Nathaniel P. Morris, M.D.
doi : 10.1056/NEJMp2107013
N Engl J Med 2021; 385:385-387
Joseph T. Kannarkat, M.P.P., and Eric T. Roberts, Ph.D.
doi : 10.1056/NEJMp2103431
N Engl J Med 2021; 385:387-389
Scott J. Becker, M.S., Jill Taylor, Ph.D., and Joshua M. Sharfstein, M.D.
doi : 10.1056/NEJMp2103859
N Engl J Med 2021; 385:389-391
Michael Gnant, M.D., Florian Fitzal, M.D., Gabriel Rinnerthaler, M.D., Guenther G. Steger, M.D., Sigrun Greil-Ressler, M.D., Marija Balic, M.D., Dietmar Heck, M.D., Raimund Jakesz, M.D., Josef Thaler, M.D., Daniel Egle, M.D., Diether Manfreda, M.D., Vesna Bjelic-Radisic, M.D., Ursula Wieder, M.D., Christian F. Singer, M.D., Elisabeth Melbinger-Zeinitzer, M.D., Ferdinand Haslbauer, M.D., Paul Sevelda, M.D., Harald Trapl, M.D., Viktor Wette, M.D., Kerstin Wimmer, M.D., Simon P. Gampenrieder, M.D., Rupert Bartsch, M.D., Stephanie Kacerovsky-Strobl, M.D., Christoph Suppan, M.D., Christine Brunner, M.D., Christine Deutschmann, M.D., Lidija Soelkner, M.Sc., Christian Fesl, Ph.D., and Richard Greil, M.D. for the Austrian Breast and Colorectal Cancer Study Group*
doi : 10.1056/NEJMoa2104162
N Engl J Med 2021; 385:395-405
Patr?cia O. Guimar?es, M.D., Ph.D., Daniel Quirk, M.D., M.P.H., Remo H. Furtado, M.D., Ph.D., Lilia N. Maia, M.D., Ph.D., José F. Saraiva, M.D., Ph.D., Murillo O. Antunes, M.D., Ph.D., Roberto Kalil Filho, M.D., Ph.D., Vagner M. Junior, M.D., Alexandre M. Soeiro, M.D., Alexandre P. Tognon, M.D., Ph.D., Viviane C. Veiga, M.D., Ph.D., Priscilla A. Martins, M.D., et al., for the STOP-COVID Trial Investigators*
doi : 10.1056/NEJMoa2101643
N Engl J Med 2021; 385:406-415
The efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia are unclear.
TODAY Study Group
doi : 10.1056/NEJMoa2100165
N Engl J Med 2021; 385:416-426
The prevalence of type 2 diabetes in youth is increasing, but little is known regarding the occurrence of related complications as these youths transition to adulthood.
Basil T. Darras, M.D., Riccardo Masson, M.D., Maria Mazurkiewicz-Be?dzi?ska, M.D., Kristy Rose, Ph.D., Hui Xiong, M.D., Edmar Zanoteli, M.D., Giovanni Baranello, M.D., Ph.D., Claudio Bruno, M.D., Ph.D., Dmitry Vlodavets, M.D., Yi Wang, M.D., Ph.D., Muna El-Khairi, Ph.D., Marianne Gerber, Ph.D., et al., for the FIREFISH Working Group*
doi : 10.1056/NEJMoa2102047
N Engl J Med 2021; 385:427-435
Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies SMN2 pre–messenger RNA splicing and increases levels of functional SMN protein in blood.
Brenna L. Hughes, M.D., Rebecca G. Clifton, Ph.D., Dwight J. Rouse, M.D., George R. Saade, M.D., Mara J. Dinsmoor, M.D., M.P.H., Uma M. Reddy, M.D., Robert Pass, M.D., Donna Allard, R.N., Gail Mallett, R.N., Lida M. Fette, M.S., Cynthia Gyamfi-Bannerman, M.D., Michael W. Varner, M.D., William H. Goodnight, M.D., Alan T.N. Tita, M.D., Ph.D., Maged M. Costantine, M.D., Geeta K. Swamy, M.D., Ronald S. Gibbs, M.D., Edward K. Chien, M.D., Suneet P. Chauhan, M.D., Yasser Y. El-Sayed, M.D., Brian M. Casey, M.D., Samuel Parry, M.D., Hyagriv N. Simhan, M.D., Peter G. Napolitano, M.D., and George A. Macones, M.D. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal–Fetal Medicine Units Network*
doi : 10.1056/NEJMoa1913569
N Engl J Med 2021; 385:436-444
Primary cytomegalovirus (CMV) infection during pregnancy carries a risk of congenital infection and possible severe sequelae. There is no established intervention for preventing congenital CMV infection.
Leslie Miller, M.D., and John V. Campo, M.D.
doi : 10.1056/NEJMra2033475
N Engl J Med 2021; 385:445-449
Cristiana Marinho-Soares, M.D., and Maria Pulido-Valente, M.D.
doi : 10.1056/NEJMicm2033023
N Engl J Med 2021; 385:450
David Avelar Rodriguez, M.D., and Julia Orkin, M.D.
doi : 10.1056/NEJMicm2034755
N Engl J Med 2021; 385:e16
Olivia C. Smibert, M.B., B.S., Onofrio A. Catalano, M.D., Katayoon Goodarzi, M.D., and Matthew B. Roberts, M.B., B.S.
doi : 10.1056/NEJMcpc2103461
N Engl J Med 2021; 385:451-460
Pamela J. Goodwin, M.D.
doi : 10.1056/NEJMe2109356
N Engl J Med 2021; 385:462-463
Justin Stebbing, M.D., Ph.D., and Volker M. Lauschke, Ph.D.
doi : 10.1056/NEJMe2108667
N Engl J Med 2021; 385:463-465
Eric J. Rubin, M.D., Ph.D., Lindsey R. Baden, M.D., and Stephen Morrissey, Ph.D.
doi : 10.1056/NEJMe2112684
N Engl J Med 2021; 385:e24
Siri R. Kadire, M.D., Sana M. Al-Khatib, M.D., M.H.S., and Hugh Calkins, M.D.
doi : 10.1056/NEJMclde2103770
N Engl J Med 2021; 385:466-468
Richard A.F. Clark, M.D.
doi : 10.1056/NEJMcibr2107204
N Engl J Med 2021; 385:469-471
doi : 10.1056/NEJMc2106083
N Engl J Med 2021; 385:472-474
doi : 10.1056/NEJMc2104849
N Engl J Med 2021; 385:474-476
doi : 10.1056/NEJMc2108129
N Engl J Med 2021; 385:477-478
doi : 10.1056/NEJMc2109411
N Engl J Med 2021; 385:479-480
doi : 10.1056/NEJMx210008
N Engl J Med 2021; 385:480
doi : 10.1056/NEJMx210009
N Engl J Med 2021; 385:480
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