Journal of Cosmetic Dermatology




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Issue Information

doi : 10.1111/jocd.14351

Volume 20, Issue 8 p. 2375-2376

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JCD—August commentary

Michael H. Gold MD

doi : 10.1111/jocd.14336

Volume 20, Issue 8 p. 2377-2377

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Cutaneous long COVID

Antonella Tammaro MD, PhD,Francesca Romana Parisella MD,Ganiyat Adenike Ralitsa Adebanjo MD,

doi : 10.1111/jocd.14291

Volume 20, Issue 8 p. 2378-2379

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Localized cutaneous reaction to an mRNA COVID-19 vaccine

Manar Edriss BS,Mehdi Farshchian MD, PhD,Steven Daveluy MD,

doi : 10.1111/jocd.14288

Volume 20, Issue 8 p. 2380-2381

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The impact of COVID-19 pandemic in dermatology outpatient clinics in Turkey: A survey study

Eda Ustaoglu MD

doi : 10.1111/jocd.14297

Volume 20, Issue 8 p. 2382-2386

The COVID-19 pandemic has substantially affected the healthcare systems around the world. It has also induced some changes in working habits at dermatology clinics. The majority of dermatology clinics limited the number of patients at outpatient clinics and postponed the elective procedures.

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Acute generalized exanthematous pustulosis following treatment with favipiravir in a patient with COVID-19 without hydroxychloroquine use: Report of the first case

Mehmet Fatih Atak MD,Banu Farabi MD,Atiye Akbayrak MD,Mehmet Berati Kalelio?lu MD,Babar K. Rao MD,

doi : 10.1111/jocd.14304

Volume 20, Issue 8 p. 2387-2389

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Bilateral foot ulcers in a COVID-19 patient under favipiravir treatment

Y?ld?z Hayran,?lke Diren Albayrak,Devrim Tuba Öcalan,Ak?n Akta?,

doi : 10.1111/jocd.14307

Volume 20, Issue 8 p. 2390-2391

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Yellow-white fluorescence on the nails: A novel finding of Favipiravir used for the treatment of COVID-19

Duygu Gülseren,Ba?ak Yal?c?-Armagan,

doi : 10.1111/jocd.14214

Volume 20, Issue 8 p. 2392-2393

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Could isotretinoin be a protective agent against COVID-19?: A dermatologist perspective

Ayman Abdelmaksoud MSc,Anant Patil MD,Recep Dursun MD,Selami Aykut Temiz MD,Erhan Ayhan MD,Mohamad Goldust MD,Michelangelo Vestita MD,

doi : 10.1111/jocd.14239

Volume 20, Issue 8 p. 2394-2395

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Virgin coconut oil as prophylactic therapy against alcohol damage on skin in COVID times

Punit Saraogi MBBS, MD, FCPS,Vaibhav Kaushik BTech, SM,Ritesh Chogale BTech,Sneha Chavan BTech,Vaishali Gode PhD,Sudhakar Mhaskar PhD,

doi : 10.1111/jocd.14258

Volume 20, Issue 8 p. 2396-2408

Increased frequency of using alcohol-based hand sanitizers (ABHS) by consumers during COVID times have resulted in increased incidences of skin issues on palms.

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Ophthalmic adverse events following facial injections of botulinum toxin A: A systemic literature review

Ron Skorochod B.MED. Sc.,Ronit Nesher MD,Gideon Nesher MD,Yoav Gronovich MD, MBA,

doi : 10.1111/jocd.14279

Volume 20, Issue 8 p. 2409-2413

Over the years, botulinum toxin has found its place as a neuromuscular blocking agent in numerous medical fields. Since the approval of botulinum toxin by the FDA for cosmetic indications in 2002, it had become the most commonly performed esthetic procedure worldwide, with ever-growing demand. The characteristics of the toxin, along with the facial areas it is injected to, could possibly account for a wide array of complication.

