Rheumatology

The coronavirus disease 2019 (COVID-19) vaccination will be the largest vaccination programme in the history of the NHS. Patients on immunosuppressive therapy will be among the earliest to be vaccinated. Some evidence indicates immunosuppressive therapy inhibits humoral response to the influenza, pneumococcal and hepatitis B vaccines. The degree to which this will translate to impaired COVID-19 vaccine responses is unclear. Other evidence suggests withholding MTX for 2 weeks post-vaccination may improve responses. Rituximab has been shown to impair humoral responses for 6?months or longer post-administration. Decisions on withholding or interrupting immunosuppressive therapy around COVID-19 vaccination will need to be made prior to the availability of data on specific COVID-19 vaccine response in these patients. With this in mind, this article outlines the existing data on the effect of antirheumatic therapy on vaccine responses in patients with inflammatory arthritis and formulates a possible pragmatic management strategy for COVID-19 vaccination.

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The role of stroma and epithelial cells in primary Sj?gren’s syndrome

Saba Asam, Georgiana Neag, Onorina Berardicurti, David Gardner, Francesca Barone

doi : 10.1093/rheumatology/kez050

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3503–3512

Primary SS (pSS) is a chronic autoimmune condition characterized by infiltration of the exocrine glands and systemic B cell hyperactivation. This glandular infiltration is associated with loss of glandular function, with pSS patients primarily presenting with severe dryness of the eyes and mouth. Within the affected glands, the infiltrating lymphocytes are organized in tertiary lymphoid structures. Tertiary lymphoid structures subvert normal tissue architecture and impact on organ function, by promoting the activation and maintenance of autoreactive lymphocytes. This review summarizes the current knowledge about the role of stromal cells (including endothelium, epithelium, nerves and fibroblasts) in the pathogenesis of pSS, in particular the interactions taking place between stromal cells and infiltrating lymphocytes. We will provide evidences pointing towards the driving role of stromal cells in the orchestration of the local inflammatory milieu, thus highlighting the need for therapies aimed at targeting this compartment alongside classical immunosuppression in pSS.

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Lymphomas complicating primary Sj?gren’s syndrome: from autoimmunity to lymphoma

Gaetane Nocturne, Elena Pontarini, Michele Bombardieri, Xavier Mariette

doi : 10.1093/rheumatology/kez052

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3513–3521

Lymphoma development is the most serious complication of SS and the main factor impacting on mortality rate in patients with this condition. Lymphomas in SS are most commonly extranodal non-Hodgkin B-cell lymphomas of the mucosa-associated lymphoid tissue and frequently arise in salivary glands that are the target of a chronic inflammatory autoimmune process. Extensive work on lymphomagenesis in SS has established that the progression towards B-cell lymphoma is a multistep process related to local chronic antigenic stimulation of B cells. These neoplastic B cells in SS frequently derived from autoreactive clones, most commonly RF-producing B cells, which undergo uncontrolled proliferation and malignant escape. In this review, we highlight the most important recent findings that have enhanced our understanding of lymphoma development in SS, with particular reference to the close link between autoimmunity and lymphomagenesis. We also discuss how the identification of key factors involved in B-cell malignancies may impact on our ability to identify at early stages patients at increased risk of lymphoma with potential significant repercussions for the clinical management of SS patients. Finally, we identified the most promising areas of current and further research with the potential to provide novel basic and translational discoveries in the field. The questions of finding new biomarkers, developing a validated score for predicting lymphoma occurrence and assessing if a better control of disease activity will decrease the risk of lymphoma in primary SS will be the enthralling questions of the next few years.

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Salivary gland ultrasonography in primary Sj?gren’s syndrome: opportunities and challenges

Valerie Devauchelle-Pensec, Alen Zabotti, Guillermo Carvajal-Alegria, Nenad Filipovic, Sandrine Jousse-Joulin, Salvatore De Vita

doi : 10.1093/rheumatology/kez079

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3522–3527

Salivary gland ultrasonography (SGUS) has an established role in detecting typical structural gland abnormalities in primary Sj?gren’s Syndrome (pSS). SGUS might be included in pSS classification and could be used as a prognostic and follow-up biomarker, but for this purpose additional efforts, new techniques and larger cohort studies are needed. HarmonicSS, an ongoing Horizon, EU-supported project in pSS, will apply artificial intelligence to SGUS in pSS. Many questions are still unresolved and challenging, but data collected up to now underscore the concept that SGUS will be an important tool for the study of pSS in the near future.

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Disease activity and patient reported outcome measures in Sj?gren’s – what are the best tools to evaluate?

Raphaèle Seror, Saaeha Rauz, Marjolaine Gosset, Simon J Bowman

doi : 10.1093/rheumatology/kez201

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3528–3539

In primary SS (pSS), clinical features in SS can be divided into two facets: the patient perceived manifestations such as dryness, pain and fatigue, and the systemic manifestations. In the past decades, with efforts made by an international collaboration, consensual clinical indexes were developed for assessing both facets: one patient reported outcome, the EULAR SS Patients Reported Index (ESSPRI), and one activity index for systemic manifestations, the EULAR SS Disease Activity Index (ESSDAI). In addition, objective measures were developed to quantify the importance and consequence of ocular and oral dryness, few being specific of pSS. Work is ongoing to develop indexes combining all these approaches. Recent changes in the assessment of pSS patients, and the emergence of new targeted therapies, have put a greater emphasis on the design of clinical trials in pSS, and led for the first time to a positive randomized clinical trial.

