دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Increasing number of implantation failures and pregnancy losses associated with elevated Th1/Th2 cell ratio
Keiji Kuroda,Koji Nakagawa,Takashi Horikawa,Azusa Moriyama,Yuko Ojiro,Satoru Takamizawa,Asako Ochiai,Yuko Matsumura,Yuko Ikemoto,Koushi Yamaguchi,Rikikazu Sugiyama,
doi : 10.1111/aji.13429
Volume 86, Issue 3 e13429
We aimed to assess whether an imbalance of T-helper (Th) 1 and Th2 cells contributes to implantation failure and pregnancy loss.
Circadian rhythm-associated Rev-erb? modulates polarization of decidual macrophage via the PI3K/Akt signaling pathway
Liyuan Cui,Xueling Jin,Feng Xu,Songcun Wang,Lu Liu,Xinyi Li,Haiyan Lin,Meirong Du,
doi : 10.1111/aji.13436
Volume 86, Issue 3 e13436
Circadian rhythms are involved not only in the repair and regeneration of the immune system, but may also be associated with regulation of inflammation and immune responses. Rev-erb? could constitute a link between immunity and circadian rhythms since it is a transcription factor that regulates circadian rhythms and has functions in multiple physiological and pathological processes. Decidual macrophages (dM?s) play crucial roles in immune balance at the maternal-fetal interface, and abnormal macrophage polarization is related to adverse pregnancy outcomes, such as infertility, recurrent spontaneous abortion, and preterm labor. However, whether Rev-erb? could modulate the polarization of macrophages is unknown.
Association of FOXP3 rs3761548 polymorphism and its reduced expression with unexplained recurrent spontaneous abortions: A South Indian study
Kethora Dirsipam,Deepika Ponnala,Dhatri Madduru,Rajeswari Bonu,Parveen Jahan,
doi : 10.1111/aji.13431
Volume 86, Issue 3 e13431
Fork Head Box Protein 3 (FOXP3) is an X-linked gene, codes for a master transcription regulatory protein that controls the development and function of immunosuppressive T regulatory (Treg) cells. They are crucial mediators of maternal foetal tolerance and successful pregnancy outcome. The aim of the study is to evaluate the association of FOXP3 rs3761548 functional polymorphism and to assess the serum concentrations of full-length FOXP3 protein in Unexplained Recurrent Spontaneous Abortions (URSA) patients of Southern India.
Recent sexual violence exposure is associated with immune biomarkers of HIV susceptibility in women
Annette M. Aldous,Christopher Joy,Jason Daniels,Mariel Jais,Samuel J. Simmens,Manya Magnus,Afsoon Roberts,Kaleigh Connors,Brendan Capozzi,Hani Mohamed,Monika Juzumaite,Heather Devore,Theresa Moriarty,Catherine Hatch Schultz,Maria Zumer,Gary Simon,Mimi Ghosh
doi : 10.1111/aji.13432
Volume 86, Issue 3 e13432
HIV/AIDS and sexual violence act synergistically and compromise women's health. Yet, immuno-biological mechanisms linking sexual violence and increased HIV susceptibility are poorly understood.
Prediction of preterm birth based on machine learning using bacterial risk score in cervicovaginal fluid
Sunwha Park,Daejoong Oh,Hanna Heo,Gain Lee,Soo Min Kim,AbuZar Ansari,Young-Ah You,Yun Ji Jung,Young-Han Kim,Myunghoon Lee,Young Ju Kim,
doi : 10.1111/aji.13435
Volume 86, Issue 3 e13435
Preterm birth (PTB) is a major cause of increased morbidity and mortality in newborns. The main cause of spontaneous PTB (sPTB) is the activation of an inflammatory response as a result of ascending genital tract infection. Despite various studies on the effects of the vaginal microbiome on PTB, a practical method for its clinical application has yet to be developed.
