Risa J. Lavizzo-Mourey, M.D., M.B.A., Richard E. Besser, M.D., and David R. Williams, Ph.D., M.P.H.
doi : 10.1056/NEJMp2008628
N Engl J Med 2021; 384:1681-1684
Jacqueline Salwa, B.A., and Christopher Robertson, J.D., Ph.D.
doi : 10.1056/NEJMp2033970
N Engl J Med 2021; 384:1684-1687
Eric Goralnick, M.D., M.H.C.M., Christoph Kaufmann, Ph.D., M.B.A., and Atul A. Gawande, M.D., M.P.H.
doi : 10.1056/NEJMp2102535
N Engl J Med 2021; 384:e67
Julia A. Beaver, M.D., and Richard Pazdur, M.D.
doi : 10.1056/NEJMp2104846
N Engl J Med 2021; 384:e68
Mark A. Mintun, M.D., Albert C. Lo, M.D., Ph.D., Cynthia Duggan Evans, Ph.D., Alette M. Wessels, Ph.D., Paul A. Ardayfio, Ph.D., Scott W. Andersen, M.S., Sergey Shcherbinin, Ph.D., JonDavid Sparks, Ph.D., John R. Sims, M.D., Miroslaw Brys, M.D., Ph.D., Liana G. Apostolova, M.D., Stephen P. Salloway, M.D., and Daniel M. Skovronsky, M.D., Ph.D.
doi : 10.1056/NEJMoa2100708
N Engl J Med 2021; 384:1691-1704
A hallmark of Alzheimer’s disease is the accumulation of amyloid-? (A?) peptide. Donanemab, an antibody that targets a modified form of deposited A?, is being investigated for the treatment of early Alzheimer’s disease.
Susan E. Dorman, M.D., Payam Nahid, M.D., M.P.H., Ekaterina V. Kurbatova, M.D., Ph.D., M.P.H., Patrick P.J. Phillips, Ph.D., Kia Bryant, M.P.H., Kelly E. Dooley, M.D., Ph.D., Melissa Engle, C.R.T., C.C.R.C., Stefan V. Goldberg, M.D., Ha T.T. Phan, Dr.P.H., M.D., James Hakim, M.D., John L. Johnson, M.D., Madeleine Lourens, M.B., Ch.B., Ph.D., Neil A. Martinson, M.B., B.Ch., M.P.H., Grace Muzanyi, M.B., Ch.B., Kim Narunsky, M.B., Ch.B., Sandy Nerette, M.D., Nhung V. Nguyen, M.D., Ph.D., Thuong H. Pham, M.D., M.P.H., Samuel Pierre, M.D., Anne E. Purfield, Ph.D., Wadzanai Samaneka, M.B., Ch.B., Radojka M. Savic, Ph.D., Ian Sanne, M.B., B.Ch., D.T.M.H., Nigel A. Scott, M.S., Justin Shenje, M.B., Ch.B., Erin Sizemore, M.P.H., Andrew Vernon, M.D., M.H.S., Ziyaad Waja, M.B., B.Ch., M.P.H., Marc Weiner, M.D., Susan Swindells, M.B., B.S., and Richard E. Chaisson, M.D. for the AIDS Clinical Trials Group and the Tuberculosis Trials Consortium
doi : 10.1056/NEJMoa2033400
N Engl J Med 2021; 384:1705-1718
Rifapentine-based regimens have potent antimycobacterial activity that may allow for a shorter course in patients with drug-susceptible pulmonary tuberculosis.
Julie R. Lundgren, M.D., Ph.D., Charlotte Janus, Ph.D., Simon B.K. Jensen, M.Sc., Christian R. Juhl, M.D., Lisa M. Olsen, M.Sc., Rasmus M. Christensen, B.Sc.Med., Maria S. Svane, M.D., Ph.D., Thomas Bandholm, Ph.D., Kirstine N. Bojsen-M?ller, M.D., Ph.D., Martin B. Blond, M.D., Ph.D., Jens-Erik B. Jensen, M.D., Ph.D., Bente M. Stallknecht, M.D., D.M.Sc., Jens J. Holst, M.D., D.M.Sc., Sten Madsbad, M.D., D.M.Sc., and Signe S. Torekov, Ph.D.
doi : 10.1056/NEJMoa2028198
N Engl J Med 2021; 384:1719-1730
Weight regain after weight loss is a major problem in the treatment of persons with obesity.
Tom?s B. Corcoran, M.D., Paul S. Myles, D.Sc., Andrew B. Forbes, Ph.D., Allen C. Cheng, Ph.D., Leon A. Bach, Ph.D., Edmond O’Loughlin, M.Clin.Res., Kate Leslie, M.D., Matthew T.V. Chan, Ph.D., David Story, M.D., Timothy G. Short, M.D., Catherine Martin, Ph.D., Pauline Coutts, P.Grad.Dip.N., and Kwok M. Ho, Ph.D. for the PADDI Investigators, the Australian and New Zealand College of Anaesthetists Clinical Trials Network, and the Australasian Society for Infectious Diseases Clinical Research Network*
doi : 10.1056/NEJMoa2028982
N Engl J Med 2021; 384:1731-1741
The glucocorticoid dexamethasone prevents nausea and vomiting after surgery, but there is concern that it may increase the risk of surgical-site infection.
Raj K. Goyal, M.D.
doi : 10.1056/NEJMra2020927
N Engl J Med 2021; 384:1742-1751
Farzahna Mohamed, M.B., B.Ch., and Frederick J. Raal, F.R.C.P., Ph.D.
doi : 10.1056/NEJMicm2018221
N Engl J Med 2021; 384:1752
Leonardo Mejia Buritica, M.D., and Amado J. Karduss Urueta, M.D.
doi : 10.1056/NEJMicm2030205
N Engl J Med 2021; 384:e69
Maximilian F. Konig, M.D., Vasanth Sathiyakumar, M.D., Casey M. Phan, M.D., Steven P. Schulman, M.D., and Allan C. Gelber, M.D.
doi : 10.1056/NEJMcps2034360
N Engl J Med 2021; 384:1753-1760
Allan I. Levey, M.D., Ph.D.
doi : 10.1056/NEJMe2103722
N Engl J Med 2021; 384:1762-1763
Eric J. Rubin, M.D., Ph.D., and Valerie Mizrahi, Ph.D.
doi : 10.1056/NEJMe2104499
N Engl J Med 2021; 384:1764-1765
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., Zarir F. Udwadia, M.D., D.N.B., F.C.C.P., F.R.C.P., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2107728
N Engl J Med 2021; 384:e84
Vittorio Sebastiano, Ph.D., and Donald J. Zack, M.D., Ph.D.
doi : 10.1056/NEJMcibr2034927
N Engl J Med 2021; 384:1766-1768
Eric Rafla-Yuan, M.D., Divya K. Chhabra, M.D., and Michael O. Mensah, M.D., M.P.H.
doi : 10.1056/NEJMms2035710
N Engl J Med 2021; 384:1769-1773
doi : 10.1056/NEJMc2101927
N Engl J Med 2021; 384:1774-1775
doi : 10.1056/NEJMc2101951
N Engl J Med 2021; 384:1775-1777
doi : 10.1056/NEJMc2030388
N Engl J Med 2021; 384:1777-1778
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