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Summarizing current refractory disease definitions in rheumatoid arthritis and polyarticular juvenile idiopathic arthritis: systematic review

Hema Chaplin, Lewis Carpenter, Anni Raz, Elena Nikiphorou, Heidi Lempp, Sam Norton

doi : 10.1093/rheumatology/keab237

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3540–3552

To identify how refractory disease (or relevant terminology variations) in RA and polyarticular JIA (polyJIA) is defined and establish the key components of such definitions.

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The role of trimethoprim/sulfametoxazole in reducing relapses and risk of infections in ANCA-associated vasculitis: a meta-analysis

Sara Monti, Paolo Delvino, Mattia Riboli, Chiara Rebuffi, Blerina Xoxi, Annalisa De Silvestri, Carlomaurizio Montecucco

doi : 10.1093/rheumatology/keab267

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3553–3564

To assess available evidence from randomized controlled trials (RCTs) and observational studies including a control group regarding the role of trimethoprim/sulfametoxazole (TMP/SMX) in reducing the relapse rate in patients with granulomatosis with polyangiitis (GPA) and the risk of infections in patients with ANCA-associated vasculitis (AAV).

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Prescribing anti-rheumatic drugs in pregnancy and breastfeeding—the British Society for Rheumatology guideline scope

Ian Giles, Alexander Allen, Amy Crossley, Julia Flint, Margreta Frishman, Mary Gayed, Munther Kamashta, Louise Moore, Sonia Panchal, Madeline Piper, Clare Reid, Katherine Saxby, Karen Schreiber, Naz Senvar, Sofia Tosounidou, Maud van de Venne, Louise Warburton, David Wiliams, Chee-Seng Yee, Caroline Gordon

doi : 10.1093/rheumatology/keab334

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3565–3569

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Effectiveness of initial methotrexate-based treatment approaches in early rheumatoid arthritis: an elicitation of rheumatologists’ beliefs

Gyanendra Pokharel, Rob Deardon, Sindhu R Johnson, George Tomlinson, Pauline M Hull, Glen S Hazlewood

doi : 10.1093/rheumatology/keaa803

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3570–3578

To quantify rheumatologists’ beliefs about the effectiveness of triple therapy (MTX + HCQ + SSZ) and other commonly used initial treatments for RA.

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Application of the OMERACT synovitis ultrasound scoring system in juvenile idiopathic arthritis: a multicenter reliability exercise

Linda Rossi-Semerano, Sylvain Breton, Luca Semerano, Marouane Boubaya, Haykanush Ohanyan, Marie Bossert, Sorina Boiu, Emmanuel Chatelus, Géraldine Durand, Sylvie Jean, Laurence Goumy, Anne Mathiot, Gaël Mouterde, Frédérique Nugues, Ahmed Ould Hennia, Bénédicte Rey, Annette Von Scheven, Laetitia Sparsa, Valérie Devauchelle-Pensec, Sandrine Jousse-Joulin

doi : 10.1093/rheumatology/keaa804

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3579–3587

To evaluate the reliability of the OMERACT paediatric ultrasound (US) synovitis definitions and scoring system in JIA.

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Relationship between motion, using the GaitSmartTM system, and radiographic knee osteoarthritis: an explorative analysis in the IMI-APPROACH cohort

Eefje M van Helvoort, Diana Hodgins, Simon C Mastbergen, Anne Karien Marijnissen, Hans Guehring, Marieke Loef, Margreet Kloppenburg, Francisco Blanco, Ida K Haugen, Francis Berenbaum, Floris P J G Lafeber, Paco M J Welsing

doi : 10.1093/rheumatology/keaa809

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3588–3597

To assess underlying domains measured by GaitSmartTMparameters and whether these are additional to established OA markers including patient reported outcome measures (PROMs) and radiographic parameters, and to evaluate if GaitSmart analysis is related to the presence and severity of radiographic knee OA.

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Influence of inflammatory and non-inflammatory rheumatic disorders on the clinical and biological profile of type-2 diabetes

Jérôme Avouac, Muriel Elhai, Marine Forien, Jérémie Sellam, Florent Eymard, Anna Molto, Frédéric Banal, Joël Damiano, Philippe Dieudé, Etienne Larger, Yannick Allanore

doi : 10.1093/rheumatology/keaa810

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3598–3606

To study the profile of type-2 diabetes (T2D) in patients with RA or OA.

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Interferon-related gene expression in response to TNF inhibitor treatment in ankylosing spondylitis patients: a pilot study

Stephanie R Harrison, Agata N Burska, Paul Emery, Helena Marzo-Ortega, Frederique Ponchel

doi : 10.1093/rheumatology/keaa817

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3607–3616

Ankylosing spondylitis (AS) is a chronic inflammatory arthritis primarily affecting the spine and sacroiliac joints. TNF inhibitor (TNFi) drugs are recommended for patients not responding to NSAIDs; however, there is a significant need for biomarkers of response. IFN-regulated genes (IRGs) and other cytokines/chemokines are linked to autoimmune diseases and have been associated with treatment response. Our objective was to explore whether IRGs and cytokines/chemokines can be associated with response to TNFiagents in AS.

