Alan D. Widgerow MBBCh, MMed, FCS, FACS, Karl Napekoski MD
doi : 10.1111/jocd.13942
Volume 20, Issue 2 p. i-i
The cover image is based on the Original Contribution New approaches to skin photodamage histology—Differentiating 'good' versus 'bad' Elastin by Alan D. Widgerow and Karl Napekoski
Michael H. Gold MD
doi : 10.1111/jocd.13924
Volume 20, Issue 2 p. 371-371
Nanze Yu, Yuwei Zhang, Meng Xiao, Wei Cao, Yan Zhang, Yang Yang, Zhengyin Liu, Yunzhu Li, Xiao Long, Zhifei Liu, Shuyang Zhang MD, Xiaojun Wang MD
doi : 10.1111/jocd.13887
Volume 20, Issue 2 p. 372-380
The emergence of COVID-19 has become a global health emergency. The transmissibility of the disease is of great interest to healthcare workers and scientists alike.
Cristina Cucu, Alexandra-Irina Butacu, Bogdan-Dimitrie Niculae, George-Sorin Tiplica
doi : 10.1111/jocd.13900
Volume 20, Issue 2 p. 381-385
Acne scars carry a huge physical and psychological impact on people. This article aims to evaluate the role of fractional radiotherapy in treatment of atrophic acne scars. The main objective includes providing an up-to-date review of existing literature, presenting the most significant studies conducted in this field.
Marc Mespreuve MD, PhD, Karl Waked MD, Benoit Hendrickx MD, PhD
doi : 10.1111/jocd.13477
Volume 20, Issue 2 p. 386-390
As the face is known for its extreme variation in vascular anatomy and the number of filler-associated complications due to intra-arterial injection is increasing, we are in need of a method to visualize anyone’s individual arterial anatomy of the face in a completely harmless way.
Mohit Kumar B. Pharm, Arpna Devi B. Pharm, Maninder Sharma B. Pharm, Palakdeep Kaur M. Pharm, Uttam Kumar Mandal PhD
doi : 10.1111/jocd.13507
Volume 20, Issue 2 p. 391-399
Perfume is basically a cosmetic product applied to human body for an amusing scent or the feeling of freshness. A certain amount of perfume penetrates and remains attached to the protein of the skin when perfume is applied on the body.
Pan Chen MD, Guangwen He PhD, Jingru Qian MASc, Yi Zhan MD, Rong Xiao MD
doi : 10.1111/jocd.13538
Volume 20, Issue 2 p. 400-409
Inflammatory skin diseases include a variety of skin diseases, such as seborrheic dermatitis, acne, atopic dermatitis, psoriasis and so on, which are more common and tend to have a significant impact on patients' quality of life.
Gabriel V. B. S. Tabosa MSc, Rafael F. Stelini Msc, Elemir M. Souza PhD, Paulo E. N. F. Velho PhD, Maria L. Cintra PhD, Michelle E. B. Florence PhD
doi : 10.1111/jocd.13592
Volume 20, Issue 2 p. 410-416
Although the development of lesions in skin areas that have undergone injury has long been known, understanding of its pathogenesis is limited. Depending on their peculiarities, those events have been described as isomorphic, reverse isomorphic, pseudoisomorphic, isotopic, and isopathic phenomena. Ruocco's immunocompromised cutaneous district (ICD) concept was proposed to include all those phenomena.
Bruna Souza Felix Bravo MD, Raquel de Melo Carvalho MD, Eduardo Souza MD, Thiago Jeunon De Souza Vargas MD, Leonardo Gonçalves Bravo MD
doi : 10.1111/jocd.13527
Volume 20, Issue 2 p. 417-419
The possibilities for facial and body treatments are wide, but when it comes to treatment for the cervical region, the options are more restricted and among them, the use of poly-l-lactic acid (PLLA) stands out.
