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Parental experience of the neuromotor development of children with congenital heart disease: an exploratory qualitative study
Elena Mitteregger, Martina Wehrli, Manuela Theiler, Jana Logoteta, Irina Nast, Brigitte Seliner & Beatrice Latal
doi : 10.1186/s12887-021-02808-8
BMC Pediatrics volume 21, Article number: 430 (2021)
Children with severe congenital heart disease (CHD) are a group of children at risk for neurodevelopmental impairments. Motor development is the first domain to show a delay during the first year of life and may significantly contribute to parental concerns, stress, and difficulties in early child-parent attachment. Thus, the aim of the study was to better understand the wishes and concerns of parents of children with CHD and explore their experience of their children’s neuromotor development in the first year of life.
“The balloon was just the kick start, I had to do the rest myself”: Adolescents living with severe obesity experiences of an intra-gastric balloon alongside a lifestyle support programme
Lindsey J. Reece, Paul Bissell, Pooja Sachdev, Neil Wright, Seema Mihrshahi & Robert J. Copeland
doi : 10.1186/s12887-021-02902-x
BMC Pediatrics volume 21, Article number: 431 (2021)
Few treatments exist for adolescents living with severe obesity. This qualitative study explored the experiences of severely obese adolescents and their families who participated in the BOB study.
Hypovitaminosis D and risk factors in pediatric epilepsy children
Napakjira Likasitthananon, Charcrin Nabangchang, Thitiwan Simasathien, Suchavadee Vichutavate, Voraluck Phatarakijnirund & Piradee Suwanpakdee
doi : 10.1186/s12887-021-02906-7
BMC Pediatrics volume 21, Article number: 432 (2021)
Anti-seizure medication (ASM) treatment is one of the significant risk factors associated with abnormal vitamin D status in epilepsy patients. Multiple studies have shown that adult epilepsy patients can exhibit vitamin D deficiency. However, there are few reports investigating pediatric epilepsy patients. In this study, we aimed to identify risk factors related to hypovitaminosis D in pediatric epilepsy patients in Thailand.
Time to death and its associated factors among infants in sub-Saharan Africa using the recent demographic and health surveys: shared frailty survival analysis
Sofonyas Abebaw Tiruneh, Ejigu Gebeye Zeleke & Yaregal Animut
doi : 10.1186/s12887-021-02895-7
BMC Pediatrics volume 21, Article number: 433 (2021)
Globally, approximately 4.1 million infants died, accounting for 75% of all under-five deaths. In sub-Saharan Africa (SSA), infant mortality was 52.7/1000 live births in 2018 This study aimed to assess the pooled estimate of infant mortality rate (IMR), time to death, and its associated factors in SSA using the recent demographic and health survey dataset between 2010 and 2018.
Effective nutrition governance is correlated with better nutrition outcomes in Nepal
Grace Namirembe, Robin Shrestha, Julieta Mezzano, Lynne M. Ausman, Dale Davis, Kedar Baral, Shibani Ghosh, Gerald Shively & Patrick Webb
doi : 10.1186/s12887-021-02898-4
BMC Pediatrics volume 21, Article number: 434 (2021)
The public health burden of undernutrition remains heavy and widespread, especially in low-income countries like Nepal. While predictors of undernutrition are well documented, few studies have examined the effects of political will and quality of policy or program implementation on child growth.
Stapled versus hand-sewn intestinal anastomosis in pediatric patients: a systematic review and meta-analysis
Takayuki Fujii, Aya Tanaka, Hiroto Katami & Ryuichi Shimono
doi : 10.1186/s12887-021-02915-6
BMC Pediatrics volume 21, Article number: 435 (2021)
The safety and feasibility of stapled intestinal anastomosis have been widely reported in adults. However, the efficacy of stapled anastomosis (SA) in children is unclear. The aim of this study was to perform a systematic review and meta-analysis to evaluate the safety and effectiveness of SA compared with hand-sewn anastomosis (HA) in pediatric patients.
Correction to: Prevention of unintentional injuries in children under five years
Sophie Jullien
doi : 10.1186/s12887-021-02908-5
BMC Pediatrics volume 21, Article number: 436 (2021)
Ileal Dieulafoy lesion arose 15?years after partial small bowel resection for meconium obstruction of the neonate: a case report
Maho Iwamoto, Tsugumichi Koshinaga, Eri Fujita, Manabu Hanada, Shuichiro Uehara & Mitsuhiko Moriyama
doi : 10.1186/s12887-021-02914-7
BMC Pediatrics volume 21, Article number: 437 (2021)
Anastomotic or perianastomotic ulcers present with symptoms such as chronic anaemia and occult bleeding as long-term complications of bowel resection performed in infancy.
