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Olopatadine (ophthalmic): Drug information

Olopatadine (ophthalmic): Drug information
(For additional information see "Olopatadine (ophthalmic): Patient drug information" and see "Olopatadine (ophthalmic): Pediatric drug information")

For abbreviations, symbols, and age group definitions used in Lexicomp (show table)
Brand Names: US
  • FT Eye Allergy Itch & Redness [OTC];
  • FT Eye Allergy Itch Relief [OTC];
  • Pataday [OTC];
  • Patanol [DSC];
  • Pazeo [DSC]
Brand Names: Canada
  • ACT Olopatadine [DSC];
  • APO-Olopatadine;
  • JAMP-Olopatadine;
  • MINT-Olopatadine;
  • Pataday;
  • Patanol;
  • Pazeo;
  • SANDOZ Olopatadine
Pharmacologic Category
  • Histamine H1 Antagonist;
  • Histamine H1 Antagonist, Second Generation;
  • Piperidine Derivative
Dosing: Adult
Allergic conjunctivitis

Allergic conjunctivitis: Ophthalmic:

0.1%: Instill 1 drop into each affected eye twice daily (allowing 6 to 8 hours between doses).

0.2%: Instill 1 drop into each affected eye once daily.

0.7%: Instill 1 drop into each affected eye once daily.

Dosing: Kidney Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer’s labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Older Adult

Refer to adult dosing.

Dosing: Pediatric

(For additional information see "Olopatadine (ophthalmic): Pediatric drug information")

Allergic conjunctivitis/ocular itching

Allergic conjunctivitis/ocular itching:

Olopatadine 0.1%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) twice daily, allowing 6 to 8 hours between doses.

Olopatadine 0.2%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) once daily.

Olopatadine 0.7%: Children ≥2 years and Adolescents: Ophthalmic: Instill 1 drop into affected eye(s) once daily.

Dosing: Kidney Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to low systemic absorption.

Adverse Reactions

The following adverse drug reactions and incidences are derived from product labeling unless otherwise specified.

Central nervous system: Headache (≤5%)

Gastrointestinal: Dysgeusia (2% to 5%), nausea (≤5%)

Infection: Cold symptoms (≤10%)

Neuromuscular & skeletal: Back pain (≤5%), weakness (≤5%)

Ocular: Abnormal sensation in eyes (2% to 5%), blurred vision (2% to 5%), dry eye syndrome (2% to 5%), superficial punctate keratitis (2% to 5%), burning sensation of eyes (≤5%), conjunctivitis (≤5%), eyelid edema (≤5%), eye pain (≤5%), eye pruritus (≤5%), foreign body sensation (≤5%), keratitis (≤5%), stinging of eyes (≤5%), hyperemia

Respiratory: Pharyngitis (≤10%), cough (≤5%), rhinitis (≤5%), sinusitis (≤5%)

Miscellaneous: Flu-like symptoms (≤5%), hypersensitivity (≤5%), infection (≤5%)

Contraindications

Hypersensitivity to olopatadine hydrochloride or any component of the formulation.

OTC labeling (Pataday): When used for self-medication, do not use if hypersensitive to olopatadine hydrochloride or any component of the formulation, or to treat contact lens-related irritation.

Warnings/Precautions

Other warnings/precautions:

• Contact lens: Not for use to treat contact lens-related irritation. Solution contains benzalkonium chloride; remove lens prior to administration and wait ≥10 minutes before reinserting. Do not use contact lenses if eyes are red.

• Self-medication (OTC use): Discontinue use and contact health care provider if eye pain or changes in vision occur, redness or irritation of the eye continues, or condition worsens or persists for >3 days. Do not use if solution changes color or becomes cloudy.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Ophthalmic:

FT Eye Allergy Itch & Redness: 0.1% (5 mL) [contains benzalkonium chloride]

FT Eye Allergy Itch Relief: 0.2% (2.5 mL) [contains benzalkonium chloride, edetate (edta) disodium]

Pataday: 0.1% (5 mL) [contains benzalkonium chloride]

Pataday: 0.2% (2.5 mL) [contains benzalkonium chloride, edetate (edta) disodium]

Pataday: 0.7% (2.5 mL) [contains benzalkonium chloride]

Patanol: 0.1% (5 mL [DSC]) [contains benzalkonium chloride]

Pazeo: 0.7% (2.5 mL [DSC]) [contains benzalkonium chloride]

Generic: 0.1% (5 mL); 0.2% (2.5 mL)