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The number of risk factors for persistent disease determines the clinical course of early arthritis

N Luurssen-Masurel, A E A M Weel, G H Koc, J M W Hazes, P H P de Jong, for the tREACH group investigators

doi : 10.1093/rheumatology/keaa820

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3617–3627

Management of early arthritis is based upon early recognition of individuals at high risk of developing persistent arthritis. Therefore, this study investigates whether the number of risk factors for persistent disease or treatment determines the clinical course of early arthritis by comparing the chance at (sustained) DMARD-free remission ((S)DFR) after 2?years follow-up.

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Effects of bariatric surgery on serum uric acid in people with obesity with or without hyperuricaemia and gout: a retrospective analysis

Jine Lu, Zhiyao Bai, Yunqing Chen, Yingxu Li, Min Tang, Ning Wang, Xingcheng Zhu, Hongbin Dai, Weiya Zhang

doi : 10.1093/rheumatology/keaa822

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3628–3634

Weight reduction may reduce serum uric acid (SUA). This study aimed to examine the changes of SUA before and after bariatric surgery in patients with obesity with or without hyperuricaemia and gout.

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Comparison of treatment retention and response to secukinumab versus tumour necrosis factor inhibitors in psoriatic arthritis

Ulf Lindstr?m, Bente Glintborg, Daniela Di Giuseppe, Tanja Schj?dt J?rgensen, Bjorn Gudbjornsson, Kathrine Lederballe Gr?n, Sella Aarrestad Provan, Brigitte Michelsen, Merete Lund Hetland, Johan K Wallman, Dan Nordstr?m, Nina Trokovic, Thorvardur Jon Love, Niels Steen Krogh, Johan Askling, Lennart T H Jacobsson, Lars Erik Kristensen

doi : 10.1093/rheumatology/keaa825

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3635–3645

To compare treatment retention and response to secukinumab vs adalimumab, including the other four TNF inhibitors (TNFi) as comparators, in PsA.

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Health-related quality of life in patients with systemic sclerosis: evolution over time and main determinants

Nina M van Leeuwen, Jacopo Ciaffi, Sophie I E Liem, Tom W J Huizinga, Jeska K de Vries-Bouwstra

doi : 10.1093/rheumatology/keaa827

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3646–3655

In SSc patients, disease specific determinants that influence health-related quality of life (HRQoL) over time have not been described. We aim to, in patients with SSc, (i) evaluate if and how HRQoL changes over time, and (ii) assess how different SSc domains and functional impairments contribute to changes in HRQoL over time.

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Risk of solid cancers overall and by subtypes in patients with psoriatic arthritis treated with TNF inhibitors – a Nordic cohort study

Karin Hellgren, Christine Ballegaard, Bénédicte Delcoigne, René Cordtz, Dan Nordstr?m, Kalle Aaltonen, Bjorn Gudbjornsson, Thorvardur Jon Love, Sella Aarrestad Provan, Joe Sexton, Kristian Zobbe, Lars Erik Kristensen, Johan Askling, Lene Dreyer

doi : 10.1093/rheumatology/keaa828

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3656–3668

To investigate whether TNF inhibitors (TNFi) are associated with increased risk of solid cancer in patients with psoriatic arthritis (PsA).

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Effect of adalimumab on axial manifestations in Japanese patients with psoriatic arthritis: a 24?week prospective, observational study

Takamitsu Makino, Hironobu Ihn, Motoo Nakagawa, Misugi Urano, Ryuhei Okuyama, Norito Katoh, Chiharu Tateishi, Koji Masuda, Eisaku Ogawa, Emi Nishida, Shohei Nishimoto, Kenzo Muramoto, Daisuke Tsuruta, Akimichi Morita

doi : 10.1093/rheumatology/keaa829

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3669–3678

PsA is characterized by enthesitis, synovitis and osseous involvement in the peripheral and axial joints. Few studies have examined axial involvement in PsA using imaging techniques. Here we examined axial involvement in PsA patients using MRI. In addition, we determined the efficacy of 24?week adalimumab treatment in improving the MRI findings of spondylitis and sacroiliitis.

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Real-world experience of effectiveness of non-medical switch from originator to biosimilar rituximab in rheumatoid arthritis

Andrew R Melville, Md Yuzaiful Md Yusof, John Fitton, Leticia Garcia-Montoya, Lynda Bailey, Shouvik Dass, Paul Emery, Maya H Buch, Benazir Saleem

doi : 10.1093/rheumatology/keaa834

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3679–3688

To evaluate the impact of non-medical switch from rituximab originator (RTX-O) to biosimilar (RTX-B) in patients with RA.

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Prevalence, incidence and cause-specific mortality of rheumatoid arthritis–associated interstitial lung disease among older rheumatoid arthritis patients

Jeffrey A Sparks, Yinzhu Jin, Soo-Kyung Cho, Seanna Vine, Rishi Desai, Tracy J Doyle, Seoyoung C Kim

doi : 10.1093/rheumatology/keaa836

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3689–3698

We aimed to investigate the prevalence, incidence and cause-specific mortality of RA-associated interstitial lung disease (RA-ILD) among older US patients with RA.

