Enriqueta Vallejo-Yagüe, Edward C Keystone, Sreemanjari Kandhasamy, Raphael Micheroli, Axel Finckh, Andrea Michelle Burden
doi : 10.1136/annrheumdis-2021-220202
Annals of the Rheumatic Diseases 2021;80:961-964
Veerle Stouten, René Westhovens, Sofia Pazmino, Diederik De Cock, Kristien Van der Elst, Johan Joly, Delphine Bertrand, Patrick Verschueren
doi : 10.1136/annrheumdis-2020-219825
Annals of the Rheumatic Diseases 2021;80:965-973
To compare outcomes of different treatment schedules from the care in early rheumatoid arthritis (CareRA) trial over 5 years.
Xanthe Marijn Edmée Matthijssen, Fenne Wouters, Navkiran Sidhu, Ellis Niemantsverdriet, Annette van der Helm-van Mil
doi : 10.1136/annrheumdis-2020-219302
Annals of the Rheumatic Diseases 2021;80:974-980
Clinically evident tenosynovitis can be seen in established rheumatoid arthritis (RA). Imaging research has recently shown that tenosynovitis at small joints occurs in early RA, contributes to typical RA symptoms (including joint swelling) and is infrequent in healthy controls. Imaging-detectable tenosynovitis is often not recognisable at joint examination, hence its prevalence can therefore be underestimated. We hypothesised that if MRI-detectable tenosynovitis is a true RA feature, the sensitivity for RA is high, in both anti-citrullinated protein antibodies (ACPA)-positive and ACPA-negative RA, and lower in other diseases that are associated with enthesitis (such as spondyloarthritis (SpA) and psoriatic arthritis (PsA)). So far, no large MRI study addressed these questions.
Ho So, Isaac T Cheng, Sze-Lok Lau, Evelyn Chow, Tommy Lam, Vivian W Hung, Edmund K Li, James F Griffith, Vivian W Lee, Lin Shi, Junbin Huang, Kitty Yan Kwok, Cheuk-Wan Yim, Tena K Li, Vincent Lo, Jolie Lee, Jack Jock-Wai Lee, Ling Qin, Lai-Shan Tam
doi : 10.1136/annrheumdis-2021-219846
Annals of the Rheumatic Diseases 2021;80:981-988
To evaluate the effects of denosumab on erosion healing at 2–4 metacarpophalangeal (MCP) head as determined by high-resolution peripheral quantitative CT (HR-pQCT) in patients with rheumatoid arthritis (RA) with stable disease.
Karen H Costenbader, Michael DiIorio, Su H Chu, Jing Cui, Jeffrey A Sparks, Bing Lu, LauraKay Moss, Lindsay Kelmenson, Marie Feser, Jess Edison, Clary Clish, Jessica Lasky-Su, Kevin D Deane, Elizabeth W Karlson
doi : 10.1136/annrheumdis-2020-219682
Annals of the Rheumatic Diseases 2021;80:989-996
We sought to identify metabolic changes potentially related to rheumatoid arthritis (RA) pathogenesis occurring in the blood prior to its diagnosis.
Wenhui Xie, Hong Huang, Guangtao Li, Yanjie Hao, Yanni Gui, Yu Wang, Xuerong Deng, Juan Zhao, Yan Geng, LanLan Ji, Xiaohui Zhang, Zhibo Song, Zhuoli Zhang
doi : 10.1136/annrheumdis-2021-220112
Annals of the Rheumatic Diseases 2021;80:997-1003
To unravel the dynamical trajectory and features of glucocorticoids (GC) tapering and discontinuation in patients with rheumatoid arthritis (RA) commencing GC with concomitant conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).
Atul Deodhar, Paula Sliwinska-Stanczyk, Huji Xu, Xenofon Baraliakos, Lianne S Gensler, Dona Fleishaker, Lisy Wang, Joseph Wu, Sujatha Menon, Cunshan Wang, Oluwaseyi Dina, Lara Fallon, Keith S Kanik, Désirée van der Heijde
doi : 10.1136/annrheumdis-2020-219601
Annals of the Rheumatic Diseases 2021;80:1004-1013
To assess the efficacy/safety of tofacitinib in adult patients with active ankylosing spondylitis (AS).
