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Probiotics in obstetrics and gynecology—Where is the future?
Ulrik S. Kesmodel,Fereshteh Dardmeh,Hiva Alipour,
doi : 10.1111/aogs.14196
Volume 100, Issue 9 p. 1547-1548
Time to reconsider: Have the 2015 FIGO and 2017 Swedish intrapartum cardiotocogram classifications led us from Charybdis to Scylla?
Per Olofsson,Frida Ekeng?rd,Andreas Herbst,
doi : 10.1111/aogs.14201
Volume 100, Issue 9 p. 1549-1556
In 2015, FIGO revised the 1987 intrapartum cardiotocography (CTG) classification (FIGO1987). A less radical FIGO2015 version was introduced in Sweden 2017 (SWE2017). Now, post hoc simulation studies show that FIGO2015 and SWE2017 are less reliable than (a modified) FIGO1987. FIGO2015 shows significantly better interobserver agreement for normal CTG traces than FIGO1987, but significantly worse for pathological traces. Agreements between templates are moderate to good, but different classifications of mainly variable decelerations and tachycardia cause significant heterogeneities. FIGO2015 shows insufficient sensitivity to identify fetal acidemia compared with FIGO1987. In connection with fetal electrocardiogram ST analysis, one study showed no template was superior in identifying fetal acidemia, but in a series of only academia, FIGO1987 had significantly higher sensitivity than FIGO2015 (73% vs. 43%) and set of an alarm for fetal acidemia considerably earlier. With SWE2017, operative interventions declined significantly in Sweden but several adverse neonatal outcomes increased significantly. It remains to investigate the development with FIGO2015.
A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil
Nicolai B. Jensen,Signe D. Justesen,Agnete Larsen,Erik Ernst,Lars H. Pedersen,
doi : 10.1111/aogs.14151
Volume 100, Issue 9 p. 1557-1580
Immunosuppressant drugs are increasingly being used in the reproductive years. Theoretically, such medications could affect fetal health either through changes in the sperm DNA or through fetal exposure caused by a presence in the seminal fluid. This systematic overview summarizes existing literature on the spermatotoxic and genotoxic potentials of methotrexate (MTX), a drug widely used to treat rheumatic and dermatologic diseases, and mycophenolate mofetil (MMF), which alone or supplemented with ganciclovir (GCV) may be crucial for the survival of organ transplants.
Impact of changing gloves during cesarean section on postoperative infective complications: A systematic review and meta-analysis
Brenda F Narice,Joana R Almeida,Tom Farrell,Priya Madhuvrata,
doi : 10.1111/aogs.14161
Volume 100, Issue 9 p. 1581-1594
The cesarean section rate around the world, currently estimated at 21.1%, continues to increase. Women who undergo a cesarean section sustain a seven- to ten-fold greater risk of infective morbidity compared with those who deliver vaginally.
Impact of exercise on pain perception in women with endometriosis: A systematic review
Sara Hansen,Una ?. Sverrisd?ttir,Martin Rudnicki,
doi : 10.1111/aogs.14169
Volume 100, Issue 9 p. 1595-1601
Endometriosis is challenging to treat. It is a painful and chronic inflammatory disorder that impacts up to 10% of women of reproductive age. Despite available surgical and medical treatment options, recurrence of symptoms is common. Available studies suggest that exercise may have a therapeutic effect on chronic inflammation and thereby on pain perception. This review evaluates whether exercise can decrease pain perception in women with symptomatic endometriosis.
The effect of Lactiplantibacillus plantarum 299v together with a low dose of iron on iron status in healthy pregnant women: A randomized clinical trial
Ulrika Axling,Gunilla ?nning,Titti Martinsson Niskanen,Niklas Larsson,Stefan R. Hansson,Lena Hulthén,
doi : 10.1111/aogs.14153
Volume 100, Issue 9 p. 1602-1610
Iron deficiency during pregnancy is a global health problem and is associated with adverse pregnancy outcomes. The aim of this randomized, double-blind, placebo-controlled study was to evaluate the effect of Lactiplantibacillus plantarum 299v (Lp299v, 1010 colony forming units), 4.2 mg iron, 12 mg ascorbic acid and 30 µg folic acid (Lp) on iron status in healthy, non-anemic, pregnant Swedish women.