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Having a co-morbidity predicts worse outcome in early rheumatoid arthritis despite intensive treatment: a post hoc evaluation of the pragmatic randomized controlled CareRA trial

Veerle Stouten, René Westhovens, Diederik De Cock, Kristien Van der Elst, Sofia Pazmino, Delphine Bertrand, Johan Joly, Patrick Verschueren

doi : 10.1093/rheumatology/keaa841

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3699–3708

To quantify the prevalence of co-morbidities in patients with early RA and determine their prognostic value for effectiveness outcomes in a randomized trial.

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The psychological impact of the COVID-19 pandemic on Dutch people with and without an inflammatory rheumatic disease

Tim Y Koppert, Johannes W G Jacobs, Rinie Geenen

doi : 10.1093/rheumatology/keaa842

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3709–3715

To determine the psychological impact of the COVID-19 pandemic on people with and without an inflammatory rheumatic disease and establish whether psychological flexibility buffers this impact.

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The impact of different (rheumatoid) arthritis phenotypes on patients’ lives

Nathalie Luurssen-Masurel, Angelique Elisabeth Adriana Maria Weel, Johanna Maria Wilhelmina Hazes, Pascal Hendrik Pieter de Jong, the tREACH group investigators

doi : 10.1093/rheumatology/keaa845

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3716–3726

To compare patient-reported outcome (PRO) domains between three arthritis phenotypes [undifferentiated arthritis (UA), autoantibody-negative RA (RA?) and autoantibody-positive RA (RA+)] at diagnosis, after 2?years and over time.

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An association between chronic widespread pain and the gut microbiome

Maxim B Freidin, Maria A Stalteri, Philippa M Wells, Genevieve Lachance, Andrei-Florin Baleanu, Ruth C E Bowyer, Alexander Kurilshikov, Alexandra Zhernakova, Claire J Steves, Frances M K Williams

doi : 10.1093/rheumatology/keaa847

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3727–3737

Chronic widespread musculoskeletal pain (CWP) is a characteristic symptom of fibromyalgia, which has been shown to be associated with an altered gut microbiome. Microbiome studies to date have not examined the milder CWP phenotype specifically nor have they explored the role of raised BMI. The aim of this study was to investigate whether the microbiome is abnormal in CWP.

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Ten-year analysis of the risk of severe outcomes related to low-dose glucocorticoids in early rheumatoid arthritis

Camille Roubille, Amandine Coffy, Nathalie Rincheval, Maxime Dougados, René-Marc Flipo, Jean-Pierre Daurès, Bernard Combe

doi : 10.1093/rheumatology/keaa850

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3738–3746

To explore the 10-year tolerability profile of glucocorticoids (GC) use in patients with early RA.

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A panel of urinary proteins predicts active lupus nephritis and response to rituximab treatment

Jennifer C Davies, Emil Carlsson, Angela Midgley, Eve M D Smith, Ian N Bruce, Michael W Beresford, Christian M Hedrich, the BILAG-BR and MRC MASTERPLANS Consortia

doi : 10.1093/rheumatology/keaa851

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3747–3759

?30% of patients with SLE develop LN. Presence and/or severity of LN are currently assessed by renal biopsy, but biomarkers in serum or urine samples may provide an avenue for non-invasive routine testing. We aimed to validate a urinary protein panel for its ability to predict active renal involvement in SLE.

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Comorbidities at diagnosis of rheumatoid arthritis: a population-based case-control study

Liselotte Tidblad, Helga Westerlind, Bénédicte Delcoigne, Johan Askling, Saedis Saevarsdottir

doi : 10.1093/rheumatology/keaa856

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3760–3769

Comorbidities contribute to the morbidity and mortality in RA, and are thus important to capture and treat early. In contrast to the well-studied comorbidity risks in established RA, less is known about the comorbidity pattern up until diagnosis of RA. We therefore compared whether the occurrence of defined conditions, and the overall comorbidity burden at RA diagnosis, is different from that in the general population, and if it differs between seropositive and seronegative RA.

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Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus

Selcan Demir, Jessica Li, Laurence S Magder, Michelle Petri

doi : 10.1093/rheumatology/keaa857

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3770–3777

We evaluated which aPL combinations increase the risk of future thrombosis in patients with SLE.

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Difficult-to-treat rheumatoid arthritis: contributing factors and burden of disease

Nadia M T Roodenrijs, Marlies C van der Goes, Paco M J Welsing, Janneke Tekstra, Floris P J G Lafeber, Johannes W G Jacobs, Jacob M van Laar

doi : 10.1093/rheumatology/keaa860

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3778–3788

Treatment of difficult-to-treat (D2T) RA patients is generally based on trial-and-error and can be challenging due to a myriad of contributing factors. We aimed to identify risk factors at RA onset, contributing factors and the burden of disease.

