دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Skin biopsy as an aid to diagnosis of disorders of the nervous system without cutaneous manifestations
Mamatha George MD,Mohan L. Noone MD, DM,Parvathy Santhosh MD,Rashmi Santhoshkumar PhD,B. K. Chandrasekhar Sagar PhD,Anita Mahadevan MD, DNB
doi : 10.1111/ijd.15513
Volume 60, Issue 10 p. 1179-1182
There are several neurological diseases wherein skin biopsy is useful for diagnosis, even in the absence of skin involvement. Skin biopsy is especially relevant in diseases in which the metabolic error is unknown or has no available diagnostic biochemical test. Skin biopsy, being relatively noninvasive, obviates the need for an invasive procedure such as a brain biopsy. These disorders wherein skin biopsies are particularly useful include the progressive myoclonic epilepsies, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), neuroaxonal dystrophy, and small fiber neuropathies (SFN). We review the role of skin biopsy in such conditions with notes on preferred sites and techniques.
Drug interactions of natural supplements in dermatology: a review
Edward K. Hadeler BA,Andrea D. Maderal MD
doi : 10.1111/ijd.15389
Volume 60, Issue 10 p. 1183-1189
Limited information is available on the drug–drug interactions of natural supplements in dermatology. Many natural supplements are available over the counter, but drug–drug interactions can occur. This study reviews the clinical use and drug interactions of six natural supplements commonly recommended in dermatology: nicotinic acid (nicotinamide), polypodium leucotomos (heliocare), turmeric, horse chestnut seed extract, zinc, and N-acetylcysteine. We reviewed the drug–drug interactions of each supplement using the PubMed database and IBM Micromedex. For nicotinic acid, zinc, horse chestnut, and N-acetylcysteine, IBM Micromedex generated 11, 23, one, and two results, respectively. Further review of literature from PubMed identified two drug interactions with polypodium leucotomos, two with turmeric, and two more with zinc. Notable interactions included an increased risk of myopathy and rhabdomyolysis when nicotinic acid is taken by patients using statins, an increased risk of bleeding associated with horse chestnut seed, especially when used in combination with warfarin, and reduced plasma concentration in many drugs when taken with zinc. Furthermore, N-acetylcysteine may interfere with concentrations of other medications used in the psychiatric setting, and polypodium leucotomos and turmeric may interfere with the CYP metabolic pathway, which may affect drugs metabolized by this pathway. Prior to recommending a treatment, dermatologists should foster awareness of these interactions. In order to advance the practice as a whole, research should continue to evaluate the drug interactions of these natural supplements.
Discoid lupus erythematosus solely involving the eyelids: case report and literature review
Xia Wang MD,Peng Wang MD, PhD,Ming Wang MD,Xian Huang MD,Cuiyan Wang MD,Xiaoying Qu MD,Jialu Xu MD,Yuan Lu MD, PhD,Bao Chai MD, PhD,Changzheng Huang MD, PhD
doi : 10.1111/ijd.15397
Volume 60, Issue 10 p. 1190-1198
The involvement of eyelids occurs in only 5–6% of patients with discoid lupus erythematosus (DLE), commonly with mucocutaneous lesions elsewhere. DLE solely involving the eyelids is relatively rare. This study aimed to describe the clinical features and treatments of all the reported cases of DLE with eyelid involvement as the only symptom.
Clinical efficacy of popular oral hair growth supplement ingredients
Madeline J. Adelman BS,Lisa M. Bedford MD,Geoff A. Potts MD
doi : 10.1111/ijd.15344
Volume 60, Issue 10 p. 1199-1210
Hair supplements are a vast and growing industry. Patients often turn to oral supplements to address hair concerns as they are easily accessible. There are numerous products on the market, many with thousands of reviews (both positive and negative). Nutritional supplements are regulated by the FDA as foods instead of drugs, meaning they do not have to prove their efficacy and safety before becoming available to consumers. While some oral supplements have strong evidence supporting their use for hair growth, many ingredients have not been tested in clinical trials, have only in vitro evidence for hair growth, or have only been tested in animals. Given these industry characteristics, it is important for dermatologists to be aware of the safety and utility of these ingredients to provide appropriate counseling to their patients. The goal of this review is to evaluate the efficacy of popular hair growth oral supplement ingredients and formulations. This review does not address the topical formulations of these ingredients and their effects on hair growth.
