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First clinical practice guideline for renal hypouricaemia: a rare disorder that aided the development of urate-lowering drugs for gout
Akiyoshi Nakayama, Hirotaka Matsuo, Abhishek Abhishek, Kimiyoshi Ichida, Nariyoshi Shinomiya, for the members of Guideline Development Committee of Clinical Practice Guideline for Renal Hypouricaemia
doi : 10.1093/rheumatology/keab322
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3961–3963
Furthering the links between osteoarthritis and other health conditions
Gillian A Hawker, Lauren K King
doi : 10.1093/rheumatology/keab376
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3964–3965
Osteoarthritis and associated comorbidities: new answers and more questions
Fiona E Watt, Elspeth M Wise
doi : 10.1093/rheumatology/keab405
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3966–3968
Infections in immunosuppressed travellers with autoimmune inflammatory diseases—a narrative review and advice for clinical practice
Victoria Allen, Nicky Longley
doi : 10.1093/rheumatology/keab445
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3969–3976
The management of autoimmune, inflammatory diseases has been revolutionized by biologic therapies. A beneficial consequence of better disease control is that more patients are well enough to travel the world. There is now a class of traveller, the significantly immunosuppressed person with autoimmune disease, with specific risks and requirements. This review introduces the concept of the pre-travel risk assessment and discusses the major vaccine-preventable and non-vaccine-preventable travel-associated infections. The challenges and controversies around vaccination and immunosuppression are reviewed with advice for clinical practice.
Precision medicine in autoimmune diseases: fact or fiction
Daniel Toro-Domínguez, Marta E Alarcón-Riquelme
doi : 10.1093/rheumatology/keab448
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3977–3985
Much is said about precision medicine, but its real significance and potential are far from certain. Several studies in each of the autoimmune diseases have provided important insights into molecular pathways, but the use of molecular studies, particularly those looking into transcriptome pathways, has seldom approached the possibility of using the data for disease stratification and then for prediction, or for diagnosis. Only the type I IFN signature has been considered for therapeutic purposes, particularly in the case of SLE. This review provides an update on precision medicine, on what can be translated into clinical practice and on what single-cell molecular studies contribute to our knowledge of autoimmune diseases, focusing on a few examples. The main message is that we should try to move from precision medicine of established diseases to preventive medicine in order to predict the development of disease.
Current and emerging biological therapy in adult-onset Still’s disease
Yuning Ma, Jianfen Meng, Jinchao Jia, Mengyan Wang, Jialin Teng, Dehao Zhu, Chengde Yang, Qiongyi Hu
doi : 10.1093/rheumatology/keab485
Rheumatology, Volume 60, Issue 9, September 2021, Pages 3986–4000
Adult-onset Still’s disease (AOSD) is a rare, but characteristic non-familial, multi-genic systemic auto-inflammatory disorder, characterized by high spiking fever, salmon-like evanescent skin rash, polyarthritis, sore throat, hyperferritinemia and leucocytosis. The hallmark of AOSD is a cytokine storm triggered by dysregulation of inflammation. Nowadays, with advances in anti-cytokine biologic agents, the treatment of AOSD is no longer limited to NSAIDs, glucocorticoids or conventional synthetic DMARDs. In this review, we focussed on the roles of these cytokines in the pathogenesis of AOSD and summarized the current and emerging biological therapy.
Prevalence and predictors of adverse events with methotrexate mono- and combination-therapy for rheumatoid arthritis: a systematic review
Ahmad A Sherbini, Seema D Sharma, James M Gwinnutt, Kimme L Hyrich, Suzanne M M Verstappen
doi : 10.1093/rheumatology/keab304
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4001–4017
This systematic review aims to summarize rates of adverse events (AEs) in patients with RA or inflammatory arthritis starting MTX as monotherapy or in combination with other csDMARDs, and to identify reported predictors of AEs.
