1 was previously characterised as a crucial factor in the pathogenesis of neurodegeneration in patients with Alzheimer’s disease. Little, if any, is known about its function in the gut. Here, we uncovered an unexpected functional role of Psen1 in gut epithelial cells during intestinal tumourigenesis.
EUS-guided drainage of large walled-off pancreatic necroses using plastic versus lumen-apposing metal stents: a single-centre randomised controlled trial
John Gásdal Karstensen, Srdan Novovic, Erik Feldager Hansen, Annette Bojer Jensen, Henrik Lovendahl Jorgensen, Morten Laksafoss Lauritsen, Mikkel Parsberg Werge, Palle Nordblad Schmidt
doi : 10.1136/gutjnl-2022-328225
Objective In treating pancreatic walled-off necrosis (WON), lumen-apposing metal stents (LAMS) have not proven superior to the traditional double pigtail technique (DPT). Among patients with large WON (>15 cm) and their associated substantial risk of treatment failure, the increased drainage capacity of a novel 20-mm LAMS might improve clinical outcomes. Hence, we conducted a study comparing the DPT and 20-mm LAMS in patients with large WON.
Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer
Feda H Hamdan, Amro M Abdelrahman, Ana Patricia Kutschat, Xin Wang, Thomas L Ekstrom, Nidhi Jalan-Sakrikar, Catherine Wegner Wippel, Negar Taheri, Liezel Tamon, Waltraut Kopp, Joana Aggrey-Fynn, Aditya V Bhagwate, Roberto Alva-Ruiz, Isaac Lynch, Jennifer Yonkus, Robyn Laura Kosinsky, Jochen Gaedcke, Stephan A Hahn, Jens T Siveke, Rondell Graham, Zeynab Najafova, Elisabeth Hessmann, Mark J Truty, Steven A Johnsen
doi : 10.1136/gutjnl-2022-328154
Objective Pancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional mechanisms enabling this are poorly understood. In this study, we aimed to identify novel mechanistic approaches to overcome or prevent resistance in PDAC.
Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections
Rani Burm, Panagiota Maravelia, Gustaf Ahlen, Sandra Ciesek, Noelia Caro Perez, Anna Pasetto, Stephan Urban, Freya Van Houtte, Lieven Verhoye, Heiner Wedemeyer, Magnus Johansson, Lars Frelin, Matti Sällberg, Philip Meuleman
doi : 10.1136/gutjnl-2022-327216
Objective Chronic HBV/HDV infections are a major cause of liver cancer. Current treatments can only rarely eliminate HBV and HDV. Our previously developed preS1-HDAg immunotherapy could induce neutralising antibodies to HBV in vivo and raise HBV/HDV-specific T-cells. Here, we further investigate if a heterologous prime-boost strategy can circumvent T-cell tolerance and preclude HDV superinfection in vivo.
Distinct single-cell immune ecosystems distinguish true and de novo HBV-related hepatocellular carcinoma recurrences
Shuling Chen, Cheng Huang, Guanrui Liao, Huichuan Sun, Yubin Xie, Changyi Liao, Jianping Wang, Minghui He, Huanjing Hu, Zihao Dai, Xiaoxue Ren, Xuezhen Zeng, Zhilong Lin, Guo-Pei Zhang, Wenxuan Xie, Shunli Shen, Shaoqiang Li, Sui Peng, Dong-Ming Kuang, Qiang Zhao, Dan G Duda, Ming Kuang
doi : 10.1136/gutjnl-2022-328428
Objective Revealing the single-cell immune ecosystems in true versus de novo hepatocellular carcinoma (HCC) recurrences could help the optimal development of immunotherapies.
It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas biology and disease
Amelia T Cephas, William L Hwang, Anirban Maitra, Oren Parnas, Kathleen E DelGiorno
doi : 10.1136/gutjnl-2022-329313
Recent advances in single-cell RNA sequencing and bioinformatics have drastically increased our ability to interrogate the cellular composition of traditionally difficult to study organs, such as the pancreas.
Plastic is as good as metal: is the ‘debris clearance’ debate for walled-off necrosis drainage finally over?
Jayanta Samanta, Jahnvi Dhar
Letter to the editor: the inflamed subclass predicts immunotherapy response – external validations
Binghua Li, Yajuan Cao, Yunzheng Li, Chunxiao Cheng, Decai YU
Response to letter to the editor: over-the-scope clips versus standard treatment
Benjamin Meier, Arthur Schmidt, Karel Caca
Fifty-point IBS-SSS responders but persistence of moderate severity IBS in over 40% of those on diet
Michael Camilleri
SARS-CoV-2 vaccination in patients with GI and hepatobiliary carcinoma: a call for booster vaccination
Malte Benedikt Monin, Leona Baier, Moritz Berger, Jens Gabriel Gorny, Taotao Zhou, Robert Mahn, Farsaneh Sadeghlar, Christian Möhring, Kathrin van Bremen, Christoph Boesecke, Jürgen Rockstroh, Christian Strassburg, Anna-Maria Eis-Hübinger, Maria Agnes Gonzalez-Carmona
COVID-19 and liver injury: hypoalbuminaemia and γGT should be observed at hospital admission
Sabine Weber, Alexander L Gerbes
Post-acute COVID-19 syndrome and gut dysbiosis linger beyond 1 year after SARS-CoV-2 clearance
Qi Su, Raphaela Iris Lau, Qin Liu, Francis Ka Leung Chan, Siew Chien Ng
Gastric variceal bleeding in a patient with alcohol abuse: business as usual?
Andreas Fischer, Burcin Özdirik, Dominik Geisel, Thomas Malinka, Stefan Pahl