Dermoscopy for venereologists: an update on patterns of tumors, inflammatory and infectious diseases of the genitalia, and tips for differential diagnosis
Ismael Maatouk MD, MPH,Zoe Apalla MD, PhD,Enzo Errichetti MD, PhD,Aimilios Lallas MD, PhD
doi : 10.1111/ijd.15333
Volume 60, Issue 10 p. 1211-1218
Dermoscopy is an integrative part of clinical dermatologic examination. For clinicians mainly dealing with genital dermatoses and other venereal diseases, the differential diagnosis includes a broad spectrum of neoplastic, inflammatory, and infectious entities. Dermoscopy might have a valuable role to enhance the clinical differential diagnosis and help avoid some biopsies done for diagnostic purposes. Although the dermoscopic patterns of most tumors and inflammatory diseases of the trunk/face have been described, their manifestations on genital areas are less elucidated. We aimed to provide a succinct summary of existing data on dermoscopy of dermatologic diseases on genital areas.
Cutaneous eruption in a patient of color
Rohan Singh BS,Gibran Shaikh MD,Marcia S. Driscoll MD, PharmD
doi : 10.1111/ijd.15545
Volume 60, Issue 10 p. 1219-1220
Lobulated swelling of the ear: a diagnostic challenge
Vishal Thakur MD,Rajat Choudhary MBBS,Divya Aggarwal MD,Debajyoti Chatterjee MD, DM,Keshavamurthy Vinay MD, DNB
doi : 10.1111/ijd.15597
Volume 60, Issue 10 p. 1221-1223
Knowledge, attitudes, and practices associated with personal health care on urticaria in peripheral health facilities of Yaoundé, Cameroon (Sub-Saharan Africa)
Emmanuel Armand Kouotou MD,Jobert Richie N. Nansseu MD,Dahlia Noelle Tounouga MD,Raissa Katy Otsali Noa MD,Elie Claude Ndjitoyap Ndam MD
doi : 10.1111/ijd.15681
Volume 60, Issue 10 p. 1224-1231
Urticaria is an acute or chronic inflammatory dermatosis that is characterized by erythematous, edematous, itchy, and transient urticarial plaques that cover the skin and mucous membranes. The aim of this study was to evaluate the knowledge of consulting staff on urticaria in Yaoundé, Cameroon, as well as the attitudes and practices resulting from it.
The effectiveness of botulinum toxin type A (BTX-A) in the treatment of facial skin oily seborrhea, enlarged pores, and symptom complex of post-acne
Maria Shirshakova MD,Elena Morozova MD,Daria Sokolova PhD,Svetlana Pervykh MD,Lyudmila Smirnova MD
doi : 10.1111/ijd.15574
Volume 60, Issue 10 p. 1232-1241
This study aimed to examine the effectiveness of botulinum toxin type A (BTX-A) in the treatment of acne.
Do we need skin toxicity? Association of immune checkpoint inhibitor and tyrosine kinase inhibitor-related cutaneous adverse events with outcomes in metastatic renal cell carcinoma
Eduardo Corona-Rodarte MD,Antonio Olivas-Martínez MD,Yuly A. Remolina-Bonilla MD,Judith G. Domínguez-Cherit MD,Elaine T. Lam MD, FACP,Maria T. Bourlon MD, MS
doi : 10.1111/ijd.15583
Volume 60, Issue 10 p. 1242-1247
Skin toxicity is a common, expected side effect of tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (ICIs) used for metastatic renal cell carcinoma (mRCC). We evaluated the association between skin toxicity and clinical efficacy outcomes of these agents in mRCC patients.
