دسترسی یکساله به بیش از ۵۰۰ ژورنال روز جهان موجود در سامانه
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Stereotactic radiosurgery for brain metastases from small cell lung cancer without prior whole-brain radiotherapy: A meta-analysis
G.A.VianiaA.G.GouveiabA.V.LouiecF.Y.Moraesd
doi : 10.1016/j.radonc.2021.06.026
Volume 162, September 2021, Pages 45-51
Assess upfront Stereotactic radiosurgery (SRS) effectiveness for small cell lung cancer (SCLC) brain metastases (BM). Where possible, a comparison with whole-brain radiotherapy (WBRT) was performed.
Stereotactic radioablation of ventricular arrhythmias in patients with structural heart disease – A systematic review
BoldizsarKovacsa1MichaelMayingerb1MatthiasSchindleraJanSteffelaNicolausAndratschkeb2Ardan M.Sagunera2
doi : 10.1016/j.radonc.2021.06.036
Volume 162, September 2021, Pages 132-139
Several studies have suggested stereotactic arrhythmia radioablation (STAR) as a treatment option for patients suffering from therapy-refractory ventricular tachycardia or fibrillation (VT/VF).
High-dose irradiation in combination with non-ablative low-dose radiation to treat metastatic disease after progression on immunotherapy: Results of a phase II trial
Roshal R.Patelai1KewenHeaj1Hampartsoum B.BarsoumianaJoe Y.ChangaChadTangaVivekVermaaNathanComeauxaStephen G.ChunaSaumilGandhiaMylene T.TruongbJeremy J.ErasmusbDavid S.HongePercy P.LeeaMatthew S.NingaQuynh-NhuNguyenaJohn V.HeymachdMehmetAltandGeorgeBlumenscheindFrank V.FosselladDuyguSezenakDaweiChenaiBrett W.CarterbMichael A.DaviescIsabella C.GlitzadAdiDiabcRenataFerrarottodMaria E.CabanillasfYingYuangShalin J.ShahaEdwin R.ParrahBaohuaSunhMaria AngelicaCortezaJames W.Welsha
doi : 10.1016/j.radonc.2021.06.037
Volume 162, September 2021, Pages 60-67
To report early findings from a phase II trial of high-dose radiotherapy (HD-RT) with or without low-dose RT (LD-RT) for metastatic cancer.
Anorectal dose–effect relations for late gastrointestinal toxicity following external beam radiotherapy for prostate cancer in the FLAME trial
Veerle H.GroenaNicolaas P.A.ZuithoffbMarcelvan SchiecEvelyn M.MonninkhofbMartinaKunze-BuschdHans C.J.de BoeraJochemvan der Voort van ZypaFloris J.PoscRobert JanSmeenkdKarinHaustermanseSofieIsebaerteCédricDraulanseTomDepuydteHelena M.VerkooijenfUulke A.van der HeidecLinda G.W.Kerkmeijerad
doi : 10.1016/j.radonc.2021.06.033
Volume 162, September 2021, Pages 98-104
The phase III FLAME trial (NCT01168479) showed an increase in five-year biochemical disease-free survival, with no significant increase in toxicity when adding a focal boost to external beam radiotherapy (EBRT) for localized prostate cancer [Kerkmeijer et al. JCO 2021]. The aim of this study was to investigate the association between delivered radiation dose to the anorectum and gastrointestinal (GI) toxicity (grade ?2).
Stereotactic body radiation therapy with sequential S-1 for patients with locally advanced pancreatic cancer and poor performance status: An open-label, single-arm, phase 2 trial
XiaofeiZhu1YangsenCao1MingzhiLu1XianzhiZhaoLingongJiang1YushengYeXiaopingJuHuojunZhang
doi : 10.1016/j.radonc.2021.07.009
Volume 162, September 2021, Pages 178-184
The optimal treatment for a particularly neglected group of patients with locally advanced pancreatic cancer (LAPC) and poor performance status, who are usually excluded from most clinical trials, is required. Therefore, we aim to investigate the efficacy and safety of stereotactic body radiation therapy (SBRT) with sequential S-1 for those patients.
Postmastectomy radiation therapy following pathologic complete nodal response to neoadjuvant chemotherapy: A prelude to NSABP B-51??
WaqarHaquea1AnukritiSinghbVivekVermacMary R.SchwartzdNeilChevlieSandraHatcheMonicaDesaifE. BrianButleraCandyArentzgAndrewFarachaBin S.Teha
doi : 10.1016/j.radonc.2021.06.032
Volume 162, September 2021, Pages 52-59
The utility of post-mastectomy radiotherapy (PMRT) in women with a nodal complete response (CRn) to neoadjuvant chemotherapy (NAC) is unknown. The NSABP B-51 trial is evaluating this question, but has not reported results thus far. Therefore, we sought to answer this question with the National Cancer Database.