Renata Przydatek-Tyrajska PhD Student, Aleksandra S?dzikowska PhD, Katarzyna Bartosik PhD Habilitated
doi : 10.1111/jocd.13542
Volume 20, Issue 2 p. 420-424
Colonization of skin by Demodex mites developing as a single facial lesion with a limited range is diagnosed relatively rarely. The presence of this type of skin lesions may hinder and thus delay the diagnostic process and application of appropriate treatment.
Raquel de Melo Carvalho MD, Taynara de Mattos Barreto MD, Flavia Weffort MD, Carla Jorge Machado MA, PhD, Daniel Fernandes Melo MSc, MD
doi : 10.1111/jocd.13554
Volume 20, Issue 2 p. 425-428
Pain evaluation during local injections is a complex process. Injections cause patient's distress, especially when the target is a sensitive area such as scalp.
Marta Carlesimo MD, Flavia Pigliacelli MD, Andrea D’Arino MD, Gemma Caro MD, Maria Caterina Fortuna MD, Alfredo Rossi PhD
doi : 10.1111/jocd.13566
Volume 20, Issue 2 p. 429-436
Since the introduction of the first chemotherapeutic regimens for the treatment of oncological disease, hundreds of drugs have been approved for cancer treatment and many more are under investigation.
Kerry Heitmiller MD, Jordan V. Wang MD, MBE, MBA, Robert D. Murgia DO, MA, Nazanin Saedi MD
doi : 10.1111/jocd.13567
Volume 20, Issue 2 p. 437-441
Platelet-rich plasma (PRP) has recently become a popular treatment for various skin conditions, including striae distensae, acne scars, traumatic scars, hair regrowth, and cutaneous rejuvenation.
Alan Durkin MD, Alexandra Lackey MD, Alyssa Tranchilla BS, Maxwell Poling PA-C, Gabriella Glassman MD, Nick Woltjen PA-C
doi : 10.1111/jocd.13881
Volume 20, Issue 2 p. 442-450
Numerous fillers can be used for midface revolumization. While rheological data, physiochemical properties, and durability measured in clinical studies can inform selection, direct comparisons between equal volumes of different fillers are lacking.
Won Lee MD, PhD, Tae-Hwan Ahn MD, PhD, Gwahn-Woo Cheon MD, MS, Min-Ji Lee MD, Eun-Jung Yang MD, PhD
doi : 10.1111/jocd.13523
Volume 20, Issue 2 p. 451-456
Deviated noses and asymmetric nostrils can be corrected using corrective rhinoplasty. However, after proper correction, adjacent facial mimetic muscles can cause recurrence of asymmetry because of preoperative habits.
Hayson Chenyu Wang MD, PhD, Yunting Wang MD, Xiao Long MD, Xiaojun Wang MD, PhD
doi : 10.1111/jocd.13575
Volume 20, Issue 2 p. 457-459
Mandibular osteomyelitis after filler injection is extremely rare.
Khaled M. M. Mekawy MSc, Ahmed Sadek MD, Ahmad K. Seddeik Abdel-Hameed MD
doi : 10.1111/jocd.13537
Volume 20, Issue 2 p. 460-465
Tranexamic acid (TXA) in oral, topical, and intra-dermal injection routes showed efficacy in melasma treatment. Micro-needling and fractional carbon dioxide (CO2) laser were reported to enhance the drug delivery of TXA.
Yiping Zhong MD, Lining Huang MD, Yongjun Chen MD, Tingting Yan MD, Bin Yang MD, Mao-Qiang Man MD
doi : 10.1111/jocd.13558
Volume 20, Issue 2 p. 466-471
Becker's nevus is a common skin disorder. Lasers and light instruments are the major modalities for the treatment of Becker's nevus, but the outcomes were mixed.
Mahmoud Abdallah MD, Hossam Fahmy MD, Shawkat Abdel Hameed MB, BCH, Azza E. Mostafa MD
doi : 10.1111/jocd.13564
Volume 20, Issue 2 p. 472-480
Different studies had evaluated the efficacy of fractional CO2 laser and platelet-rich plasma (PRP) in treating striae distensae (SD). Lyophilized growth factors (LGF) represent another form of delivering growth factors similar to PRP with a more standardized method. To the best of our knowledge, no previous trials have been reported using LGF in SD.