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Non-surgical rhinoplasty using hyaluronic acid dermal fillers: A systematic review

Vaibhav Kumar MDS, FRSPH,Anuj Jain MDS, FIBOMS, FIBCSOMS, FISOI,Swarali Atre BDS,Debraj Shome MD, FRCS, FACS, FAACS, MBA,Rinky Kapoor MD,Komal Doshi MDS,Sapna Vadera MDS,

doi : 10.1111/jocd.14173

Volume 20, Issue 8 p. 2414-2424

Non-surgical rhinoplasty using hyaluronic acid dermal fillers is a cosmetic procedure that has been becoming increasingly popular among patients wanting to correct nasal deformities or nasal irregularities, in the recent years.

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A new era of moisturizers

Neha Chandan MD, MPH,Jeffrey R. Rajkumar BS,Vivian Y. Shi MD,Peter A. Lio MD,

doi : 10.1111/jocd.14217

Volume 20, Issue 8 p. 2425-2430

Moisturizers traditionally function to replenish both the intercellular lipid lamella and natural moisturizing factors, and form a hydrolipid film on the skin surface to decrease transepidermal water loss and improve hydration. As we continue to identify epidermal lipid imbalance in patients with atopic dermatitis, we turn to the use of bioactive ingredients in moisturizers for improving barrier repair and function.

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Platelet-rich plasma is a promising therapy for melasma

Ankita Tuknayat MBBS MD DNB SCE,Mala Bhalla MBBS MD MNAMS,Gurvinder Pal Thami MBBS MD,

doi : 10.1111/jocd.14229

Volume 20, Issue 8 p. 2431-2436

Platelet-rich plasma (PRP) is an autologous blood product which has recently been used in multiple spheres of dermatology including facial rejuvenation, androgenetic alopecia, acne scars, and wound healing. Its use in melasma is comparatively an understudied topic.

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Skin cancer knowledge, attitudes, and practices among non-medical skin care professionals: A narrative review of cross-sectional and interventional studies

Ross L. Pearlman MD,Amanda H. Wilkerson PhD,Taylor S. Ferris BA,David B. Griffin MD,Emily K. Cobb MS,Hannah K. McCowan BS,Kaustuv Bhattacharya PhD, MS,Jonathan T. Leo PhD,Sheree C. Melton MD,Vinayak K. Nahar MD, PhD, MS

doi : 10.1111/jocd.14260

Volume 20, Issue 8 p. 2437-2457

Skin cancers are the most common malignancies in the United States. Total body skin examination by a physician, especially a dermatologist, is the gold standard for detecting suspicious lesions that may require further evaluation. Non-medical professionals (NMPs) including massage therapists, estheticians, hairdressers, and cosmetologists have the unique opportunity to frequently examine their client's skin outside of a clinical setting. By evaluating their knowledge of and comfort with evaluation of suspicious lesions, multiple studies have gauged the utility of patient encounters with NMPs for skin cancer detection. Several studies have also focused on assessment of intervention strategies for assessing and improving NMPs ability to detect suspicious lesions and to refer for physician evaluation when necessary.

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Biorevitalization of the skin with skin boosters: Concepts, variables, and limitations

Gulhima Arora DNB, MNAMS,Sandeep Arora MD,Roxanna Sadoughifar MD,Neha Batra MD, MSc,

doi : 10.1111/jocd.13871

Volume 20, Issue 8 p. 2458-2462

Aging leads to diminished capacity in the functionality of all the skin layers, which in turn leads to a structurally weak and esthetically unappealing skin which is dull, dehydrated, and inelastic. Skin boosters can be defined as biological materials or bio-actives that help or encourage the skin to increase or improve its function. Boosters have been used in treating skin structural changes associated with aging as well as other factors such as corticosteroid-induced skin atrophy. Restoring the loss in skin nourishment and vital components is the concept involved in biorevitalization of the skin. The authors aim to present an update and a short review of skin boosters in this commentary.

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Cold contact urticaria triggered by a permanent tattoo

Nadia Raison-Peyron MD,Julie Litovsky MBBS,Pascale Huet MD,Olivier Dereure MD, PhD,

doi : 10.1111/jocd.13874

Volume 20, Issue 8 p. 2463-2465

Cold contact urticaria is an inducible urticaria triggered by exposure to cold air, liquids, or objects. Symptoms may range from mild, localized urticaria to genuine anaphylaxis particularly after extensive contact of large skin areas to cold. Treatment mainly requires a strict avoidance of cold exposure and the use of second-generation H1 antihistamine. In most cases, it is not associated with any specific etiology although in rare cases it can be secondary to various associated diseases or triggered by a number of external factors. We present the observation of a 38-year-old woman for whom cold contact urticaria began on a recent tattoo area.