Maternal and neonatal outcomes in pregnant women with psoriasis and psoriatic arthritis: a systematic review and meta-analysis
Wenhui Xie, Hong Huang, Lanlan Ji, Zhuoli Zhang
doi : 10.1093/rheumatology/keab357
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4018–4028
Psoriasis and PsA are inflammatory diseases that affect women in their reproductive years. We aimed to investigate whether maternal psoriasis and PsA are associated with adverse pregnancy outcomes.
Mortality in patients with primary Sjögren’s syndrome: a systematic review and meta-analysis
Hong Huang, Wenhui Xie, Yan Geng, Yong Fan, Zhuoli Zhang
doi : 10.1093/rheumatology/keab364
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4029–4038
It remains debated whether patients with primary Sjögren’s syndrome (pSS) are at greater risk of mortality. We aimed to determine the magnitude of all-cause mortality risk in patients with pSS compared with the general population through a systematic review and meta-analysis.
Therapeutic options for cutaneous polyarteritis nodosa: a systematic review
Eleni Papachristodoulou, Loukas Kakoullis, Eleni Tiniakou, Konstantinos Parperis
doi : 10.1093/rheumatology/keab402
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4039–4047
Cutaneous polyarteritis nodosa (CPAN) is a necrotizing vasculitis of the middle-size vessels, confined to the skin. We conducted a systematic review in order to identify studies evaluating the different treatment modalities used in CPAN.
Real-world single centre use of JAK inhibitors across the rheumatoid arthritis pathway
John Fitton, Andrew R Melville, Paul Emery, Jacqueline L Nam, Maya H Buch
doi : 10.1093/rheumatology/keaa858
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4048–4054
To evaluate real-world efficacy of approved JAK inhibitors (JAKi) tofacitinib and baricitinib in a large, single-centre cohort of RA patients across the treatment pathway, including those refractory to multiple biologic drugs.
Higher prevalence of non-skeletal comorbidity related to X-linked hypophosphataemia: a UK parallel cohort study using CPRD
Samuel Hawley, Nick J Shaw, Antonella Delmestri, Daniel Prieto-Alhambra, Cyrus Cooper, Rafael Pinedo-Villanueva, M Kassim Javaid
doi : 10.1093/rheumatology/keaa859
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4055–4062
X-Linked hypophosphataemic rickets (XLH) is a rare multi-systemic disease of mineral homeostasis that has a prominent skeletal phenotype. The aim of this study was to describe additional comorbidities in XLH patients compared with general population controls.
Comparative effectiveness and persistence of TNFi and non-TNFi in juvenile idiopathic arthritis: a large paediatric rheumatology centre in the USA
Xiaomeng Yue, Bin Huang, Ana L Hincapie, Patricia R Wigle, Yuxiang Li, Tingting Qiu, Daniel J Lovell, Esi M Morgan, Jeff J Guo
doi : 10.1093/rheumatology/keaa877
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4063–4073
To evaluate the persistence and effectiveness of TNF inhibitors (TNFi) vs non-TNFi among newly diagnosed JIA patients after initiation of biologic DMARD (bDMARD).
Anti-NuMA antibodies: clinical associations and significance in patients with primary Sjögren’s syndrome or systemic lupus erythematosus
Robin Arcani, Daniel Bertin, Nathalie Bardin, Karin Mazodier, Rodolphe Jean, Pierre Suchon, Geoffroy Venton, Aurélie Daumas, Estelle Jean, Patrick Villani, Gilles Kaplanski, Pierre-André Jarrot
doi : 10.1093/rheumatology/keaa881
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4074–4084
To determine the clinical significance of anti-nuclear mitotic apparatus (NuMA) antibodies (AC-26 or AC-25) in patients with primary Sjögren’s syndrome (pSS) and SLE.
Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis: a longitudinal Swedish study
Lan Do, Gabriel Granåsen, Urban Hellman, Kristina Lejon, Mats Geijer, Xenofon Baraliakos, Torsten Witte, Helena Forsblad-d’Elia
doi : 10.1093/rheumatology/keaa882
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4085–4093
Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD74 and radiographic spinal changes.