COVID-19 in pregnancy—characteristics and outcomes of pregnant women admitted to hospital because of SARS-CoV-2 infection in the Nordic countries
Hilde Engjom,Anna J.M. Aabakke,Kari Klungs?yr,Teresia Svanvik,Outi ?yr?s,Eva Jonasdottir,Lars Thurn,Elin Jones,Karin Pettersson,Lill T. Nyfl?t,Iqbal Al-Zirqi,Siri Vangen,Pétur B. J?l?usson,Karin K?llén,Mika Gissler,Lone Krebs
doi : 10.1111/aogs.14160
Volume 100, Issue 9 p. 1611-1619
Population-based studies about the consequences of SARS-CoV-2 infection (COVID-19) in pregnancy are few and have limited generalizability to the Nordic population and healthcare systems.
Progression from isolated gestational proteinuria to preeclampsia with severe features
Yossi Tzur,Eli Rimon,Gil Geva,Jacky Herzlich,Michael J. Kupferminc,
doi : 10.1111/aogs.14198
Volume 100, Issue 9 p. 1620-1626
The association between the degree of isolated gestational proteinuria and preeclampsia with severe features and other placental-mediated complications is controversial. The aim of this study was to evaluate whether a higher isolated proteinuria level is associated with an increased frequency of preeclampsia with severe features.
Changes in rate of preterm birth and adverse pregnancy outcomes attributed to preeclampsia after introduction of a refined definition of preeclampsia: A population-based study
Shiri Shinar,Nir Melamed,Kasim E. Abdulaziz,Joel G. Ray,Catherine Riddell,Jon Barrett,Beth Murray-Davis,Karizma Mawjee,Sarah D. McDonald,Michael Geary,Howard Berger,for DOH-NET (Diabetes, Obesity, Hypertension in Pregnancy Research Network), SOON (Southern Ontario Obstetrical Network) InvestigatorsTM
doi : 10.1111/aogs.14199
Volume 100, Issue 9 p. 1627-1635
Since 2013, various guidelines for hypertension in pregnancy have been refined, no longer requiring proteinuria as a requisite criterion for preeclampsia. We aimed to evaluate the impact of the new definition on preterm birth (PTB) and adverse pregnancy outcomes.
Recurrence, postponing pregnancy, and termination rates after hyperemesis gravidarum: Follow up of the MOTHER study
Kelly Nijsten,Caitlin Dean,Loïs M. van der Minnen,Joke M. J. Bais,Carrie Ris-Stalpers,Rik van Eekelen,Henk A. Bremer,David P. van der Ham,Wieteke M. Heidema,Anjoke Huisjes,Gunilla Kleiverda,Simone M. Kuppens,Judith O. E. H. van Laar,Josje Langenveld,Flip van der Made,Dimitri Papatsonis,Marie-José Pelinck,Paula J. Pernet,Leonie van Rheenen-Flach,Robbert J. Rijnders,Hubertina C. J. Scheepers,Tatjana Vogelvang,Ben W. Mol,Tessa J. Roseboom,Marjette H. Koot,Iris J. Grooten,Rebecca C. Painter
doi : 10.1111/aogs.14197
Volume 100, Issue 9 p. 1636-1643
Hyperemesis gravidarum (HG) complicates 1% of pregnancies and has a major impact on maternal quality of life and well-being. We know very little about HG’s long-term impact after an affected pregnancy, including recurrence rates in future pregnancies, which is essential information for women considering subsequent pregnancies. In this study, we aimed to prospectively measure the recurrence rate of HG and the number of postponed and terminated subsequent pregnancies due to HG. We also aimed to evaluate if there were predictive factors that could identify women at increased risk for HG recurrence, and postponing and terminating subsequent pregnancies.