Generic Equivalent Available: US

Yes

Pricing: US

Solution (Olopatadine HCl Ophthalmic)

0.1% (per mL): $1.82 - $3.65

0.2% (per mL): $4.22 - $71.76

Solution (Pataday Ophthalmic)

0.1% (per mL): $2.98

0.2% (per mL): $5.71

0.7% (per mL): $5.76

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Solution, Ophthalmic:

Pataday: 0.2% (0.5 mL, 2.5 mL) [contains benzalkonium chloride, edetate (edta) disodium]

Patanol: 0.1% (5 mL, 10 mL, 15 mL) [contains benzalkonium chloride]

Pazeo: 0.7% (2.5 mL) [contains benzalkonium chloride]

Generic: 0.1% (1 mL, 5 mL, 10 mL, 15 mL); 0.2% (2.5 mL)

Administration: Adult

Ophthalmic: For topical ophthalmic use only. Wash hands prior to use. Do not touch tip of container to eye. After instilling drops, wait ≥10 minutes before inserting contact lenses. Do not insert contacts if eyes are red. If using other eye drops, wait at least 5 minutes before administering other eye drops.

Administration: Pediatric

Ophthalmic: For topical ophthalmic use only; not for injection or oral use. Wash hands prior to use. Do not touch tip of container to eye, eyelid, or other surfaces. After instilling drops, wait ≥10 minutes before inserting contact lenses (contains benzalkonium chloride). Do not insert contacts if eyes are red. If using other eye drops/ointments, wait ≥5 minutes before or after administering other eye drops.

Use: Labeled Indications

Allergic conjunctivitis: Treatment of ocular itching associated with allergic conjunctivitis.

OTC labeling (Pataday): Temporary relief of itching and redness of the eye(s) caused by grass, ragweed, pollen, and animal dander and hair.

Medication Safety Issues
Sound-alike/look-alike issues:

Patanol may be confused with Platinol

International issues:

Patanol [US, Canada, and multiple international markets] may be confused with Bétanol brand name for metipranolol [Monaco]

Metabolism/Transport Effects

None known.

Drug Interactions

There are no known significant interactions.

Pregnancy Considerations

Olopatadine has minimal systemic absorption following ophthalmic administration. Systemic absorption would be required in order for olopatadine to cross the placenta and reach the fetus.

Breastfeeding Considerations

It is not known if olopatadine (ophthalmic) is excreted in breast milk. The manufacturer recommends that caution be exercised when administering olopatadine (ophthalmic) to nursing women.

Mechanism of Action

Selective histamine H1-antagonist; inhibits release of histamine from mast cells. Inhibits histamine induced effects on conjunctival epithelial cells.

Pharmacokinetics (Adult Data Unless Noted)

Absorption: Low systemic absorption (Patanol prescribing information 2018).

Half-life elimination: ~3 hours (Meier 2017; Patanol prescribing Information 2018).

Excretion: Urine (60% to 70%, mostly as unchanged drug) (Patanol prescribing Information 2018).

Brand Names: International
International Brand Names by Country
For country code abbreviations (show table)

