New England Journal of Medicine

Shabir A. Madhi, Ph.D., Vicky Baillie, Ph.D., Clare L. Cutland, Ph.D., Merryn Voysey, D.Phil., Anthonet L. Koen, M.B., B.Ch., Lee Fairlie, F.C.Paeds., Sherman D. Padayachee, M.B., Ch.B., Keertan Dheda, Ph.D., Shaun L. Barnabas, Ph.D., Qasim E. Bhorat, M.Sc., Carmen Briner, M.B., B.Ch., Gaurav Kwatra, Ph.D., Khatija Ahmed, F.C.Path. (Micro), Parvinder Aley, D.Phil., Sutika Bhikha, M.B., B.Ch., Jinal N. Bhiman, Ph.D., As’ad E. Bhorat, F.R.A.C.G.P., Jeanine du Plessis, B.Sc., Aliasgar Esmail, M.D., Marisa Groenewald, M.B., B.Ch., Elizea Horne, M.B., B.Ch., Shi-Hsia Hwa, M.Sc., Aylin Jose, M.B., B.Ch., Teresa Lambe, Ph.D., Matt Laubscher, M.Sc., Mookho Malahleha, M.B., Ch.B., Masebole Masenya, M.B., Ch.B., Mduduzi Masilela, M.B., Ch.B., Shakeel McKenzie, B.Sc., Kgaogelo Molapo, Nat.Dip.O.H.S., Andrew Moultrie, B.Sc., Suzette Oelofse, M.B., Ch.B., Faeezah Patel, M.B., B.Ch., Sureshnee Pillay, B.Sc., Sarah Rhead, M.B., Ch.B., Hylton Rodel, B.Sc., Lindie Rossouw, M.B., B.Ch., Carol Taoushanis, B.Pharm., Houriiyah Tegally, M.Sc., Asha Thombrayil, M.B., B.Ch., Samuel van Eck, R.N., Constantinos K. Wibmer, Ph.D., Nicholas M. Durham, Ph.D., Elizabeth J. Kelly, Ph.D., Tonya L. Villafana, Ph.D., Sarah Gilbert, Ph.D., Andrew J. Pollard, F.Med.Sci., Tulio de Oliveira, Ph.D., Penny L. Moore, Ph.D., Alex Sigal, Ph.D., and Alane Izu, Ph.D. for the NGS-SA Group, and the Wits-VIDA COVID Group*

doi : 10.1056/NEJMoa2102214

N Engl J Med 2021; 384:1885-1898

Assessment of the safety and efficacy of vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in different populations is essential, as is investigation of the efficacy of the vaccines against emerging SARS-CoV-2 variants of concern, including the B.1.351 (501Y.V2) variant first identified in South Africa.

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Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant

Vivek Shinde, M.D., M.P.H., Sutika Bhikha, M.B., B.S., Zaheer Hoosain, M.B., Ch.B., Moherndran Archary, Ph.D., Qasim Bhorat, M.B., B.Ch., Lee Fairlie, M.B., Ch.B., Umesh Lalloo, M.B., Ch.B., Mduduzi S.L. Masilela, M.B., Ch.B., Dhayendre Moodley, Ph.D., Sherika Hanley, M.B., B.S., Leon Fouche, M.B., Ch.B., Cheryl Louw, M.B., Ch.B., Michele Tameris, M.B., Ch.B., Nishanta Singh, M.B., Ch.B., Ameena Goga, M.B., Ch.B., Keertan Dheda, M.B., B.Ch., Coert Grobbelaar, M.B., Ch.B., Gertruida Kruger, M.B., Ch.B., Nazira Carrim-Ganey, M.B., B.Ch., Vicky Baillie, Ph.D., Tulio de Oliveira, Ph.D., Anthonet Lombard Koen, M.B., Ch.B., Johan J. Lombaard, M.B., Ch.B., Rosie Mngqibisa, M.B., Ch.B., As’ad E. Bhorat, M.B., B.Ch., Gabriella Benadé, M.B., B.S., M.P.H., Natasha Lalloo, M.B., Ch.B., Annah Pitsi, M.B., Ch.B., Pieter-Louis Vollgraaff, M.B., Ch.B., Angelique Luabeya, M.B., Ch.B., Aliasgar Esmail, M.B., Ch.B., Friedrich G. Petrick, M.B., Ch.B., Aylin Oommen-Jose, M.B., Ch.B., Sharne Foulkes, M.B., Ch.B., Khatija Ahmed, M.B., Ch.B., Asha Thombrayil, M.B., Ch.B., Lou Fries, M.D., Shane Cloney-Clark, B.S., Mingzhu Zhu, Ph.D., Chijioke Bennett, M.D., M.P.H., Gary Albert, M.S., Emmanuel Faust, Ph.D., Joyce S. Plested, Ph.D., Andreana Robertson, M.S., Susan Neal, B.S., Iksung Cho, M.S., Greg M. Glenn, M.D., Filip Dubovsky, M.D., M.P.H., and Shabir A. Madhi, M.B., B.Ch., Ph.D. for the 2019nCoV-501 Study Group*

