Myosin Modulation in Hypertrophic Cardiomyopathy and Systolic Heart Failure: Getting Inside the Engine

Matthew J. Daniels, Luca Fusi, Christopher Semsarian, Srihari S. Naidu

doi : 10.1161/CIRCULATIONAHA.121.056324

Circulation. 2021;144:759–762

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Cerebrovascular Events in Patients With Centrifugal-Flow Left Ventricular Assist Devices: Propensity Score–Matched Analysis From the Intermacs Registry

Sung-Min Cho, J. Hunter Mehaffey, Susan L. Meyers, Ryan S. Cantor, Randall C. Starling, James K. Kirklin, Jeffrey P. Jacobs, John Kern, Ken Uchino, Leora T. Yarboro

doi : 10.1161/CIRCULATIONAHA.121.055716

Circulation. 2021;144:763–772

Ischemic and hemorrhagic cerebrovascular accidents remain common among patients with centrifugal-flow left ventricular assist devices, despite improvements in survival and device longevity. We compared the incidence of neurologic adverse events (NAEs) associated with 2 contemporary centrifugal-flow left ventricular assist devices: the Abbott HeartMate3 (HM3) and the Medtronic HeartWare HVAD (HVAD).

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Novel Criteria for the Observe-Zone of the ESC 0/1h-hs-cTnT Algorithm

Pedro Lopez-Ayala, Thomas Nestelberger, Jasper Boeddinghaus, Luca Koechlin, Paul David Ratmann, Ivo Strebel, Juliane Gehrke, Severin Meier, Joan Walter, Maria Rubini Gimenez, Eugenio Mutschler, Òscar Miró, Beatriz López-Barbeito, Francisco Javier Martín-Sánchez, Esther Rodríguez-Adrada, Dagmar I. Keller, L. Kristin Newby, Raphael Twerenbold, Evangelos Giannitsis, Bertil Lindahl, Christian Mueller,

doi : 10.1161/CIRCULATIONAHA.120.052982

Circulation. 2021;144:773–787

The non–ST-segment–elevation myocardial infarction (NSTEMI) guidelines of the European Society of Cardiology (ESC) recommend a 3h cardiac troponin determination in patients triaged to the observe-zone of the ESC 0/1h-algorithm; however, no specific cutoff for further triage is endorsed. Recently, a specific cutoff for 0/3h high-sensitivity cardiac troponin T (hs-cTnT) change (7 ng/L) was proposed, warranting external validation.

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Functional Calsequestrin-1 Is Expressed in the Heart and Its Deficiency Is Causally Related to Malignant Hyperthermia-Like Arrhythmia

Zhipeng Sun, Luqi Wang, Lu Han, Yue Wang, Yuan Zhou, Qiang Li, Yongquan Wu, Shaletanati Talabieke, Yunlong Hou, Lulin Wu, Ronghua Liu, Zhiping Fu, Hongjie You, Bai-Yan Li, Yuanyuan Zheng, Dali Luo

doi : 10.1161/CIRCULATIONAHA.121.053255

Circulation. 2021;144:788–804

Calsequestrins (Casqs), comprising the Casq1 and Casq2 isoforms, buffer Ca2+ and regulate its release in the sarcoplasmic reticulum of skeletal and cardiac muscle, respectively. Human inherited diseases associated with mutations in CASQ1 or CASQ2 include malignant hyperthermia/environmental heat stroke (MH/EHS) and catecholaminergic polymorphic ventricular tachycardia. However, patients with an MH/EHS event often experience arrhythmia for which the underlying mechanism remains unknown.

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Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia

Hyojin Park, Jessica Furtado, Mathilde Poulet, Minhwan Chung, Sanguk Yun, Sungwoon Lee, William C. Sessa, Claudio A. Franco, Martin A. Schwartz, Anne Eichmann

doi : 10.1161/CIRCULATIONAHA.120.053047

Circulation. 2021;144:805–822

Activin receptor-like kinase 1 (ALK1) is an endothelial transmembrane serine threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular development and pathology. Loss-of-function mutations in the ALK1 gene cause type 2 hereditary hemorrhagic telangiectasia, a devastating disorder that leads to arteriovenous malformations. Here, we show that ALK1 controls endothelial cell polarization against the direction of blood flow and flow-induced endothelial migration from veins through capillaries into arterioles.

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Polymorphic Ventricular Tachycardia: Terminology, Mechanism, Diagnosis, and Emergency Therapy

Sami Viskin, Ehud Chorin, Dana Viskin, Aviram Hochstadt, Arie Lorin Schwartz, Raphael Rosso

doi : 10.1161/CIRCULATIONAHA.121.055783

Circulation. 2021;144:823–839

Polymorphic ventricular tachyarrhythmias are highly lethal arrhythmias. Several types of polymorphic ventricular tachycardia have similar electrocardiographic characteristics but have different modes of therapy. In fact, medications considered the treatment of choice for one form of polymorphic ventricular tachycardia, are contraindicated for the other. Yet confusion about terminology, and thus diagnosis and therapy, continues. We present an in-depth review of the different forms of polymorphic ventricular tachycardia and propose a practical step-by-step approach for distinguishing these malignant arrhythmias.

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Association Between Cervical Artery Dissection and Aortic Dissection

Jens Witsch, Saad A. Mir, Neal S. Parikh, Santosh B. Murthy, Hooman Kamel, Babak B. Navi, Alan Z. Segal, Matthew E. Fink, Stephanie B. Rutrick, Monika M. Safford, Nupoor Narula, Parag Goyal, Mario Gaudino, Leonard N. Girardi, Richard B. Devereux, Mary J. Roman, Cenai Zhang, Alexander E. Merkler

doi : 10.1161/CIRCULATIONAHA.121.055274

Circulation. 2021;144:840–842

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Preemption: A Threat to Building Healthy, Equitable Communities

Keith Churchwell, Donald M. Lloyd-Jones, Allyson L. Frazier

doi : 10.1161/CIRCULATIONAHA.121.056759

Circulation. 2021;144:e194–e195

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Letter by Amadio et al Regarding Article, “Cell-Free DNA to Detect Heart Allograft Acute Rejection”

Jennifer M. Amadio, Myriam Lafreniere-Roula, Michael McDonald

doi : 10.1161/CIRCULATIONAHA.121.054333

Circulation. 2021;144:e196–e197

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Response by Shah et al to Letter Regarding Article, “Cell-Free DNA to Detect Heart Allograft Acute Rejection”

Palak Shah, Sean Agbor-Enoh, Ilker Tunc, Steven Hsu, Stuart Russell, Erika Feller, Keyur Shah, Maria E. Rodrigo, Samer S. Najjar, Hyesik Kong, Mehdi Pirooznia, Ulgen Fideli, Alfiya Bikineyeva, Argit Marishta, Kenneth Bhatti, Yanqin Yang, Cedric Mutebi, Kai Yu, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Hannah A. Valantine, and on behalf of the GRAfT (Genomic Research Alliance for Transplantation) Investigators

doi : 10.1161/CIRCULATIONAHA.121.055697

Circulation. 2021;144:e198–e199

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Correction to: Cerebrovascular Events in Patients With Centrifugal-Flow Left Ventricular Assist Devices: Propensity Score–Matched Analysis From the Intermacs Registry

doi : 10.1161/CIR.0000000000001021

Circulation. 2021;144:e200

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