Base of thumb osteoarthritis in UK interface services—a cohort and survey-based study to assess current practice
Benjamin J F Dean, Stefan Kluzek, Andrew J Carr, Sally Hopewell, Duncan Richards, Nicholas Riley, Andrew Cuff, Oxford Base of Thumb Collaborative
doi : 10.1093/rheumatology/keaa884
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4094–4102
Base of thumb OA (BTOA) is a common age-related disease that has a significant negative impact on quality of life, while little is known about the structure and pathways of interface services. Our aim was to assess disease burden, referral pathways, service structure and management pathways in UK interface services.
Sensitivity to change and clinical correlations of the novel DACtylitis glObal Sonographic (DACTOS) score in psoriatic arthritis
Nicolò Girolimetto, Alen Zabotti, Ilaria Tinazzi, Niccolò Possemato, Luisa Costa, Alberto Batticciotto, Marco Canzoni, Giorgia Citriniti, Orazio De Lucia, Fabiana Figus, Luca Idolazzi, Rebecca McConnel, Rosario Peluso, Garifallia Sakellariou, Annarita Tullio, Carlo Salvarani, Raffaele Scarpa, Annamaria Iagnocco, Francesco Caso, Pierluigi Macchioni
doi : 10.1093/rheumatology/keaa885
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4103–4111
The aim of the study is to assess the performance of the DACTOS (DACtylitis glObal Sonographic) score in a PsA dactylitis clinical setting. In particular, we evaluated the ability of DACTOS to identify the affected fingers, its sensitivity to change after treatment, the correlations between DACTOS and clinical parameters, and the capacity of the score to identify the treatment responders.
Increased proportion of comorbidities but no deterioration of sexual quality of life during a 5-year follow-up in patients with axial spondyloarthritis in the biologic treatment era
Kari Hansen Berg, Gudrun Rohde, Are Pripp, Anne Prøven, Esben Ester Pirelli Benestad, Monika Østensen, Glenn Haugeberg
doi : 10.1093/rheumatology/keaa887
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4112–4120
To explore patient perception of sexual quality of life (SQOL), an important category of QOL, in male and female patients with axial SpA (axSpA) after a 5?year follow-up.
The changing states of fibromyalgia in patients with axial spondyloarthritis: results from the British Society of Rheumatology Biologics Register for Ankylosing Spondylitis
Sella A Provan, Linda E Dean, Gareth T Jones, Gary J Macfarlane
doi : 10.1093/rheumatology/keaa888
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4121–4129
To identify factors associated with FM development and recovery in patients with axial SpA (axSpA).
Management of fatigue with physical activity and behavioural change support in vasculitis: a feasibility study
Lorraine Harper, Catherine A Hewitt, Ian Litchfield, Matthew D Morgan, Dimitrios Chanouzas, Hollie K Caulfield, Linda Coughlan, Caroline Dean, Kate Fletcher, Fiona Cramp, Sheila Greenfield, Natalie J Ives, Sue Jowett, Shalela Kodabuckus, Sarah Tearne, Sukhwant Sehmi, Charlotte Edwardson, Nathan P Dawkins, Amanda J Daley
doi : 10.1093/rheumatology/keaa890
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4130–4140
Patients with ANCA-associated vasculitis (AAV) experience high levels of fatigue, despite disease remission. This study assessed the feasibility and acceptability of a definitive randomized controlled trial of a behavioural-based physical activity intervention to support fatigue self-management in AAV patients.
Changes in the pharmacological management of rheumatoid arthritis over two decades
Samantha S R Crossfield, Maya H Buch, Paul Baxter, Sarah R Kingsbury, Mar Pujades-Rodriguez, Philip G Conaghan
doi : 10.1093/rheumatology/keaa892
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4141–4151
To assess whether modern management of RA has reduced the prescription of oral corticosteroids and NSAIDs and to evaluate use of pharmacological prophylaxis strategies.
Adult-onset Still’s disease with neurological involvement: a single-centre report
Mengzhu Zhao, Di Wu, Min Shen
doi : 10.1093/rheumatology/keaa899
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4152–4157
Adult-onset Still’s disease (AOSD) is a multifactorial systemic autoinflammatory disease. Neurological damage has been rarely reported in AOSD. We aimed to characterize the clinical features of AOSD patients with neurological involvement.
