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When Not to Use a Generic: Measuring HRQoL in Chronic Digestive Disease Necessitates the Use of Disease-Specific Questionnaires
Tiffany H. Taft
doi : 10.1007/s10620-020-06780-8
Digestive Diseases and Sciences volume 66, pages3219–3221 (2021)
Which Comes First: Increased Intestinal Paracellular Permeability or Subepithelial Inflammation?
Yasutada Akiba
doi : 10.1007/s10620-020-06724-2
Digestive Diseases and Sciences volume 66, pages3222–3223 (2021)
Doppler Endoscopic Probe-Guided Treatment of Dieulafoy’s Bleeding: Hearing Is Believing
Babu P. Mohan
doi : 10.1007/s10620-020-06712-6
Digestive Diseases and Sciences volume 66, pages3224–3225 (2021)
Highs and Lows of Proactive Therapeutic Drug Monitoring in Crohn’s Patients
Shana T. Rakowsky & Joseph D. Feuerstein
doi : 10.1007/s10620-020-06774-6
Digestive Diseases and Sciences volume 66, pages3226–3227 (2021)
GI-COVID: Are There COVID-19 Patients with Primary Gastrointestinal SARS-CoV-2 Infection and Symptoms?
John Ong & Yock Young Dan
doi : 10.1007/s10620-020-06767-5
Digestive Diseases and Sciences volume 66, pages3228–3230 (2021)
Learning to Love Endoscopy: Lessons from the Five Love Languages About Creating an Optimal Learning Environment for Endoscopic Trainees
Alexander S. Vogel & Navin L. Kumar
doi : 10.1007/s10620-021-07207-8
Digestive Diseases and Sciences volume 66, pages3231–3233 (2021)
Diagnosing and Monitoring Celiac Patients with Selective IgA Deficiency: Still an Open Issue
Marco Di Tola, Nicola Bizzaro, Mariarosa Gaudio, Carlotta Maida, Danilo Villalta, Maria Grazia Alessio, Giulia Previtali, Martina Fabris, Gaia Deleonardi, Marilina Tampoia, Ignazio Brusca, Giampaola Pesce, Brunetta Porcelli, Mariangela Manfredi & Maria Infantino On behalf of the Study Group on Autoimmune Diseases of the Italian Society of Clinical Pathology and Laboratory Medicine
doi : 10.1007/s10620-021-07204-x
Digestive Diseases and Sciences volume 66, pages3234–3241 (2021)
Although, the association between celiac disease (CD) and selective immunoglobulin A deficiency (SIgAD) has been known for more than fifty years, the procedures for diagnosing and monitoring patients with both conditions are still far from definitive. When serological markers were introduced as pre-bioptic investigations, it was immediately clear that searching for specific IgA antibodies without checking total serum IgA could lead to a failure in diagnosing IgA-deficient CD patients, while specific IgG antibodies could be useful as additional tests, because they are frequently found in the serum of affected patients. Nonetheless, until recently the diagnosis of CD in IgA-deficient patients was based on the few, fragmentary and often contradictory data available in literature. The introduction of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) guidelines in 2012 provided the current criteria for diagnosing CD in IgA-deficient patients, although some issues remained open, such as the selection of patients who should undergo specific IgG antibody testing and the choice of the most reliable IgG-based test for both diagnosis and follow-up. A real-life study recently assessed the impact of the 2012 ESPGHAN guidelines in diagnosing and monitoring CD in SIgAD patients, highlighting several pitfalls that can lead to operational uncertainties and difficulties in patient management. In the present report, the evolution of diagnostic tools and criteria for CD in SIgAD patients has been critically assessed, both strengths and open issues have been highlighted, and future perspectives for improving the current diagnostic protocols have been suggested.