Extreme weekly locoregional hypofractionated radiation in elderly women with non-metastatic breast cancer
FadouaRaisJames Man GitTsuiAlyssaDaianskaMame DaroFayeChristineLambertMarcDavidValeriePanet-RaymondMelissaAzoulayAsmaSaidiTarekHijal
doi : 10.1016/j.radonc.2021.07.008
Volume 162, September 2021, Pages 156-161
Breast cancer locoregional (LR) radiation in the elderly requires careful consideration between the benefits of aggressive treatment and its potential toll on these patients. Extreme weekly LR hypofractionated radiation (HFRT), delivering >5 Gy per fraction, may be better suited in such a population. It represents a good compromise between RT omission and exhaustive daily radiation. This study aims to report the local and LR control rate as well as the acute and long-term side effects of the elderly patients treated with HFRT in our institution, and to compare these results to those from the literature.
Tricks and tips for target volume definition and delineation in breast cancer: Lessons learned from ESTRO breast courses
OritKaidar-PersonabBirgitte V.OffersencLiesbethBoersmadIcroMeattinieDavidDodwellfLyndaWyldgMarianneAznarhTiborMajoriThorstenKuehnjVratislavStrnadkMiikaPalmulSandraHolmPhilipPoortmansn
doi : 10.1016/j.radonc.2021.07.015
Volume 162, September 2021, Pages 185-194
Delineation of target and ‘organ at risk’ volumes is a critical part of modern radiation therapy planning, the next essential step after deciding the indication, patient discussion and image acquisition. Adoption of volume-based treatment planning for non-metastatic breast cancer has increased greatly along with the use of improved planning techniques, essential for modern therapy. However, identifying the volumes on a planning CT is no easy task. The current paper is written by ESTRO’s breast course faculty, providing tricks and tips for target volume definition and delineation for optimal postoperative breast cancer irradiation.
Chemical exchange saturation transfer MRI in central nervous system tumours on a 1.5 T MR-Linac
Rachel W.ChanaLiam S.P.LawrencebRyan T.OglesbyabHanboChencJamesStewartcAimeeTheriaultcMikkiCampbellcMarkRuschincStenMyrehaugcEshetu G.AtenafudBrianKellerdBrigeChughceScottMacKenziecChia-LinTsengcJayDetskycPejman J.MaralanifGreg J.CzarnotaabcGreg J.StaniszabgArjunSahgalcAngus Z.Lauab
doi : 10.1016/j.radonc.2021.07.010
Volume 162, September 2021, Pages 140-149
To describe the implementation and initial results of using Chemical Exchange Saturation Transfer (CEST) for monitoring patients with central nervous system (CNS) tumours treated using a 1.5 tesla MR-guided radiotherapy system.
A multicentre retrospective review of SABR reirradiation in rectal cancer recurrence
PhilippaJohnstoneaLeroyOkontabKatharineAitkenbJaneHolmescMarkHarrisondDeenaHarjieSean M.O'CathailfClaireTaylorgYatTsangdMarkWinghRebeccaMuirheada
doi : 10.1016/j.radonc.2021.06.030
Volume 162, September 2021, Pages 1-6
Locally recurrent rectal cancer (LRRC) is associated with considerable morbidity, poor quality of life and an overall survival of 9 months. The non-operative treatment of LRRC is an understudied area, there is no consensus on management in this setting.
Definitive chemoradiotherapy versus esophagectomy in patients with clinical T1bN0M0 esophageal squamous cell carcinoma: A retrospective study
Yoon YoungJoaJesangYuaKye JinSongaJeong YunJangaYe JinYooaSung-BaeKimbSook RyunParkbYong-HeeKimcHyeong RyulKimcJong HoonKima
doi : 10.1016/j.radonc.2021.07.006
Volume 162, September 2021, Pages 112-118
This study aimed to determine the equivalence between definitive chemoradiotherapy (DCRT) and radical esophagectomy in clinical T1bN0M0 esophageal squamous cell carcinoma (ESCC).
A radiomic signature model to predict the chemoradiation-induced alteration in tumor-infiltrating CD8+ cells in locally advanced rectal cancer
Seung HyuckJeonab1Yu JinLimc1JaemoonKohdWon IckChangaSehuiKimdKyuboKimeEui KyuChieaf
doi : 10.1016/j.radonc.2021.07.004
Volume 162, September 2021, Pages 124-131
Regarding the altered tumor immune status following cytotoxic treatment, this study aims to develop a radiomic signature to predict CD8+ tumor-infiltrating lymphocyte (TIL) density changes in chemoradiotherapy (CRT) of rectal cancer.