Reminder system for health screening in early childhood – an analysis regarding different social circumstances
Simone Weyers, Annika Höhmann, Simon Götz & Katharina Kreffter
doi : 10.1186/s12887-021-02917-4
BMC Pediatrics volume 21, Article number: 438 (2021)
Children with a low socio-economic position (SEP) participate in prevention and health examinations less often. In order to increase participation, reminder systems have been implemented in Germany since 2009. The aim of the study is to investigate whether this implementation is associated with an increased participation in health examination in early childhood for children in disadvantaged social circumstances.
The shadow challenges to improve the state essential newborn care practices in healthcare providers: evidence from a multicentre cross-sectional study in Ethiopia
Ermias Sisay Chanie, Amare Kassaw, Melkamu Senbeta, Fisha Alebel GebreEyesus, Aragaw Tesfaw, Abenezer Melkie, Tekalign Amera Birlie, Biruk Demissie, Demeke Mesfin Belay, Demewoze Kefale Mekone, Biniam Minuye Birhan & Wubet Alebachew Bayih
doi : 10.1186/s12887-021-02903-w
BMC Pediatrics volume 21, Article number: 439 (2021)
Neonatal mortality can be reduced by providing essential newborn care. However, it is overlooked by most healthcare providers in Ethiopia. Hence, this study aims to examine immediate essential newborn care practices and associated factors among healthcare providers in Ethiopia.
Diffusion tensor imaging based multiparametric characterization of renal lesions in infants with urinary tract infections: an explorative study
Yvonne Simrén, Eira Stokland, Sverker Hansson, Hanna Hebelka, Par-Arne Svensson & Kerstin M. Lagerstrand
doi : 10.1186/s12887-021-02769-y
BMC Pediatrics volume 21, Article number: 440 (2021)
Conventional diffusion weighted imaging (DWI) is a promising non-invasive tool in the evaluation of infants with symptomatic urinary tract infections (UTI). The use of multiparametric diffusion tensor imaging (DTI) provides further information on renal pathology by reflecting renal microstructure. However, its potential to characterize and distinguish between renal lesions, such as acute pyelonephritic lesions, permanent renal damages or dysplastic changes has not been shown. This study aimed to evaluate the potential of multiparametric DTI for characterization of renal lesions with purpose to distinguish acute pyelonephritis from other renal lesions in young infants with their first UTI.
Duplex kidney complicated with preoperative inferior nephroblastoma rupture in children: a case report and literature review
Yongxiang Zhao, Haiyan Cheng, Hongcheng Song, Ruimin Zhang, Xiangming Wu, Haowei Li, Jun Wang, Huanmin Wang & Chunmei Jia
doi : 10.1186/s12887-021-02919-2
BMC Pediatrics volume 21, Article number: 441 (2021)
We admitted a child with a duplex kidney combined with preoperative rupture of nephroblastoma and used this case to discuss the clinical features and treatment of this disease.
Component of oligomeric Golgi complex 1 deficiency leads to hypoglycemia: a case report and literature review
Yizhou Huang, Han Dai, Gangyi Yang, Lili Zhang, Shiyao Xue & Min Zhu
doi : 10.1186/s12887-021-02922-7
BMC Pediatrics volume 21, Article number: 442 (2021)
Congenital disorders of glycosylation (CDG) are a group of metabolic diseases with clinical and genetic heterogeneity, and CDG-IIg is one of the rare reported types of CDG. The aim of this study is to report the clinical manifestations and gene-phenotype characteristics of a rare case of CDG caused by a COG1 gene mutation and review literatures of CDG disease.
Cultural variation in factors associated with sudden infant death during sleep
Young Mee Ahn, Kyung-moo Yang, Hong Il Ha & Jung Ae Cho
doi : 10.1186/s12887-021-02894-8
BMC Pediatrics volume 21, Article number: 443 (2021)
Despite the significant reduction decades ago in sudden unexpected death in infancy (SUDI), decline of rates has slowed and stalled in some countries, including the USA. This led to an appreciation of ethnic variations in SUDI rates and the need to increase cultural sensitivity regarding sleep practices and circumstantial factors of SUDI. The study explored SUDI-related factors, in journal articles from two geo-cultural regions (Asian and Western countries), particularly for factors related to infant sleep practices.