Peroral Endoscopic Myotomy Is a Safe and Feasible Option in Management of Esophageal Diverticula: Systematic Review and Meta-Analysis
Faisal Kamal, Muhammad Ali Khan, Wade Lee-Smith, Sachit Sharma, Hemnishil K. Marella, Umair Iqbal, Stephanie Mcdonough, Aysha Aslam, Mohammad K. Ismail, Claudio Tombazzi & Douglas G. Adler
doi : 10.1007/s10620-020-06678-5
Digestive Diseases and Sciences volume 66, pages3242–3249 (2021)
Esophageal diverticula can cause significant symptoms and affect the quality of life. There has been recent interest in the use of peroral endoscopic myotomy in the management of esophageal diverticula (D-POEM). In this meta-analysis, we have evaluated the efficacy and safety of D-POEM in the management of esophageal diverticula. Several databases were reviewed from inception to 6/19/2020 to identify the studies evaluating the feasibility, efficacy and safety of D-POEM in the management of esophageal diverticula. Our outcomes of interest were technical success, adverse events and difference in mean pre- and post-procedure symptom score. We performed subgroup analysis including patients with Zenker’s diverticulum who underwent POEM (Z-POEM). Pooled rates with 95% confidence intervals (CI) for all outcomes were calculated using random effect model. We calculated standard mean difference (SMD) with 95% CI to compare mean pre- and post-procedure symptom score. We included 7 studies with 233 patients. For D-POEM, pooled rates (95% CI) for technical success and adverse events were 95% (91%, 97%) and 6% (3%, 10%) respectively. For Z-POEM, pooled rates (95% CI) for technical success and adverse events were 95% (90%, 97%) and 6% (3%, 10%) respectively. Mean post-procedure symptom score for all patients who underwent D-POEM was significantly lower compared to mean pre-procedure symptom score, SMD (95% CI) 2.17 (1.51, 2.83). This meta-analysis demonstrated that D-POEM is a safe and feasible option for patients with symptomatic esophageal diverticula.
Evolving Role of Thiopurines in Inflammatory Bowel Disease in the Era of Biologics and New Small Molecules
Anke L. H. Nguyen & Miles P. Sparrow
doi : 10.1007/s10620-020-06662-z
Digestive Diseases and Sciences volume 66, pages3250–3262 (2021)
In recent years, with the increasing availability of biologic therapies and due to safety concerns, the role of thiopurines in the management of inflammatory bowel disease has been questioned. While acknowledging that the benefit/risk ratio of biologic therapies is very high, they are expensive and are not required by a majority of patients. Therefore, thiopurines do retain an important role as steroid-sparing and maintenance agents when used as monotherapy, and in combination therapy with biologics due to their clinical and pharmacokinetic optimization of anti-tumor necrosis factor agents in particular. Safety concerns with thiopurines are real but also relatively rare, and with careful pre-treatment screening and ongoing monitoring thiopurine benefits outweigh risks in the majority of appropriately selected patients. Measurement of newer pharmacogenomic markers such as nudix hydrolase 15 (NUDT15), when combined with knowledge of existing known mutations (e.g., thiopurine S-methyltransferase—TPMT), will hopefully minimize the risk of potentially life-threatening leukopenia by allowing for pre-treatment dosing stratification. Further optimization of thiopurine dosing via measurement of thiopurine metabolites should be performed routinely and is superior to weight-based dosing. The association of thiopurines with malignancies including lymphoproliferative disorders needs to be recognized in all patients and individualized in each patient. The decrease in lymphoma risk after thiopurine cessation provides an incentive for thiopurine de-escalation in appropriate patients after a period of prolonged deep remission. This review will summarize the current role of thiopurines in inflammatory bowel disease management and provide recommendations for commencing and monitoring therapy, and when to consider de-escalation.
Importance of Hepcidin in the Etiopathogenesis of Anemia in Inflammatory Bowel Disease
Eva Karaskova, Dagmar Pospisilova, Maria Velganova-Veghova, Milos Geryk, Jana Volejnikova, Dusan Holub & Marian Hajduch
doi : 10.1007/s10620-020-06652-1
Digestive Diseases and Sciences volume 66, pages3263–3269 (2021)
Anemia is the most common extraintestinal systemic complication of inflammatory bowel disease. Iron deficiency anemia and anemia of chronic disease are among the most frequent types. Intestinal iron absorption is controlled by the activity of ferroportin. Cells with high expression of ferroportin include enterocytes, and also macrophages and hepatocytes. Iron homeostasis is controlled by the hepcidin-ferroportin axis. Hepcidin is a central regulator of iron metabolism and can also serve as a marker of systemic inflammation. During systemic inflammatory response, the synthesis of hepcidin increases, and hepcidin binds to ferroportin and inhibits its activity. Thus, iron is not absorbed from the bowel into the circulation and also remains sequestered in macrophages. Conversely, hepcidin synthesis is suppressed during conditions requiring increased iron intake for enhanced erythropoiesis, such as iron deficiency anemia or hypoxia. Here, ferroportin is not blocked, and iron is actively absorbed into the bloodstream and also released from the stores. Production of hepcidin is influenced by the status of total body iron stores, systemic inflammatory activity and erythropoietic activity. Oral iron therapy is limited in inflammatory bowel diseases due to ongoing gastrointestinal inflammation. It is less effective and may worsen the underlying disease. Therefore, the choice between oral and parenteral iron therapy must be made with caution. Oral iron would be ineffective at high hepcidin levels due to concurrent ferroportin blockage. Contrarily, low levels of hepcidin indicate that oral iron therapy should be successful. An understanding of hepcidin can help in understanding the body’s reaction to iron depletion during the inflammatory process.
