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A review on the traditional uses, phytochemistry, and pharmacology of the genus Veronicastrum (Plantaginaceae)
Elizabeth Syowai Mutinda a,b,c,1, Elijah Mbandi Mkala a,b,c,1, Jing Ren a,c,f,1, Festus Kimutai a,b,c,e, Emmanuel Nyongesa Waswa a,b,c, Wyclif Ochieng Odago a,b,c, Consolata Nanjala a,b,c, Moses Kirega Gichua d, Moses Muguci Njire d, Guang-Wan Hu
doi : 10.1016/j.jep.2022.115695
Volume 300, 10 January 2023, 115695
Veronicastrum Heist. ex Fabr. (Plantaginaceae) is a multifunctional plant in China and other parts of the continent. It has traditionally been used in the treatment of ascites, edema, blood stasis, pain relief, chronic nephritis injury, fever, cough, headache, arthritis, dysentery, rheumatism, pleural effusion, liver damage, and other disorders.
The history, stereochemistry, ethnopharmacology and quality assessment of borneol
Yuqi Mei a, Linnan Li a, Linghong Fan a, Wenxiang Fan a, Longchan Liu a, Fangli Zhang a, Zhizhi Hu b, Kang Wang b, Li Yang a,b,*, Zhengtao Wang
doi : 10.1016/j.jep.2022.115697
Volume 300, 10 January 2023, 115697
Borneol (BO) represents a global trade-driven spreading of ethnic medicine traceable to the classical age, and won its name specific to its original habitat “Borneo�. BO shows broad spectral pharmacological effects, such as anti-inflammatory, analgesic, antipyretic, inducing resuscitation, and widely applied in the protection and treatment of cardiovascular and cerebrovascular diseases, used singly or mostly in compound formulae.
Swertia chirayita: A comprehensive review on traditional uses, phytochemistry, quality assessment and pharmacology
Km Swati a,b, Vinod Bhatt a, Nitisha Sendri a,b, Pooja Bhatt a,b, Pamita Bhandari
doi : 10.1016/j.jep.2022.115714
Volume 300, 10 January 2023, 115714
Swertia chirayita (Roxb.) H. Karst. is a traditionally used, well-recognized medicinal plant of the family Gentianaceae with significant therapeutic potential. It has been traditionally used to cure various ailments such as fever, vomiting, jaundice, digestive disorders, heart diseases, diabetes, malaria, scorpion bite, and skin diseases.
Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review
Zhicheng Wei a,*, Jing Chen a, Fang Zuo c, Julie Guo a, Xiaodong Sun a, Deming Liu b,**, Conghai Liu
doi : 10.1016/j.jep.2022.115748
Volume 300, 10 January 2023, 115748
With high mortality and morbidity rates, lung cancer (LC) has become one of the major threats to human health. The treatment strategies for LC currently face issues, such as drug resistance and body tolerance.
Anadenanthera colubrina (Vell) Brenan: Ethnobotanical, phytochemical, pharmacological and toxicological aspects
Merline Delices a, Jessica de Araujo Isaias Muller a, Karuppusamy Arunachalam b,c, Domingos Tabajara de Oliveira Martins
doi : 10.1016/j.jep.2022.115745
Volume 300, 10 January 2023, 115745
Anadenanthera colubrina (Vell.) Brenan is an endemic tree to South America and different parts of it are used by the population for the treatment of various diseases, as well as in indigenous rituals. This species has high pharmacological potential but may present toxic potential due to the presence of psychotropic compounds.
NMR-based metabolomic analysis for the effects of moxibustion on imiquimod-induced psoriatic mice
Feng Huang a,c,*, Tong Zhang b,d, Bin Li a, Shaosong Wang a, Chang Xu f, Caihua Huang e, Donghai Lin
doi : 10.1016/j.jep.2022.115626
Volume 300, 10 January 2023, 115626
Moxibustion is a traditional medical intervention of traditional Chinese medicine. It refers to the direct or indirect application of ignited moxa wool made of mugwort leaves to acupuncture points or other specific parts of the body for either treating or preventing diseases. Moxibustion has been proven to be effective in treating skin lesions of psoriasis.