An updated review on the effects of depot medroxyprogesterone acetate on the mucosal biology of the female genital tract
Hossaena Ayele,Michelle Perner,Lyle R. McKinnon,Kenzie Birse,Christina Farr Zuend,Adam Burgener,
doi : 10.1111/aji.13455
Volume 86, Issue 3 e13455
Access to safe, effective, and affordable contraception is important for women’s health and essential to mitigate maternal and fetal mortality rates. The progestin-based contraceptive depot medroxyprogesterone acetate (DMPA) is a popular contraceptive choice with a low failure rate and convenient administration schedule.
Interleukin-9 produced by helper T cells stimulates interleukin-8 expression in endometriosis
Yosuke Tarumi,Taisuke Mori,Hiroyuki Okimura,Eiko Maeda,Yukiko Tanaka,Hisashi Kataoka,Fumitake Ito,Akemi Koshiba,Izumi Kusuki,Jo Kitawaki,
doi : 10.1111/aji.13380
Volume 86, Issue 3 e13380
Inflammation and immune responses play crucial roles in the development of endometriosis. Although interleukin-9 (IL-9) has a pro-inflammatory function in chronic inflammatory diseases, its function in endometriosis remains unknown. Here, we aimed to investigate the significance of IL-9 and IL-9-producing lymphocytes in endometriosis.
Abnormal expression of the costimulatory molecule B7-H4 in placental chorionic villous and decidual basalis tissues of patients with preeclampsia and HELLP syndrome
Liyan Duan,Beatrix Reisch,Antonella Iannaccone,Elina Hadrovic,Yuqing Wu,Rebekka Vogtmann,Elke Winterhager,Rainer Kimmig,Angela K?ninger,Pawel Mach,Alexandra Gellhaus,
doi : 10.1111/aji.13430
Volume 86, Issue 3 e13430
B7-H4, a checkpoint molecule of the B7 family, regulates a broad spectrum such as T-cell activation, cytokine secretion, tumour progression, and invasion capacities. Our previous data revealed that soluble B7-H4 (sB7-H4) blood serum levels are elevated in women at high risk for the hypertensive pregnancy disorder preeclampsia (PE) in the first trimester, as well as in patients with confirmed early/late-onset PE.
Placentas associated with female neonates from pregnancies complicated by urinary tract infections have higher cAMP content and cytokines expression than males
Andrea Olmos-Ortiz,Alberto Olivares-Huerta,Janice Garc?a-Quiroz,Teresa Zari??n,Roberto Chavira,Ver?nica Zaga-Clavellina,Euclides Avila,Ali Halhali,Marta Durand,Fernando Larrea,Lorenza D?az,
doi : 10.1111/aji.13434
Volume 86, Issue 3 e13434
The cAMP pathway is involved in important biological processes including immune regulation and hormone signaling. At the feto-maternal unit, cAMP participates in placental function/physiology and the establishment of immunoendocrine networks. Low cAMP in male fetuses cord blood has been linked to poorer perinatal outcomes; however, cAMP placental content and its relationship with immune factors and fetal sex in an infectious condition have not been investigated.
The decidual expression of Interleukin-7 is upregulated in early pregnancy loss
Theresa Vilsmaier,Niklas Amann,Sanja L?b,Elisa Schmoeckel,Christina Kuhn,Alaleh Zati zehni,Sarah Meister,Susanne Beyer,Theresa M. Kolben,Johanna Becker,Jan-Niclas Mumm,Sven Mahner,Udo Jeschke,Thomas Kolben
doi : 10.1111/aji.13437
Volume 86, Issue 3 e13437
Maternal immunological rejection of the semi-allogenic fetus is discussed as one of the significant factors involved in early pregnancy loss. An array of cytokines secreted by both maternal and fetal cells is involved in generating a delicate maternal immune tolerance. Interleukin-7 (IL-7) is discussed to play a key role in pro-inflammatory processes, but there is still limited insight into the pathophysiological input on placentation and embryonic development in early pregnancy loss.