Associations between body composition and fundamental motor skill competency in children
E. Kipling Webster, Indica Sur, Alicia Stevens & Leah E. Robinson
doi : 10.1186/s12887-021-02912-9
BMC Pediatrics volume 21, Article number: 444 (2021)
Evidence supports an inverse relationship between weight status and motor competence, but most work utilizes body mass index as the proxy for weight status. Body mass index fails to account for essential components of body composition, which may be critical for motor performance. The purpose of this investigation was to examine the relationship between fundamental motor skills competency and body composition (i.e., fat mass, fat percentage, and fatfree mass) as measured by bio-electrical impedance analysis and body mass index in children.
Study protocol: childhood outcomes of fetal genomic variants: the PrenatAL Microarray (PALM) cohort study
Lisa Hui, Cecilia Pynaker, Joanne Kennedy, Sharon Lewis, David J. Amor, Susan P. Walker & Jane Halliday On behalf of the PALM cohort study group
doi : 10.1186/s12887-021-02809-7
BMC Pediatrics volume 21, Article number: 447 (2021)
The implementation of genomic testing in pregnancy means that couples have access to more information about their child’s genetic make-up before birth than ever before. One of the resulting challenges is the management of genetic variations with unclear clinical significance. This population-based study will help to close this critical knowledge gap through a multidisciplinary cohort study of children with and without genomic copy number variants (CNVs) diagnosed before birth. By comparing children with prenatally-ascertained CNVs to children without a CNV, we aim to (1) examine their developmental, social-emotional and health status; (2) measure the impact of prenatal diagnosis of a CNV on maternal perceptions of child health, behavior and development; and (3) determine the proportion of prenatally-ascertained CNVs of unknown or uncertain significance that are reclassified as benign or pathogenic after 2 or more years.
Neuroimaging findings of posterior reversible encephalopathy syndrome (PRES) following haematopoietic stem cell transplantation in paediatric recipients
Ali Önder Atça, Berrin Erok & Selime Aydo?du
doi : 10.1186/s12887-021-02890-y
BMC Pediatrics volume 21, Article number: 445 (2021)
Haematopoietic stem cell transplantation (HSCT) is used worldwide in various malignant and nonmalignant childhood diseases, including haematologic, genetic, autoimmune and metabolic disorders, and is the only curative treatment for many of these illnesses. The survival rates of many childhood diseases have been increased due to HSCT treatment. However, associated complications are still important for management. Central nervous system (CNS) complications in paediatric HSCT recipients can be associated with high morbidity and significantly contribute to mortality. Posterior reversible encephalopathy syndrome (PRES) is one of the most common CNS complications in patients with neurological symptoms following HSCT. Magnetic resonance imaging (MRI) is the modality of choice and shows typical bilateral vasogenic oedema at the posterior parts of the cerebral hemispheres; however, various atypical imaging manifestations can also occur. In this study, we retrospectively examined CNS complications in our paediatric HSCT recipients with a focus on the typical and atypical neuroimaging manifestations of PRES following HSCT.
Estimating trunk fat in children according to sex using basic somatic readings: an opportunity for improving evaluation among girls
Manuel Moya & Virginia Pérez-Fernandez
doi : 10.1186/s12887-021-02918-3
BMC Pediatrics volume 21, Article number: 446 (2021)
The fat mass estimators waist-to-height ratio (WHtR) and relative fat mass—pediatric (RFMp) complement the widely accepted body mass index (BMI) in obesity evaluation. Aims of the Study: Conduct an easy appraisal of trunk fat and the cardiometabolic risk associated with pediatric obesity.
Conjunctival granulomatous capillary haemangioma in children: case report and review of the literature
Caiping Shi, Yanhong Ren, Jia Feng, Weizhong Guo & Xiaoyu Zheng
doi : 10.1186/s12887-021-02924-5
BMC Pediatrics volume 21, Article number: 448 (2021)
Granulomatous capillary haemangioma refers to a benign vascular tumour that commonly affects the skin, with occasional involvement of the mucosa. Reports of conjunctival granulomatous capillary haemangioma in children are uncommon. In this article, we present a case of granulomatous capillary haemangioma and a brief review of the relevant literature.
Chylomicron retention disease caused by a new pathogenic variant in sar1b protein: a rare case report from Syria
Leen Jamel Doya, Lava Mohammad, Razan Omran, Alexander Ali Ibrahim, Nizar Yousef, Ali Ibrahim & Mohammad Adib Houreih
doi : 10.1186/s12887-021-02897-5
BMC Pediatrics volume 21, Article number: 449 (2021)
Chylomicron retention disease (Anderson disease) is a result for variant of the SAR1B gene. It is a rare autosomal recessive hereditary disorder with most incidence in infant. It is characterized by lipid malabsorption syndrome with fatty, chronic diarrhea, and growth retardation.