A unique insight for Xiaoyao San exerts antidepressant effects by modulating hippocampal glucose catabolism using stable isotope-resolved metabolomics
Wen-ze Wu a,b,c, Ting Ling-hu a,b,c, Yun-hao Zhao a,b,c, Wei-di Zhao d, Cui Ji d, Jun-sheng Tian a,b,c,***, Yan Ren e,f,**, Xue-mei Qin
doi : 10.1016/j.jep.2022.115702
Volume 300, 10 January 2023, 115702
Revealing the active ingredients of the traditional Chinese medicine decoction by the supramolecular strategies and multitechnologies
Zhijia Wang a,1, Wen Li a,1, Jihui Lu a, Zhihua Yuan a, Wenmin Pi a, Yaozhi Zhang a, Haimin Lei a, Wenguang Jing b,*, Penglong Wang a,**
doi : 10.1016/j.jep.2022.115704
Volume 300, 10 January 2023, 115704
Integrated Chinese herbal medicine with Western Medicine versus Western Medicine in the effectiveness of primary hypertension treatment: A systematic review and meta-analysis of randomized controlled trials
Shadi A.D. Mohammed a,c,1, Liu Hanxing a,1, Lu Fang a, Adnan Mohammed Algradi b, Mohammed Alradhi d, Mohammed Safi e, Liu Shumin
doi : 10.1016/j.jep.2022.115703
Volume 300, 10 January 2023, 115703
Anti-Streptococcus mutans, anti-adherence and anti-acidogenic activity of Uvaria chamae P. Beauv
M. Madiba a, B.B. Oluremi b, Z. Gulube c, O.O. Oderinlo d, M. Marimani a, P.M. Osamudiamen e, M. Patel
doi : 10.1016/j.jep.2022.115673
Volume 300, 10 January 2023, 115673
Exploring the mechanism of the antithrombotic effects of Pueraria lobata and Pueraria lobata var. thomsonii based on network pharmacology
Song Wang a,c,1, Wei Yao a,c,1, Xudong Zhu a,c, Jingjing Wang a,c, Longhui Lu a,c, Na Zhu a,c, Tong Lan a, Yunxia Kuang a, Weifeng Zhu b, Ronghua Liu a,**, Liping Huang
doi : 10.1016/j.jep.2022.115701
Volume 300, 10 January 2023, 115701
Integrated network pharmacology and DSS-induced colitis model to determine the anti-colitis effect of Rheum palmatum L. and Coptis chinensis Franch in granules
Wenxin Yan a, Qian Feng a, Yu Li a, Yuefang Lin a, Jingjing Yao a, Zhen Jia a, Linlin Lu a,***, Liang Liu b,c,**, Hua Zhou
doi : 10.1016/j.jep.2022.115675
Volume 300, 10 January 2023, 115675
Chemical composition and antinociceptive and anti-inflammatory activity of the essential oil of Hyptis crenata Pohl ex Benth. from the Brazilian Amazon
Maria Nancy N. de Lima a,b, Bruna A. Guimar?aes b, Ana L?dia S. de Castro c, Kevellen B. Ribeiro c, Daniele C. Miller d, Pedro Iuri C. da Silva c, Jofre Jacob S. Freitas c, Anderson B. de Lima c, William N. Setzer e, Joyce Kelly R. da Silva a,e, Jos´e Guilherme S. Maia a,f, Pablo Luis B. Figueiredo
doi : 10.1016/j.jep.2022.115720
Volume 300, 10 January 2023, 115720
Protease inhibitor from Libidibia ferrea seeds attenuates inflammatory and nociceptive responses in mice
Raquel Carvalho a,b, Iluska Senna Bonf´a b, J´essica de Ara?jo Isa?as Muller b,c, Silvana Cristina Pando d, Mˆonica Cristina Toffoli-Kadri
doi : 10.1016/j.jep.2022.115694