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Rise in male cosmetic procedures in dermatology: A 4.5-year clinical evaluation

Jordan V. Wang MD, MBE, MBA,Alexander Valiga MD,Christian A. Albornoz MD,Roy G. Geronemus MD,

doi : 10.1111/jocd.13895

Volume 20, Issue 8 p. 2466-2468

This commentary examines the growing popularity of cosmetic procedures in men. With the recent increase in aesthetic procedures across the nation, it is important for physicians to understand trends as they evolve, which can help to optimize clinical training, business operations, and practice management. Although the popularity of cosmetic procedures in men has increased, available data on consumer behavior is limited. Our data fills this gap by examining the patterns of cosmetic procedures in men. Due to hormonal and anatomic differences, the pathophysiology of cutaneous aging differs between sexes, which can have significant implications for treatment. Our data demonstrates a positive trend in recent years and also breaks it down by individual procedures.

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Comparison of injectable filler locations in men and women: An age-matched case analysis

Jordan V. Wang MD, MBE, MBA,Alexander Valiga MD,Christian A. Albornoz MD,Roy G. Geronemus MD,

doi : 10.1111/jocd.14293

Volume 20, Issue 8 p. 2469-2471

In recent years, the popularity of fillers has risen significantly. Traditionally, women have undergone the vast majority of cosmetic procedures, but men have steadily shown increasing interest. Recently, significant research has been dedicated to understanding the anatomic differences between male and female facial structures and their clinical aesthetic implications, especially for filler placement. In order to compare actual treatment data to evidence these discussions, we randomly selected 100 cases each of men and women, who were matched for age, and documented their filler placement locations. Facial heat maps were constructed to provide readers with visual evidence. Injections for male cheeks were more inferiomedial, while female cheeks were more superolateral. Men had more jawline fillers, while women had more lip and perioral fillers. Our study builds upon gender-specific considerations. It is important for physicians to be knowledgeable regarding the unique approaches to fillers in men and women in order to deliver more effective, tailored, and high-quality care.

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A prospective, open-label, multicentric, single-arm, post-marketing clinical study to evaluate effectiveness and safety of Cross-Linked Sodium Hyaluronate 24mg with Lidocaine 3mg Injection in subjects undergoing treatment for facial wrinkles and lip augmentation

Debraj Shome MD, FRCS, FACS, FAACS, MBA,Radha Atal Shah MBBS, MD, DDV, FCPS,Dinesh Gowda MBBS, DVD,Sapna Vadera MDS,Vaibhav Kumar MDS, FPFA, FRSPH,Manish Raj BDS,Ali Atif MDS,Komal Doshi MDS,Mrudul Vekaria MPharm,Meghna Pathak MSc,Rinky Kapoor MD,

doi : 10.1111/jocd.14249

Volume 20, Issue 8 p. 2472-2479

Hyaluronic acid (HA) fillers are quite commonly used since several years for soft tissue augmentation.

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Autologous whole fat injection stimulates hair growth in resistant Androgenetic Alopecia: Report of nine cases

Mohammad Ali Nilforoushzadeh MD,Elaheh Lotfi MD,Maryam Heidari-Kharaji PhD,Elham Torkamaniha MSc,Amir Reza Hanifnia MD,

doi : 10.1111/jocd.13907

Volume 20, Issue 8 p. 2480-2485

The changes in morphology of hair follicle and aberrant cycling of hair follicle are the main reasons of the most common forms of hair loss (alopecia). However, existing alopecia treatments do not specifically target these processes.