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Comorbidities at diagnosis of rheumatoid arthritis: a population-based case-control study

Liselotte Tidblad, Helga Westerlind, Bénédicte Delcoigne, Johan Askling, Saedis Saevarsdottir

doi : 10.1093/rheumatology/keaa856

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3760–3769

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Defining colchicine resistance/intolerance in patients with familial Mediterranean fever: a modified-Delphi consensus approach

Seza ?zen, Erdal Sag, Eldad Ben-Chetrit, Marco Gattorno, Ahmet Gül, Philip J Hashkes, Isabelle Kone-Paut, Helen J Lachmann, Elena Tsitsami, Marinka Twilt, Fabrizio de Benedetti, Jasmin B Kuemmerle-Deschner

doi : 10.1093/rheumatology/keaa863

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3799–3808

Colchicine is the main treatment for FMF. Although a number of individuals with FMF are intolerant/resistant to colchicine, there is no standard definition of colchicine resistance/intolerance. We developed a set of evidence-based core statements defining colchicine resistance/intolerance in patients with FMF that may serve as a guide for clinicians and health authorities.

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Difficult-to-treat rheumatoid arthritis: contributing factors and burden of disease

Nadia M T Roodenrijs, Marlies C van der Goes, Paco M J Welsing, Janneke Tekstra, Floris P J G Lafeber, Johannes W G Jacobs, Jacob M van Laar

doi : 10.1093/rheumatology/keaa860

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3778–3788

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Preliminary evidence on abatacept safety and efficacy in refractory juvenile localized scleroderma

Suzanne C Li, Kathryn S Torok, Sarah S Ishaq, Mary Buckley, Barbara Edelheit, Kaleo C Ede, Christopher Liu, C Egla Rabinovich

doi : 10.1093/rheumatology/keaa873

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3817–3825

To evaluate the safety and efficacy of abatacept treatment for refractory juvenile localized scleroderma (jLS) in a retrospective study.

خرید پکیج و مشاهده آنلاین مقاله

Beta-cell function?is disrupted in patients with systemic lupus erythematosus

Alicia Garc?a-Dorta, Juan Carlos Quevedo-Abeledo, ??igo Rua-Figueroa, Antonia M de Vera-Gonz?lez, Alejandra Gonz?lez-Delgado, Lilian Medina-Vega, Agust?n F Gonz?lez-Rivero, Felix Francisco-Hern?ndez, Miguel A Gonz?lez-Gay, Iv?n Ferraz-Amaro

doi : 10.1093/rheumatology/keaa874

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3826–3833

To investigate how markers of beta-cell secretion (proinsulin-processing metabolites) are expressed in SLE patients and their potential relation to features associated with the disease such as activity or damage.

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Risk of serious infections in arthritis patients treated with biological drugs: a matched cohort study and development of prediction model

Simon Krabbe, Kathrine L Gr?n, Bente Glintborg, Mette N?rgaard, Frank Mehnert, Dorte E Jarb?l, Mikkel ?stergaard, Merete L Hetland

doi : 10.1093/rheumatology/keaa876

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3834–3844

Serious infection is a concern for patients with inflammatory joint diseases treated with biological drugs (bDMARDs). The objectives were to compare risk of serious infection, defined as infection leading to hospitalization, in patients initiating bDMARD treatment with that in the general population and, second, to develop a simple clinical prediction model and to obtain risk estimates for individual patients.

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What is the meaning of ANCA positivity in IgG4-related disease?

Eduardo Mart?n-Nares, Gabriela Hernandez-Molina

doi : 10.1093/rheumatology/keab124

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3845–3850

To evaluate the prevalence and meaning of antineutrophil cytoplasmic antibodies (ANCA) positivity in a cohort of IgG4-related disease (IgG4-RD).

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Resolution of vascular inflammation in patients with new-onset giant cell arteritis: data from the RIGA study

Verena Sch?nau, Jessica Roth, Koray Tascilar, Giulia Corte, Bernhard Manger, Juergen Rech, Daniela Schmidt, Alexander Cavallaro, Michael Uder, Filippo Crescentini, Luigi Boiardi, Massimiliano Casali, Lucia Spaggiari, Elena Galli, Torsten Kuwert, Annibale Versari, Carlo Salvarani, Georg Schett, Francesco Muratore

doi : 10.1093/rheumatology/keab332

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3851–3861

Efficacy evaluation of GCA treatment is primarily based on non-specific symptoms and laboratory markers. We aimed to assess the change in vascular inflammation in patients with large vessel (LV)-GCA under different treatments using [18F]FDG PET/CT.

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Comparison between low cost USB nailfold capillaroscopy and videocapillaroscopy: a pilot study

Michael Berks, Graham Dinsdale, Elizabeth Marjanovic, Andrea Murray, Chris Taylor, Ariane L Herrick

doi : 10.1093/rheumatology/keaa723

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3862–3867

Universal serial bus (USB) microscopy (capillaroscopy) could provide all rheumatologists with an easy-to-use, low-cost tool to examine the nailfold capillaries to facilitate early diagnosis of SSc. The objectives of this pilot study were to examine the feasibility of acquiring and analysing images using USB microscopy and to compare results to videocapillaroscopy.

خرید پکیج و مشاهده آنلاین مقاله

Intravenous immunoglobulin for corticosteroid-resistant intestinal Henoch-Sch?nlein purpura: worth a controlled trial against corticosteroids?

