Charles C. Flippen II, MD1
doi : 10.1001/jamaneurol.2021.0428
JAMA Neurol. 2021;78(6):645-646
Patrick M. Briley, PhD1; Charles Ellis Jr, PhD1; Molly M. Jacobs, PhD2
doi : 10.1001/jamaneurol.2021.0633
JAMA Neurol. 2021;78(6):646-647
Matthew Castelo, MD1,2
doi : 10.1001/jamaneurol.2021.0980
JAMA Neurol. 2021;78(6):648-649
Claudia H. Kawas, MD1,2,3; María M. Corrada, ScM, ScD1,2,4; Rachel A. Whitmer, PhD5
doi : 10.1001/jamaneurol.2021.0285
JAMA Neurol. 2021;78(6):650-652
Deborah I. Friedman, MD, MPH1,2
doi : 10.1001/jamaneurol.2021.0364
JAMA Neurol. 2021;78(6):652-654
Safi U. Khan, MD, MS1; Erin D. Michos, MD, MHS2
doi : 10.1001/jamaneurol.2021.0624
JAMA Neurol. 2021;78(6):654-656
Elena Tsoy, PhD1; Rachel E. Kiekhofer, BA1; Elan L. Guterman, MD2; Boon Lead Tee, MD1; Charles C. Windon, MD1; Karen A. Dorsman, BA3; Serggio C. Lanata, MD1,4; Gil D. Rabinovici, MD1,5,6; Bruce L. Miller, MD1,4; Amy J. H. Kind, MD, PhD7,8; Katherine L. Possin, PhD1,4
doi : 10.1001/jamaneurol.2021.0399
JAMA Neurol. 2021;78(6):657-665
The US aging population is rapidly becoming more racially and ethnically diverse. Early diagnosis of dementia is a health care priority.
Brent Strong1; Julia Pudar, BS1; Amanda G. Thrift, PhD2; Virginia J. Howard, PhD3; Murtaza Hussain, MD1; Cheryl Carcel, MD, PhD4; Gustavo de los Campos, PhD1; Mathew J. Reeves, BVSc, PhD1
doi : 10.1001/jamaneurol.2021.0873
JAMA Neurol. 2021;78(6):666-677
The underenrollment of women in randomized clinical trials represents a threat to the validity of the evidence supporting clinical guidelines and potential disparities in access to novel treatments.
Susan P. Mollan, MBcHB1; James L. Mitchell, MBcHB2,3; Ryan S. Ottridge, MPhil4; Magda Aguiar, PhD5; Andreas Yiangou, MBBS2,3,6; Zerin Alimajstorovic, PhD2,6,7; David M. Cartwright, MRes6,7; Olivia Grech, MRes2,6,7; Gareth G. Lavery, PhD6,7; Connar S. J. Westgate, PhD2; Vivek Vijay, MBBS2,3; William Scotton, MBBS3; Ben R. Wakerley, PhD8; Tim D. Matthews, MBcHB1; Alec Ansons, MBcHB9; Simon J. Hickman, PhD10; James Benzimra, BM, BCh11; Caroline Rick, PhD12; Rishi Singhal, MD13,14; Abd A. Tahrani, PhD6,7,15; Kristian Brock, PhD16; Emma Frew, PhD5; Alexandra J. Sinclair, PhD2,3,6
doi : 10.1001/jamaneurol.2021.0659
JAMA Neurol. 2021;78(6):678-686
Idiopathic intracranial hypertension (IIH) causes headaches, vision loss, and reduced quality of life. Sustained weight loss among patients with IIH is necessary to modify the disease and prevent relapse.