James Cheng-Chung Wei, Tae-Hwan Kim, Mitsumasa Kishimoto, Naoki Ogusu, Haeyoun Jeong, Shigeto Kobayashi
doi : 10.1136/annrheumdis-2020-219406
Annals of the Rheumatic Diseases 2021;80:1014-1021
To investigate the efficacy and safety of brodalumab, a fully human anti-interleukin-17 receptor A monoclonal antibody, in patients with axial spondyloarthritis (axSpA).
Robert BM Landewé, Lianne S Gensler, Denis Poddubnyy, Proton Rahman, Maja Hojnik, Xiaoqi Li, Soyi Liu Leage, David Adams, Hilde Carlier, Filip Van den Bosch
doi : 10.1136/annrheumdis-2020-219717
Annals of the Rheumatic Diseases 2021;80:1022-1030
The objective of COAST-Y was to evaluate the effect of continuing versus withdrawing ixekizumab (IXE) in patients with axial spondyloarthritis (axSpA) who had achieved remission.
Hiroyuki Nakamura, Tsutomu Tanaka, Thomas Pranzatelli, Youngmi Ji, Hongen Yin, Paola Perez, Sandra A Afione, Shyh-Ing Jang, Corrine Goldsmith, Chang Yu Zheng, William D Swaim, Blake M Warner, Noriyuki Hirata, Masayuki Noguchi, Tatsuya Atsumi, John A Chiorini
doi : 10.1136/annrheumdis-2020-219649
Annals of the Rheumatic Diseases 2021;80:1031-1039
Sjögren’s syndrome (SS) is an autoimmune sialadenitis with unknown aetiology. Although extensive research implicated an abnormal immune response associated with lymphocytes, an initiating event mediated by salivary gland epithelial cell (SGEC) abnormalities causing activation is poorly characterised. Transcriptome studies have suggested alternations in lysosomal function are associated with SS, but a cause and effect linkage has not been established. In this study, we demonstrated that altered lysosome activity in SGECs by expression of lysosome-associated membrane protein 3 (LAMP3) can initiate an autoimmune response with autoantibody production and salivary dysfunction similar to SS.
Marialbert Acosta-Herrera, Martin Kerick, Elena Lopéz-Isac, Shervin Assassi, Lorenzo Beretta, Carmen Pilar Simeón-Aznar, Norberto Ortego-Centeno, International SSc Group, Susanna M Proudman, Australian Scleroderma Interest Group (ASIG), Nicolas Hunzelmann, Gianluca Moroncini, Jeska K de Vries-Bouwstra, Gisela Orozco, Anne Barton, Ariane L Herrick, Chikashi Terao, Yannick Allanore, Matthew A Brown, Timothy RDJ Radstake, Carmen Fonseca, Christopher P Denton, Maureen D Mayes, Javier Martin
doi : 10.1136/annrheumdis-2021-219884
Annals of the Rheumatic Diseases 2021;80:1040-1047
The greatest genetic effect reported for systemic sclerosis (SSc) lies in the major histocompatibility complex (MHC) locus. Leveraging the largest SSc genome-wide association study, we aimed to fine-map this region to identify novel human leucocyte antigen (HLA) genetic variants associated with SSc susceptibility and its main clinical and serological subtypes.
Christina Bergmann, Ludwig Hallenberger, Sara Chenguiti Fakhouri, Benita Merlevede, Amelie Brandt, Clara Dees, Honglin Zhu, Ariella Zehender, Xiang Zhou, Annemarie Schwab, Chih-Wei Chen, Andrea Hermina Györfi, Alexandru Emil Matei, Debomita Chakraborty, Thuong Trinh-Minh, Simon Rauber, Roland Coras, Aline Bozec, Alexander Kreuter, Mirjana Ziemer, Georg Schett, Jörg H W Distler
doi : 10.1136/annrheumdis-2020-219822
Annals of the Rheumatic Diseases 2021;80:1048-1056
X-linked inhibitor of apoptosis protein (XIAP) is a multifunctional protein with important functions in apoptosis, cellular differentiation and cytoskeletal organisation and is emerging as potential target for the treatment of various cancers. The aim of the current study was to investigate the role of XIAP in the pathogenesis of systemic sclerosis (SSc).