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Preclinical and clinical evaluation on the performance and safety of a novel energy-based device for body shaping: A pilot study

Paolo Mezzana MD, PhD,Maria Giordana Antonucci MD,Irene Fusco PhD,

doi : 10.1111/jocd.14206

Volume 20, Issue 8 p. 2486-2492

The emergence on the market of non-invasive mechanisms aimed at reducing subcutaneous fat achieving a slimming effect arouses great interest in doctors and patients. Several methods for the destruction of adipocytes are today on the market.

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Fate of abstracts from American Society for Laser Medicine and Surgery Annual Meetings

Eric J. Beltrami BS,Hao Feng MD, MHS,

doi : 10.1111/jocd.13862

Volume 20, Issue 8 p. 2493-2497

The American Society for Laser Medicine and Surgery (ASLMS) Annual Meeting provides a unique platform for the dissemination of research in laser and energy-based technologies, which are regularly utilized in cosmetic dermatology. We sought to elucidate the fate of the abstracts presented at ASLMS meetings over 3 years.

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Evaluating the efficacy and safety of topical sirolimus 0.2% cream as adjuvant therapy with pulsed dye laser for the treatment of port wine stain: A randomized, double-blind, placebo-controlled trial

Mahsa Fallahi MD,Zahra Hallaji MD,Soheil Tavakolpour PhD,Somayeh Niknam PharmD, PhD,Ali Salehi Farid PharmD,Ali Nili MD,Amir Teimourpour PhD,Maryam Daneshpazhooh MD,Javad Rahmati MD,Shahriar Haddady Abianeh MD,Hamidreza Mahmoudi MD,

doi : 10.1111/jocd.13867

Volume 20, Issue 8 p. 2498-2506

Port Wine Stain (PWS) is a congenital capillary malformation. Although multiple treatments are required, the gold standard treatment for PWS is Pulsed Dye Laser (PDL). Given its anti-angiogenic effects, sirolimus can be considered as an adjuvant to PDL in PWS.

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Efficacy of focused radiofrequency with ultrasound in body contouring: A study of 64 patients

Huray Hugul MD,Muazzez Cigdem Oba MD,Zekayi Kutlubay MD,

doi : 10.1111/jocd.13896

Volume 20, Issue 8 p. 2507-2511

Energy-based devices are increasingly used for noninvasive body contouring. Our aim was to investigate the clinical efficacy of combined radiofrequency and ultrasound device for reduction in body circumference in various body parts.

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Treatment of pincer nail deformity with 1064-nm Nd:YAG laser

Munise Daye MD,Koray Durmaz MD,

doi : 10.1111/jocd.13911

Volume 20, Issue 8 p. 2512-2514

Pincer nail (PN) is a nail disorder that cannot resolve spontaneously and sometimes necessitates surgical intervention. The etiological factors and gold standard treatment for the PN are still uncertain. We present a 24-year-old woman suffering from the PN and were treated with 1064-nm long-pulsed Nd:YAG laser. There were PN deformities in the left and right thumbnails. The left one was treated with four sessions of 1064-nm. Nd:YAG laser.

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A combination of 1064 nm Q-switched fractional ND-YAG laser with a nonfractional microsecond pulsed technology has a synergistic effect for nonablative facial rejuvenation

Lehavit Akerman MD,Moshe Lapidoth MD, MPH,Assi Levi MD,Eran Sharon MD,Daniel Hilewitz BSc,Efrat Solomon-Cohen MD, MOccH,

doi : 10.1111/jocd.13912

Volume 20, Issue 8 p. 2515-2518

Non-ablative fractionated lasers for facial rejuvenation are increasingly preferred over ablative lasers due to their minimal downtime and fewer adverse events. The synergistic effect of the Q-switched fractional (QSF) 1064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser, in combination with the non-fractional microsecond pulsed technology has yet to be fully evaluated.

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Differences in the response in the dermis of the tails of young and old SD rats to treatment with bipolar RF

E. Beltrán-Frutos PhD,C. Ferrer PhD,V. Seco-Rovira PhD,J. Martínez-Hernández PhD,M. I. Serrano-Sánchez PhD,L. M. Pastor PhD,

doi : 10.1111/jocd.13918

Volume 20, Issue 8 p. 2519-2526

The passing of the years is marked by intrinsic (chronological) and extrinsic aging, caused by photoaging, which is characterized by a decrease in collagen and the deposition of abnormal elastic fibers in the dermis. The use of bipolar radiofrequency (RF) increases fibroblast proliferation and differentiation, accompanied by collagen synthesis and a subsequent increase in connective tissue, and it is not known whether the biological effects of this type of radiofrequency on the dermis are similar regardless of the age of the individual or whether such effects are altered by the aging process itself.