Erika A. Petersen, MD1; Thomas G. Stauss, MD2; James A. Scowcroft, MD3; Elizabeth S. Brooks, PhD4; Judith L. White, MD5; Shawn M. Sills, MD6; Kasra Amirdelfan, MD7; Maged N. Guirguis, MD8; Jijun Xu, MD, PhD9; Cong Yu, MD10; Ali Nairizi, MD11; Denis G. Patterson, DO11; Kostandinos C. Tsoulfas, MD2; Michael J. Creamer, DO12; Vincent Galan, MD13; Richard H. Bundschu, MD14; Christopher A. Paul, MD15; Neel D. Mehta, MD16; Heejung Choi, MD15; Dawood Sayed, MD17; Shivanand P. Lad, MD, PhD18; David J. DiBenedetto, MD19; Khalid A. Sethi, MD20; Johnathan H. Goree, MD15; Matthew T. Bennett, MD20; Nathan J. Harrison, MD8; Atef F. Israel, MD3; Paul Chang, MD13; Paul W. Wu, MD21; Gennady Gekht, MD14; Charles E. Argoff, MD22; Christian E. Nasr, MD23; Rod S. Taylor, PhD24; Jeyakumar Subbaroyan, PhD25; Bradford E. Gliner, MS26; David L. Caraway, MD, PhD4; Nagy A. Mekhail, MD, PhD9
doi : 10.1001/jamaneurol.2021.0538
JAMA Neurol. 2021;78(6):687-698
Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments.
Amber Salter, PhD1; Robert J. Fox, MD2; Scott D. Newsome, DO3; June Halper, MSCN4; David K. B. Li, MD5; Pamela Kanellis, PhD6; Kathleen Costello, MSCN7; Bruce Bebo, PhD7; Kottil Rammohan, MD8; Gary R. Cutter, PhD9; Anne H. Cross, MD1
doi : 10.1001/jamaneurol.2021.0688
JAMA Neurol. 2021;78(6):699-708
Emergence of SARS-CoV-2 causing COVID-19 prompted the need to gather information on clinical outcomes and risk factors associated with morbidity and mortality in patients with multiple sclerosis (MS) and concomitant SARS-CoV-2 infections.
Mohammed A. Almekhlafi, MD, MSc1,2,3,4; Mayank Goyal, MD, PhD1,2,3,4; Diederik W. J. Dippel, MD5; Charles B. L. M. Majoie, MD, PhD6; Bruce C. V. Campbell, MD7; Keith W. Muir, MD8; Andrew M. Demchuk, MD1,3; Serge Bracard, MD9; Francis Guillemin, MD, PhD10; Tudor G. Jovin, MD11; Peter Mitchell, MD12; Philip White, MD13; Michael D. Hill, MD, MSc1,2,3,14; Scott Brown, PhD15; Jeffrey L. Saver, MD16; for the HERMES Trialists Collaboration
doi : 10.1001/jamaneurol.2021.1055
JAMA Neurol. 2021;78(6):709-717
The benefits of endovascular thrombectomy (EVT) are time dependent. Prior studies may have underestimated the time-benefit association because time of onset is imprecisely known.
Benson S. Chen, MBChB, MSc1; Benjamin I. Meyer, BS1; Amit M. Saindane, MD, MBA2; Beau B. Bruce, MD, PhD1,3; Nancy J. Newman, MD1,4,5; Valérie Biousse, MD1,4
doi : 10.1001/jamaneurol.2021.0710
JAMA Neurol. 2021;78(6):718-725
Magnetic resonance imaging (MRI) signs of intracranial hypertension (IH) are traditionally associated with idiopathic intracranial hypertension (IIH), but these signs are also detected among individuals with primary headaches and among asymptomatic individuals without papilledema.
Damiano Baroncini, MD1; Marta Simone, MD2; Pietro Iaffaldano, MD3; Vincenzo Brescia Morra, MD4; Roberta Lanzillo, MD, PhD4; Massimo Filippi, MD5; Marzia Romeo, MD6; Francesco Patti, MD7; Clara Grazia Chisari, MD7; Eleonora Cocco, MD8; Giuseppe Fenu, MD8; Giuseppe Salemi, MD9; Paolo Ragonese, MD9; Matilde Inglese, MD, PhD10,11; Maria Cellerino, MD10; Lucia Margari, MD2; Giancarlo Comi, MD1,12; Mauro Zaffaroni, MD1; Angelo Ghezzi, MD1; for the Italian MS registry
doi : 10.1001/jamaneurol.2021.1008
JAMA Neurol. 2021;78(6):726-735
Availability of new disease-modifying therapies (DMTs) and changes of therapeutic paradigms have led to a general improvement of multiple sclerosis (MS) prognosis in adults. It is still unclear whether this improvement also involves patients with pediatric-onset MS (POMS), whose early management is more challenging.