Francesco Morotti, Giulia Bracciolini, Roberta Caorsi, Lorella Cattaneo, Marco Gattorno, Angelo Ravelli, Enrico Felici

doi : 10.1093/rheumatology/keaa743

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3868–3871

Henoch–Sch?nlein purpura (HScP) may present in children with severe, occasionally refractory, gastrointestinal (GI) involvement. The use of corticosteroids (CSs) is commonplace in the management of the disease, but to date no standardized protocol is available and, although rare, resistance to CS therapy may be challenging to clinicians. IVIG has been proposed as an effective alternative to CSs, but to date no controlled trial has been conducted to ascertain their real efficacy. We share our personal experience of successful IVIG treatment in two cases of GI HScP, comparing it with similar experiences reported in literature.

خرید پکیج و مشاهده آنلاین مقاله

Subclinical synovitis in arthralgia: how often does it result in clinical arthritis? Reflecting on starting points for disease-modifying anti-rheumatic drug treatment

Cleo Rogier, Fenne Wouters, Laurette van Boheemen, Dirkjan van Schaardenburg, Pascal H P de Jong, Annette H M van der Helm-van Mil

doi : 10.1093/rheumatology/keaa774

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3872–3878

According to guidelines, clinical arthritis is mandatory for diagnosing RA. However, in the absence of clinical synovitis, imaging-detected subclinical synovitis is increasingly used instead and is considered as a starting point for DMARD therapy. To search for evidence we studied the natural course of arthralgia patients with subclinical synovitis from three longitudinal cohorts and determined the frequencies of non-progression to clinically apparent inflammatory arthritis (IA) (i.e. ‘false positives’).

خرید پکیج و مشاهده آنلاین مقاله

Collagens in primary frozen shoulder: expression of collagen mRNA isoforms in the different phases of the disease

Line Marker, Peter Schjerling, Abigail L Mackey, Thomas Hansen, Jens Jakobsen, Michael Kj?r, Michael R Krogsgaard

doi : 10.1093/rheumatology/keaa802

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3879–3887

Primary frozen shoulder (pFS) has three phases that differ in clinical presentation. It is characterized by contracture of the joint capsule. We hypothesized that there is a general upregulation of collagens in pFS, and that this is highest in the first phase of the disease. The aims of this study were to investigate the expression of various collagens and degradation of collagens in patients with primary pFS and relate this to the three phases of the condition.

خرید پکیج و مشاهده آنلاین مقاله

Elevated serum gasdermin D N-terminal implicates monocyte and macrophage pyroptosis in adult-onset Still's disease

Hideto Nagai, Yohei Kirino, Hiroto Nakano, Yosuke Kunishita, Riko Henmi, Ann Marie Szymanski, Ryusuke Yoshimi, Michael J Ombrello, Hideaki Nakajima

doi : 10.1093/rheumatology/keaa814

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3888–3895

Elevation of serum IL-18 in adult-onset Still's disease (AOSD) and systemic JIA (sJIA) suggests the role of the inflammasome in these diseases. Gasdermin D is a pore-forming protein playing central roles in inflammasome-mediated inflammation, but its role in rheumatic disease is unknown. We aimed to elucidate the auto-inflammatory mechanisms in AOSD and sJIA.

خرید پکیج و مشاهده آنلاین مقاله

Elevated carcinoembryonic antigen predicts rapidly progressive interstitial lung disease in clinically amyopathic dermatomyositis

Dingxian Zhu, Jianjun Qiao, Shunli Tang, Yunlei Pan, Sheng Li, Changyi Yang, Hong Fang

doi : 10.1093/rheumatology/keaa819

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3896–3903

The present study aimed to determine the correlation between serum carcinoembryonic antigen (CEA) level and the severity of interstitial lung disease (ILD) in clinically amyopathic DM (CADM) patients.

خرید پکیج و مشاهده آنلاین مقاله

Rare immunofluorescence patterns of autoantibodies on HEp-2 cells defined by ICAP identify different autoimmune diseases in the absence of associated specificities: a Spanish multicentre study

Juan Irure-Ventura, Carmen Rodr?guez, Esther Vergara-Prieto, Maria Luisa Vargas, Bibiana Quirant, Aurora Jurado, Luis Fern?ndez-Pereira, Eva Mart?nez-C?ceres, Miriam San José, Marcos L?pez-Hoyos, the GEAI and EASI groups

doi : 10.1093/rheumatology/keaa831

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3904–3912

ANA are the most extensively used test for the diagnosis of systemic autoimmune diseases. However, testing by indirect immunofluorescence assays (IIFAs) on HEp-2 cells, the gold standard test, is time-consuming and needs expertise. Thus there is a trend to replace it with other automated solid-phase assays directed against specific ANA. Nonetheless, the Hep-2 cell is an autoantigen array and ANA have been classified into 29 types, some of them with no clear association with a specificity to be detected. It is especially in these uncommon patterns where no clinical relationship is found and no antigenic specificity is detected. Here we retrospectively collected clinical data from patients with confirmed uncommon HEp-2 IIFA patterns to search for an associated clinical condition.