  • (AE) United Arab Emirates: Olopat | Pataday | Patanol;
  • (AR) Argentina: Keim aler | Olopat f | Oloratan | Patanol | Pazeo | Timalerg | Zepiken | Zoloatlas;
  • (AT) Austria: Olopatadin unimed pharma;
  • (AU) Australia: Apo olopatadine | Paladopt | Patanol;
  • (BD) Bangladesh: Alacot | Alacot max | Aladay | Alchek | Alercon | Alleloc ds | Allet | Contova | Lopadine max | Olarif | Olodin | Ologen max | Olopan | Olopan pro | Opatin | Patadin | Patadin max | Patalon | Patanol;
  • (BE) Belgium: Opatanol;
  • (BF) Burkina Faso: Alerchek;
  • (BG) Bulgaria: Olopatadine unimed pharma | Olovision | Opatanol;
  • (BR) Brazil: Clor olopatadina | Cloridrato de olopatadina | Holli | Lodina | Patanol | Patanol s | Visodina;
  • (CI) Côte d'Ivoire: Allercheck;
  • (CL) Chile: Alergiol forte | Olodina | Olof | Patanol | Patanol s | Zepiken;
  • (CN) China: Patanol;
  • (CO) Colombia: Alap | Alercare | Alercare plus | Alernit | Atapol | Expotadina | Oftalmotrialer | Oftipat | Olodina | Olodina pf | Olodinex | Oloftal | Oloftal pf | Oloftal ud | Olopadex | Olopat | Olopatadina | Olopharm | Olopharm o | Olvision | Olvision s | Optyline | Pataler | Patanol | Patanol s | Pazeo | Sinnaleroft;
  • (CZ) Czech Republic: Alerpalux | Ofnol | Olopatadine unimed pharma | Opatanol;
  • (DE) Germany: Olopatadin micro labs | Opatanol;
  • (DO) Dominican Republic: Alergalop | Fermal | Hapatox | Kuara | Oftadina | Olof | Patadine Plus | Patanol | Patanol s;
  • (EC) Ecuador: Alap | Alerfin | Alergiol forte | Alergiol forte nf | Alergiol nf | Olof | Patanol | Patanol s;
  • (EE) Estonia: Olopatadine unimed pharma | Opatanol;
  • (EG) Egypt: Conjyclear | Olohistine | Olomansys | Olopat | Olopatanol | Patanergic | Patanol;
  • (ES) Spain: Apadin | Olopatadina abamed | Opatanol;
  • (ET) Ethiopia: Alercon | Olodin | Olopan | Olopat | Patanol | Rapidon;
  • (FI) Finland: Opatanol;
  • (FR) France: Opatanol;
  • (GB) United Kingdom: Olopatadine | Opatanol;
  • (GR) Greece: Alopatan | Opatanol;
  • (HK) Hong Kong: Paradin | Pataday | Patanol;
  • (HR) Croatia: Opatanol;
  • (HU) Hungary: Opatanol;
  • (ID) Indonesia: Lergio;
  • (IE) Ireland: Opatanol;
  • (IN) India: Alerchek | Arest | Bell patadine | If1 | If2 | Lopine | Nayanpat | Neolap | Odin | Olasial | Olaz od | Olo | Olo 1 | Olobet | Oloblu | Oloday | Olomed | Olopat max | Olopine | Oloplus | Olotak | Olotop | Olozi | Olways | Optihist pat | Pataday | Patalo | Patanol | Patdrop ds | Patif | Petolo | Polo | Rapidon | Winolap;
  • (IT) Italy: Opatanol;
  • (JO) Jordan: Conjyclear | Olopat | Patanol;
  • (JP) Japan: Olopatadine | Olopatadine kyorin | Olopatadine nissin | Olopatadine nitten | Olopatadine nitto | Olopatadine sandoz | Olopatadine sawai | Olopatadine towa | Olopatadine ts | Olopatadine wakamoto | Patanol;
  • (KE) Kenya: Alacot ds | Aladay | Aladay ds | Alerchek | Lopadine | Neolap | Olopat | Olopat od | Optihist pat | Patanol | Winolap | Winolap ds;
  • (KR) Korea, Republic of: Alinol | Alleless | Allenol | Allenold | Allepatadine | Allervid | Alpaday Ophthalmic Solution 0.2% | Alpadin | Alphaday | Bearnol | Cleaday | Dailyonce | Exol | Eye padine | Eyepatadin | Huons olopatadine hcl | I olo | I padine | Litaday | Lite olon | Lopadine | Luce p | Oculadine | Ocuolo | Oleone | Olo I | Olo once | Olobella | Olobella sd | Olobid M | Oloeye | Olopa | Olopadine | Olopanol | Oloscar | Olotadine | Oloten | Oloten plus | Olpaday | Olpadin | Olpadine | Oltadine | Opadine | Optipadin | Paradine | Pataday | Patadin q | Patadine | Pataeyen | Patanol | Pataol | Pataonce | Pazeo | Ritanol | Tapadine | Unipadine | Vitanol;
  • (KW) Kuwait: Olopat | Pataday | Patanol;
  • (LB) Lebanon: Allervid | Conjyclear | Olopat | Pataday | Patanol;