Unilateral clubbing-like digital thickening as a clinical manifestation of low-flow vascular malformations: a series of 13 cases
Fernando García-Souto MD,Juan Carlos López-Gutiérrez PhD,Basilio Narváez-Moreno PhD,Israel Fernández-Pineda PhD,José Bernabéu-Wittel PhD
doi : 10.1111/ijd.15585
Volume 60, Issue 10 p. 1248-1252
Digital clubbing is a well-known clinical sign characterized by thickening of the distal phalanges of the fingers and toes. Unilateral clubbing occurs less frequently. A previous report showed for the first time two cases of unilateral clubbing as a clinical manifestation of lower limb venous malformation. The objective of the present study is to describe a series of 13 patients with a low-flow vascular malformation where a clubbing-like unilateral digital thickening is also observed.
Natural evolution in pediatric cutaneous mastocytosis: 10-year follow-up
Justyna Czarny MD, PhD,Joanna Renke MD, PhD,Anton ?awrocki MD, PhD,Roman J. Nowicki MD, PhD,Magdalena Lange MD, PhD
doi : 10.1111/ijd.15542
Volume 60, Issue 10 p. 1253-1257
Mastocytosis is a heterogeneous group of myeloproliferative disorders characterized by accumulation of clonal mast cells in various tissues. The aim of this study was to determine the symptoms evolution and outcome after 10 years observation.
Effects of ?sotretinoin on the growth rate and thickness of the nail plate
Sinan Özçelik MD,Fatma A. K?l?ç MD
doi : 10.1111/ijd.15635
Volume 60, Issue 10 p. 1258-1262
Isotretinoin has various effects on nails. However, the mechanism of how isotretinoin affects the nail plate is unknown. We aimed to investigate the effects of isotretinoin on morphology, growth rate, and thickness of the nail plate.
Evaluation of plasma and urinary levels of vascular endothelial growth factor and matrix metalloproteinase-9 in patients with infantile hemangioma
Anita Rotter MD, PhD,Xinaida T. Lima MD, PhD,Zilda N. P. Oliveira MD, PhD
doi : 10.1111/ijd.15640
Volume 60, Issue 10 p. 1263-1269
The pathogenesis of infantile hemangioma (IH) is not fully understood. It has been suggested that angiogenic factors increase in the proliferative stage, decreasing subsequently in the regression phase.
Serum resistin levels and resistin gene polymorphism in patients with acne vulgaris: does it correlate with disease severity?
Wafaa A. Shehata MD,Alaa Maraee MD,Tagreed A. A. Wahab MB, BCh,Rania Azmy MD
doi : 10.1111/ijd.15727
Volume 60, Issue 10 p. 1270-1277
Acne vulgaris is a disease that inflames the sebaceous gland with multiple etiologies. Many proinflammatory adipokines contribute to this pathogenesis. Resistin is a proinflammatory mediator that activates kappa B, a nuclear factor, and c-Jun N-terminal kinases pathways inducing toll-like receptor-2, interleukin-1, 6, and tumor necrosis factor alpha. Resistin gene affects the promoter and intron regions' polymorphisms' expression levels. We aimed to study the association of resistin gene polymorphisms (RETN -420 C/G) and the development of acne vulgaris and whether it is associated with serum resistin levels and disease severity.
Clinico-epidemiological profile of lichen scrofulosorum: a 22-year, single-center, retrospective study
Archana Singal MD, FAMS,Ishmeet Kaur MD,Deepika Pandhi MD, MNAMS,Vijay Gandhi MD,Deepak Jakhar MD,Chander Grover MD, DNB, MNAMS
doi : 10.1111/ijd.15737
Volume 60, Issue 10 p. 1278-1284
Lichen scrofulosorum (LS) represents immunologic reaction to the Mycobacterium tuberculosis antigen and presents with subtle, asymptomatic, grouped follicular papules over the trunk and shows good therapeutic response to antitubercular drugs.