Traditional Mongolian swaddling and developmental dysplasia of the hip: a randomized controlled trial
Munkhtulga Ulziibat, Bayalag Munkhuu, Ariun-Erdene Bataa, Raoul Schmid, Thomas Baumann & Stefan Essig
doi : 10.1186/s12887-021-02910-x
BMC Pediatrics volume 21, Article number: 450 (2021)
Mongolian traditional swaddling of infants, where arms and legs are extended with a tight wrapping and hips are in adduction position, may lead to abnormal maturation and formation of the hip joint; and is a contributing factor for developmental dysplasia of the hip (DDH). This hypothesis was tested in this randomized controlled trial.
Changes in the availability of medical oxygen and its clinical practice in Ethiopia during a national scale-up program: a time series design from thirty-two public hospitals
Habtamu Seyoum Tolla, Yigeremu Abebe Asemere, Alebel Yaregal Desale, Dinkineh Bikila Woyessa, Zinabie Feleke Fekadu, Alemayehu Berhanu Belete, Audrey Battu & Felix Lam
doi : 10.1186/s12887-021-02844-4
BMC Pediatrics volume 21, Article number: 451 (2021)
Oxygen therapy is a lifesaving treatment, however, in Ethiopia, oxygen is not readily available in many healthcare facilities. In 2015, the Federal Ministry of Health launched a national roadmap to increase access to oxygen. This study aims to evaluate whether availability of oxygen and its clinical practice in public hospitals of Ethiopia changed during the time the roadmap was being implemented.
Pregnancy and Infant Development (PRIDE)—a preliminary observational study of maternal adversity and infant development
Katherine Bowers, Lili Ding, Kimberly Yolton, Hong Ji, Nichole Nidey, Jerrold Meyer, Robert T. Ammerman, Judith Van Ginkel & Alonzo Folger
doi : 10.1186/s12887-021-02801-1
BMC Pediatrics volume 21, Article number: 452 (2021)
Children from socioeconomically disadvantaged families have a markedly elevated risk for impaired cognitive and social-emotional development. Children in poverty experience have a high risk for developmental delays. Poverty engenders disproportionate exposure to psychological adversity which may contribute to impaired offspring development; however the effect may be mitigated by social support and other aspects of resilience. Our objective was to determine the association between maternal stress, adversity and social support and early infant neurobehavior and child behavior at two and three years.
Severe protein C deficiency in a newborn caused by a homozygous pathogenic variant in the PROC gene: a case report
Uisook Song, Young Hye Ryu, Kiteak Hong, So-Yeon Shim, Seongyeol Park, Jeong Seok Lee, Young Seok Ju, Seung Han Shin & Soyoung Lee
doi : 10.1186/s12887-021-02923-6
BMC Pediatrics volume 21, Article number: 453 (2021)
Severe protein C deficiency is a rare and inherited cause of thrombophilia in neonates. Protein C acts as an anticoagulant, and its deficiency results in vascular thrombosis. Herein, we report a case of protein C deficiency with a homozygous pathogenic variant in a term neonate, with good outcomes after proper treatment.
Lipid enemas for meconium evacuation in preterm infants – a retrospective cohort study
Maximilian Gross & Christian F. Poets
doi : 10.1186/s12887-021-02905-8
BMC Pediatrics volume 21, Article number: 454 (2021)
Enemas are used in preterm infants to promote meconium evacuation, but frequent high-volume enemas might contribute to focal intestinal perforation (FIP). To replace a regime consisting of frequent enemas of varying volume and composition, we implemented a once-daily, low-volume lipid enema (LE) regimen. We investigated its impact on meconium evacuation, enteral nutrition, and gastrointestinal complications in preterm infants.
Association between parental divorce and mental health outcomes among Lebanese adolescents: results of a national study
Sahar Obeid, Gloria Al Karaki, Chadia Haddad, Hala Sacre, Michel Soufia, Rabih Hallit, Pascale Salameh & Souheil Hallit
doi : 10.1186/s12887-021-02926-3
BMC Pediatrics volume 21, Article number: 455 (2021)
In Lebanon, divorce rates have jumped from nearly 7000 in recent years to 8580 in 2017, an increase of 22.5%, with North Lebanon recording the highest number, followed by Beirut, likely resulting in increased behavioral problems in the offspring of divorced parents. Furthermore, one out of two Lebanese adolescents whose biological parents were divorced, separated, or deceased has a psychiatric disorder. More information regarding the impact of divorce on the mental health of Lebanese adolescents is still missing. The objective of this study was to explore the association between divorce and mental health outcomes, particularly depression, anxiety, and suicidal ideation among Lebanese adolescents.