Comorbidity and response to TNF inhibitors in axial spondyloarthritis: longitudinal analysis of the BSRBR-AS
Sizheng Steven Zhao, Gareth T Jones, Gary J Macfarlane, David M Hughes, Robert J Moots, Nicola J Goodson
doi : 10.1093/rheumatology/keaa900
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4158–4165
Comorbidities influence disease assessment in axial spondyloarthritis (axSpA), but their association with response to TNF inhibitors (TNFi) is unclear. We examined associations between comorbidity history at TNFi initiation and: (i) change in disease indices over time; (ii) binary response definitions; and (iii) time to treatment discontinuation.
Demyelination with autoimmune features: a distinct clinical entity? Results from a longitudinal cohort
Dionysis Nikolopoulos, Dimitris Kitsos, Matilda Papathanasiou, Maria Chondrogianni, Aikaterini Theodorou, Panagiotis Garantziotis, Antigone Pieta, Triantafyllos Doskas, George Bertsias, Konstantinos Voumvourakis, Dimitrios T Boumpas, Antonis Fanouriakis
doi : 10.1093/rheumatology/keaa902
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4166–4174
CNS demyelinating syndromes occurring in the context of SLE may represent a manifestation of neuropsychiatric lupus, or an overlap of SLE and multiple sclerosis (MS). We evaluated prospectively patients presenting with demyelinating syndrome for clinical and serological evidence of SLE and characterized the evolution of their clinical syndrome to a defined disease.
The cost-effectiveness of different approaches to exercise and corticosteroid injection for subacromial pain (impingement) syndrome
Raymond Oppong, Sue Jowett, Martyn Lewis, Edward Roddy, Reuben O Ogollah, Irena Zwierska, Praveen Datta, Alison Hall, Elaine Hay, Julie Shufflebotham, Kay Stevenson, Danielle A van der Windt, Julie Young, Nadine E Foster
doi : 10.1093/rheumatology/keaa903
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4175–4184
To determine whether physiotherapist-led exercise intervention and US-guided subacromial CS injection is cost-effective when compared with standard advice and exercise leaflet and unguided injection in patients with subacromial pain (impingement) syndrome.
Total plaque area and plaque echogenicity are novel measures of subclinical atherosclerosis in patients with systemic lupus erythematosus
Sara C Croca, Maura Griffin, Filipa Farinha, David A Isenberg, Andrew Nicolaides, Anisur Rahman
doi : 10.1093/rheumatology/keaa905
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4185–4198
Patients with SLE have an increased risk of developing cardiovascular disease (CVD). Multiple studies have shown that these patients have increased numbers of carotid plaques and greater intima-media thickness (IMT) than healthy controls. Measures such as total plaque area (TPA) and plaque echogenicity may be more sensitive and more relevant to cardiovascular risk than presence of plaque and IMT alone. Our objective was to produce the first report of TPA and echogenicity in a population of patients with SLE.
Initiation of febuxostat for acute gout flare does not prolong the current episode: a randomized clinical trial
Ertao Jia, Yanying Zhang, Wukai Ma, Bo Li, Hongling Geng, Li Zhong, Xueming Yao, Jingjing Xie, Yuya Xiao, Yubao Jiang, Xia Qiu, Min Xiao, Xiang Cui, Jiaxin Wei, Jianyong Zhang
doi : 10.1093/rheumatology/keaa908
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4199–4204
Our objective was to determine whether initiation of febuxostat during an acute gout flare prolongs the current episode.
Contribution of abnormal BMI to adverse health-related quality of life outcomes after a 52-week therapy in patients with SLE
Alexander Borg, Alvaro Gomez, Arvid Cederlund, Flordelyn Cobar, Victor Qiu, Julius Lindblom, Sharzad Emamikia, Yvonne Enman, Susanne Pettersson, Ioannis Parodis
doi : 10.1093/rheumatology/keaa909
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4205–4217
To investigate whether abnormal BMI is associated with adverse health-related quality of life (HRQoL) outcome, including severe fatigue, after 52?weeks of standard therapy plus belimumab or placebo in patients with SLE.