Phenolic Compounds Promote Diversity of Gut Microbiota and Maintain Colonic Health
J. Abraham Domínguez-Avila, Jose A. Villa-Rodriguez, Marcelino Montiel-Herrera, Ramón Pacheco-Ordaz, Diana E. Roopchand, Koen Venema & Gustavo A. González-Aguilar
doi : 10.1007/s10620-020-06676-7
Digestive Diseases and Sciences volume 66, pages3270–3289 (2021)
The role of non-energy-yielding nutrients on health has been meticulously studied, and the evidence shows that a compound can exert significant effects on health even if not strictly required by the organism. Phenolic compounds are among the most widely studied molecules that fit this description; they are found in plants as secondary metabolites and are not required by humans for growth or development, but they can influence a wide array of processes that modulate health across multiple organs and systems. The lower gastrointestinal tract is a prime site of action of phenolic compounds, namely, by their effects on gut microbiota and colonic health. As with humans, phenolic compounds are not required by most bacteria but can be substrates of others; in fact, some phenolic compounds exert antibacterial actions. A diet rich in phenolic compounds can lead to qualitative and quantitative effects on gut microbiota, thereby inducing indirect health effects in mammals through the action of these microorganisms. Moreover, phenolic compounds may be fermented by the gut microbiota, thereby modulating the compounds bioactivity. In the colon, phenolic compounds promote anti-inflammatory, anti-oxidant and antiproliferative actions. The aim of the present review is to highlight the role of phenolic compounds on maintaining or restoring a healthy microbiota and overall colonic health. Mechanisms of action that substantiate the reported evidence will also be discussed.
Gas in the Portal Vein: An Emergency or Just Hot Air?
N. Zorzetti, A. Lauro, A. Ruffato, V. D’Andrea, L. Ferruzzi, N. Antonacci & R. M. Tranchino
doi : 10.1007/s10620-021-07126-8
Digestive Diseases and Sciences volume 66, pages3290–3295 (2021)
We report the case of a 87-year-old woman admitted to our Emergency Department for mild abdominal pain associated with vomiting. An abdominal X-ray showed gas present in the portal venules of the left hepatic lobe, a finding associated with numerous surgical and medical conditions. The patient was successfully managed with conservative treatment. Isolated intrahepatic gas is a rare radiologic finding; emergency surgery should be performed only when there are signs of associated acute intestinal infarction.
Magnifying Power: New Endoscopic Tools for the Diagnosis of Krukenberg Tumor
Hannah Ramrakhiani, Aarushi K. Thaker, Albert Pisani, Ankur Sangoi & George Triadafilopoulos
doi : 10.1007/s10620-020-06799-x
Digestive Diseases and Sciences volume 66, pages3296–3299 (2021)
Clinical Challenge: From Ulcerative Colitis to Crohn’s Disease-Like Pouch Inflammation
Maia Kayal, Bhavana Bhagya Rao, Abhik Bhattacharya & Ryan Ungaro
doi : 10.1007/s10620-021-07220-x
Digestive Diseases and Sciences volume 66, pages3300–3302 (2021)
Absence of Toxemia in Clostridioides difficile Infection: Results from Ultrasensitive Toxin Assay of Serum
Rebecca Sprague, Karolyne Warny, Nira Pollock, Kaitlyn Daugherty, Qianyun Lin, Hua Xu, Christine Cuddemi, Caitlin Barrett, Xinhua Chen, Alice Banz, Aude Lantz, Kevin W. Garey, Anne J. Gonzales-Luna, Carolyn D. Alonso, Javier A. Villafuerte Galvez & Ciarán P. Kelly
doi : 10.1007/s10620-020-06683-8
Digestive Diseases and Sciences volume 66, pages3303–3306 (2021)
Clostridioides difficile infection (CDI) is caused by Toxins A and B, secreted from pathogenic strains of C. difficle. This infection can vary greatly in symptom severity and in clinical presentation. Current assays used to diagnose CDI may lack the required sensitivity to detect the exotoxins circulating in blood. The ultrasensitive single molecule array (Simoa) assay was modified to separately detect toxin A and toxin B in serum with a limit of detection at the low picogram level. When applied to a diverse cohort, Simoa was unable to detect toxins A or B in serum from patients with CDI, including many classified as having severe disease. The detection of toxin may be limited by the inference of antitoxin antibodies circulating in serum. This result does not support the hypothesis that toxemia occurs in C. difficile infection, conflicting with the findings of other published reports.