Chronic pain among children with cerebral palsy attending a Ugandan tertiary hospital: a cross-sectional study
Emma Nsalazi Bambi, Angelina Kakooza Mwesige, Hervé Monka Lekuya, Philip Kasirye & Richard Idro
doi : 10.1186/s12887-021-02928-1
BMC Pediatrics volume 21, Article number: 456 (2021)
Children with cerebral palsy (CP) frequently experience chronic pain. The burden and severity of such pain is often underestimated in relation to their other impairments. Recognition and awareness of this chronic pain among children with CP constitute the cornerstone for caretakers and clinicians to improve the quality of life of those children. This study aimed to determine the prevalence of chronic pain among children with CP, and the factors associated.
Retrospective comparison of death or neurodevelopmental outcomes in extremely low birth weight preterm infants following different management options of haemodynamically significant patent ductus arteriosus
Jania Jia-Ying Wu, Krishnamoorthy Niduvaje, Le ye Lee & Zubair Amin
doi : 10.1186/s12887-021-02920-9
BMC Pediatrics volume 21, Article number: 457 (2021)
Optimal management of haemodynamically significant patent ductus arteriosus (HsPDA) in premature babies remains controversial. Our aim is to compare death and/or adverse neurodevelopmental outcomes in extremely low birth weight (ELBW) infants with HsPDA who were managed with conservative [C], medical [M] and/or surgical [S] treatment, with secondary aim to examine short-term morbidities among [S] and [C] groups. The study also compared outcomes in very low birth weight (VLBW) infants with HsPDA and non-HsPDA.
Diagnostic value of monocyte chemoattractant Protein-1, soluble mannose receptor, Presepsin, and Procalcitonin in critically ill children admitted with suspected sepsis
Noha A. Hassuna, Ebtesam Elgezawy, Suzan O. Mousa, Reem A. AbdelAziz, Reham A. Ibrahem, Wafaa Yousif Abdel Wahed, Khalid A. Nasif & Enas M. Hefzy
doi : 10.1186/s12887-021-02930-7
BMC Pediatrics volume 21, Article number: 458 (2021)
The differentiation between systemic inflammatory response syndrome and sepsis is very important as it determines essential treatment decisions, such as selection, initiation, and duration of antibiotic therapy.
Relationship between the more-affected upper limb function and daily activity performance in children with cerebral palsy: a cross-sectional study
Hyerin Park, Ja Young Choi, Sook-hee Yi, Eun Sook Park, Dain Shim, Tae Young Choi & Dong-wook Rha
doi : 10.1186/s12887-021-02927-2
BMC Pediatrics volume 21, Article number: 459 (2021)
There are differences in roles between the more-affected and less-affected upper limb of children with cerebral palsy (CP). However, there is a lack of studies of the relationship between the more-affected limb function and activities of daily living (ADL) in children with CP. Thus, the aim of this prospective cross-sectional study was to investigate the relationship between more-affected upper limb function and ADL in children with CP.
Prenatal prognostic factors for isolated right congenital diaphragmatic hernia: a single center’s experience
Jiyoon Jeong, Byong Sop Lee, Teahyen Cha, Euiseok Jung, Ellen Ai-Rhan Kim, Ki-Soo Kim, Dae Yeon Kim, Jung-Man Namgoong, Seong Chul Kim, Mi-Young Lee & Hye-Sung Won
doi : 10.1186/s12887-021-02931-6
BMC Pediatrics volume 21, Article number: 460 (2021)
Right-sided congenital diaphragmatic hernia (RCDH) is relatively rare compared with left-sided congenital diaphragmatic hernia (LCDH). Clinical data of RCDH, especially with respect to antenatal prediction of neonatal outcome, are lacking. The aim of this study was to report the treatment outcomes of patients with antenatally diagnosed RCDH and to evaluate the predictability of observed-to-expected lung area-to-head circumference ratio (O/E LHR) for perinatal outcomes, focused on mortality or extracorporeal membrane oxygenation (ECMO) requirement.
The salutary effect of peritoneal dialysis catheters on enhanced recovery among high-risk pediatric patients undergoing the left coronary transfer procedure: a cohort study
Chunrong Wang, Yuefu Wang, Fuxia Yan, Peng Fu, Jun Li, Lijing Yang, Sheng Shi, Jianhui Wang, Yuchen Gao, Sudena Wang & Yu Tian
doi : 10.1186/s12887-021-02913-8
BMC Pediatrics volume 21, Article number: 461 (2021)
Evidence for peritoneal dialysis catheter (PDC) usage in pediatric patients undergoing surgery for deteriorating cardiac dysfunction is lacking. This investigation explored factors associated with PDC usage and its effectiveness in children with anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA).
