Patients with abnormal cold tolerance, cold urticaria, cryoglobulinemia, cryofibrinogenemia, or Raynaud's disease/phenomenon |
High-risk SCCs or tumors located in high-risk, critical sites (nose, lips, ears, periocular and periauricular areas, and genitals) |
SCCs located on the lower legs or scalp |
SCCs located on free margins such as the eyelid, nasal alae, or helical rim |
SCCs located near the external auditory canal |
Tumors overlying nerves |
Recurrent or ill-defined tumors |
Deeply invasive SCCs (invading muscle, bone, or cartilage) |
Tumors in darkly pigmented patients |
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