Volume 300, 10 January 2023, 115694
A novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis
Xin Deng a,b,1, Hong-Yuan Lei a,1, Yong-Shen Ren a,*, Jiao Ai a, Yan-Qiu Li a, Shuai Liang a, Lin-Lin Chen c, Mao-Chuan Liao
doi : 10.1016/j.jep.2022.115677
Volume 300, 10 January 2023, 115677
Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221
Jie Yang a,1, Zi-Xuan Wang a,1, Lei Fang b, Tu-Shuai Li a, Zhi-Hong Liu a, Ying Pan a,**, Ling- Dong Kong
doi : 10.1016/j.jep.2022.115688
Volume 300, 10 January 2023, 115688
Xianglian Pill attenuates ulcerative colitis through TLR4/MyD88/NF-κB signaling pathway
Yuxin Dai a,b,1, Qiulu Lu c,1, Peiyi Li a,b, Junyu Zhu a, Jiaxin Jiang a, Tong Zhao a, Yue Hu a, Kang Ding d, Min Zhao
doi : 10.1016/j.jep.2022.115690
Volume 300, 10 January 2023, 115690
Hericium caput-medusae (Bull.:Fr.) Pers. fermentation concentrate polysaccharides improves intestinal bacteria by activating chloride channels and mucus secretion
Cong Zhao a, Chang Sun a, Jing Yuan a, Ivan Steve Nguepi Tsopmejio a, Yuting Li a, Yu Jiang a,**, Hui Song
doi : 10.1016/j.jep.2022.115721
Volume 300, 10 January 2023, 115721
Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms
Jinjin Chen a,1, Qingxia Huang a,b,1, Jing Li a, Yao Yao a, Weichen Sun b, Zepeng Zhang b, Hongyu Qi a, Zhaoqiang Chen b, Jiaqi Liu b, Daqing Zhao b, Jia Mi c,**, Xiangyan Li
doi : 10.1016/j.jep.2022.115715
Volume 300, 10 January 2023, 115715
Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics
Jiao Song a, Wei Liao a, Xuan Deng a, Dingkun Zhang a, Junzhi Lin b,**, Runchun Xu a,***, Li Han
doi : 10.1016/j.jep.2022.115723
Volume 300, 10 January 2023, 115723
XCHT alleviates the pancreatic fibrosis via VDR/NLRP3 signaling pathway in a mouse model of CP
Guixian Zhang a,1, Xiumei Zhao a,1, Jun Cai a,1, Sainan Li b, Xijing Li a, Wenchang Li a, Pengcheng Shi a, Dawei Liu a, Duo Zheng a, Ting Zhang a, Renrui Feng a, Hongbin Liu a
doi : 10.1016/j.jep.2022.115689
Volume 300, 10 January 2023, 115689
23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways
Chunyan Chen a,1, Lin Li a,b,1, Xiaomei Liu a, Deqin Zhang a,b, Yang Liu c,*, Yuhong Li
doi : 10.1016/j.jep.2022.115725
Volume 300, 10 January 2023, 115725
Antibacterial and anti-inflammatory activity of plant species used in traditional poultry ethnomedicine in Zimbabwe: A first step to developing alternatives to antibiotic poultry feed additives
P. Jambwa a,b, S.M. Nkadimeng a, T.N. Mudimba c, G. Matope d, L.J. McGaw
doi : 10.1016/j.jep.2022.115687
Volume 300, 10 January 2023, 115687
Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-?B signaling pathway in rats
Hai-Dong Chen a,b, Ming-Zhao Jiang a, Ying-Ying Zhao a, Xin Li a, Hai Lan a,b, Wan-Qi Yang a,b,**, Yong Lai
doi : 10.1016/j.jep.2022.115691
Volume 300, 10 January 2023, 115691
Low concentrations of Ambrosia maritima L. phenolic extract protect endothelial cells from oxidative cell death induced by H2O2 and sera from Crohn's disease patients