Screening for post-traumatic stress disorder among adolescents following floods- a comparative study from private and public schools in Kerala, India
Geethu Mathew, Aby Dany Varghese, Ans Mary Sabu & Aleena Joseph
doi : 10.1186/s12887-021-02933-4
BMC Pediatrics volume 21, Article number: 462 (2021)
Disasters can have deep physical and psychological impact among survivors. An extraordinary southwest monsoon has unleashed floods and landslides in Kerala state in 2018. Adolescents are more vulnerable to psychological impairment after a disaster and trauma during initial stages of life can etch an indelible signature in the individual’s development and may lead to future disorders.
Clinical features and prognosis of paediatric rhabdomyosarcoma with bone marrow metastasis: a single Centre experiences in China
Cheng Huang, Binglin Jian, Yan Su, Na Xu, Tong Yu, Lejian He, Xue Zhang, Yi Liu, Mei Jin & Xiaoli Ma
doi : 10.1186/s12887-021-02904-9
BMC Pediatrics volume 21, Article number: 463 (2021)
The aim of this study was to summarize the clinical characteristics, therapeutic effects and prognosis of patients with rhabdomyosarcoma (RMS) and bone marrow metastasis, improve the understanding of this disease.
Health risk behaviours among adolescents in Argentina: trends between 2007, 2012 and 2018 national cross-sectional school surveys
Karl Peltzer & Supa Pengpid
doi : 10.1186/s12887-021-02929-0
BMC Pediatrics volume 21, Article number: 464 (2021)
The aim of this study was to assess trends of various health risk behaviours among adolescents across three different surveys in Argentina.
Social and environmental risk factors for unintentional suffocation among infants in China: a descriptive analysis
Xue Yu, Lei Miao, Jun Zhu, Juan Liang, Li Dai, Xiaohong Li, Qi Li, Rui Rao, Chunhua Yuan, Yanping Wang, Chunhua He & Leni Kang
doi : 10.1186/s12887-021-02925-4
BMC Pediatrics volume 21, Article number: 465 (2021)
This retrospective study aimed to determine the epidemiological features of deaths caused by unintentional suffocation among infants in China.
Preemptive analgesic effectiveness of single dose intravenous ibuprofen in infants undergoing cleft palate repair: a randomized controlled trial
Zhe Zhe Peng, Yan Ting Wang, Ma Zhong Zhang, Ji Jian Zheng, Jie Hu, Wan Ru Zhou & Ying Sun
doi : 10.1186/s12887-021-02907-6
BMC Pediatrics volume 21, Article number: 466 (2021)
Correction surgery for cleft palate is recommended between 9 and 18?months of age. Patients suffer from acute pain after palatoplasty. Clinicians are hesitant to use opioids for analgesia concerning the potential high risk of respiratory adverse events. Intravenous ibuprofen perhaps be a suitable adjuvant to pain relief. We try to assess whether preoperative administration of intravenous ibuprofen can decrease opioid requirements following cleft palate repair in infants.
A systematic scoping review of early interventions for parents of deaf infants
B. Wright, R. Hargate, M. Garside, G. Carr, T. Wakefield, R. Swanwick, I. Noon & P. Simpson
doi : 10.1186/s12887-021-02893-9
BMC Pediatrics volume 21, Article number: 467 (2021)
Over 90% of the 50,000 deaf children in the UK have hearing parents, many of whom were not expecting a deaf child and may require specialist support. Deaf children can experience poorer long-term outcomes than hearing children across a range of domains. After early detection by the Universal Newborn Hearing Screening Programme, parents in the UK receive support from Qualified Teachers of the Deaf and audiologists but resources are tight and intervention support can vary by locality. There are challenges faced due to a lack of clarity around what specific parenting support interventions are most helpful.
The effect of zinc deficiency and iron overload on endocrine and exocrine pancreatic function in children with transfusion-dependent thalassemia: a cross-sectional study
Suzan O. Mousa, Ebtihal M. Abd Alsamia, Hend M. Moness & Osama G. Mohamed
doi : 10.1186/s12887-021-02940-5
BMC Pediatrics volume 21, Article number: 468 (2021)
Children with transfusion-dependent thalassemia (TDT) suffer from secondary hemosiderosis and the delirious effects this iron overload has on their different body organs, including the pancreas. They are also more prone to develop zinc deficiency than the general pediatric population. This study aimed to determine the effect of zinc deficiency and iron overload on the endocrine and exocrine pancreas in TDT children.