Infliximab in leprosy type 1 reaction: a case report
Julie Valentin MD,Kinan Drak Alsibai MD, PhD,Chloe Bertin MD,Pierre Couppie MD, PhD,Romain Blaizot MD
doi : 10.1111/ijd.15645
Volume 60, Issue 10 p. 1285-1287
Long hair follicular unit excision: personal experience
Jae Hyun Park MD, PhD,Seung Hyun You MD,Na Rae Kim MD,Yeh Hong Ho MD
doi : 10.1111/ijd.15648
Volume 60, Issue 10 p. 1288-1295
Long hair follicular unit excision (FUE) is the most state-of-the-art surgical technique in the field of hair transplantation surgery. Long hair FUE reduces the signs of surgery by camouflaging the recipient area with long hair, and allows hair curl identification when placing grafts. In addition, donor area shaving can be omitted.
One size does not fit all: the need for individualized treatment based on factors that may affect the therapeutic outcome of efinaconazole 10% solution for the treatment of toenail onychomycosis
Aditya K. Gupta MD, PhD,Maanasa Venkataraman MSc,Naveen Anbalagan MD, MBA,Eric P. Guenin Pharm D, PhD, MPH
doi : 10.1111/ijd.15739
Volume 60, Issue 10 p. 1296-1302
Successful management of onychomycosis is a challenge because cure rates with most antifungals are relatively low and recurrence rates are high. A drug-based approach by treating the nail alone may not suffice. There are several host-related factors (age, sex, body mass index [BMI], and patient’s quality of life), disease-related factors (disease severity, duration, and the number of toenails affected), and comorbidities (tinea pedis and diabetes) that may affect treatment efficacy. Here, we review the post hoc analyses of the phase III trials of efinaconazole 10% solution that have investigated the impact of these factors on topical therapy for toenail onychomycosis. The significant clinical variables that may affect the efficacy of efinaconazole include sex, BMI, disease severity, disease duration, and tinea pedis. As older patients may have slower toenail growth and more severe, longstanding disease compared with younger patients, they may require longer treatment duration, beyond the 48-week standard regimen. Treatment compliance may need to be discussed for an improved health outcome. Therefore, these prognostic factors need to be carefully evaluated, which may aid in formulating individualized therapy to maximize treatment success.
Predatory journals, publishers, conferences, and indexing systems: who is responsible for their growth?
Anuradha Bishnoi MD,Ashwini Reddy MD,Keshavamurthy Vinay MD, DNB
doi : 10.1111/ijd.15684
Volume 60, Issue 10 p. 1303-1304
New-onset leukocytoclastic vasculitis after COVID-19 vaccine
Ecem Bostan MD,Duygu Gulseren MD,Ozay Gokoz MD
doi : 10.1111/ijd.15777
Volume 60, Issue 10 p. 1305-1306
Scabies outbreak during COVID-19: an Italian experience
Mario De Lucia MD,Luca Potestio MD,Luca Costanzo MD,Gabriella Fabbrocini PhD,Lucia Gallo MD
doi : 10.1111/ijd.15809
Volume 60, Issue 10 p. 1307-1308
Neuropathic ulcers: a focused review
Brittany Urso MD,Mondana Ghias MD,Anan John MD,Amor Khachemoune MD, FAAD, FACMS
doi : 10.1111/ijd.15362
Volume 60, Issue 10 p. e383-e389
Neuropathic ulcers or diabetic foot ulcers are preventable ulcers associated with diabetes mellitus. These ulcers occur in the setting of unrecognized trauma, peripheral neuropathy, and foot deformities; however, they are often complicated by peripheral arterial disease and infection. Approximately 15% of individuals with a neuropathic ulcer require limb amputation as a result of infection. Not only are neuropathic ulcers a burden to the patient but also to the economy. The cost of diabetic foot ulcer care is approximately $1.38 billion per year. This makes neuropathic ulcers an important therapeutic target. This review presents the pathophysiology, clinical presentation, evaluation, management, and prevention of neuropathic ulcers.