Naomi Tsuchida, Yosuke Kunishita, Yuri Uchiyama, Yohei Kirino, Makiko Enaka, Yukie Yamaguchi, Masataka Taguri, Shoji Yamanaka, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Satoshi Fujii, Hideaki Nakajima, Naomichi Matsumoto
doi : 10.1136/annrheumdis-2021-220089
Annals of the Rheumatic Diseases 2021;80:1057-1061
To determine clinical and genetic features of individuals with relapsing polychondritis (RP) likely caused by pathogenic somatic variants in ubiquitin-like modifier activating enzyme 1 (UBA1).
Felix Eckstein, Marc C Hochberg, Hans Guehring, Flavie Moreau, Victor Ona, Asger Reinstrup Bihlet, Inger Byrjalsen, Jeppe Ragnar Andersen, Benjamin Daelken, Oliver Guenther, Christoph Ladel, Martin Michaelis, Philip G Conaghan
doi : 10.1136/annrheumdis-2020-219181
Annals of the Rheumatic Diseases 2021;80:1062-1069
The FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administration of Repeated Doses) trial assessed efficacy and safety of the potential disease-modifying osteoarthritis drug (DMOAD) sprifermin in patients with knee osteoarthritis. Here, we report 5-year efficacy and safety results.
Julia Steinberg, Lorraine Southam, Andreas Fontalis, Matthew J Clark, Raveen L Jayasuriya, Diane Swift, Karan M Shah, Roger A Brooks, Andrew W McCaskie, Jeremy Mark Wilkinson, Eleftheria Zeggini
doi : 10.1136/annrheumdis-2020-219760
Annals of the Rheumatic Diseases 2021;80:1070-1074
To determine how gene expression profiles in osteoarthritis joint tissues relate to patient phenotypes and whether molecular subtypes can be reproducibly captured by a molecular classification algorithm.
Emma Garcia-Melchor, Giacomo Cafaro, Lucy MacDonald, Lindsay A N Crowe, Shatakshi Sood, Michael McLean, Umberto G Fazzi, Iain B McInnes, Moeed Akbar, Neal L Millar
doi : 10.1136/annrheumdis-2020-219335
Annals of the Rheumatic Diseases 2021;80:1075-1085
Increasing evidence suggests that inflammatory mechanisms play a key role in chronic tendon disease. After observing T cell signatures in human tendinopathy, we explored the interaction between T cells and tendon stromal cells or tenocytes to define their functional contribution to tissue remodelling and inflammation amplification and hence disease perpetuation.
Hannah Bower, Thomas Frisell, Daniela Di Giuseppe, Bénédicte Delcoigne, Gerd-Marie Ahlenius, Eva Baecklund, Katerina Chatzidionysiou, Nils Feltelius, Helena Forsblad-d'Elia, Alf Kastbom, Lars Klareskog, Elisabet Lindqvist, Ulf Lindström, Carl Turesson, Christopher Sjöwall, Johan Askling
doi : 10.1136/annrheumdis-2021-219845
Annals of the Rheumatic Diseases 2021;80:1086-1093
To estimate absolute and relative risks for all-cause mortality and for severe COVID-19 in inflammatory joint diseases (IJDs) and with antirheumatic therapies.
Huixin Wang, Sarah Stewart, Ben Darlow, Ben Horgan, Graham Hosie, Jane Clark, Nicola Dalbeth
doi : 10.1136/annrheumdis-2021-220138
Annals of the Rheumatic Diseases 2021;80:1095-1096
Veerle F A M Derksen, Theresa Kissel, Femke B G Lamers-Karnebeek, Arie E van der Bijl, Annemarie C Venhuizen, Tom W J Huizinga, René E M Toes, Anna H E Roukens, Diane van der Woude
doi : 10.1136/annrheumdis-2021-219859
Annals of the Rheumatic Diseases 2021;80:1096-1098
Brian J Boyarsky, Jake A Ruddy, Caoilfhionn M Connolly, Michael T Ou, William A Werbel, Jacqueline M Garonzik-Wang, Dorry L Segev, Julie J Paik