  • (LT) Lithuania: Alerpalux | Olopatadine unimed pharma | Opatanol;
  • (LU) Luxembourg: Opatanol;
  • (LV) Latvia: Alerpalux | Olopatadine unimed pharma | Opatanol;
  • (MA) Morocco: Opatanol;
  • (MX) Mexico: Imbalza | Olofcon | Olopatadina | Patanol | Provigenol | Sunolap | Ulopat;
  • (MY) Malaysia: Olodin | Olopan | Pataday | Patanol;
  • (NG) Nigeria: Alerchek | Katanol | Norotadin | Olopat | Olpadin | Opatanol | Rapidon eye drops | Vispadin;
  • (NL) Netherlands: Opatanol;
  • (NO) Norway: Opatanol | Patanol | Toredin;
  • (NZ) New Zealand: Olopatadine | Patanol;
  • (PE) Peru: Alergipat | Alergoftal | Lergitin | Melius | Olof | Patanol | Patanol s | Winolap ds;
  • (PH) Philippines: Olotop | Patanol;
  • (PK) Pakistan: Eyepat | Liper | Ocudine | Ogate | Ogate forte | Oloblu | Olomine ds | Olopat | Olopharm forte | Olopine | Oloptik | Oloptik forte | Olosaf | Olosir ds | Olotek | Olotek ds | Opat | Opat forte | Opdine | Optidine | Otadine | Pataday | Patadin | Patanol | Patlerg forte | Plop forte | Raypat | Valopat | Valopat ds | Winolap | Xepat | Zolopat;
  • (PL) Poland: Alerpalux | Nolodon | Oftahist | Olodon Free | Opatanol | Starazolin alergia | Starelltec Alergia;
  • (PR) Puerto Rico: Olopatadine | Olopatadine HCL | Pataday | Patanol | Pazeo;
  • (PT) Portugal: Opatanol;
  • (PY) Paraguay: Alergiol forte nf | Alergiol nf | Mastobloc | Oftalmol aler | Olof | Patanol | Patanol s | Zoloatlas;
  • (QA) Qatar: Olopat | Pataday | Patanol;
  • (RO) Romania: Olopatadina | Olopatadina unimed pharma | Opatanol;
  • (RU) Russian Federation: Oloftadin eco | Olopatallerg | Oloridin | Visallergol;
  • (SA) Saudi Arabia: Olopat | Pataday | Patanol;
  • (SE) Sweden: Olopatadin orifarm | Opatanol | Toredin;
  • (SG) Singapore: Pataday | Patanol | Pazeo;
  • (SI) Slovenia: Olopatadin unimed pharma | Opatanol;
  • (SK) Slovakia: Alerpalux | Olopatadine unimed pharma | Opatanol;
  • (TH) Thailand: Olo a day | Olopa mac | Patanol;
  • (TN) Tunisia: Olopan | Opatanol;
  • (TR) Turkey: Dupatin | Ofnol | Ofnol s | Oladin | Pallada | Patanol;
  • (TW) Taiwan: Olopan | Patanol;
  • (UA) Ukraine: Olopatadine | Pallada | Vizallergol;
  • (UG) Uganda: Alacot | Alerchek | Olohistine | Olopat;
  • (UY) Uruguay: Criptinal | Kuara | Olopatadina | Patanol;
  • (VE) Venezuela, Bolivarian Republic of: Alap | Alerpat | Kuara | Olocof | Olopatadina | Opat | Patanol | Patanol s;
  • (ZA) South Africa: Patanol;
  • (ZM) Zambia: Neolap;
  • (ZW) Zimbabwe: Patanol
  1. Meier E, Narvekar A, Iyer GR, et al. Pharmacokinetics and safety of olopatadine hydrochloride 0.77% in healthy subjects with asymptomatic eyes: data from 2 independent clinical studies. Clin Ophthalmol. 2017;11:669-681. doi:10.2147/OPTH.S126690 [PubMed 28435218]
  2. Olopatadine hydrochloride ophthalmic solution, 0.1% [prescribing information]. Mendham, NJ: Somerset Therapeutics, LLC; June 2016.
  3. Olopatadine hydrochloride ophthalmic solution, 0.1% [prescribing information]. Morgantown, WV: Mylan; July 2017.
  4. Olopatadine hydrochloride ophthalmic solution, 0.2% [prescribing information]. Lake Forest, IL: Akorn; December 2017.
  5. Pataday 0.1% Twice a Day Relief (olopatadine hydrochloride) [prescribing information]. Fort Worth, TX: Alcon; November 2021.
  6. Pataday 0.2% Once Daily Relief (olopatadine hydrochloride) [prescribing information]. Fort Worth, TX: Alcon; April 2021.
  7. Pataday 0.7% Once Daily Relief (olopatadine hydrochloride) [prescribing information]. Fort Worth, TX: Alcon; April 2021.
  8. Patanol (olopatadine hydrochloride) [prescribing information]. Fort Worth, TX: Alcon; April 2018.
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