Impact of COVID-19 Pandemic on Training: Global Perceptions of Gastroenterology and Hepatology Fellows in the USA
Kofi Clarke, Mohammad Bilal, Sergio A. Sánchez-Luna, Shannon Dalessio, Jennifer L. Maranki & Shazia Mehmood Siddique
doi : 10.1007/s10620-020-06655-y
Digestive Diseases and Sciences volume 66, pages3307–3311 (2021)
The COVID-19 pandemic has impacted numerous facets of healthcare workers’ lives. There have also been significant changes in Gastroenterology (GI) fellowship training as a result of the challenges presented by the pandemic.
Generic Measures of Quality of Life Are Not Correlated with Disease Activity in Eosinophilic Esophagitis
Nicole Chang, Soha Raja, Renee Betancourt, Cara Randall, Staci Keene, Amy Lilly, Mark Fowler, John T. Woosley, Nicholas J. Shaheen & Evan S. Dellon
doi : 10.1007/s10620-020-06719-z
Digestive Diseases and Sciences volume 66, pages3312–3321 (2021)
The relationship between histologic disease activity in eosinophilic esophagitis (EoE) and generic measures of quality of life (QoL) is unclear.
Impaired Quality of Life in Patients with Autoimmune Atrophic Gastritis
Emanuela Miceli, Natascia Brondino, Marco Vincenzo Lenti, Michele Di Stefano, Martina Staiani, Francesca Zugnoni, Martina Pisati, Costanza Caccia Dominioni, Gino Roberto Corazza, Pierluigi Politi & Antonio Di Sabatino
doi : 10.1007/s10620-020-06656-x
Digestive Diseases and Sciences volume 66, pages3322–3329 (2021)
Autoimmune atrophic gastritis (AAG) leads to vitamin B12 deficiency that may manifest with neuropsychiatric disorders, such as emotional instability, cognitive deficits, depression, and personality changes.
Patient Strategies for Managing the Vicious Cycle of Fatigue, Pain and Urgency in Inflammatory Bowel Disease: Impact, Planning and Support
Lesley Dibley, Bernadette Khoshaba, Micol Artom, Victoria Van Loo, Louise Sweeney, Jonathan Syred, Sula Windgassen, Georgia Moffatt, Christine Norton & and members of the IBD-BOOST PPI team
doi : 10.1007/s10620-020-06698-1
Digestive Diseases and Sciences volume 66, pages3330–3342 (2021)
Inflammatory bowel disease (IBD) causes inter-related symptoms of fatigue, pain and urgency which can persist in remission.
Frailty Does Not Impact Caregiver Burden in Patients with Cirrhosis
Elizabeth S. Aby, Nguyen V. Pham, Jung J. Yum, Tien S. Dong, Hussein Ghasham, Fatima Bedier, Claire Malley, Joanna Schaenman & Sammy Saab
doi : 10.1007/s10620-020-06687-4
Digestive Diseases and Sciences volume 66, pages3343–3351 (2021)
Frailty is common and is associated with increased mortality, lower quality of life, and higher readmission rates in cirrhotic patients. Not only are these outcomes important, but further understanding the impact of frailty on a caregiver’s life is crucial to better comprehend caregiver burden in cirrhotic patients and develop strategies to improve care for patients and their caregivers.
A New Intraepithelial ?? T-Lymphocyte Marker for Celiac Disease Classification in Formalin-Fixed Paraffin-Embedded (FFPE) Duodenal Biopsies
Alina Popp, Juha Taavela, Paolo Graziano, Paola Parente, Claudia Covelli, Carmela Lamacchia, Angelo Andriulli, Markku Mäki & Jorma Isola
doi : 10.1007/s10620-020-06680-x
Digestive Diseases and Sciences volume 66, pages3352–3358 (2021)
The histopathologic diagnosis of celiac disease (CD) may be challenging when the duodenal biopsies mucosal injury is limited. Intraepithelial T-lymphocytes (IELs) can be useful to characterize the degree of mucosal inflammation. A small fraction of IELs expresses the ?? T-cell receptor (named ??-IELs), whose density, determined by flow cytometry or frozen section immunohistochemistry (IHC), is a specific marker for CD.