Arpan Patel, MD1; James Sul, MD1; Marc L. Gordon, MD2,3; Jared Steinklein, MD4; Shayna Sanguinetti, MD1; Bidyut Pramanik, MD4; Dushyant Purohit, MD5,6; Vahram Haroutunian, PhD6,7,8; Alex Williamson, MD9; Igor Koralnik, MD10; Asaff Harel, MD, MSc11
doi : 10.1001/jamaneurol.2021.0627
JAMA Neurol. 2021;78(6):736-740
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection caused by the JC virus that has no proven effective treatment. Although rare cases of PML have occurred with other anti-CD20 therapies, there had been no prior cases associated with ocrelizumab.
Elia Sechi, MD1,2; Marina Buciuc, MD1; Sean J. Pittock, MD1,3; John J. Chen, MD, PhD1,4; James P. Fryer, MS3; Sarah M. Jenkins, MS5; Adrian Budhram, MD1,6; Brian G. Weinshenker, MD1; A. Sebastian Lopez-Chiriboga, MD7; Jan-Mendelt Tillema, MD1; Andrew McKeon, MD1,3; John R. Mills, PhD3; W. Oliver Tobin, MB BCh, BAO, PhD1; Eoin P. Flanagan, MD1,3
doi : 10.1001/jamaneurol.2021.0912
JAMA Neurol. 2021;78(6):741-746
Myelin oligodendrocyte glycoprotein-IgG1–associated disorder (MOGAD) is a distinct central nervous system–demyelinating disease. Positive results on MOG-IgG1 testing by live cell-based assays can confirm a MOGAD diagnosis, but false-positive results may occur.
Nicole Rosendale, MD1,2; Jeffrey O. Wong, BS3; Jason D. Flatt, PhD, MPH4; Evans Whitaker, MD, MLIS5
doi : 10.1001/jamaneurol.2020.5536
JAMA Neurol. 2021;78(6):747-754
Little is known about the neurologic health needs of sexual and gender minority (SGM) individuals, and existing research indicates health care disparities for this group.
Roel Haeren, MD, PhD1,2; Rahul Raj, MD, PhD1; Mika Niemelä, MD, PhD1
doi : 10.1001/jamaneurol.2021.0526
JAMA Neurol. 2021;78(6):755-756
Rongfei Wang, MD1; Huijuan Yuan, MB1,2; Zhao Dong, MD, PhD1
doi : 10.1001/jamaneurol.2021.0750
JAMA Neurol. 2021;78(6):757-758
Neal S. Parikh, MD, MS1; Babak B. Navi, MD, MS1; Alexander E. Merkler, MD, MS1; Hooman Kamel, MD, MS1,2
doi : 10.1001/jamaneurol.2021.0636
JAMA Neurol. 2021;78(6):759-760
David W. Nauen, MD, PhD1; Jody E. Hooper, MD1; C. Matthew Stewart, MD, PhD2; Isaac H. Solomon, MD, PhD3
doi : 10.1001/jamaneurol.2021.0225
JAMA Neurol. 2021;78(6):760-762
Wai Yan Yau, MBBS, BMedSci, MMed1; Henry Houlden, MD, PhD1; Jana Vandrovcova, PhD1
doi : 10.1001/jamaneurol.2021.0747
JAMA Neurol. 2021;78(6):762-763
Dongrui Ma, PhD1; Yi Jayne Tan, BSc2; Eng-King Tan, MD1,2,3
doi : 10.1001/jamaneurol.2021.0768
JAMA Neurol. 2021;78(6):763
Fujun Liu, MD1; Xin Tang, MD1; Liangxue Zhou, MD, PhD1
doi : 10.1001/jamaneurol.2021.0890
JAMA Neurol. 2021;78(6):763-764
Daniel B. Rubin, MD, PhD1; Caron Jacobson, MD2; Henrikas Vaitkevicius, MD3,4
doi : 10.1001/jamaneurol.2021.0893
JAMA Neurol. 2021;78(6):764-765
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