Simvastatin in vitiligo: an update with recent review of the literature
Rashidul Hasan MD, BBS,Komal Agarwal MD,Indrashis Podder MD, DNB,Angelica Misitzis MD,Robert A. Schwartz MD,Uwe Wollina MD,Torello Lotti MD,Stephan Grabbe MD,Mohamad Goldust MD
doi : 10.1111/ijd.15330
Volume 60, Issue 10 p. e390-e396
Patients with vitiligo often seek medical attention, as it diminishes their quality of life resulting in significant morbidity. Several topical and systemic therapies are in vogue targeting the immunological aspect of this disease, but results are often unsatisfactory, and complete cure remains elusive. Recently, simvastatin, a 3-hydroxy-3-methylyglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, is being evaluated for vitiligo management because of its multimodal action, easy availability, and low cost. The proposed multimodal actions range from anti-inflammatory, antioxidant, to immunomodulatory properties which may be of therapeutic benefit in vitiligo patients. The authors intend to evaluate the role of simvastatin as a novel therapeutic agent for vitiligo along with relevant review of literature.
Nivolumab-induced lichenoid reaction in a patient with advanced renal cancer
Juliana Martínez del Sel MD,Nadia Benítez MD,Miguel Allevato MD
doi : 10.1111/ijd.15831
Volume 60, Issue 10 p. e397-e398
Toxic epidermal necrolysis induced by doxycycline
Madeline J. Adelman BS,Gregory Messenger MD,Mehdi Farshchian MD, PhD,Meena Moossavi MD, MPH
doi : 10.1111/ijd.15470
Volume 60, Issue 10 p. e398-e400
BASCULE syndrome associated with presyncopal episodes and first-degree atrioventricular block
Santiago Guillen-Climent MD,Saray Porcar Saura MD,Martí Pons Benavent MD,Alejandro García-Vázquez MD,José María Martín PhD
doi : 10.1111/ijd.15568
Volume 60, Issue 10 p. e400-e402
Perspectives on the Twitter presence of hidradenitis suppurativa
Ximena Wortsman MD,Cristian Ramírez-Cornejo MD,Camila Ferreira-Wortsman MS,Robert Howes
doi : 10.1111/ijd.15631
Volume 60, Issue 10 p. e402-e403
Pustulotic arthro-osteitis with generalized pustulosis lagging 20 years behind the onset of joint symptoms
Shiho Sunami MD,Tetsuya Honda MD, PhD,Yo Kaku MD,Yuichiro Endo MD,Alshimaa Mostafa MD,Gyohei Egawa MD, PhD,Kenji Kabashima MD, PhD
doi : 10.1111/ijd.15603
Volume 60, Issue 10 p. e403-e405
Demodex tails on dermoscopy beyond demodicosis: another pitfall to avoid
Enzo Errichetti MD,Matteo Figini MD,Arturo Galvan MD
doi : 10.1111/ijd.15564
Volume 60, Issue 10 p. e405-e407
Drug resistance to rifampicin in a case of steroid-dependent erythema nodosum leprosum and the therapeutic implications of resistance and reactions in leprosy
Aishwarya Muddebihal MBBS,Kabir Sardana MBBS, MD, DNB, MNAMS,Sinu R. Mathachan MBBS, MD, MRCP (SCE),Ananta Khurana MBBS, MD, DNB, MNAMS,Itu Singh PhD,Rahul Sharma MSc
doi : 10.1111/ijd.15559
Volume 60, Issue 10 p. e407-e409
Reactive capillary hemangiomas induced by camrelizumab in a patient with hepatocarcinoma
Xue Zhang MPhil,Mengxin Wang MPhil,Bingjun Shi MD, PhD
doi : 10.1111/ijd.15606
Volume 60, Issue 10 p. e409-e410