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Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis in female patients

Enzo Berardesca MD,Norma Cameli PhD,Marco Piacentini PhD,Stefano Veraldi MD,Leonardo Celleno MD,

doi : 10.1111/jocd.13893

Volume 20, Issue 8 p. 2527-2530

Treatment of unwanted body hair is a challenging area in cosmetic dermatology. Topical soy isoflavones and derivatives or eflornithine have been utilized in dermatocosmetology for their estrogenic and antiandrogenic activity.

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Soluble Pearl Extract provides effective skin lightening by antagonizing endothelin

Jing Wang MD,Zhixiong Chen MSc,Yaojia Lu BSc,Lihua Zhang BSc,Jiahuan Mo BSc,Fumin Cao BSc,Min Xie BSc,Xinzhong Shen BSc,Anquan Yang BSc,

doi : 10.1111/jocd.13899

Volume 20, Issue 8 p. 2531-2537

Incidence of skin pigmentation disorders has been on the rise globally. This calls for safer and more effective topical skin lightening and freckle-removing products. In this study, we hypothesized that Soluble Pearl Extract (SPE) may possess endothelin antagonizing compounds with good skin whitening effects.

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Innovative use of concentrated growth factors combined with corticosteroids to treat discoid lupus erythematosus alopecia: A case report

Huijuan Fang MBBS,Qingwu Liu MMS,Tiantian Cheng MBBS,Chaowei Yang MMS,Ruiying Wu MBBS,Zhishan Yang MBBS,Dingquan Yang MD,

doi : 10.1111/jocd.13904

Volume 20, Issue 8 p. 2538-2541

Alopecia for patients with discoid lupus erythematosus can sometimes be a refractory condition, where mixed infiltrates of T lymphocytes and histiocytes leads to destruction of hair follicles, which might cause permanent scarring. Early diagnosis and timely treatment can achieve hair regeneration and prevent further disease progression. Concentrated growth factor, a novel autologous plasma extract, contains various growth factors that could promote tissue regeneration. In this article, we report a case of cell growth factor combined with corticosteroids for the treatment of discoid lupus erythematosus alopecia. This case study concludes with satisfactory clinical effect.

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Comparative analysis of effects induced by hyaluronic acid and its combined formula on skin functional parameters in second-degree photoaging

Helen G. Azaryan MD,Khachik M. Khachikyan MD, PhD,Ahmed Taha MD, PhD,Ezzat Badawy MD, PhD,

doi : 10.1111/jocd.14298

Volume 20, Issue 8 p. 2542-2551

The study aimed to compare the effectiveness of intradermal injections of modified hyaluronic acid (mHA) and combined injections of platelet-rich plasma (PRP) and mHA (HA-PRP) on clinical and functional parameters in women with second-degree photoaging.

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Attitudes toward organic cosmetics: A cross-sectional population-based survey from the Middle East

Feroze Kaliyadan MD, DNB, SCE-RCP European board, FRCP (Lond),Mahdi Al Dhafiri MD,Mohammad Aatif PhD,

doi : 10.1111/jocd.13909

Volume 20, Issue 8 p. 2552-2555

The exponential increase in the market for cosmetics has been accompanied by an increasing demand for organic cosmetics. However, this demand and awareness of organic cosmetics and awareness of its relation to environmental sustainability is likely to vary according to the geographical region. The available literature related to the subject is sparse in our region.

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Social media use in patients with acne vulgaris: What do patients expect from social media?