doi : 10.1056/NEJMoa2103055

N Engl J Med 2021; 384:1899-1909

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants threatens progress toward control of the coronavirus disease 2019 (Covid-19) pandemic. In a phase 1–2 trial involving healthy adults, the NVX-CoV2373 nanoparticle vaccine had an acceptable safety profile and was associated with strong neutralizing-antibody and antigen-specific polyfunctional CD4+ T-cell responses. Evaluation of vaccine efficacy was needed in a setting of ongoing SARS-CoV-2 transmission.

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Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion

Lucianne C.M. Langezaal, M.D., Erik J.R.J. van der Hoeven, M.D., Ph.D., Francisco J.A. Mont’Alverne, M.D., Ph.D., Jo?o J.F. de Carvalho, M.D., Fabr?cio O. Lima, M.D., Ph.D., Diederik W.J. Dippel, M.D., Ph.D., Aad van der Lugt, M.D., Ph.D., Rob T.H. Lo, M.D., Ph.D., Jelis Boiten, M.D., Ph.D., Geert J. Lycklama à Nijeholt, M.D., Ph.D., Julie Staals, M.D., Ph.D., Wim H. van Zwam, M.D., Ph.D., Paul J. Nederkoorn, M.D., Ph.D., Charles B.L.M. Majoie, M.D., Ph.D., Johannes C. Gerber, M.D., Mikael Mazighi, M.D., Ph.D., Michel Piotin, M.D., Ph.D., Andrea Zini, M.D., Stefano Vallone, M.D., Jeannette Hofmeijer, M.D., Ph.D., Sheila O. Martins, M.D., Ph.D., Christian H. Nolte, M.D., Ph.D., Kristina Szabo, M.D., Ph.D., Francisco A. Dias, M.D., Ph.D., Daniel G. Abud, M.D., Ph.D., Marieke J.H. Wermer, M.D., Ph.D., Michel J.M. Remmers, M.D., Hauke Schneider, M.D., Ph.D., Christina M. Rueckert, M.D., Karlijn F. de Laat, M.D., Ph.D., Albert J. Yoo, M.D., Ph.D., Pieter-Jan van Doormaal, M.D., Adriaan C.G.M. van Es, M.D., Ph.D., Bart J. Emmer, M.D., Ph.D., Patrik Michel, M.D., Ph.D., Volker Puetz, M.D., Heinrich J. Audebert, M.D., Ph.D., Octavio M. Pontes-Neto, M.D., Ph.D., Jan-Albert Vos, M.D., Ph.D., L. Jaap Kappelle, M.D., Ph.D., Ale Algra, M.D., Ph.D., and Wouter J. Schonewille, M.D., Ph.D. for the BASICS Study Group*

doi : 10.1056/NEJMoa2030297

N Engl J Med 2021; 384:1910-1920

The effectiveness of endovascular therapy in patients with stroke caused by basilar-artery occlusion has not been well studied.

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Final Report of a Trial of Intensive versus Standard Blood-Pressure Control

The SPRINT Research Group

doi : 10.1056/NEJMoa1901281

N Engl J Med 2021; 384:1921-1930

In a previously reported randomized trial of standard and intensive systolic blood-pressure control, data on some outcome events had yet to be adjudicated and post-trial follow-up data had not yet been collected.

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