Langerhans cell histiocytosis misdiagnosed as cow protein allergy: a case report
Xintong Lv, Libo Wang, Zhuang Pi & Chunyan Zhang
doi : 10.1186/s12887-021-02921-8
BMC Pediatrics volume 21, Article number: 469 (2021)
Langerhans cell histiocytosis (LCH) is a heterogeneous disease with diverse clinical manifestations. Abdominal organ involvement is rare. Early diagnosis and active treatment are needed. The purpose of this article is to enable readers to have a better knowledge of LCH and prevent misdiagnosis.
A cluster of children with facial nerve palsy in a high prevalence area for COVID-19
David Barron, Owen Richards, Fleur Archer, Mohamed Abdelrazek, Rajesh Ranjan & Omotakin Omolokun
doi : 10.1186/s12887-021-02831-9
BMC Pediatrics volume 21, Article number: 470 (2021)
COVID-19 is a disease of varying presentation and neurological sequelae of the disease are being studied. Following a cluster of paediatric facial nerve palsy (FNP) cases in an area of South Wales with a high prevalence of COVID-19, we conducted an opportunistic study to determine whether there has been an increase of incidence of FNP and if there is an association between the FNP and COVID-19 in children.
Factors associated with mortality of pediatric sepsis patients at the pediatric intensive care unit in a low-resource setting
Desy Rusmawatiningtyas, Arini Rahmawati, Firdian Makrufardi, Nurul Mardhiah, Indah Kartika Murni, Cuno S. P. M. Uiterwaal, Ary I. Savitri, Intan Fatah Kumara & Nurnaningsih
doi : 10.1186/s12887-021-02945-0
BMC Pediatrics volume 21, Article number: 471 (2021)
Sepsis is the leading cause of death worldwide in pediatric populations. Studies in low-resource settings showed that the majority of pediatric patients with sepsis still have a high mortality rate.
Evaluation of problematic screen exposure in pre-schoolers using a unique tool called “seven-in-seven screen exposure questionnaire”: cross-sectional study
S. Songül Yalçin, Özlem Tezol, Nilgün Çaylan, Meryem Erat Nergiz, Deniz Yildiz, ?eyma Çiçek & Ay?e Oflu
doi : 10.1186/s12887-021-02939-y
BMC Pediatrics volume 21, Article number: 472 (2021)
Screen media exposure has been increasing in the preschool years. Risky aspects of screen exposure have many potential negative effects on children’s health. We aimed to evaluate problematic screen exposure in Turkish preschool children by using a unique tool called the “Seven-in-Seven Screen Exposure Questionnaire” and to investigate factors associated with problematic screen exposure.
Are maternal and child health initiatives helping to reduce under-five mortality in Ghana? Results of a quasi-experimental study using coarsened exact matching
Augusta Kolekang, Bismark Sarfo, Anthony Danso-Appiah, Duah Dwomoh & Patricia Akweongo
doi : 10.1186/s12887-021-02934-3
BMC Pediatrics volume 21, Article number: 473 (2021)
Despite a 53?% decline in under-five mortality (U5M) worldwide during the period of the Millennium Development Goals (MDGs), U5M remains a challenge. Under-five mortality decline in Ghana is slow and not parallel with the level of coverage of child health interventions. The interventions promoted to improve child survival include early initiation of breastfeeding, clean postnatal care, and skilled delivery. This study sought to assess the effectiveness of these interventions on U5M in Ghana.
Association between early fluid overload and mortality in critically-ill mechanically ventilated children: a single-center retrospective cohort study
Xiangmei Kong, Yueniu Zhu & Xiaodong Zhu
doi : 10.1186/s12887-021-02949-w
BMC Pediatrics volume 21, Article number: 474 (2021)
Positive fluid overload (FO) may cause adverse effect. This study retrospectively analyzed the relationship between early FO and in-hospital mortality in children with mechanical ventilation (MV) in pediatric intensive care unit (PICU).
Do adolescents consider mind-body skills groups an acceptable treatment for depression: results from a pilot study
Lindsey D. Cunningham, Eduardo F. Salgado, Matthew C. Aalsma, Jennifer M. Garabrant, Julie K. Staples, James S. Gordon & Michelle P. Salyers
doi : 10.1186/s12887-021-02942-3
BMC Pediatrics volume 21, Article number: 475 (2021)
Mind-Body Skills Groups (MBSGs) have shown promise in reducing adolescent depression symptoms; however, little is known about adolescents’ perspectives on this treatment. The objective of this study was to understand the acceptability of a new treatment for depressed adolescents in primary care settings.