Melek Aslan Kay?ran MD,Ay?e Serap Karada? MD,Gökçen Alyamaç MD,Bengü Çevirgen Cemil MD,Düriye Deniz Demirseren MD,Hasan Aksoy MD,Sevilay O?uz K?l?ç MD,Yuhanize Ta? Demircan MD,Esma ?nan Yüksel MD,Göknur Kalkan MD,Gülbin Ya?ar MD,Aysun ?ikar Aktürk MD,Ömer Kutlu MD,Sümeyye Alt?nta? Kak?i MD,Sema Elibüyük Aksaç MD,Hilal Kaya Erdo?an MD,Hatice Kaya Özden MD,Sezgi Sar?kaya Solak MD,Mahmut Can Koska MD,Serkan Yaz?c? MD,

doi : 10.1111/jocd.14272

Volume 20, Issue 8 p. 2556-2564

Acne vulgaris (AV) may affect external appearance and significantly deteriorate the quality of life of patients. Therefore, patients make various inquiries about their disease and seek treatment options.

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Alopecia areata severity index (AASI): A reliable scoring system to assess the severity of alopecia areata on face and scalp—a pilot study

Imran Majid MD, FRCP,Farah Sameem MD,Javeed Sultan MD,Samia Aleem MD,

doi : 10.1111/jocd.14289

Volume 20, Issue 8 p. 2565-2570

All scoring systems used in Alopecia Areata (AA) focus mainly on scalp and cannot assess the severity or treatment response when AA involves the beard hair, eyebrows, or eyelashes.

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A microneedling device for the treatment of spider vein: A case report

Mohammadnejad Atefeh MD

doi : 10.1111/jocd.13858

Volume 20, Issue 8 p. 2571-2573

Spider vein is mostly seen in patients with liver disease, although the underlying problem is sometimes unknown. If spider vein appears on the face, it can affect the self-esteem and self-image of patients. Particularly, females are more vulnerable to these complications. Spider nevi are mostly left untreated since they are considered a cosmetic matter; in case of treatment, the procedure is costly with limited satisfaction. Therefore, this study reports the successful treatment of a spider vein case using a microneedling procedure.

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First report of tamoxifen-induced baboon syndrome

Ramin Mofarrah MD,Ramina Mofarrah MD,Birger Kränke MD,Maziar Rahmani MD PHD,Kousar Jahani Amiri MD,Maryam Ghasemi MD,Naghmeh Jallab MD,Sueshianth Ghobadiaski MD,Nazgol Rahmani BSc,Narges Hashemi MD

doi : 10.1111/jocd.13863

Volume 20, Issue 8 p. 2574-2578

Baboon syndrome is a rare, type IV hypersensitivity reaction causing a maculopapular rash. Tamoxifen is an antineoplastic agent, working as an estrogen receptor antagonist, also called a selective estrogen receptor modulator. A variety of rashes were reported with Tamoxifen use to-date except baboon syndrome. The Tamoxifen-induced baboon syndrome seems to be reversible, as discontinuation of the drug improves clinical outcomes.

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Efficacy evaluation of Endolift-based Subcision on acne scar treatment

Mohammad Ali Nilforoushzadeh MD,Tannaz Fakhim MD,Maryam Heidari-Kharaji PhD,Amir Reza Hanifnia MD,Somayeh Hejazi MD,Elham Torkamaniha MSc,

doi : 10.1111/jocd.13876

Volume 20, Issue 8 p. 2579-2582

People with acne scar suffer from destruction to the surface of the skin. Treating acne scars is a challenge that might need several methods.

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Quantitative evaluation of facial sagging in different body postures using a three-dimensional imaging technique

June Whan Park MS,Myeongryeol Lee MS,Jihyun Kim MS,Eunjoo Kim PhD,

doi : 10.1111/jocd.13880

Volume 20, Issue 8 p. 2583-2592

The possible contribution of head flexion posture while using a smartphone to the formation of “smartphone face,” is an increasing concern. Smartphone face describes the facial changes in a stooped posture receiving more gravitational pull on the jowl area.