High-Fat Diet Induces Disruption of the Tight Junction-Mediated Paracellular Barrier in the Proximal Small Intestine Before the Onset of Type 2 Diabetes and Endotoxemia
J. C. Nascimento, V. A. Matheus, R. B. Oliveira, S. F. S. Tada & Carla B. Collares-Buzato
doi : 10.1007/s10620-020-06664-x
Digestive Diseases and Sciences volume 66, pages3359–3374 (2021)
A link between an impaired intestinal barrier, endotoxemia, and the pathogenesis of metabolic diseases, such as type 2 diabetes mellitus (T2DM), has been proposed. In previous work, we have demonstrated that the tight junction (TJ)-mediated intestinal barrier in ileum/colon was marginally changed in prediabetic mice; therefore, it does not seem to mainly contribute to the T2DM onset. In this study, the TJ-mediated epithelial barrier in the duodenum and jejunum was evaluated in mice during the development of type 2 prediabetes.
DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease
Yu Zhang, Xiaozhi Li, Yaoting Li, Ying Li, Ying Wang, Liguo Zhu, Peng Chen, Zhenyi Tian, Yun Qiu, Rui Feng, Zhirong Zeng, Yao He, Baili Chen, Shenghong Zhang, Ren Mao & Minhu Chen
doi : 10.1007/s10620-020-06697-2
Digestive Diseases and Sciences volume 66, pages3375–3390 (2021)
DNA damage-regulated autophagy modulator 1 (DRAM1) is required for induction of autophagy and apoptosis. However, the influence of DRAM1 on the pathogenesis of inflammatory bowel disease (IBD) has not been explored.
Long Non-coding RNA LINC01503 Promotes Gastric Cardia Adenocarcinoma Progression via miR-133a-5p/VIM Axis and EMT Process
Yanli Guo, Pingping Sun, Wei Guo & Zhiming Dong
doi : 10.1007/s10620-020-06690-9
Digestive Diseases and Sciences volume 66, pages3391–3403 (2021)
LINC01503 has been reported to act as a candidate oncogenic lncRNA in several types of human cancer. However, the functions and underlying mechanisms of LINC01503 in gastric cardia adenocarcinoma (GCA) remain unclear.
Knockdown of Long Non-coding RNA LINC00200 Inhibits Gastric Cancer Progression by Regulating miR-143-3p/SERPINE1 Axis
Wenting He, Dachuan Zhang, Dong Li, Danxia Zhu, Yiting Geng, Qi Wang, Jiajia He & Jun Wu
doi : 10.1007/s10620-020-06691-8
Digestive Diseases and Sciences volume 66, pages3404–3414 (2021)
An increasing number of studies have found that long non-coding RNAs (lncRNAs) play an important role in carcinogenesis and tumor progression, whereas their molecular mechanisms of function remain largely unknown.
Protective Mechanism of MIF Inhibitor ISO-1 on Intrahepatic Bile Duct Cells in Rats with Severe Acute Pancreatitis
Bin Wang, Kailiang Zhao, Wenjuan Hu, Youming Ding & Weixing Wang
doi : 10.1007/s10620-020-06674-9
Digestive Diseases and Sciences volume 66, pages3415–3426 (2021)
This study aimed to explore the protection mechanism of ISO-1 on severe acute pancreatitis-associated intrahepatic bile duct (IBD) injury in rats.
Inflammation, Tumoral Markers and Interleukin-17, -10, and -6 Profiles in Pancreatic Adenocarcinoma and Chronic Pancreatitis
Alina Tan??u, Daniel-Corneliu Leucu?a, Marcel Tan??u, Emil Bo?an, Roxana Zaharie, Alina Mândru?iu & Ionu?-Ciprian Tomuleasa
doi : 10.1007/s10620-020-06700-w
Digestive Diseases and Sciences volume 66, pages3427–3438 (2021)
Interleukin profiles can be used as biochemical markers regarding the early diagnosis of pancreatic cancer.
HIPK3 Circular RNA Promotes Metastases of HCC Through Sponging miR-338-3p to Induce ZEB2 Expression
Weizhi Li, Hui Xue, Yingchao Li, Peijie Li, Fuquan Ma, Mengying Liu & Shuzhen Kong
doi : 10.1007/s10620-020-06688-3
Digestive Diseases and Sciences volume 66, pages3439–3447 (2021)
Upregulation of circHIPK3 has been observed in several kinds of malignancies. However, the mechanisms of circHIPK3 in HCC metastases remains unclear. We investigated the role and the mechanisms of circHIPK3 in the development of HCC.
Dietary Habits and Risk of Esophagitis and Barrett’s Esophagus: A Multicenter Italian Case–Control Study
Rosa Angela Filiberti, Vincenzo Fontana, Antonella De Ceglie, Sabrina Blanchi, Teresa Lacchin, Marina De Matthaeis, Orazio Ignomirelli, Roberta Cappiello, Alessandra Rosa, Vittorio D’Onofrio, Gaetano Iaquinto & Massimo Conio
doi : 10.1007/s10620-020-06658-9
Digestive Diseases and Sciences volume 66, pages3448–3460 (2021)
Barrett’s esophagus (BE) and esophagitis share potentially modifiable risk factors such as obesity, smoking, and alcohol. The role of diet on BE and esophagitis is still debated.