Effect of second-trimester sonographic cervical length on the risk of spontaneous preterm delivery in different risk groups: A prospective observational multicenter study
Tove Wikstr?m,Henrik Hagberg,Bo Jacobsson,Pihla Kuusela,Jan Wesstr?m,Peter Lindgren,Helena Fadl,Ulla-Britt Wennerholm,Lil Valentin,
doi : 10.1111/aogs.14203
Volume 100, Issue 9 p. 1644-1655
The aim of the study is to compare the effect of cervical length measured with transvaginal ultrasound in the second trimester on the risk of spontaneous preterm delivery (PTD) between different risk groups of asymptomatic women with a singleton pregnancy.
Clinical value of early viscoelastometric point-of-care testing during postpartum hemorrhage for the prediction of severity of bleeding: A multicenter prospective cohort study in the Netherlands
Paul I. Ramler,Ada Gillissen,Dacia D. C. A. Henriquez,Camila Caram-Deelder,Alexander A. Markovski,Moniek P. M. de Maat,Johannes J. Duvekot,Jeroen C. J. Eikenboom,Kitty W. M. Bloemenkamp,Jan M. M. van Lith,Thomas van den Akker,Johanna G van der Bom
doi : 10.1111/aogs.14172
Volume 100, Issue 9 p. 1656-1664
To evaluate rotational fibrin-based thromboelastometry (ROTEM® FIBTEM) with amplitude of clot firmness at 5 min (A5) as an early point-of-care parameter for predicting progression to severe postpartum hemorrhage, and compare its predictive value with that of fibrinogen.
Challenges in migrant women’s maternity care in a high-income country: A population-based cohort study of maternal and perinatal outcomes
Embla ?r Gu?mundsd?ttir,Helga Gottfre?sd?ttir,Berglind H?lfd?nsd?ttir,Marianne Nieuwenhuijze,Mika Gissler,Kristjana Einarsd?ttir,
doi : 10.1111/aogs.14186
Volume 100, Issue 9 p. 1665-1677
This study aims to explore maternal and perinatal outcomes of migrant women in Iceland.
Severe recalled labor pain and elective cesarean section in a subsequent delivery: a cohort study of Norwegian parous women
Carolin Junge,Tilmann von Soest,Andreas Seidler,Malin Eberhard-Gran,Susan Garthus-Niegel,
doi : 10.1111/aogs.14212
Volume 100, Issue 9 p. 1678-1687
Some women keep on recalling intense labor pain experienced at childbirth to a degree that may negatively affect their life during the postpartum period or lead them to request a cesarean section (CS) in the subsequent delivery. This longitudinal study aimed to assess the impact of severe recalled labor pain from the previous birth on the preference for and delivery by an elective CS in the subsequent delivery. Furthermore, we investigated whether co-occurring maternal demographic, somatic and mental health factors related to the previous and subsequent delivery, explain parts of a potential association.
Placental characteristics in different types of selective fetal growth restriction in monochorionic diamniotic twins
Xueju Wang,Luyao Li,Pengbo Yuan,Yangyu Zhao,Yuan Wei,
doi : 10.1111/aogs.14204
Volume 100, Issue 9 p. 1688-1693
This study aimed to explore the differences in placental characteristics among three types of selective fetal growth restriction (sFGR) in monochorionic diamniotic twin pregnancies.
Systematic screening for vasa previa at the 20-week anomaly scan
Anna Gross,Barbara Markota Ajd,Christian Specht,Matthias Scheier,
doi : 10.1111/aogs.14205
Volume 100, Issue 9 p. 1694-1699
The presence of vasa previa carries a high risk for severe fetal morbidity and mortality due to fetal bleeding caused by injury to unprotected fetal vessels when rupture of membranes occurs. Previously, it has been shown that prenatal diagnosis significantly improves the outcome. However, systematic screening for vasa previa is not generally performed and clinical studies demonstrating the performance of systematic screening for vasa previa in routine clinical practice are rare. The objective of this study was to assess the performance of systematic screening for vasa previa by determining placental cord insertion at the 20-week anomaly scan.