خرید پکیج و مشاهده آنلاین مقاله

Cytokeratin 19 fragment is associated with severity and poor prognosis of interstitial lung disease in anti-MDA5 antibody-positive dermatomyositis

Xianhua Gui, Miao Ma, Jingjing Ding, ShenYun Shi, Xiaoyan Xin, Xiaohua Qiu, Yingwei Zhang, Yuying Qiu, Min Cao, Mei Huang, Mengshu Cao, Jinghong Dai, Hourong Cai, Yonglong Xiao

doi : 10.1093/rheumatology/keaa843

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3913–3922

In the present study, we aimed to assess the clinical significance of cytokeratin 19 fragment (CYFRA21-1) in patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive DM-interstitial lung disease (MDA5-DM-ILD).

خرید پکیج و مشاهده آنلاین مقاله

STAT3 phosphorylation inhibition for treating inflammation and new bone formation in ankylosing spondylitis

Sungsin Jo, Eun Jeong Won, Moon-Ju Kim, Yu Jeong Lee, So-Hee Jin, Pu-Reum Park, Ho-Chun Song, Jahae Kim, Yoo-Duk Choi, Ji-Young Kim, Seung Cheol Shim, Sung Hoon Choi, Ye-Soo Park, Tae-Hwan Kim, Tae-Jong Kim

doi : 10.1093/rheumatology/keaa846

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3923–3935

AS is a rheumatic disease characterized by chronic inflammation and bony ankylosis. This study was to evaluate whether a signal transducer and activator of transcription 3 phosphorylation inhibitor (stat3-p Inh) could treat both chronic inflammation and bone formation in AS.

خرید پکیج و مشاهده آنلاین مقاله

CD34+CD133+CD309+ circulating angiogenic cell level is reduced but positively related to hydroxychloroquine use in SLE patients—a case–control study and meta-regression analysis

Jinghui Huang, Nien Yee Kow, Hui Yin Lee, Anna-Marie Fairhurst, Anselm Mak

doi : 10.1093/rheumatology/keaa875

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3936–3944

To identify and quantify the level of CD34+CD133+CD309+ circulating angiogenic cells (CAC) and explore factors associated with the level of CAC in patients with SLE.

خرید پکیج و مشاهده آنلاین مقاله

Real-world experience of tocilizumab in systemic sclerosis: potential benefit on lung function for anti-topoisomerase-positive patients

Yasir Suleman, Kristina E N Clark, Alice R Cole, Voon H Ong, Christopher P Denton

doi : 10.1093/rheumatology/keab273

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3945–3946

خرید پکیج و مشاهده آنلاین مقاله

Persistence of circulating T-follicular helper cells after rituximab is associated with relapse of IgG4-related disease

Gaia Mancuso, Tatiana Jofra, Marco Lanzillotta, , Alessandro Aiuti, Maria Pia Cicalese, Giulia di Colo, Lorenzo Dagna, , Georgia Fousteri, Emanuel Della-Torre

doi : 10.1093/rheumatology/keab344

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3947–3949

خرید پکیج و مشاهده آنلاین مقاله

Hyperlipidaemia in psoriatic disease: higher prevalence in psoriatic arthritis and inverse association with systemic therapy

Rubén Queiro, Sabela Fern?ndez, Estefan?a Pardo

doi : 10.1093/rheumatology/keab365

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3949–3951

خرید پکیج و مشاهده آنلاین مقاله

IgG vs IgG + IgM anti–double stranded DNA measurement: a comparative report for clinical practice

Rym Abida, Emily Apsley, David Isenberg

doi : 10.1093/rheumatology/keab387

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3951–3952

خرید پکیج و مشاهده آنلاین مقاله

Tiger man sign in sarcoid myopathy

Ayumi Kuzume, Toshiki Terao, Daisuke Miura, Kengo Takeuchi, Kosei Matsue

doi : 10.1093/rheumatology/keaa833

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3953–3954

خرید پکیج و مشاهده آنلاین مقاله

Cricoarytenoid arthritis in rheumatoid arthritis

Shinji Izuka, Shunta Kaneko, Takuya Harada, Hidenori Sakai, Yuko Takahashi, Hiroyuki Yamashita, Hiroshi Kaneko

doi : 10.1093/rheumatology/keaa838

Rheumatology, Volume 60, Issue 8, August 2021, Page 3955

خرید پکیج و مشاهده آنلاین مقاله

A rare case of small-vessel necrotizing vasculitis of the bone marrow revealing granulomatosis with polyangiitis

Jonathan Broner, Erik Arnaud, Sirivanh Bisiou, Agathe Artiaga, Myriam Fantone, Samia Gonzalez, Radjiv Goulabchand

doi : 10.1093/rheumatology/keaa866

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3956–3957

خرید پکیج و مشاهده آنلاین مقاله

Pleuroparenchymal fibroelastosis in a patient with systemic sclerosis

Furkan Ufuk, Goksel Altinisik, Ugur Karasu

doi : 10.1093/rheumatology/keaa879

Rheumatology, Volume 60, Issue 8, August 2021, Pages 3958–3959

خرید پکیج و مشاهده آنلاین مقاله

Corrigendum to: The aetiopathogenic significance, clinical relevance and therapeutic implications of vasculopathy in idiopathic inflammatory myopathy