Planning target volume margin assessment for online adaptive MR-guided dose-escalation in rectal cancer on a 1.5 T MR-Linac
HiddeEijkelenkampaMick R.BoekhoffaMaaike E.VerweijaFemke P.PetersbcGert J.MeijeraMartijn P.W.Intvena
doi : 10.1016/j.radonc.2021.07.011
Volume 162, September 2021, Pages 150-155
This study assessed the margins needed to cover tumor intrafraction motion during an MR-guided radiotherapy (MRgRT) dose-escalation strategy in intermediate risk rectal cancer.
A multi-centre analysis of adjuvant contact X-ray brachytherapy (CXB) in rectal cancer patients treated with local excision – Preliminary results of the CONTEM1 study
AmandeepDhaddaaArthurSun MyintbBriceThamphyacIainHunteraM.HershmandJean-PierreGerardc
doi : 10.1016/j.radonc.2021.07.021
Volume 162, September 2021, Pages 195-201
Early rectal cancers are increasingly diagnosed through screening programmes and are often treated using local excision (LE). In the case of adverse pathological features completion total mesorectal excision surgery (TME) is the standard recommendation. The morbidity and mortality risks of TME have stimulated the use of adjunctive treatments following LE to achieve organ preservation.
Impact of smoking on survival in nasopharyngeal carcinoma: A cohort study with 23,325 patients diagnosed from 1990 to 2016
Xue-SongSunab1Si-YiXieab1Dong-HuaLuoab1Li-TingLiuabShan-ShanGuoabSai-LanLiuabLin-QuanTangabQiu-YanChenabHai-QiangMaiab
doi : 10.1016/j.radonc.2021.06.029
Volume 162, September 2021, Pages 7-17
We aimed to compare the survival outcomes of patients with nasopharyngeal carcinoma (NPC) who had different smoking behaviors and were treated with two- or three-dimensional radiotherapy (2D/3DRT) or intensity-modulated radiotherapy (IMRT) with a long-term follow up.
Quality of life and toxicity guided treatment plan optimisation for head and neck cancer?
Hans Paulvan der LaanArjenvan der SchaafLisaVan den BoschErik W.KorevaarRoel J.H.M.SteenbakkersStefanBothJohannes A.Langendijk
doi : 10.1016/j.radonc.2021.06.035
Volume 162, September 2021, Pages 85-90
To evaluate the feasibility of semi-automatic Quality of Life (QOL)-weighted normal tissue complication probability (NTCP)-guided VMAT treatment plan optimisation in head and neck cancer (HNC) and compare predicted QOL to that obtained with conventional treatment.
Reduction of GTV to high-risk CTV radiation margin in head and neck squamous cell carcinoma significantly reduced acute and late radiation-related toxicity with comparable outcomes
AbrahimAl-MamganiaRobKesselsbArashNavranaOlgaHamming-VriezeaCharlotte L.ZuurcdeJanPaul de BoerfMarcel C.J.JonkeraTomasJanssenaJan-JakobSonkeaCorrie A.M.Marijnena
doi : 10.1016/j.radonc.2021.07.016
Volume 162, September 2021, Pages 170-177
We aim to retrospectively investigate whether reducing GTV to high-risk CTV margin will significantly reduce acute and late toxicity without jeopardizing outcome in head-and-neck squamous cell carcinoma (HNSCC) treated with definitive (chemo)radiation.
Establishment and validation of a prognostic nomogram to predict early metastasis in nasopharyngeal carcinoma patients within six months after radiotherapy and to guide intensive treatment
Zi-JianLuab1Li-TingLiuab1Xue-SongSunab1Shan-ShanGuoabQiYangabSai-LanLiuabXiao-YunLiabHui-ZhiQiuabZhen-ChongYangabBei-BeiXiaoabChaoLinabDong-HuaLuoabRuiSunabHuan-XinLinacQiu-YanChenabLin-QuanTangabLingGuoabHai-QiangMaiab
doi : 10.1016/j.radonc.2021.03.035
Volume 162, September 2021, Pages 202-211
This study aimed to establish an effective prognostic nomogram to predict the risk of early metastasis (EM) in nasopharyngeal carcinoma (NPC) patients, as a guide for intensive treatment.
Impact of effective dose to immune cells (EDIC) on lymphocyte nadir and survival in limited-stage SCLC
YishanYuabPingfuFudJian-YueJincSimingGaoabWeiliWangcMitchellMachtaycLinlinWangbFeng-Ming (Spring)KongceJinmingYub
doi : 10.1016/j.radonc.2021.06.020
Volume 162, September 2021, Pages 26-33
Effective dose to immune cell (EDIC), an estimated radiation dose to the circulating lymphocytes, is of significance for overall survival (OS) in non-small cell lung cancer. This study aimed to validate the EDIC’s OS effect on limited-stage small cell lung cancer (LS-SCLC).