A prospective study comparing rectal water contrast-transvaginal ultrasonography with sonovaginography for the diagnosis of deep posterior endometriosis
Fabio Barra,Umberto Leone Roberti Maggiore,Giulio Evangelisti,Carolina Scala,Franco Alessandri,Valerio Gaetano Vellone,Cesare Stabilini,Simone Ferrero,
doi : 10.1111/aogs.14209
Volume 100, Issue 9 p. 1700-1711
Preoperative assessment of deep endometriotic (DE) nodules is necessary to inform patients about the possible treatments and provide informed consent in case of surgery. This study aims to investigate the diagnostic performance of rectal water-contrast transvaginal ultrasonography (RWC-TVS) and sonovaginography (SVG) in women with suspicion of posterior DE.
Treatment with assisted reproduction technologies in women with acute hepatic porphyria
Daphne Vassiliou,Angelica Lindén Hirschberg,Eliane Sardh,
doi : 10.1111/aogs.14200
Volume 100, Issue 9 p. 1712-1721
Acute porphyrias are rare disorders of the heme biosynthetic pathway and present with acute neurovisceral symptoms that can be induced by hormonal changes and medications. Women are far more likely to present with clinical symptoms than men, particularly during parts of their lifetime with changes in the level of female sex hormones such as ovulation, menstruation, and pregnancy. Treatment of ovulatory dysfunction and controlled ovarian hyperstimulation require the administration of hormones, which are considered porphyrinogenic. Women with acute hepatic porphyria have therefore been considered unsuitable for such treatments in the past.
Decreasing trend and changing indications of hysterectomy in Finland
Jenni Hakkarainen,Aapeli Nevala,Eija Tom?s,Kari Nieminen,Nea Malila,Janne Pitk?niemi,Annika Auranen,
doi : 10.1111/aogs.14159
Volume 100, Issue 9 p. 1722-1729
Hysterectomy has been one of the most common surgical procedures in women in Finland. We studied the population-based trends of hysterectomy and its indications from 1986 to 2017.
Assessment of surgeon and hospital volume for robot-assisted and laparoscopic benign hysterectomy in Sweden
Malin Brunes,Catharina Forsgren,Anna Warnqvist,Marion Ek,Ulrika Johannesson,
doi : 10.1111/aogs.14166
Volume 100, Issue 9 p. 1730-1739
The study aims to analyze differences between robot-assisted total laparoscopic hysterectomy (RATLH) and total laparoscopic hysterectomy (TLH) in benign indications, emphasizing surgeon and hospital volume.
Comparison of perioperative outcomes between standard laparoscopic and robot-assisted approach in patients with rectosigmoid endometriosis
Diego Raimondo,Carlo Alboni,Benedetta Orsini,Anna Chiara Aru,Antonino Farulla,Manuela Maletta,Alessandro Arena,Simona Del Forno,Veronica Sampogna,Manuela Mastronardi,Marco Petrillo,Renato Seracchioli
doi : 10.1111/aogs.14170
Volume 100, Issue 9 p. 1740-1746
Robot-assisted laparoscopic surgery (RALS) has gained widespread application in several surgical specialties. Previous studies on the feasibility and safety of RALS vs standard laparoscopy (S-LPS) for rectosigmoid endometriosis are limited and reported conflicting data. This study aims to compare S-LPS and RALS in patients with rectosigmoid endometriosis in terms of perioperative surgical and clinical data.
Need updating fetal blood sampling guidelines since lactate levels indicating acidemia are specific to the measuring instrument
Junaid Rafi
doi : 10.1111/aogs.14173
Volume 100, Issue 9 p. 1747-1747
Differences between lactate meters and the importance of considering lactate concentration as a continuum
Malin Holzmann,Lennart Nordstr?m,Philip Steer,
doi : 10.1111/aogs.14187
Volume 100, Issue 9 p. 1748-1748
Levonorgestrel-releasing intrauterine system and breast cancer; Is there an association?
Maisa Hamed Al Kiyumi,Kauthar Al Battashi,Hana Ali Al-Riyami,
doi : 10.1111/aogs.14188
Volume 100, Issue 9 p. 1749-1749
Association between breast cancer risk and levonorgestrel-releasing intrauterine system
Livia Conz,Bruna S. Mota,Luis Bahamondes,Ma?ra T. D?ria,Sophie Derchain,Rachel Riera,Luis O. Sarian,
doi : 10.1111/aogs.14207
Volume 100, Issue 9 p. 1750-1750