Imbalanced MMP-3 and MMP-12 serum levels in systemic lupus erythematosus patients with Jaccoud’s arthropathy and a distinctive MRI pattern
Matteo Piga, Mattia Congia, Antonella Balestrieri, Maria Maddalena Angioni, Ignazio Cangemi, Riccardo Cau, Elisabetta Chessa, Alberto Floris, Fabiana Figus, Annamaria Iagnocco, Alberto Cauli, Luca Saba
doi : 10.1093/rheumatology/keaa915
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4218–4228
Metalloproteinase (MMP)-3 and MMP-12 are proteolytic enzymes especially implicated in joint inflammation. This study aims to evaluate their association with arthritis features and hand MRI abnormalities in patients with SLE.
Contextualizing temporal arterial magnetic resonance angiography in the diagnosis of giant cell arteritis: a retrospective cohort study
Mats Junek, Angela Hu, Stephanie Garner, Ryan Rebello, Kim Legault, Karen Beattie, Nader Khalidi
doi : 10.1093/rheumatology/keaa916
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4229–4237
Imaging modalities have become common in evaluating patients for a possible diagnosis of GCA. This study seeks to contextualize how temporal arterial magnetic resonance angiography (TA-MRA) can be used in facilitating the diagnosis of GCA.
Mortality in SLE patients compared with population controls in Finland in years 2000–2015
Pia Elfving, Simo Kariniemi, Hannu Kautiainen, Lauri J Virta, Oili Kaipiainen-Seppänen, Kari Puolakka
doi : 10.1093/rheumatology/keaa917
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4238–4244
To estimate the risk of mortality in the Finnish incident SLE cohort in a 16-year period compared with the general population.
Impact of aging on phenotype and prognosis in IgA vasculitis
Alexandra Audemard-Verger, Evangéline Pillebout, Aurélie Baldolli, Noémie Le Gouellec, Jean-François Augusto, Noémie Jourde-Chiche, Loic Raffray, Eric Thervet, Alban Deroux, Julie Goutte, Aurélie Hummel, Bertrand Lioger, Sébastien Sanges, Patrice Cacoub, Zahir Amoura, Guillaume Moulis, Francois Maurier, Christian Lavigne, Geoffrey Urbanski, Johan Chanal, Stanislas Faguer, Sophie Deriaz, Nicole Feirreira-Maldent, Elisabeth Diot, Francois Maillot, Loïc Guillevin, Benjamin Terrier
doi : 10.1093/rheumatology/keaa921
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4245–4251
Immunoglobulin A vasculitis (IgAV) is a small-vessel vasculitis most frequently benign in children while more severe in adults. We aimed to study the impact of age on presentation and outcome of adult IgAV.
Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study
Takahiko Sugihara, Tatsuro Ishizaki, Wataru Onoguchi, Hiroyuki Baba, Takumi Matsumoto, Shoko Iga, Kanae Kubo, Mari Kamiya, Fumio Hirano, Tadashi Hosoya, Nobuyuki Miyasaka, Masayoshi Harigai
doi : 10.1093/rheumatology/keaa922
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4252–4261
To evaluate 3-year outcomes of following a treat-to-target (T2T) strategy targeting low disease activity for patients with elderly-onset RA (EORA) and to confirm safety profile of T2T.
Low rate of subsequent surgery and serious complications following intra-articular steroid injection for base of thumb osteoarthritis: national cohort analysis
Jennifer C E Lane, Richard S Craig, Jonathan L Rees, Matthew D Gardiner, Abigail V Shaw, Michelle Spiteri, Rachel Kuo, Benjamin F Dean, Jane Green, Daniel Prieto-Alhambra, Dominic Furniss
doi : 10.1093/rheumatology/keaa925
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4262–4271
Intra-articular steroid injection is commonly used to treat base of thumb osteoarthritis (BTOA), despite a lack of large-scale data on safety and effectiveness. We estimate the incidence of serious complications and further procedures following BTOA injection, including the risk of post-operative serious surgical site infection for subsequent operative intervention.
