Thrombosis with thrombocytopenia after vaccination with the ChAdOx1 nCoV-19 vaccine (Oxford–AstraZeneca): implications of gender-specific tissue-factor gene polymorphisms?

Raffaella Mormile

doi : 10.1080/17512433.2023.2154650

Expert Review of Clinical Pharmacology, Volume 16, Issue 1 (2023)

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Treatment options for children with multi-drug resistant tuberculosis

Gianluca Bossù, Giovanni Autore, Luca Bernardi, Danilo Buonsenso, Giovanni Battista Migliori & Susanna Esposito

doi : 10.1080/17512433.2023.2148653

According to the latest report from the World Health Organization (WHO), approximately 10.0 million people fell ill with tuberculosis (TB) in 2020, 12% of which were children aged under 15 years. There is very few experience on treatment of multi-drug resistant (MDR)-TB in pediatrics.

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How to treat histone 3 altered gliomas: molecular landscape and therapeutic developments

Vincenzo Di Nunno, Enrico Franceschi, Lidia Gatto, Alicia Tosoni, Stefania Bartolini & Alba Ariela Brandes

doi : 10.1080/17512433.2023.2163385

Diffuse midline gliomas (DMG) and diffuse hemispheric glioma (DHG) are both rare tumors characterized and recognized for specific alterations of histone 3 including H3K27 (DMG) and H3G34 (DHG). Despite these tumors arising from alterations of the same gene their clinical, radiological, and molecular behaviors strongly diverge, requiring a personalized therapeutic approach.

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Dual pathway inhibition in patients with atherosclerotic disease: pharmacodynamic considerations and clinical implications

Mattia Galli, Francesco Franchi, Fabiana Rollini, Luis Ortega-Paz, Domenico D’Amario, Raffaele De Caterina, Roxana Mehran, C Michael Gibson & Dominick J. Angiolillo

doi : 10.1080/17512433.2023.2154651

The persistence of elevated rates of ischemic recurrences despite the use of antiplatelet therapy among patients with atherosclerotic disease together with the understanding of the pivotal role of coagulation in the thrombo-inflammatory processes involved in the pathogenesis of atherosclerosis and its complications has fostered the development of treatments targeting both platelets and coagulation, a strategy known as dual-pathway inhibition (DPI).

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Dipeptidyl peptidase 4 (DPP-4) inhibitors and the risk of lung cancer: current evidence and future directions

doi : 10.1080/17512433.2023.2161045

Recent evidence has linked long-term use of angiotensin converting enzyme (ACE) inhibitors with the risk of developing lung cancer by increasing levels of substance P (SP) and bradykinin in lung tissue. DPP-4 inhibitors, by virtue of their mechanism of action, may increase the level of SP and pose a similar risk of incident lung cancer. Concomitant use of DPP-4 inhibitors and ACE inhibitors may further exaggerate this plausible risk.

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Potential approaches using teneligliptin for the treatment of type 2 diabetes mellitus: current status and future prospects

Harmanjit Singh, Jasbir Singh, Ravneet Kaur Bhangu, Mandeep Singla, Jagjit Singh & Farideh Javid

doi : 10.1080/17512433.2023.2163386

Based on pharmacological properties and results from clinical studies, teneligliptin has a great potential to be used as an alternate-day therapy and also the daily dose can be reduced to 10 mg. Clinical data also suggest its excellent efficacy and safety among older subjects.

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Clinical efficacy and safety of dasiglucagon in severe hypoglycemia associated with patients of type 1 diabetes mellitus: a systematic review and meta-analysis

Sagar Dholariya, Deepak Parchwani, Siddhartha Dutta & Ragini Singh

doi : 10.1080/17512433.2023.2138343

This study was carried out to analyze the clinical safety and efficacy of dasiglucagon for the treatment of severe hypoglycemia in patients with type 1 diabetes mellitus (T1DM).

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Impact of red yeast rice supplementation on lipid profile: a systematic review and meta-analysis of randomized-controlled trials

Parisa Rahmani, Ebru Melekoglu, Sogand Tavakoli, Nasser Malekpour Alamdari, Pejman Rohani & Mohammad Hassan Sohouli

doi : 10.1080/17512433.2023.2138342

Dyslipidemia/hyperlipidemia are among the risk factors for chronic diseases, especially cardiovascular diseases. Red Yeast Rice (RYR) herbal supplement may be helpful in improving serum fat levels due to some mechanisms. Therefore, the aim of this study was to evaluate the effects of RYR consumption on total serum cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and triglyceride (TG) levels in adults.

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A model based on machine learning for the prediction of cyclosporin A trough concentration in Chinese allo-HSCT patients

Lin Song, Chen-Rong Huang, Shi-Zheng Pan, Jian-Guo Zhu, Zong-Qi Cheng, Xun Yu, Ling Xue, Fan Xia, Jin-Yuan Zhang, De-Pei Wu & Li-Yan Miao

doi : 10.1080/17512433.2023.2142561

Cyclosporin A is a calcineurin inhibitor which has a narrow therapeutic window and high interindividual variability. Various population pharmacokinetic models have been reported; however, professional software and technical personnel were needed and the variables of the models were limited. Therefore, the aim of this study was to establish a model based on machine learning to predict CsA trough concentrations in Chinese allo-HSCT patients.

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