Paraptosis: a non-classical paradigm of cell death for cancer therapy

Chun-cao Xu1 , Yi-fan Lin 2 , Mu-yang Huang 1 , Xiao-lei Zhang 3 , Pei Wang 4 , Ming-qing Huang 2 ? and Jin-jian Lu

doi : 10.1038/s41401-023-01159-7

Volume 45 Issue 2, February 2024

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Development of PI3Kγ selective inhibitors: the strategies and application

Dong-yan Gu, Meng-meng Zhang, Jia Li, Yu-bo Zhou & Rong ShengÂ

doi : 10.1038/s41401-023-01166-8

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Caffeic acid alleviates cerebral ischemic injury in rats by resisting ferroptosis via Nrf2 signaling pathway

Xin-nan Li, Nian-ying Shang, Yu-ying Kang, Ning Sheng, Jia-qi Lan, Jing-shu Tang, Lei Wu, Jin-lan Zhang & Ying PengÂ

doi : 10.1038/s41401-023-01177-5

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Cell senescence induced by toxic interaction between α-synuclein and iron precedes nigral dopaminergic neuron loss in a mouse model of Parkinson’s disease

Qing-qing Shen, Xian-hui Jv, Xi-zhen Ma, Chong Li, Lin Liu, Wen-ting Jia, Le Qu, Lei-lei Chen & Jun-xia XieÂ

doi : 10.1038/s41401-023-01153-z

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Adapting the endoplasmic reticulum proteostasis rescues epilepsy-associated NMDA receptor variants

Pei-pei Zhang, Taylor M. Benske, Lucie Y. Ahn, Ashleigh E. Schaffer, James C. Paton, Adrienne W. Paton, Ting-wei Mu & Ya-juan WangÂ

doi : 10.1038/s41401-023-01172-w

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Neuron-derived exosomes mediate sevoflurane-induced neurotoxicity in neonatal mice via transferring lncRNA Gas5 and promoting M1 polarization of microglia

Li-li Xu, Jia-qian Xie, Jian-jun Shen, Mei-dan Ying & Xin-zhong ChenÂ

doi : 10.1038/s41401-023-01173-9

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Sphingosylphosphorylcholine alleviates pressure overload-induced myocardial remodeling in mice via inhibiting CaM-JNK/p38 signaling pathway

Fang-fang Ren 1 , Lin Zhao 1 , Xian-yun Jiang 1 , Jing-jing Zhang1 , Jia-min Gou1 , Xiao-yu Yu 1 , Shu-jin Wu1 and Lei Li 1

doi : 10.1038/s41401-023-01168-6

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Protective effects of curcumin on desipramine-induced islet β-cell damage via AKAP150/PKA/PP2B complex

Min Hu, Jia-ying Cai, Yao He, Kui Chen, Feng Hao, Jin-sen Kang, Yan Pan, Lu Tie & Xue-jun LiÂ

doi : 10.1038/s41401-023-01176-6

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A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy

Barbara Hutka, Anett Várallyay, Szilvia B. László, András S. Tóth, Bálint Scheich, Sándor Paku, Imre Vörös, Zoltán Pós, Zoltán V. Varga, Derek D. Norman, Andrea Balogh, Zoltán Benyó, Gábor Tigyi, Klára Gyires & Zoltán S. ZádoriÂ

doi : 10.1038/s41401-023-01175-7

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Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2

Li-jiao Sun, Xin Chen, Sai Zhu, Jin-jin Xu, Xiao-feng Li, Shao-xi Diao, Ying-li Yang, Jin-yu Liu, Jia-nan Wang, Ying-yin Sun, Cheng Huang, Xiao-ming Meng, Hua Wang, Xiong-wen Lv & Jun LiÂ

doi : 10.1038/s41401-023-01171-x

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Acetyl-CoA synthetase 2 promotes diabetic renal tubular injury in mice by rewiring fatty acid metabolism through SIRT1/ChREBP pathway

Jian Lu, Xue-qi Li, Pei-pei Chen, Jia-xiu Zhang, Liang Li, Gui-hua Wang, Xiao-qi Liu, Chun-ming Jiang & Kun-ling MaÂ

doi : 10.1038/s41401-023-01160-0

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Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction

SungJu Ryu 1,2 , Hui Long 1 , Xin-ling Zheng 1 , Yuan-yuan Song 1 , Yan Wang1 , Yu-jie Zhou 1 , Xiao-jing Quan 1 , Lu-yuan Li1 ? and Zhi-song Zhang

doi : 10.1038/s41401-023-01163-x

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Deep learning enables the discovery of a novel cuproptosis-inducing molecule for the inhibition of hepatocellular carcinoma

Fan Yang, Lin Jia, Hong-chao Zhou, Jing-nan Huang, Meng-yun Hou, Feng-ting Liu, Nayana Prabhu, Zhi-jie Li, Chuan-bin Yang, Chang Zou, Pär Nordlund, Ji-gang Wang & Ling-yun DaiÂ

doi : 10.1038/s41401-023-01167-7

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Targeting PRSS23 with tipranavir induces gastric cancer stem cell apoptosis and inhibits growth of gastric cancer via the MKK3/p38 MAPK-IL24 pathway

Ji-xian Xiong, Yu-ting Li, Xiang-yu Tan, Tie Chen, Bao-hua Liu & Li FuÂ

doi : 10.1038/s41401-023-01165-9

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A novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer

Cheng-Yao Chiang, Min Zhang, Junrong Huang, Juan Zeng, Chunlan Chen, Dongmei Pan, Heng Yang, Tiantian Zhang, Min Yang, Qiangqiang Han, Zou Wang, Tian Xiao, Yangchao Chen, Yongdong Zou, Feng Yin, Zigang Li, Lizhi Zhu & Duo ZhengÂ

doi : 10.1038/s41401-023-01164-w

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124I-labeled anti-CD147 antibody for noninvasive detection of CD147-positive pan-cancers: construction and preclinical studies

Xiao-kun Ma, Te-li Liu, Ya-nan Ren, Xiao-pan Ma, Yuan Yao, Xing-guo Hou, Jin Ding, Feng Wang, Hai-feng Huang, Hua Zhu & Zhi YangÂ

doi : 10.1038/s41401-023-01162-y

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