Comprehensive Cognitive-Behavioral Interventions Augment Diaphragmatic Breathing for Rumination Syndrome: A Proof-of-Concept Trial
Helen Burton Murray, Fengqing Zhang, Christine C. Call, Ani Keshishian, Rowan A. Hunt, Adrienne S. Juarascio & Jennifer J. Thomas
doi : 10.1007/s10620-020-06685-6
Digestive Diseases and Sciences volume 66, pages3461–3469 (2021)
Rumination syndrome (RS) is often treated in medical settings with 1–2 sessions of diaphragmatic breathing to target reflexive abdominal wall contraction in response to conditioned cues (e.g., food). However, many patients remain symptomatic and require additional behavioral interventions.
Risk of Progression of Gastric Intestinal Metaplasia Is Significantly Greater When Detected in Both Antrum and Body
Anthony O’Connor, Adam Bowden, Eoin Farrell, Joshua Weininger, Stephen Crowther, Deirdre McNamara, Paul Ridgway & Colm O’Morain
doi : 10.1007/s10620-020-06659-8
Digestive Diseases and Sciences volume 66, pages3470–3475 (2021)
Gastric cancer (GC) is the fifth leading cause of cancer-related death worldwide. GC is usually preceded by a cascade of well-defined precursor lesions, set in place by an environmental trigger (H. pylori) including intestinal metaplasia (GIM) and dysplasia.
Underutilization of Peptic Ulcer Disease Prophylaxis Among Elderly Users of Antiplatelets and Anticoagulants
Ahmad M. Al-Taee, Elie Ghoulam, Preston Lee, Mitchell Edwards, Kahee A. Mohammed & Christine Y. Hachem
doi : 10.1007/s10620-020-06665-w
Digestive Diseases and Sciences volume 66, pages3476–3481 (2021)
Peptic ulcer disease (PUD) develops in approximately 25% of chronic users of non-steroidal anti-inflammatory drugs (NSAIDs). The incidence of uncomplicated PUD has been declining over the past 3 decades unlike that of complicated PUD in the elderly. An expert consensus document published jointly in 2008 by the American College of Gastroenterology (ACG), the American College of Cardiology Foundation (ACCF), and the American Heart Association (AHA) provided recommendations on prevention of PUD among users of antiplatelets and anticoagulants. This work aimed to evaluate physicians’ compliance with these guidelines in a tertiary academic setting.
Functional Dyspepsia and Duodenal Eosinophil Count and Degranulation: A Multiethnic US Veteran Cohort Study
M. Ellionore Järbrink-Sehgal, Jordan Sparkman, Alexander Damron, Marjorie M. Walker, Linda K. Green, Daniel G. Rosen, David Y. Graham & Hashem E. El-Serag
doi : 10.1007/s10620-020-06689-2
Digestive Diseases and Sciences volume 66, pages3482–3489 (2021)
Duodenal eosinophilia may play a role in functional dyspepsia (FD), but existing study results are conflicted. We investigated the association between duodenal eosinophils (count and degranulation) and FD symptoms, accounting for atopic conditions, medications, and seasonal variations.
Type II Achalasia Is Increasing in Prevalence
Margaret J. Zhou, Afrin Kamal, Daniel E. Freedberg, David Markowitz, John O. Clarke & Daniela Jodorkovsky
doi : 10.1007/s10620-020-06668-7
Digestive Diseases and Sciences volume 66, pages3490–3494 (2021)
Three manometric subtypes of achalasia were defined in the Chicago Classification approximately 10 years ago: type I (aperistalsis), type II (pan-pressurization), and type III (spastic). Since the widespread use of this classification scheme, the evolving prevalence of these subtypes has not been elucidated. We aim to determine the prevalence of each subtype a decade after the adoption of the Chicago Classification.
Outcomes in Severe Upper GI Hemorrhage from Dieulafoy’s Lesion with Monitoring of Arterial Blood Flow
B. Nulsen, D. M. Jensen, T. O. G. Kovacs, K. A. Ghassemi, M. Kaneshiro, G. S. Dulai, R. Jutabha & J. A. Gornbein
doi : 10.1007/s10620-020-06679-4
Digestive Diseases and Sciences volume 66, pages3495–3504 (2021)
Dieulafoy’s lesion (DL) is a rare but increasingly recognized cause of severe upper GI hemorrhage (SUGIH). There is little consensus regarding the endoscopic approach to management of bleeding from DL.
