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Contraindications to cryosurgical treatment of cutaneous squamous cell carcinoma (SCC)

Contraindications to cryosurgical treatment of cutaneous squamous cell carcinoma (SCC)
Patients with abnormal cold tolerance, cold urticaria, cryoglobulinemia, cryofibrinogenemia, or Raynaud's disease/phenomenon
High-risk SCCs or tumors located in high-risk, critical sites (nose, lips, ears, periocular and periauricular areas, and genitals)
SCCs located on the lower legs or scalp
SCCs located on free margins such as the eyelid, nasal alae, or helical rim
SCCs located near the external auditory canal
Tumors overlying nerves
Recurrent or ill-defined tumors
Deeply invasive SCCs (invading muscle, bone, or cartilage)
Tumors in darkly pigmented patients
Data from:
  1. Holt PJ. Cryotherapy for skin cancer: results over a 5-year period using liquid nitrogen spray cryosurgery. Br J Dermatol 1988; 119:231.
  2. Kuflik EG, Gage AA. The five-year cure rate achieved by cryosurgery for skin cancer. J Am Acad Dermatol 1991; 24:1002.
  3. Zacarian SA. Cryosurgery of cutaneous carcinomas. An 18-year study of 3,022 patients with 4,228 carcinomas. J Am Acad Dermatol 1983; 9:947.
  4. Graham GF. Advances in cryosurgery during the past decade. Cutis 1993; 52:365.
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