Differences in the factors associated with tongue pressure between children with class I and Class II malocclusions
Yuko Fujita, Yoma Ohno, Keitaro Ohno, Tomohiro Takeshima & Kenshi Maki
doi : 10.1186/s12887-021-02956-x
BMC Pediatrics volume 21, Article number: 476 (2021)
The relationship between tongue pressure and masticatory performance during the mixed dentition period in cases of Class II malocclusion has not been clarified. The aim of this study was to determine differences in tongue pressure-related factors, including maxillofacial morphology and masticatory performance, between Class I and Class II malocclusions during the mixed dentition period.
Early initial video-electro-encephalography combined with variant location predict prognosis of KCNQ2-related disorder
Yan Xu, Ya-lan Dou, Xiang Chen, Xin-ran Dong, Xin-hua Wang, Bing-bing Wu, Guo-qiang Cheng & Yuan-feng Zhou
doi : 10.1186/s12887-021-02946-z
BMC Pediatrics volume 21, Article number: 477 (2021)
The clinical features of KCNQ2-related disorders range from benign familial neonatal seizures 1 to early infantile epileptic encephalopathy 7. The genotype-phenotypic association is difficult to establish.
Clinical spectrum and predictors of severity of dengue among children in 2019 outbreak: a multicenter hospital-based study in Bangladesh
Md. Abdullah Saeed Khan, Abdullah Al Mosabbir, Enayetur Raheem, Ahsan Ahmed, Rashawan Raziur Rouf, Mahmudul Hasan, Fawzia Bente Alam, Nahida Hannan, Sabrina Yesmin, Robed Amin, Nazmul Ahsan, Sayeeda Anwar, Syeda Afroza & Mohammad Sorowar Hossain
doi : 10.1186/s12887-021-02947-y
BMC Pediatrics volume 21, Article number: 478 (2021)
The mosquito-borne arboviral disease dengue has become a global public health concern. However, very few studies have reported atypical clinical features of dengue among children. Because an understanding of various spectrums of presentation of dengue is necessary for timely diagnosis and management, we aimed to document the typical and atypical clinical features along with predictors of severity among children with dengue during the largest outbreak in Bangladesh in 2019.
Gender-specific associations of pregnancy-related anxiety with placental epigenetic patterning of glucocorticoid response genes and preschooler’s emotional symptoms and hyperactivity
Hui Liu, Yuwei Liu, Kun Huang, Shuangqin Yan, Jiahu Hao, Peng Zhu, Fangbiao Tao & Shanshan Shao
doi : 10.1186/s12887-021-02938-z
BMC Pediatrics volume 21, Article number: 479 (2021)
We have recently reported that maternal prenatal pregnancy-related anxiety predicts preschoolers’ emotional and behavioral development in a gender-dependent manner. This study aims to test for this gender-specific effect in a different cohort and investigate whether the gender difference was specific to placental methylation of genes regulating glucocorticoids.
Anemia among children living with HIV/AIDS on HAART in Mekelle Hospital, Tigray regional state of northern ethiopia – a cross-sectional study
Feven Tesfay, Abrha Gebregerges, Haftay Gebrehiwot, Haftu Hailekiros, Letegebriel Girmay, Hadush Bekuretsion, Gebrekidan Gebrezigher, Gebreslassie Gebremariam & Gebreyohannes Teklehaimanot
doi : 10.1186/s12887-021-02960-1
BMC Pediatrics volume 21, Article number: 480 (2021)
Anemia is a common complication of HIV/AIDS in children. There is lack of evidence on anemia prevalence among children living with HIV/AIDS on highly active antiretroviral therapy (HAART) in Tigray regional state, which the current study aimed to generate.
Concentrations of oligosaccharides in human milk and child growth
Philipp Menzel, Mandy Vogel, Sean Austin, Norbert Sprenger, Nico Grafe, Cornelia Hilbert, Anne Jurkutat, Wieland Kiess & Aristea Binia
doi : 10.1186/s12887-021-02953-0
BMC Pediatrics volume 21, Article number: 481 (2021)
The relationship between human milk oligosaccharides (HMO) and child growth has been investigated only insufficiently with ambiguous results. Therefore, this study examines potential influencing factors of HMO concentrations and how HMO are associated with child growth parameters.
Post-Ebola sequelae among Ebola child survivors in Sierra Leone
Claudette Amuzu, Peter Bai James, Abdulai Jawo Bah, Alex Vandy Saffa Bayoh & Shepherd Roee Singer
doi : 10.1186/s12887-021-02957-w
BMC Pediatrics volume 21, Article number: 482 (2021)
There are limited data regarding the long-term health effects of child survivors of the 2013-2016 West African Ebola virus disease (EVD) outbreak. Here, we assess post-Ebola sequelae among EVD child survivors by comparing the self-reported symptoms between EVD child survivors and their close household contacts over one year after the end of the outbreak.