Zhi Yang MD, Song Jiang MM, Yiqiong Zhang MM, Yuan Chen MM, Yaxin Tan MM, Hong Su MM, Ying Xiong MM, Qiongyan Li MD, Li He MD
doi : 10.1111/jocd.13568
Volume 20, Issue 2 p. 481-490
This study is to evaluate the clinical efficacy and safety of a “double-layer” mode of super pulse fractional CO2 laser and a combined treatment of pinprick therapy with fractional CO2 laser for the treatment of atrophic acne scars.
Osman K?se MD
doi : 10.1111/jocd.13579
Volume 20, Issue 2 p. 491-496
Junctional melanocytic nevi are common. Furthermore, surgical treatment of these nevi can be challenging due to scar formation.
Yun Ho Lee MD, Heun Joo Lee MD, Won-Serk Kim MD, PhD, Ga-Young Lee MD, PhD, Young-Jun Choi MD
doi : 10.1111/jocd.13580
Volume 20, Issue 2 p. 497-505
Laser treatment has emerged as a novel treatment modality for onychodystrophy. Only a few small series have assessed the efficacy of laser treatment in onychodystrophy, most of which were case reports. The therapeutic effect of the 1064 nm neodymium-doped:yttrium aluminum garnet (Nd:YAG) laser for onychodystrophy has been demonstrated.
An?e Zorman MD, Ne?a Koron PhD
doi : 10.1111/jocd.13593
Volume 20, Issue 2 p. 506-512
Warts are benign epithelial proliferations that result from human papillomavirus (HPV) infection occurring on the skin and mucosa. Patients express a significant reduction in quality of life due to this cosmetic nuisance, as well as functional problems and physical discomfort. Newer methods of wart removal include different energy-based devices, mostly lasers. Nonablative lasers such as Nd:YAG have a higher success rate and are usually used with topical or infiltrative anesthesia
Mridvika Narda PhD, Carles Trullas MSc, Anthony Brown PhD, Jaime Piquero-Casals MD, PhD, Corinne Granger MD, MSc, Gabriella Fabbrocini MD
doi : 10.1111/jocd.13570
Volume 20, Issue 2 p. 513-521
Glycolic acid (GA) is an effective way of reversing the signs of age and photodamage. GA enhances desquamation of the stratum corneum and induces biological responses that can help restore skin's integrity. GA can, however, cause irritation, especially when its concentration is high, and its pH is low.
Zoe Diana Draelos MD, Hemali Gunt PhD, Stanley B. Levy MD
doi : 10.1111/jocd.13879
Volume 20, Issue 2 p. 522-525
UV-induced oxidative skin stress leads to cutaneous photoaging. The objective of these 2 studies was to evaluate a nature-based botanical facial oil for the ability to decrease UV-induced oxidative skin stress.
Alan D. Widgerow MBBCh, MMed, FCS, FACS, Karl Napekoski MD
doi : 10.1111/jocd.13865
Volume 20, Issue 2 p. 526-531
Photodamage creates changes within the skin layers known as solar elastosis. This presents as fragmentation of collagen and elastin fibers, decreases in the extracellular matrix (ECM) ground substance, as well as hyaluronic acid decrease in the thinning epidermis. Traditional immunohistochemistry (IHC) staining has failed to differentiate degenerated elastin from new elastin fibers generated with various topical strategies.
Eric F. Bernstein MD, MSE, Harry W. Sarkas PhD, Patricia Boland BA
doi : 10.1111/jocd.13803
Volume 20, Issue 2 p. 532-537
Ultraviolet (UV) radiation is a main cause of aging of sun-exposed skin, but greater attention is being focused on the damaging effects of high-energy visible (HEV) light (400 and 500 nm). HEV light exposure has increased with expanding use of consumer electronics, such as smartphones, which have a peak emission in the 400-490 nm range. Sunscreens containing titanium dioxide and zinc oxide protect against UVA and UVB radiation but provide limited protection against HEV light.