Iman Ramli a, Anna Maria Posadino b, Sakina Zerizer a, Ylenia Spissu c, Antonio Barberis c, Hanane Djeghim d, Emanuela Azara e, Chawki Bensouici d, Zahia Kabouche f, Khellaf Rebbas g,h, Guy D’hallewin c, Leonardo Antonio Sechi b,i, Gianfranco Pintus
doi : 10.1016/j.jep.2022.115722
Volume 300, 10 January 2023, 115722
Zhenwu decoction ameliorates cardiac hypertrophy through activating sGC (soluble guanylate cyclase) - cGMP (cyclic guanosine monophosphate) - PKG (protein kinase G) pathway
Liqian Chen a,1, Xinghong Zhou a,1, Yijian Deng a,1, Ying Yang a, Xiaohu Chen a, Qinghong Chen a, Yanyan Liu a, Xiuqiong Fu b, Hiu Yee Kwan b, Yanting You a,***, Wen Jin c,**, Xiaoshan Zhao
doi : 10.1016/j.jep.2022.115705
Volume 300, 10 January 2023, 115705
Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy
Yisa Wang a,b,1, Peng Ma a,1, Zijing Wang a, Mingxia Sun c, Biyu Hou a, Tianshu Xu a, Wenlan Li b, Xiuying Yang a, Guanhua Du a, Tengfei Ji c,*, Guifen Qiang
doi : 10.1016/j.jep.2022.115680
Volume 300, 10 January 2023, 115680
Ginseng polysaccharide attenuates red blood cells oxidative stress injury by regulating red blood cells glycolysis and liver gluconeogenesis
Siming Wang a,1, Yuchu Zhao a,1, Junjie Yang a, Shichao Liu c, Weifeng Ni a, Xueyuan Bai a, Ze Yang b, Daqing Zhao a, Meichen Liu
doi : 10.1016/j.jep.2022.115716
Volume 300, 10 January 2023, 115716
Immunomodulatory efficacy of Cousinia thomsonii C.B. Clarke in ameliorating inflammatory cascade expressions
Khalid Bashir Dar a,1, Ruhban Ansar Parry a,1, Aashiq Hussain Bhat a, Afaq Hameed Beigh b, Maroof Ahmed a, Umer Majeed Khaja a,f, Aijaz Hassan Ganie c, Manzoor Ahmad Mir d, Bilal Ahmad Reshi e, Ishfaq Shafi Khan g, Showkat Ahmad Ganie
doi : 10.1016/j.jep.2022.115727
Volume 300, 10 January 2023, 115727
Danhong injection alleviates cerebral ischemia-reperfusion injury by inhibiting autophagy through miRNA-132-3p/ATG12 signal axis
Hongrui Zhang , Xinyi Wang , Weiwei Chen, Yixuan Yang, Yu Wang, Haitong Wan **, Zhenhong Zhu
doi : 10.1016/j.jep.2022.115724
Volume 300, 10 January 2023, 115724
Efficacy confirmation of Scutellaria baicalensis Georgi in the treatment of periodontitis via topical administration and active ingredients screening
Zhen Huang a,1, Yi Yu b,1, Xiao-Liang Lin b, Ting Zhang b, Jin-Lian Huang b, Lei Xiao b, Ming Liang b, Yu-Fei Wang c,**, Jin Qi
doi : 10.1016/j.jep.2022.115699
Volume 300, 10 January 2023, 115699
Liver protection and hemostatic effects of medicinal plant Arnebia euchroma (Royle) I.M.Johnst extract in a rat model
Nuramatjan Ablat a, Mihray Ablimit b, Abudoureheman Abudoukadier c, Buhaiqiemu Kadeer d, Abulaitijiang Maihemuti e, Alibati Bakewaiyi e, Atike Tuerxun f, Adilijiang Aihemaiti
doi : 10.1016/j.jep.2022.115739
Volume 300, 10 January 2023, 115739