John D Pauling, Lisa Christopher-Stine

doi : 10.1093/rheumatology/keab431

Rheumatology, Volume 60, Issue 8, August 2021, Page 3960

خرید پکیج و مشاهده آنلاین مقاله

The beauty and the beast: the butterfly of lupus revisited

Tajamul H Mir, Bushra Jabeen

doi : 10.1093/rheumatology/keab002

Rheumatology, Volume 60, Issue 8, August 2021, Pages e272–e274

خرید پکیج و مشاهده آنلاین مقاله

Dancing muscles: the value of real-time ultrasound evaluation of muscle in myositis and mimics

Jemima Albayda, Lindsey R Hayes, Lisa Christopher-Stine

doi : 10.1093/rheumatology/keab088

Rheumatology, Volume 60, Issue 8, August 2021, Pages e275–e276

خرید پکیج و مشاهده آنلاین مقاله

Anti-PL-7 antibody positive antisynthetase syndrome diagnosed after the onset of pulmonary hypertension and right-sided heart failure

Shota Okamoto, Yuya Kondo, Kimi Sato, Taihei Nishiyama, Hirofumi Toko, Mizuki Yagishita, Masahiro Yokosawa, Hiroto Tsuboi, Masaki Ieda, Isao Matsumoto

doi : 10.1093/rheumatology/keab142

Rheumatology, Volume 60, Issue 8, August 2021, Pages e277–e279

خرید پکیج و مشاهده آنلاین مقاله

A case of gastric antral vascular ectasia (GAVE) in primary Sj?gren’s syndrome

Yvonne Tan, Andrew Gough

doi : 10.1093/rheumatology/keab171

Rheumatology, Volume 60, Issue 8, August 2021, Pages e280–e281

خرید پکیج و مشاهده آنلاین مقاله

A case of multifocal motor neuropathy after initiation of ixekizumab for psoriatic arthopathy

Mary Clare McKenna, Michael Marnane, Barry J Sheane, Se?n Connolly

doi : 10.1093/rheumatology/keab186

Rheumatology, Volume 60, Issue 8, August 2021, Pages e282–e283

خرید پکیج و مشاهده آنلاین مقاله

Chronic periaortitis presenting with isolated pulmonary artery involvement: description of two cases

Claudio Galluzzo, Chiara Marvisi, Giulia Besutti, Lucia Spaggiari, Francesco Muratore, Giulia Pazzola, Gianluigi Bajocchi, Carlo Salvarani

doi : 10.1093/rheumatology/keab188

Rheumatology, Volume 60, Issue 8, August 2021, Pages e285–e287

خرید پکیج و مشاهده آنلاین مقاله

Pyoderma gangrenosum induced by adalimumab in a seropositive rheumatoid arthritis patient: a paradoxical effect of adalimumab?

Yvonne Tan, Svetlana Kavaklieva, Fiona Wood

doi : 10.1093/rheumatology/keab194

Rheumatology, Volume 60, Issue 8, August 2021, Pages e288–e289

خرید پکیج و مشاهده آنلاین مقاله

Comment on: Different treatment options for Takayasu arteritis patients with moderate-to- severe aortic regurgitation: long-term outcomes

Keiichiro Kadoba, Ryu Watanabe, Motomu Hashimoto, Akio Morinobu, Chikashi Terao, Hajime Yoshifuji

doi : 10.1093/rheumatology/keab184

Rheumatology, Volume 60, Issue 8, August 2021, Pages e290–e291

خرید پکیج و مشاهده آنلاین مقاله

Comment on: Proprotein convertase subtilisin/kexin type 9 in the dyslipidaemia of patients with axial spondyloarthritis is related to disease activity

Maaike Heslinga, Gilles Lambert, Aurélie Thédrez, John Kastelein, Michael T Nurmohamed

doi : 10.1093/rheumatology/keab187

Rheumatology, Volume 60, Issue 8, August 2021, Pages e292–e293

خرید پکیج و مشاهده آنلاین مقاله

Comment on: Clinical significance of E148Q heterozygous variant in paediatric Familial Mediterranean Fever

Ay?e Tanatar, Hafize Emine S?nmez, Betül S?zeri, Nuray Aktay Ayaz

doi : 10.1093/rheumatology/keab205

Rheumatology, Volume 60, Issue 8, August 2021, Pages e294–e295

خرید پکیج و مشاهده آنلاین مقاله

Comment on: Association between environmental air pollution and rheumatoid arthritis flares

Mickael Essouma

doi : 10.1093/rheumatology/keab212

Rheumatology, Volume 60, Issue 8, August 2021, Page e296

خرید پکیج و مشاهده آنلاین مقاله

Comment on: Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg–Strauss)

C Comarmond, S Bensalha, A Lopes, F Dor, I Brocheriou, S Mouly, D Sène

doi : 10.1093/rheumatology/keab213

Rheumatology, Volume 60, Issue 8, August 2021, Pages e297–e299

خرید پکیج و مشاهده آنلاین مقاله

The IL-33/ST2 axis and vitamin D as a possible emerging therapeutic target in osteoarthritis

Maria Maddalena Sirufo, Lia Ginaldi, Massimo De Martinis

doi : 10.1093/rheumatology/keab292

Rheumatology, Volume 60, Issue 8, August 2021, Page e300

خرید پکیج و مشاهده آنلاین مقاله