Gabriela Maria D'Angelo Costa MSc, Patr?cia Maria Berardo Gonçalves Maia Campos PhD
doi : 10.1111/jocd.13804
Volume 20, Issue 2 p. 538-545
Some in vitro studies have reported the potential of antioxidants for the reduction of melanogenesis. However, it is important to assess the clinical efficacy of these substances in reducing skin hyperpigmentation. Thus, the aim of this study was to evaluate the clinical efficacy of dermocosmetic formulations based on antioxidants using Reflectance confocal microscopy (RCM).
Moetaz El-Domyati MD, Wael Hosam El-Din MD, Walid Medhat MD, Michel R. Ibrahim MD, Yasmin khaled Msc
doi : 10.1111/jocd.13844
Volume 20, Issue 2 p. 546-553
Striae distensae (SD) is a very common skin problem. Although a lot of treatment modalities have been proposed, few of them are effective. Recently, carbon dioxide therapy (CDT) or carboxytherapy was used in many indications of cosmetic dermatology such as SD.
Nattaya Lourith PhD, Sathaporn Pungprom MSc, Mayuree Kanlayavattanakul PhD
doi : 10.1111/jocd.13543
Volume 20, Issue 2 p. 554-560
Snow fungus or snow mushroom or white jelly mushroom (Tremella fuciformis), the edible mushroom, was formulated into hand sanitizer in form of moisturizing alcohol-based hand rub (ABHR) gel.
Ivan D. da Silva Souza PhD, Lorraine Lampe Bachelor of Chemistry, Daniel Winn PhD
doi : 10.1111/jocd.13545
Volume 20, Issue 2 p. 561-565
Skin-lightening products are used worldwide to treat persistent pigmentation disorders that impact our quality of life and self-confidence.
Christian A. Albornoz MD, Saloni Shah BS, Robert D. Murgia DO, MA, Jordan V. Wang MD, MBE, MBA, Nazanin Saedi MD
doi : 10.1111/jocd.13555
Volume 20, Issue 2 p. 566-568
Oral supplementation with collagen peptides has recently grown in popularity. It has been marketed to offer skin rejuvenating properties, such as wrinkle reduction, skin plumping, and moisturizing effects. However, current data are limited regarding its effects on the skin. Despite the controversial status of oral collagen supplements, its popularity has continued to rise. Here, we examine the consumer interest in oral collagen peptides over a 5-year period in the United States.
Or Friedman MD, Ava Shamban MD, Sabrina Fabi MD, Diane I. Duncan MD, Ofir Artzi MD
doi : 10.1111/jocd.13877
Volume 20, Issue 2 p. 569-576
Effective nonsurgical treatments for the aging face are widely accepted and utilized. Although changes in the aging neck, often patients to seek esthetic rejuvenation protocols are neither well defined nor well designed. Increasingly, patients desire less invasive cosmetic treatments with less morbidity and downtime.
Aditya K. Gupta MD, PhD, Iordanka A. Ivanova PhD
doi : 10.1111/jocd.13830
Volume 20, Issue 2 p. 577-583
Facebook is the biggest online social networking platform, and it is being utilized by patients for peer support as well as to explore treatment options. Hair loss patients can experience negative psychological effects and are likely to turn to social networking platforms for support and treatment information.
Muhammad Ahmad MD, ABHRS, Mohammad Humayun Mohmand MD, FISHRS
doi : 10.1111/jocd.13524
Volume 20, Issue 2 p. 584-587
There has been an increase in the hair transplant surgeries especially FUE all over the world during last two decades. The more the number of grafts being harvested result in increase in transection. Unfortunately, there is no classification dealing with the hair transection. The authors have proposed the first comprehensive classification for document different levels of hair transections.
