دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Time-dependent changes in placental mRNA expression after delivery due to delayed specimen collection
Alexa A. Freedman,Britney P. Smart,Lauren S. Keenan-Devlin,Janedelie Romero,Andrew Franklin,Ann Borders,Linda M. Ernst,Gregory E. Miller,
doi : 10.1111/aji.13452
Volume 86, Issue 4 e13452
Current scientific guidelines recommend collecting placental specimens within two hours of delivery for gene expression analysis. However, collecting samples in a narrow time window is a challenge in the dynamic and unpredictable clinical setting, so delays in placental specimen collection are possible. The purpose of our analysis was to investigate temporal changes in placental gene expression by longitudinally sampling placentas over a 24 h period.
Extracellular superoxide produced by Enterococcus faecalis reduces endometrial receptivity via inflammatory injury
Zhanhu Zhang,Tianqi Li,Lili Xu,Qiuhong Wang,Haibo Li,Xingmin Wang,
doi : 10.1111/aji.13453
Volume 86, Issue 4 e13453
Chronic endometritis (CE) can cause infertility. Enterococcus faecalis is an opportunistic pathogen that is often found in the endometrium of CE patients. However, the mechanisms by which E. faecalis affects endometrial health are still unclear. In this study, we investigated the mechanism how extracellular superoxide produced by E. faecalis affected the endometrial receptivity.
Alpha-linolenic acid regulates the gut microbiota and the inflammatory environment in a mouse model of endometriosis
Zhexin Ni,Jie Ding,Qianqian Zhao,Wen Cheng,Jin Yu,Ling Zhou,Shuai Sun,Chaoqin Yu,
doi : 10.1111/aji.13471
Volume 86, Issue 4 e13471
This study aims to investigate the effects of alpha-linolenic acid (ALA) on the gut microbiota (GM) and the abdominal environment in mice with endometriosis (EMS).
IFN-alpha receptor deficiency enhances host resistance to oral Salmonella enterica serovar Typhimurium infection during murine pregnancy
Gerard Agbayani,Kristina Clark,Jagdeep K. Sandhu,Melissa Hewitt,Subash Sad,Shawn P. Murphy,Lakshmi Krishnan,
doi : 10.1111/aji.13454
Volume 86, Issue 4 e13454
Maternal tolerance during pregnancy increases the risk of infection with certain intracellular pathogens. Systemic Salmonella enterica serovar Typhimurium (S.Tm) infection during pregnancy in normally resistant 129X1/SvJ mice leads to severe placental infection, as well as fetal and maternal deaths. However, the effect of oral infection with S.Tm in pregnant mice and the roles of infection-induced inflammation and cell death pathways in contributing to susceptibility to infection are unclear.
Identifying novel ovarian tumor biomarkers through mining of the transcriptome of circulating immune cells: A proof-of-concept study
Shitanshu Uppal,Erin Medlin,Mildred Felder,Arvinder Kapur,Robert C. Sterner,Jessica Vazquez,Payton N. Lindner,Aleksandar K. Stanic,Lisa Barroilhet,Jesus Gonzalez-Bosquet,Manish S. Patankar,
doi : 10.1111/aji.13469
Volume 86, Issue 4 e13469
Treatment of high-grade serous ovarian cancer (HGSOC) will benefit from early detection of cancer. Here, we provide proof-of-concept data supporting the hypothesis that circulating immune cells, because of their early recognition of tumors and the tumor microenvironment, can be considered for biomarker discovery.
First-trimester serum BAFF:sFlt-1 ratio as a candidate early biomarker of spontaneous abortion
Hindi E. Stohl,Ning Yu,William Stohl,
doi : 10.1111/aji.13428
Volume 86, Issue 4 e13428
Immunologic, angiogenic, and anti-angiogenic factors are associated with spontaneous abortion (SAB). B cell–activating factor (BAFF), a proliferation-inducing ligand (APRIL), placental growth factor (PlGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) may play a role in SAB and may serve singly or in combination as an early biomarker of SAB.
Potential biomarkers of infertility associated with microbiome imbalances
Maria Agustina Azpiroz,Lucila Orguilia,Maria Ines Palacio,Alejandro Malpartida,Soledad Mayol,Gil Mor,Gabriela Gutiérrez,
doi : 10.1111/aji.13438
Volume 86, Issue 4 e13438
The aim of this study was to investigate the possible relationship between vaginal/rectal microbiome disbalances and miRNA expression with infertility.
Can altered colostrum miRNA expression profile after cesarean delivery be a risk factor for autoimmune diseases?
Fatma Humeyra Yerlikaya,Duygu Eryavuz Onmaz,Huseyin Altunhan,Merve Ilhan,
doi : 10.1111/aji.13472
Volume 86, Issue 4 e13472
The cesarean section (CS) rate has increased significantly in North America, Western Europe, and Latin America. However, it has been reported that the incidence of inflammatory and autoimmune diseases such as asthma and type 1 diabetes increased in parallel with CS in these countries. Our aim was to investigate the expression level of miRNAs associated with inflammatory response and autoimmune diseases in colostrum samples and contribute to elucidating the role of CS in the pathogenesis of immune system–related diseases.
Antiphospholipid antibodies and pregnancy outcome of assisted reproductive treatment: A systematic review and meta-analysis
Rui Gao,Rujun Zeng,Pingying Qing,Cheng Meng,Kemin Cheng,Sirui Zhang,Hanxiao Chen,Xiaolei Jin,Lang Qin,Tao Li,
doi : 10.1111/aji.13470
Volume 86, Issue 4 e13470
Antiphospholipid antibodies (aPLs) are a group of autoantibodies associated with a variety of pregnancy complications, but the impact of aPL on the outcomes of assisted fertility treatment (ART) is controversial. This systematic review and meta-analysis were designed to explore the association between aPL and ART outcomes and to explore in which stages does aPL play a role.
Evaluation of paternal lymphocyte immunotherapy and potential biomarker mixed lymphocyte reaction-blocking factor in an Argentinian cohort of women with unexplained recurrent spontaneous abortion and unexplained infertility
Manoel Sarno,Carolina Carneiro,Marcelo Cavalcante,Ricardo Barini,
doi : 10.1111/aji.13456
Volume 86, Issue 4 e13456