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“Pingpong racket” flap model for evaluating flap survival

Lijun Wu,Suyue Gao,Kai Tian,Tianlan Zhao,Ke Li,

doi : 10.1111/jocd.13886

Volume 20, Issue 8 p. 2593-2597

Random skin flap is widely used to repair tissue defects; however, it is often accompanied by ischemia and necrosis of the distal flap due to inferior axial vascularity. Even though different drugs, biomaterials, and stem cell therapies have been developed to improve the survival of random flap, evaluating the promotion of flap survival remains a big challenge. Based on successful clinical practice, we designed a “Pingpong racket” shape flap in the rat. Without the predetected blood vessels procedure, the “pingpong racket” flap provides a preferable option to evaluate the function of drugs and biomaterials in promoting flap survival.

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A rare case of atrophic dermatofibroma with dermoscopic findings

Ezgi Akta? Karabay MD,Damla Demir MD,Fat?ma Gürsoy MD,?lkin Zindanc? MD,

doi : 10.1111/jocd.13917

Volume 20, Issue 8 p. 2598-2601

Dermatofibroma, also known as cutaneous benign fibrous histiocytoma, is a common skin tumour.

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Hair transplantation Follicular Unit Excision (FUE): Introducing the multipurpose octagonal ring punch

Roberto Trivellini MD,Aditya K Gupta MD, PhD,

doi : 10.1111/jocd.14225

Volume 20, Issue 8 p. 2602-2605

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Intralesional combined digoxin and furosemide in plantar warts: Does it work?

Ghada Fathy MD,Wessam Moustafa Abo-Elmagd MBBCh,Ahmed Abdelfattah Afify MD,

doi : 10.1111/jocd.13913

Volume 20, Issue 8 p. 2606-2611

Warts are small, benign growths caused by human papilloma virus. No treatment has yet proven 100% effective for a cure. DNA viruses rely on K + influx for replication. Both digoxin and furosemide inhibit the K + influx by interacting with cell membrane ion co-transporters. Therefore, it is hypothesized that these two compounds may be valuable in the treatment of warts.

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Necrostatin-1, RIP1/RIP3 inhibitor, relieves transforming growth factor ?-induced wound-healing process in formation of hypertrophic scars

Pei-Ting Lin MD,Xiao-Dong Xue MD,Zhong-Dong Zhao MD,Jun-Yang Lu MD,Pei-Lin Xie MD,

doi : 10.1111/jocd.13860

Volume 20, Issue 8 p. 2612-2618

Hypertrophic scars (HS) are common pathologic processes emerged during wound-healing process. The receptor-interacting protein kinase (RIP) might participate in keloid formation.

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Transcriptome comparison of isotretinoin-effective and isotretinoin-ineffective severe acne vulgaris patients

Yuchen Jiang MD,Jie Zhang PhD,Hongen Guo MD,Qiaoping Chen MD,Wei Lai MD,Yue Zheng PhD,

doi : 10.1111/jocd.13898

Volume 20, Issue 8 p. 2619-2626

Oral isotretinoin is the first-line treatment of severe nodular acne. However, patients presenting ineffective or poor effective to oral isotretinoin are still a clinical problem, and its molecular genetic mechanisms remain unclear.

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Contact sensitization to cosmetic series of allergens in female patients with rosacea: A prospective controlled study in China

Bangtao Chen PhD,Fubing Yu MD,WenChieh Chen PhD,Zhengqiu Yao MD,Xi Yang MD,Daojun Zhang PhD,Fei Hao PhD,

doi : 10.1111/jocd.13902

Volume 20, Issue 8 p. 2627-2634

Allergic contact dermatitis to cosmetics (ACDC) complicates the diagnosis and treatment of rosacea, and is increasingly observed in daily practice.

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The relationship between lichen planus and metabolic syndrome

Munise Daye MD,Selami Aykut Temiz MD,Begüm Is?k MD,

doi : 10.1111/jocd.13905

Volume 20, Issue 8 p. 2635-2639

Lichen planus (LP) is an idiopathic, chronic inflammatory disease. Chronic inflammatory diseases can cause metabolic complications. In the literature, data related to the relationship between lichen planus and metabolic syndrome (MS) are limited. We aimed to evaluate the relationship between MS and lichen planus with disease activity.