doi : 10.1136/annrheumdis-2021-220289
Annals of the Rheumatic Diseases 2021;80:1098-1099
Caoilfhionn M Connolly, Jake A Ruddy, Brian J Boyarsky, Robin K Avery, William A Werbel, Dorry L Segev, Jacqueline Garonzik-Wang, Julie J Paik
doi : 10.1136/annrheumdis-2021-220231
Annals of the Rheumatic Diseases 2021;80:1100-1101
Arthur Mageau, Geoffrey Aldebert, Damien Van Gysel, Thomas Papo, Jean-François Timsit, Karim Sacre
doi : 10.1136/annrheumdis-2021-220010
Annals of the Rheumatic Diseases 2021;80:1101-1102
Marcia A Friedman, Kevin L Winthrop
doi : 10.1136/annrheumdis-2021-220088
Annals of the Rheumatic Diseases 2021;80:1102-1104
Florence Assan, Raphaele Seror, Xavier Mariette, Gaetane Nocturne
doi : 10.1136/annrheumdis-2019-216222
Annals of the Rheumatic Diseases 2021;80:e122
Martin Aringer, Karen Costenbader, Thomas Dörner, Sindhu R Johnson
doi : 10.1136/annrheumdis-2019-216250
Annals of the Rheumatic Diseases 2021;80:e123
David S Pisetsky1,2, Diane M Spencer1,2, Brad Rovin3, Peter E Lipsky
doi : 10.1136/annrheumdis-2019-216259
Annals of the Rheumatic Diseases 2021;80:e124
Martin Aringer, Karen H Costenbader, Thomas Dörner, Sindhu R Johnson
doi : 10.1136/annrheumdis-2019-216337
Annals of the Rheumatic Diseases 2021;80:e125
Huihui Chi, Jialin Teng, Zhihong Wang, Chengde Yang, Yutong Su
doi : 10.1136/annrheumdis-2019-216253
Annals of the Rheumatic Diseases 2021;80:e126
Martin Aringer, Karen H Costenbader, Thomas Dörner, Sindhu R Johnson
doi : 10.1136/annrheumdis-2019-216338
Annals of the Rheumatic Diseases 2021;80:e127
Jean-Baptiste Vulsteke, Lieve Van Hoovels, Philippe Willems, Bert Vander Cruyssen, Steven Vanderschueren, Rene Westhovens, Daniel Blockmans, Ellen De Langhe, Xavier Bossuyt
doi : 10.1136/annrheumdis-2019-216245
Annals of the Rheumatic Diseases 2021;80:e128
Jan Damoiseaux, Luís Eduardo Coelho Andrade, Marvin J Fritzler, Manfred Herold, Maria Infantino, Carlos von Muhlen
doi : 10.1136/annrheumdis-2019-216266
Annals of the Rheumatic Diseases 2021;80:e129
Sheng-Xiao Zhang, Jia Wang, He-Hua Sun, Jia-Qian Zhang, Guang-Ying Liu, Jing Luo, Pei-Feng He, Xiao-Feng Li
doi : 10.1136/annrheumdis-2019-216246
Annals of the Rheumatic Diseases 2021;80:e130
David Klatzmann
doi : 10.1136/annrheumdis-2019-216267
Annals of the Rheumatic Diseases 2021;80:e131
Michael Mahler, Jean-Baptiste Vulsteke, Xavier Bossuyt, Ellen De Langhe, Minoru Satoh
doi : 10.1136/annrheumdis-2019-216003
Annals of the Rheumatic Diseases 2021;80:e132
Jean Jacques Dubost, Bruno Pereira, Angelique Fan, Martin Soubrier
doi : 10.1136/annrheumdis-2019-216050
Annals of the Rheumatic Diseases 2021;80:e133
Kuan-Fu Liao, Yu-Hung Kuo, Shih-Wei Lai
doi : 10.1136/annrheumdis-2019-216221
Annals of the Rheumatic Diseases 2021;80:e134
Sylvain Mathieu, Martin Soubrier
doi : 10.1136/annrheumdis-2019-216249
Annals of the Rheumatic Diseases 2021;80:e135
Shih-Wei Lai
doi : 10.1136/annrheumdis-2019-215854
Annals of the Rheumatic Diseases 2021;80:e136
Shih-Wei Lai, Yu-Hung Kuo, Kuan-Fu Liao
doi : 10.1136/annrheumdis-2019-216146
Annals of the Rheumatic Diseases 2021;80:e137
Nupoor Acharya, Arghya Chattopadhyay, Varun Dhir
doi : 10.1136/annrheumdis-2019-216236
Annals of the Rheumatic Diseases 2021;80:e138
doi : 10.1136/annrheumdis-2017-211351ret
Annals of the Rheumatic Diseases 2021;80:e139
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