The nocebo phenomenon in the COVID-19 pandemic: a nocebodemic effect

Martina Amanzio, Giuseppina Elena Cipriani & Dimos D. Mitsikostas

doi : 10.1080/17512433.2022.2142115

Expert Review of Clinical Pharmacology, Volume 15, Issue 12 (2022)

The COVID-19 pandemic had remarkable effects on psychological distress. The main stressors were prolonged quarantine and social isolation, fear of infection and death, stigmatization, infodemic, financial difficulties, and job loss. These negative stressors, which affect mental and physical health, make people more vulnerable to nocebo-related risk behaviors. We aimed to summarize data on nocebo behaviors, such as the negative psychological consequences of the COVID-19 pandemic in terms of how people perceive and interpret medical services and treatments.

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Cannabidiol drug interaction considerations for prescribers and pharmacists

Myfanwy Graham, Jennifer H Martin, Catherine J Lucas, Bridin Murnion & Jennifer Schneider

doi : 10.1080/17512433.2022.2142114

In light of the widespread use of non-prescribed and prescribed cannabidiol, the use of cannabidiol with other medications is likely, and this may result in drug interactions.

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Combination immunotherapy strategies for triple-negative breast cancer: current progress and barriers within the pharmacological landscape

Jacopo Uliano, Eleonora Nicol?, Carla Corvaja, Beatrice Taurelli Salimbeni, Dario Trapani & Giuseppe Curigliano

doi : 10.1080/17512433.2022.2142559

Triple-negative breast cancer (TNBC) is a breast cancer subtype characterized by poorer prognosis. Despite that TNBC can display immunogenic features, anti-PD(L)1 monotherapy strategies have resulted in disappointing results, underscoring the need to optimize their use in TNBC.

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Heparin infusions in aneurysmal subarachnoid hemorrhages: clinical considerations for use beyond anticoagulation

Zsanett Kormanyos, Justin P. Reinert & Paul Brady

doi : 10.1080/17512433.2022.2148654

Patients who have experienced an aneurysmal subarachnoid hemorrhage (aSAH) may face a significant morbidity burden following the acute phase of their injury. Though commonly employed as an anticoagulant, heparin may have clinical utility related to its ability to mitigate the production of pro-inflammatory cytokines and chelate oxidized blood.

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Identifying and categorizing compounds that reduce corneal transforming growth factor beta induced protein levels: a scoping review

Gabriella Guo Sciriha, Janet Sultana & Joseph Borg

doi : 10.1080/17512433.2022.2142560

Transforming growth factor beta induced (TGFBI) gene mutations have been reported as the cause of a group of genetically inherited, visually debilitating, corneal dystrophies (CD). A scoping literature review to identify and categorize compounds that inhibit corneal TGFBI expression and/or promote TGFBIp degradation was performed. Emphasis was given to their potential to be used as a cost-effective approach via drug repurposing.

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Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy

Keti Bardhi, Shelby Coates, Christy J.W. Watson & Philip Lazarus

doi : 10.1080/17512433.2022.2148655

Cannabis is an increasingly popular recreational and medicinal drug in the USA. While cannabis is still a Schedule 1 drug federally, many states have lifted the ban on its use. With its increased usage, there is an increased possibility for potential drug-drug interactions (DDI) that may occur with concomitant use of cannabis and pharmaceuticals.

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Efficacy and safety of liraglutide for obesity and people who are overweight: a systematic review and meta-analysis of randomized controlled trials

Qiucen Lin, Yan Xue, Huimin Zou, Zhen Ruan, Carolina Oi Lam Ung & Hao Hu

doi : 10.1080/17512433.2022.2130760

As the pandemic of obesity presents an increasing serious health challenge worldwide, additional medical interventions, especially pharmacotherapy, should be addressed for the affected people. Liraglutide 3.0 mg, is one of the possible options for long-term anti-obesity treatment.

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Clinical efficacy and safety of topical difamilast in the treatment of patients with atopic dermatitis: a systematic review and meta-analysis of randomized controlled trials

Li-Chin Lu, Chien-Ming Chao, Shen-Peng Chang, Shao-Huan Lan & Chih- Cheng Lai

doi : 10.1080/17512433.2022.2134114

To investigate the clinical efficacy and safety of topical difamilast in mild-to-moderate atopic dermatitis (AD).

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Vestibular function in children with generalized epilepsy and treated with valproate

Sherifa Ahmed Hamed & Amira Mohamed Osiely

doi : 10.1080/17512433.2022.2130759

Studies that evaluated vestibular function with epilepsy are fewer than auditory studies. We assessed vestibular function in children with epilepsy in inter-ictal period.

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