Hidradenitis suppurativa research from Africa: a bibliometric analysis
Justine Seivright BS,Alyssa M. Thompson BS,Swetha Atluri BS,Amanda Ederle BS,Anna Swigert BS,Joanna Jaros MD,Vivian Y. Shi MD,Jennifer L. Hsiao MD
doi : 10.1111/ijd.15571
Volume 60, Issue 10 p. e410-e414
Avelumab-induced lichen planopilaris, a novel association
Miguel Dominguez-Santas MD,Diego Fernandez-Nieto MD,Borja Diaz-Guimaraens MD,Ana Suarez-Valle MD,Juan Jimenez-Cauhe MD,David Saceda-Corralo MD, PhD
doi : 10.1111/ijd.15595
Volume 60, Issue 10 p. e414-e416
Atypical eosinophilic annular erythema clinically resembling granuloma annulare
Yasushi Matsuzaki MD,Satoko Minakawa MD,Chihiro Sagara MD,Akinobu Matsui MD,Hajime Nakano MD,Daisuke Sawamura MD
doi : 10.1111/ijd.15591
Volume 60, Issue 10 p. e416-e417
Efficacy of tocilizumab in adult H syndrome: a promising therapeutic option
Pierre Hamann MD,Philippe Moguelet MD,François Chasset MD, PhD,Jeremie Delaleu MD,Annick Barbaud MD, PhD,Patricia Senet MD,Camille Frances MD, PhD,Tullia De Risi-Pugliese MD
doi : 10.1111/ijd.15649
Volume 60, Issue 10 p. e417-e419
Hair loss, facial dysmorphology, and skeletal alterations – a diagnostic challenge
Rogério Nabor Kondo MD,Fitnat Buket Basmanav PhD,Sabrina Wolf,Lorivaldo Minelli MD,Jorge Frank MD,Regina C. Betz MD
doi : 10.1111/ijd.15718
Volume 60, Issue 10 p. e419-e421
Comment on “Lipoatrophia semicircularis – a distinct entity?”
Mariabeatrice Bertolani MD,Sonia Mele MD,Roberta Manuguerra MD,Michele M. Dominici MD,Torello Lotti MD, FRCP,Claudio Feliciani MD, PhD,Francesca Satolli MD
doi : 10.1111/ijd.15600
Volume 60, Issue 10 p. e421-e422
Childhood atopic dermatitis: outpatient visit trends, demographics, and topical agents in the United States, 1995–2015
Yasmin Gutierrez BS,Andrea J. Borba MD,Dominic J. Grisafe PhD,April W. Armstrong MD, MPH
doi : 10.1111/ijd.15576
Volume 60, Issue 10 p. e423-e424
Atypical fibroxanthoma relapse as pleomorphic dermal sarcoma after slow Mohs micrographic surgery
Cristina López-Llunell MD,Mireia Yébenes MD,Patricia Garbayo-Salmons MD,Lorena Leal MD,Alfonso Mogedas-Vergara MD, PhD
doi : 10.1111/ijd.15581
Volume 60, Issue 10 p. e424-e427
The prognostic value of inositol polyphosphate 5-phosphatase in cutaneous squamous cell carcinoma in the general population
Meera H Patel BS,Caitlin M Brumfiel MS,Kevin J Severson BS,David J DiCaudo MD,Steven A Nelson MD,Richard J Butterfield MS,Nan Zhang MS,Christian Baum MD,Aleksander Sekulic MD,Aaron R Mangold MD
doi : 10.1111/ijd.15565
Volume 60, Issue 10 p. e427-e429
Dermoscopy and reflectance confocal microscopy features of acquired lymphangiectasias following surgery and radiotherapy of breast cancer
Maria Penalba-Torres MD,Mario Puerta-Peña MD,Jose L. Rodríguez-Peralto MD, PhD,Pablo L. Ortiz-Romero MD, PhD,Virginia Velasco-Tamariz MD
doi : 10.1111/ijd.15596
Volume 60, Issue 10 p. e429-e431
Clinical practice gap: annual skin cancer screening examinations for visually impaired patients
Nora S. Ali MD,Beija K. Villalpando BS,Gavin W. Roddy MD, PhD,Julio C. Sartori-Valinotti MD
doi : 10.1111/ijd.15614
Volume 60, Issue 10 p. e431-e432