Pilot Validation of a New Wireless Patch System as an Ambulatory, Noninvasive Tool That Measures Gut Myoelectrical Signals: Physiologic and Disease Correlations
Lindsay Axelrod, Steve Axelrod, Anand Navalgund & George Triadafilopoulos
doi : 10.1007/s10620-020-06663-y
Digestive Diseases and Sciences volume 66, pages3505–3515 (2021)
Limited means exist to assess gastrointestinal activity in a noninvasive, objective way that is highly predictive of underlying motility disorders. The aim of this paper is to demonstrate the feasibility of recording myoelectric gastrointestinal activity by cutaneous patches and to correlate myoelectric signals with gastrointestinal function in various clinical settings.
The Sphincter of O’Beirne – Part 1: Study of 18 Normal Subjects
Ji-Hong Chen, Sharjana Nirmalathasan, Maham Pervez, Natalija Milkova & Jan D. Huizinga
doi : 10.1007/s10620-020-06657-w
Digestive Diseases and Sciences volume 66, pages3516–3528 (2021)
Gastroenterologists have ignored or emphasized the importance of the rectosigmoid junction in continence or constipation on and off for 200 years. Here, we revisit its significance using high-resolution colonic manometry.
The Sphincter of O’Beirne—Part 2: Report of a Case of Chronic Constipation with Autonomous Dyssynergia
Ji-Hong Chen, Stephen M. Collins, Natalija Milkova, Maham Pervez, Sharjana Nirmalathasan, Wei Tan, Alicia Hanman & Jan D. Huizinga
doi : 10.1007/s10620-020-06723-3
Digestive Diseases and Sciences volume 66, pages3529–3541 (2021)
Chronic constipation can have one or more of many etiologies, and a diagnosis based on symptoms is not sufficient as a basis for treatment, in particular surgery.
Microscopic Colitis Is Not an Independent Risk Factor for Low Bone Density
Elliot J. Graziano, Byron P. Vaughn, Qi Wang, Lisa S. Chow & James P. Campbell
doi : 10.1007/s10620-020-06651-2
Digestive Diseases and Sciences volume 66, pages3542–3547 (2021)
Microscopic colitis (MC) is a subtype of inflammatory bowel disease (IBD) with overlapping risk factors for low bone density (LBD). While LBD is a known complication of IBD, its association with MC is not well-established.
Infliximab Trough Levels Are Not Predictive of Relapse in Patients with IBD in Endoscopic Remission: A Multicenter Cohort Study
Nienke Z. Borren, Emma Paulides, Jody L. Frinack, Ryan N. Olson, Maria Alice V. Willrich, C. Janneke van der Woude & Ashwin N. Ananthakrishnan
doi : 10.1007/s10620-020-06645-0
Digestive Diseases and Sciences volume 66, pages3548–3554 (2021)
Therapeutic drug monitoring (TDM) is important in optimizing use of biologics in inflammatory bowel diseases (IBD). However, the role of proactive TDM during remission remains uncertain.
Infliximab Therapy in Very Early Onset Crohn’s Disease: Real-World Experience in China
Youyou Luo, Qi Cheng, Youhong Fang, Jindan Yu, Jingan Lou & Jie Chen
doi : 10.1007/s10620-020-06699-0
Digestive Diseases and Sciences volume 66, pages3555–3562 (2021)
Data concerning of the effectiveness of infliximab in very early onset Crohn’s disease patients are rare.
Association Between Vedolizumab Levels, Anti-vedolizumab Antibodies, and Endoscopic Healing Index in a Large Population of Patients with Inflammatory Bowel Diseases
Andres J. Yarur, Parakkal Deepak, Niels Vande Casteele, Robert Battat, Anjali Jain, Lauren Okada, Mark Osterman & Miguel Regueiro
doi : 10.1007/s10620-020-06669-6
Digestive Diseases and Sciences volume 66, pages3563–3569 (2021)
The aim of this study was to assess the relationship between serum vedolizumab (VDZ) concentrations and antibodies to VDZ (ATV) in a large cohort of patients with inflammatory bowel diseases. Furthermore, we evaluated the association between serum VDZ concentrations and a novel serum-based biomarker panel designated as the endoscopic healing index (EHI), developed and validated for identifying mucosal inflammation in patients with Crohn’s disease (CD).
Long-Term Outcome of Endoscopic Balloon Dilation for Duodenal Crohn’s Disease-Associated Strictures
Juanjuan Zhang, Yi Li, Yanqing Diao, Binlin Da & Zhiming Wang
doi : 10.1007/s10620-020-06675-8
Digestive Diseases and Sciences volume 66, pages3570–3577 (2021)
Duodenal Crohn’s disease (CD) is rare and may present with obstructive symptoms, and few reports have focused on endoscopic balloon dilation (EBD) for duodenal CD-associated strictures.