Assessing ISUP prostate cancer grade groups in patients treated with definitive dose escalated external beam radiation
JonathanTobyaThomasEadeabcGeorgeHrubybcAndrewKneeboneabcNoelAhernedChrisBrownbeLesleyGuobMatthewHoffmannfThomas P.Shakespearedfg
doi : 10.1016/j.radonc.2021.06.025
Volume 162, September 2021, Pages 91-97
The five grade group system has been validated for men treated with radical prostatectomy. However, the prognostic value for men treated with radiation therapy is uncertain, with prior studies utilising old techniques and doses. We aimed to validate the International Society of Urological Pathology (ISUP) groupings for men treated with contemporary radiation therapy.
Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac
D.M.Muinck KeizerdeaT.WilligenburgaJ.R.N.der Voort van ZypvanaB.W.RaaymakersaJ.J.W.LagendijkaJ.C.J.Boerdea
doi : 10.1016/j.radonc.2021.07.014
Volume 162, September 2021, Pages 162-169
Delivered dose–effect analysis of radiation induced rib fractures after thoracic SBRT
CeliaJuan-CruzBarbaraStamJoséBelderbosJan-JakobSonke
doi : 10.1016/j.radonc.2021.06.028
Volume 162, September 2021, Pages 18-25
Anatomical changes during the stereotactic body radiation therapy (SBRT) of early stage non-small cell lung cancer (NSCLC) may cause the delivered dose to deviate from the planned dose. We investigate if normal tissue complication probability (NTCP) models based on the delivered dose predict radiation-induced rib fractures better than models based on the planned dose.
May oxygen depletion explain the FLASH effect? A chemical track structure analysis
DariaBoscoloaEmanueleScifonibMarcoDuranteacMichaelKrämeraMartina C.Fussa
doi : 10.1016/j.radonc.2021.06.031
Volume 162, September 2021, Pages 68-75
Recent observations in animal models show that ultra-high dose rate (“FLASH”) radiation treatment significantly reduces normal tissue toxicity maintaining an equivalent tumor control. The dependence of this “FLASH” effect on target oxygenation has led to the assumption that oxygen “depletion” could be its major driving force.
An in-silico assessment of the dosimetric benefits of MR-guided radiotherapy for esophageal cancer patients
MickBoekhoffa2IngmarDefizeabAliciaBorggreveabRichardvan HillegersbergbAlexisKotteaJanLagendijkaAstridvan LieraJelleRuurdabNoriyoshiTakahashiacStellaMooka1GertMeijera13
doi : 10.1016/j.radonc.2021.06.038
Volume 162, September 2021, Pages 76-84
To assess the dosimetric benefits of online MR-guided radiotherapy (MRgRT) for esophageal cancer patients and to assess how these benefits could be translated into a local boosting strategy to improve future outcomes.
Margin calculation for multiple lung metastases treated with single-isocenter SBRT
Janita E.van TimmerenaMischa S.HoogemanbStefanieEhrbaraMichaelMayingeraNicolausAndratschkeaMatthiasGuckenbergeraStephanieTanadini-Langa
doi : 10.1016/j.radonc.2021.07.001
Volume 162, September 2021, Pages 105-111
A single-isocenter stereotactic body radiotherapy (SBRT) approach for multiple lung metastases has the potential to lower cumulative patient dose and reduce overall treatment time. However, the magnitude of inter-lesion position variation is currently unknown and not incorporated in margin calculations. The aim of this study was to quantify inter-lesion position variation and calculate safety margins for single-isocenter lung SBRT.
Wnt/?-catenin inhibitor ICG-001 enhances the antitumor efficacy of radiotherapy by increasing radiation-induced DNA damage and improving tumor immune microenvironment in hepatocellular carcinoma
YanHuanga1HailongShenga1YazhiXiaoa1WeiHub1ZhihongZhangaYiyaoChenaZhenruZhuaDehuaWuaChuanhuiCaoaJingyuanSuna
doi : 10.1016/j.radonc.2021.06.034
Volume 162, September 2021, Pages 34-44
Radiotherapy (RT) has a promising anti-tumor effect depending on its effects on both cancer cells and tumor immune microenvironment (TIME). As one of the most common alterations in hepatocellular carcinoma (HCC), wnt/?-catenin pathway activation, has been reported to induce radioresistance and suppressive TIME. In this study, we aim to explore the effect of wnt/?-catenin inhibitor ICG-001 on radiosensitivity and RT-related TIME of HCC and the underlying mechanism.
“It’s good for the soul:” Perceptions of a formal junior faculty mentorship program at a large academic cancer centre
JenniferCrokeabSarahTosoniabJolieRingashab
doi : 10.1016/j.radonc.2021.07.003
Volume 162, September 2021, Pages 119-123
Mentorship fosters professional and personal growth; however, the components essential to program success remain unclear. Our objective was to evaluate and explore the impact of a junior faculty mentorship program within an academic radiation oncology department.