Jun Fujita MD, PhD
doi : 10.1111/jocd.13526
Volume 20, Issue 2 p. 588-590
Androgenetic alopecia (AGA) is the most common type of alopecia. Currently, various methods have been tried to treat male AGA, but the outcomes are often unsatisfactory, especially for elderly persons.
Chihyeon Sohng MD, Eun Hye Lee MD, Soo Kyeong Woo MD, Jun Young Kim MD, Kyung Duck Park MD, PhD, Seok-Jong Lee MD, PhD, Weon Ju Lee MD, PhD
doi : 10.1111/jocd.13540
Volume 20, Issue 2 p. 591-596
Microneedle devices have been used to reduce scarring and wrinkling as well as for the treatment of pattern hair loss.
Krzysztof Bojanowski PhD, Pedro Corona BS, Stephanie Ma BS, Hui Zhao MD, DMD
doi : 10.1111/jocd.13547
Volume 20, Issue 2 p. 597-601
The opportunity to shape facial appearance through noninvasive muscle relaxation procedures remains largely unfulfilled. Here, a hypothesis was tested whether an intraoral application of a mucoadhesive, biodegradable slow release formulation may trigger beneficial cosmetic outcomes in and around the mouth.
Giulio Gualdi MD, Antonella Fabiano MD, Ruggero Moro MD, Anna Venturuzzo MD, Paola Monari MD, Piergiacomo Calzavara-Pinton MD, Paolo Amerio MD
doi : 10.1111/jocd.13548
Volume 20, Issue 2 p. 602-604
The popularity of tattoos in the today's society brings with it a significant increase of the incidence of associated cutaneous reactions. Among the several complications that may occur after a tattooing procedure, allergic and photo-allergic reactions, infections, and Koebner phenomenon are the most common ones observed. Most of these complications may be avoided by identifying, before tattooing, the presence of risk factors or comorbidities that may increase the risk of their onset.
Muhammet Avcil PhD, Gokhan Akman PhD, Jens Klokkers PhD, Dohyeon Jeong PhD, Ayhan ?elik PhD
doi : 10.1111/jocd.13571
Volume 20, Issue 2 p. 605-614
Hyperpigmentation is a complex physiological process associated with alterations of skin color due to melanin overproduction and distribution.
Sara Grassi MD, Giulia Tadiotto Cicogna MD, Francesca Magri MD, Maria Caterina Fortuna MD, Gemma Caro MD, Angelina Pernazza MD, Giuseppe Soda MD, Emanuele Miraglia MD, Sandra Giustini MD, PhD, Marta Carlesimo MD, Alfredo Rossi MD, PhD
doi : 10.1111/jocd.13573
Volume 20, Issue 2 p. 615-620
Despite the incidence of Frontal fibrosing alopecia (FFA) has been increasing in last two decades, the pathophysiology and trigger factors of FFA have not been yet fully understood.
Ibrahim Fouda MD, Zakaria M. Obaid MD, Shimaa F. Hegazy MSc, Hesham Samir Abd Al-Samie MD, Ahmad Nofal MD
doi : 10.1111/jocd.13574
Volume 20, Issue 2 p. 621-625
Acne vulgaris (AV) is a common inflammatory skin disease involving dysfunction of the pilosebaceous unit. Many mechanisms for the pathogenesis of acne have been postulated; however, the precise pathogenesis is still uncertain.
Yue Xin MD, Xiang Wen MD?PhD, Michael R. Hamblin PhD, Xian Jiang MD, PhD
doi : 10.1111/jocd.13581
Volume 20, Issue 2 p. 626-635
Topical anesthetics are widely used in dermatology and cosmetology to alleviate the pain from nonsurgical cosmetic procedures, while the transdermal drug delivery is limited by the skin barrier. Cold atmospheric plasma (CAP) is a potential approach used for skin pretreatment to enhance transdermal delivery of topical medications.
Olga Krasilnikova, Marina Pozdnyakova D.Sc. in Medicine
doi : 10.1111/jocd.13584
Volume 20, Issue 2 p. 636-646
Recently, both doctors and patients pay particular attention to aesthetic medical services quality and efficacy of aesthetic adjustment implemented.