Gastrointestinal Symptoms Onset in COVID-19 Patients in Wuhan, China
Ping An, Hongbin Chen, Haixia Ren, Juan Su, Mengyao Ji, Jian Kang, Xiaoda Jiang, Yifei Yang, Jiao Li, Xiaoguang Lv, Anning Yin, Di Chen, Mingkai Chen, Zhongyin Zhou, Weiguo Dong, Yijuan Ding & Honggang Yu
doi : 10.1007/s10620-020-06693-6
Digestive Diseases and Sciences volume 66, pages3578–3587 (2021)
Early detection is critical in limiting the spread of 2019 novel coronavirus (COVID-19). Although previous data revealed characteristics of GI symptoms in COVID-19, for patients with only GI symptoms onset, their diagnostic process and potential transmission risk are still unclear.
Biopsychosocial Model and Perceived Constipation Severity According to the Constipation Phenotype
Michel Bouchoucha, Marinos Fysekidis, David Deutsch, Bakhtiar Bejou, Jean-Marc Sabate & Robert Benamouzig
doi : 10.1007/s10620-020-06654-z
Digestive Diseases and Sciences volume 66, pages3588–3596 (2021)
Constipation is a frequent complaint of patients with functional bowel disorders. The present study aimed to evaluate the relationship between the perceived constipation severity with demographics, clinical, physiological, and psychological parameters in constipated patients.
Heparin-Binding Protein Levels at Admission and Within 24 h Are Associated with Persistent Organ Failure in Acute Pancreatitis
Wenqing Shu, Jianhua Wan, Xiaoyu Yang, Jie Chen, Qinyu Yang, Fen Liu & Liang Xia
doi : 10.1007/s10620-020-06660-1
Digestive Diseases and Sciences volume 66, pages3597–3603 (2021)
Identification of patients at risk for persistent organ failure (POF) early in the course of acute pancreatitis (AP) is critical for early intervention. Heparin-binding protein (HBP) levels are closely related to inflammation. Therefore, we investigated the relationship between HBP levels and POF in patients with AP.
Breaking Down Barriers to Physical Activity in Patients with Nonalcoholic Fatty Liver Disease
Jonathan G. Stine, Christopher Soriano, Ian Schreibman, Gloriany Rivas, Breianna Hummer, Esther Yoo, Kathryn Schmitz & Christopher Sciamanna
doi : 10.1007/s10620-020-06673-w
Digestive Diseases and Sciences volume 66, pages3604–3611 (2021)
Lifestyle changes, including physical activity, are the cornerstones of the treatment of nonalcoholic fatty liver disease (NAFLD). For unclear reasons, most NAFLD patients do not achieve the recommended amount of weekly activity.
Increased Risk of ACLF and Inpatient Mortality in Hospitalized Patients with Cirrhosis and Hepatic Hydrothorax
Jacqueline G. O’Leary, K. Rajender Reddy, Puneeta Tandon, Scott W. Biggins, Florence Wong, Patrick S. Kamath, Guadalupe Garcia-Tsao, Benedict Maliakkal, Jennifer C. Lai, Michael Fallon, Hugo E. Vargas, Paul Thuluvath, Ram Subramanian, Leroy R. Thacker & Jasmohan S. Bajaj
doi : 10.1007/s10620-020-06677-6
Digestive Diseases and Sciences volume 66, pages3612–3618 (2021)
Hepatic hydrothorax (HH) remains a difficult-to-treat complication of cirrhosis.
Safety, Efficacy, and Long-Term Outcomes of Anticoagulation in Cirrhotic Portal Vein Thrombosis
Leonard Naymagon, Douglas Tremblay, Nicole Zubizarreta, Erin Moshier, John Mascarenhas & Thomas Schiano
doi : 10.1007/s10620-020-06695-4
Digestive Diseases and Sciences volume 66, pages3619–3629 (2021)
The role of anticoagulation (AC) in the management of cirrhotic patients with portal vein thrombosis (PVT) remains unclear.
Gastric Antral Vascular Ectasia and Vitamin D Deficiency: New Associated Disease and Proposed Pathogenetic Mechanisms
Rumen Tenev, Maya Gulubova, Julian Ananiev, Nikola Mumdzhiev, Zlatina Vasileva & Koni Ivanova
doi : 10.1007/s10620-020-06666-9
Digestive Diseases and Sciences volume 66, pages3630–3634 (2021)
