Calculator: Clinical criteria for exudative pleural effusion in adults (pleural fluid only-3 criteria)

Input

Pleural fluid protein
Pleural fluid cholesterol
Pleural fluid LDH
Upper limit of normal serum LDH

Results

Important: Inputs must be complete to perform calculation.


Pleural fluid LDH to upper limit of normal serum LDH ratio

Decimal precision

Pleural fluid interpretation

Criteria for an exudative effusion (criteria met are highlighted )

Pleural fluid protein >3.0 g/dL [30 g/L]

Pleural fluid cholesterol >55 mg/dL [1.42 mmol/L]

Pleural fluid LDH to upper limit of normal ratio serum LDH >0.66666

Classification

Transudative effusion is likely

Exudative effusion is likely

Notes

If the Pleural fluid protein is >3.0 g/dL [>30 g/L], then an exudate is likely.
If the Pleural fluid cholesterol is >55 mg/dL [>1.42 mmol/L], then an exudate is likely.
If the Pleural fluid LDH is greater than two-thirds the upper limit of the laboratory’s normal serum LDH, then an exudate is likely.
Please refer to UpToDate topic review on evaluation of pleural effusions for more information.
LDH: lactate dehydrogenase enzyme activity; PFP: pleural fluid protein; PFL: pleural fluid LDH; SL: serum LDH; ULN: upper limit normal.

Equations used

PFL_to_ULN_SL_ratio = PFL / ULN_SL

References

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Topic 139616 Version 2.0

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Calculator: Clinical criteria for exudative pleural effusion in adults (pleural fluid only-3 criteria)