Bingying Wang MD, Meiling Tai MD, Kun Zhang PhD, Huixiong Chen PhD, Xiaoshuang Gan MD, Biao Che DOC, N. Abudukelimu PhD, Guoping Wang PhD, Xuelei Xin PhD, Li Lin MD, Ping Han MD, Yi Peng MD, Zhiyun Du PhD, Haji Aker Aisa PhD
doi : 10.1111/jocd.13541
Volume 20, Issue 2 p. 647-656
Dry skin is a common skin condition caused by reduction of water-holding capacity, which is regulated by skin barrier function. Dry skin can also be a symptom that indicates a more serious diagnosis. There are a number of moisturizers on the market, which play an important role in dermatologic and cosmetic therapies. However, the demand for these products with good and therapeutic efficiency is still growing.
Sylwia Jarz?bek MSc, Helena Rotsztejn MD
doi : 10.1111/jocd.13557
Volume 20, Issue 2 p. 657-663
Oxybrasion is one of the types of microdermabrasion. This method removes a superficial epidermal layer with the use of a stream of 0.9% saline solution and compressed air.
Silas Arandas Monteiro e Silva PhD, Joel Gonçalves de Souza PhD, Priscilla Siqueira Melo PhD, Ivani Aparecida Marchetto Moreno Tech, Severino Matias Alencar PhD, Renata Fonseca Vianna Lopez PhD, Gislaine Ricci Leonardi PhD
doi : 10.1111/jocd.13560
Volume 20, Issue 2 p. 664-676
The use of antioxidants in applications for topical use seems promising, however, many studies must be performed to ensure processes and products that can effectively bring benefits to combat the action of free radicals in the skin. For topical antioxidants to be effective against free radicals from the skin, it is essential that the antioxidants compounds permeate the different skin layers, to reach deeper layers of the epidermis in active form and stay there for a sufficient time to cause the beneficial effects.
Jingjing Qin, Liyuan Qiao, Jingjing Hu, Jichao Xu, Le Du, Qianqian Wang, Rui Ye
doi : 10.1111/jocd.13576
Volume 20, Issue 2 p. 677-683
The demand for personalized skin care is increasing rapidly in recent years. In order to provide suitable products for different customers, an accurate assessment of the skin condition is required. It is necessary to establish a remote and convenient method for quantifying skin condition.
Jun Ye PhD, Xiaoli Tang MD, Yunzhu Long PhD, Zhou Chu MD, Qing Zhou MD, Bojie Lin PhD
doi : 10.1111/jocd.13578
Volume 20, Issue 2 p. 684-690
Hypoxia is of great significance for stem cells to maintain the proliferation and differentiation capacity. As a specialized mesenchymal component of the hair follicle (HF), the dermal papilla cell (DPC) not only regulates HF cycle, but also plays a pivotal role in differentiating hair follicle stem cell(HFSC) into HF. However, whether hypoxia could affect DPCs on proliferation or metabolism remains unclear.
Neïla Hajem MSc, Léana Manzato MSc, Marie-Christine Branchet PhD, Amélie Herlin MSc, Shalina Hassanaly PhD, Elise Huguet MSc, Frank Himbert PhD, Philippe Bernard PhD, Anne-Sophie Dussert PhD, Jean-Christophe Choulot PhD, Sylvie Boisnic MD, Mayoura Kéophiphath PhD
doi : 10.1111/jocd.13583
Volume 20, Issue 2 p. 691-702
Purple tulip extract is a rich source of flavonoids which are powerful antioxidants and can hence be considered as an ideal candidate for use in skin care products.
?mer Faruk Elmas MD, Abdullah Demirba? MD
doi : 10.1111/jocd.13551
Volume 20, Issue 2 p. 703-704
Selami Aykut Temiz MD, Shohrat Arazov MD, Arzu Ataseven MD, Recep Dursun MD
doi : 10.1111/jocd.13882
Volume 20, Issue 2 p. 705-706
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