Standardization and Ameliorative effect of Kalyanaka ghrita in β-amyloid induced memory impairment in wistar rats
Snehalatha Diddi a, Sathiyanarayanan Lohidasan b, S. Arulmozhi a,*, Kakasaheb R. Mahadik
doi : 10.1016/j.jep.2022.115671
Volume 300, 10 January 2023, 115671
Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand
Subhadip Banerjee a, Amrendra Tiwari a, Amit Kar c, Joydeb Chanda a, Sayan Biswas c, Gudrun Ulrich-Merzenich b, Pulok K. Mukherjee
doi : 10.1016/j.jep.2022.115633
Volume 300, 10 January 2023, 115633
Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo
Qian-Wen Kong a,1, Jiao Yang a,1, Dan Li b, Ya-Wei Ding a, Yu-Jie Hu a, Xiao-Chuan Xue c, Mei-Zhi Shi a, Bo Jiang a, Yang-Yun Zhou a, Min Zhang a, Jiu-Dong Hu a, Cheng Guo a, Jun-Jun Chen a,**, Yong-Long Han
doi : 10.1016/j.jep.2022.115728
Volume 300, 10 January 2023, 115728
Antimicrobial potential of the Mayan medicine plant Matayba oppositifolia (A. Rich.) Britton against antibiotic-resistant priority pathogens
Angel de Jes?s Dzul-Beh a, Andr´es Humberto Uc-Cach´on a, Avel Adolfo Gonz´alez-S´anchez b, Haziel Eleazar Dzib-Baak a, Rolffy Ortiz-Andrade c, Hugo B. Barrios-Garc?a d, Bertha Jim´enez-Delgadillo e, Gloria Mar?a Molina-Salinas a,*
doi : 10.1016/j.jep.2022.115738
Volume 300, 10 January 2023, 115738
Anti-inflammatory and osteoprotective effects of Shi-Wei-Ru-Xiang pills on collagen-induced arthritis in rats via inhibiting MAPK and STAT3 pathways
Hui Xiong a,1, Fengping Meng a,1, Miao Luo a, Weiwu Chen b, Juan Tian b, Lunju Chen b, Yankun Ju a, Zhinan Mei
doi : 10.1016/j.jep.2022.115693
Volume 300, 10 January 2023, 115693
The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway
Yuxi Liang a,b,1, Xiaoli Liu c,1, Jingyan Hu a, Songli Huang a, Xin Ma a, Xiaoyan Liu b,***, Rufeng Wang a,**, Xiuhua Hu
doi : 10.1016/j.jep.2022.115743
Volume 300, 10 January 2023, 115743
Efficacy of Trevesia palmata (Roxb. ex Lindl.) Vis. Extract on MG 63Â cell lines and arthritis-induced animal models
Ashwini Lydia Manoharan a, Gayathri Jagadeesan a, Gayathri Nataraj a, Kasipandi Muniyandi a, Gurusubramanian Guruswami b, Karuppusamy Arunachalam c,d, Parimelazhagan Thangaraj
doi : 10.1016/j.jep.2022.115742
Volume 300, 10 January 2023, 115742
A hydroalcoholic extract of Senecio nutans SCh. Bip (Asteraceae); its effects on cardiac function and chemical characterization
Javier Palacios a,*, Adri´an Paredes b,c, Fredi Cifuentes c,d, Marcelo A. Catal´an e, Angel Luis Garc?a-Villal´on f, Jorge Borquez b, Mario J. Simirgiotis g, Matthew Jones h, Amy Foster h, David J. Greensmith
doi : 10.1016/j.jep.2022.115747
Volume 300, 10 January 2023, 115747
Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway
Ziwei Chen a,1, Jinping Gu a,1, Susu Lin b,a, Zijin Xu c,a, Hongyu Xu a, Jiajing Zhao a, Peishi Feng a, Yi Tao a, Suhong Chen a,**, Ping Wang
doi : 10.1016/j.jep.2022.115719
Volume 300, 10 January 2023, 115719
Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity
Chun Niu , Xiao-li Hu , Zi-wen Yuan , Ying Xiao , Peng Ji , Yan-ming Wei , Yong-li Hua
doi : 10.1016/j.jep.2022.115741
Volume 300, 10 January 2023, 115741
Integrated serum pharmacochemistry and network pharmacology analyses reveal the bioactive metabolites and potential functional mechanism of ground cherry (Physalis pruinosa L.) in treatment of type 2 diabetes mellitus in rats
Asmaa Mahana a, Hala M. Hammoda a, Asmaa A. Khalifa b, Samar S. Elblehi c, Fathallah M. Harraz a, Eman Shawky
doi : 10.1016/j.jep.2022.115750
Volume 300, 10 January 2023, 115750
Uncovering the molecular mechanisms of Curcumae Rhizoma against myocardial fibrosis using network pharmacology and experimental validation
Meng Zhang a,1, Pengyu Lu a,1, Fusen Zhao a,1, Xuemei Sun b,1, Wenqi Ma a, Jiahui Tang a, Chengbo Zhang a, Haigang Ji b,**, Xindong Wang
doi : 10.1016/j.jep.2022.115751
Volume 300, 10 January 2023, 115751
A review on the protective effect of active components in Antrodia camphorata against alcoholic liver injury
Xiaofeng Liu a,1, Shuzhen Yu a,1, Yao Zhang b, Wei Zhang a, Hao Zhong a, Xiaoqin Lu a, Rongfa Guan
doi : 10.1016/j.jep.2022.115740
Volume 300, 10 January 2023, 115740
Effect of acetone fraction of Ottelia alismoides on the G2/M cell cycle arrest and apoptosis in the human carcinoma cell lines
Subrata Das a,1, Ashikur Rahaman b,1, Rajat Nath a, Anupam Das Talukdar a,**, Deepa Nath c, Shamee Bhattacharjee b, Deba Prasad Mandal b, Manabendra Dutta Choudhury a, Dipika Das a, Gitishree Das d, Jayanta Kumar Patra
doi : 10.1016/j.jep.2022.115729
Volume 300, 10 January 2023, 115729
In vivo investigation of the inhibitory effect of Peganum harmala L. and its major alkaloids on ethylene glycol-induced urolithiasis in rats
Summya Rashid a, Maryam Sameti b, Mohammed H. Alqarni b, Fatma M. Abdel Bar
doi : 10.1016/j.jep.2022.115752
Volume 300, 10 January 2023, 115752
Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception
Rodrigo Vargas-Ruiz a,b, Rosa Mariana Montiel-Ruiz b,*, Alejandro Zamilpa b, Manases Gonzalez-Cortazar b, Maribel Lucila Herrera-Ruiz b, Jaqueline Molina-Cabrera b, Mar?a Cruz Ju´arez-Arag´on c, Francisco Javier Flores-Murrieta
doi : 10.1016/j.jep.2022.115756
Volume 300, 10 January 2023, 115756
Analgesic, anti-inflammatory activity and metabolite profiling of the methanolic extract of Callicarpa arborea Roxb. leaves
Rubaet Sharmin Ema a, S.M. Neamul Kabir Zihad b, Md Naharul Islam a, Nazifa Sifat c, Razina Rouf d, Jamil A. Shilpi a, Shaikh Jamal Uddin
doi : 10.1016/j.jep.2022.115757
Volume 300, 10 January 2023, 115757
Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies
Bilqis Abiola Lawal a, Yusuf Oloruntoyin Ayipo b,c,*, Abisola Oyindamola Adekunle a, Mohammed Otuofu Amali d, Umar Muhammad Badeggi e, Waleed A. Alananzeh b, Mohd Nizam Mordi
doi : 10.1016/j.jep.2022.115753
Volume 300, 10 January 2023, 115753