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Elevated serum level of interleukin-15 in vitiligo patients and its correlation with disease severity but not activity

Mona A. Atwa MD,Sara Mohammed Mohammed Ali MD,Nahed Youssef MD,Radwa El-Sayed Mahmoud Marie MD,

doi : 10.1111/jocd.13908

Volume 20, Issue 8 p. 2640-2644

Vitiligo is a common acquired disorder of depigmentation. Its pathogenesis entails a T helper (Th) 1-cytotoxic T (cT) lymphocytes mediated autoimmune melanocyte destruction. Interleukin (IL)-15 is one of the IL-2 family of cytokines and shares several actions with IL-2. IL-15 enhances survival, maturation, and functional activity of natural killer, neutrophils, and dendritic cells. Furthermore, it potentiates survival, maturation, and cytotoxicity of memory cT cells. IL-15 has been shown to play a crucial role in the pathogenesis of several autoimmune diseases but was poorly investigated in patients with vitiligo.

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Nivolumab-induced plaque morphea in a malign melanoma patient

Ayda Acar MD,Gokturk Oraloglu MD,Banu Yaman MD,Isil Karaarslan MD,

doi : 10.1111/jocd.13914

Volume 20, Issue 8 p. 2645-2647

Nivolumab is one of the targeted cancer therapy agent that acts to increase the immune responses by inhibition of antiprogrammed-death-receptor 1, which is one of the check points of the immune response. Nivolumab can be used to treat malign melanoma, lung, renal, head and neck, colorectal, hepatocellular cancers, and special cases of Hodgkin lymphoma.

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Inhibition of persimmon tannin extract on guinea pig skin pigmentation

Wanting Sun ME,Xuanhong Chen ME,Xijun Nan ME,Jun Zhang ME,Leichao Dong ME,Wei Ji ME,Guihua Sheng PhD,Quancheng Zhou PhD,

doi : 10.1111/jocd.13915

Volume 20, Issue 8 p. 2648-2656

In daily life, excessive exposure to ultraviolet light can lead to pigmentation.

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Immunotherapy in cutaneous warts: comparative clinical Study between MMR vaccine, tuberculin, and BCG Vaccine

Engi Seif E. Shaker MD,Noha N. Doghim MD,Arwa Mhammad Hassan MD,Samia S. Musafa Msc,Mohamed M. Fawzy MD,

doi : 10.1111/jocd.13921

Volume 20, Issue 8 p. 2657-2666

Warts are common viral infection of the skin. Treating warts are still an ongoing challenge and no general agreement is reached, on the best treatment, despite different therapeutic approaches. Intralesional (IL) immunotherapy has recently been shown to be effective in treating various wart forms.

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Reactivity of cosmetic mineral pigments to picosecond laser

Candice Menozzi-Smarrito PhD,Stéphane Smarrito MD,

doi : 10.1111/jocd.13872

Volume 20, Issue 8 p. 2667-2668

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Crescent-shaped incisional cuts: An unusual complication with Q-switched Nd:YAG 1064 laser tattoo removal

Mahima Agrawal MD, DNB, MRCP(SCE),Manjul Agrawal MD,

doi : 10.1111/jocd.13873

Volume 20, Issue 8 p. 2669-2670

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Response to “Pityriasis capitis: Causes, pathophysiology, current modalities, and future approach”

James R. Schwartz PhD

doi : 10.1111/jocd.13878

Volume 20, Issue 8 p. 2671-2672

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Perifollicular elastolysis caused by repeatedly shaving armpit hairs

Yue Zheng MD, PhD,Xiangyang Su MD,Zhirui Chen MD,Le Han MD,

doi : 10.1111/jocd.13901

Volume 20, Issue 8 p. 2673-2674

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The dermoscopic features of seborrheic keratoses according to patient age and anatomic localization

Duygu Gulseren MD,Ecem Bostan MD,Sibel Ersoy-Evans MD,

doi : 10.1111/jocd.13910

Volume 20, Issue 8 p. 2675-2677

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Schwarzy: The new system for muscle toning and body shaping

Paolo Mezzana MD, PhD,Laura Pieri PhD,Alessandro Leone MD,Irene Fusco PhD,

doi : 10.1111/jocd.14275

Volume 20, Issue 8 p. 2678-2680

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