Prevalence of gastrointestinal, cardiovascular, autonomic and allergic manifestations in hospitalized patients with Ehlers-Danlos syndrome: a case-control study
Rachel S Brooks, James Grady, Thomas W Lowder, Svetlana Blitshteyn
doi : 10.1093/rheumatology/keaa926
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4272–4280
Previous observations suggest an association between Ehlers-Danlos syndrome (EDS) and gastrointestinal (GI), cardiovascular, immune, and autonomic nervous system dysfunction. We sought to determine whether a hospital diagnosis of EDS is associated with a higher prevalence of these manifestations vs hospitalized patients without EDS. We also evaluated hospital outcomes.
High early mortality in idiopathic inflammatory myopathies: results from the inception cohort at a tertiary care centre in northern India
Pankti Mehta, Vikas Agarwal, Latika Gupta
doi : 10.1093/rheumatology/keab001
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4281–4290
We determined the mortality along with the proportion of disease related adverse events measured individually and by a composite adverse outcome (devised by including deaths, disability, relapses and minimal response) and its predictors in an inception cohort of idiopathic inflammatory myopathies (IIM).
Algorithm for calculating high disease activity in SLE
Alberta Hoi, Hieu T Nim, Rachel Koelmeyer, Ying Sun, Amy Kao, Oliver Gunther, Eric Morand
doi : 10.1093/rheumatology/keab003
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4291–4297
The ability to identify lupus patients in high disease activity status (HDAS) without knowledge of the SLEDAI could have application in selection of patients for treatment escalation or enrolment in trials. We sought to generate an algorithm that could calculate via model fitting the presence of HDAS using simple demographic and laboratory values.
Remission in SLE—do DORIS criteria match the treating physician’s judgment? A cross-sectional study to assess reasons for discordance
Johanna Mucke, Christina Düsing, Nora Klose, Matthias Schneider, Gamal Chehab
doi : 10.1093/rheumatology/keab005
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4298–4305
The definition of an accurate target for a treat-to-target approach in SLE has been challenging over past years, and recently the DORIS definitions of remission were presented by the international DORIS task force. It was our aim to assess the frequency of DORIS remission and LLDAS in our SLE cohort and their agreement with the treating physician’s (DORIS-) independent remission judgement. Patient characteristics leading to lack of agreement and incoherence ought to be identified.
Patients and clinicians define symptom levels and meaningful change for PROMIS pain interference and fatigue in RA using bookmarking
Clifton O Bingham, III, Alessandra L Butanis, Ana Maria Orbai, Michelle Jones, Victoria Ruffing, Anne Lyddiatt, Mary Suzanne Schrandt, Vivian P Bykerk, Karon F Cook, Susan J Bartlett
doi : 10.1093/rheumatology/keab014
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4306–4314
Using patient-reported outcomes to inform clinical decision-making depends on knowing how to interpret scores. Patient-Reported Outcome Measurement Information System® (PROMIS®) instruments are increasingly used in rheumatology research and care, but there is little information available to guide interpretation of scores. We sought to identify thresholds and meaningful change for PROMIS Pain Interference and Fatigue scores from the perspective of RA patients and clinicians.
High burden of infections in Indian patients with Idiopathic Inflammatory Myopathy: validation of observations from the MyoCite dataset
Rudrarpan Chatterjee, Pankti Mehta, Vikas Agarwal, Latika Gupta
doi : 10.1093/rheumatology/keab015
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4315–4326
To determine the prevalence, profile and predictors of infections in an Indian cohort with idiopathic inflammatory myopathies (IIM).
Temporal relationship between osteoarthritis and comorbidities: a combined case control and cohort study in the UK primary care setting
Subhashisa Swain, Carol Coupland, Christian Mallen, Chang Fu Kuo, Aliya Sarmanova, Sita M A Bierma-Zeinstra, Martin Englund, Daniel Prieto-Alhambra, Michael Doherty, Weiya Zhang
doi : 10.1093/rheumatology/keab067
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4327–4339
To determine the burden of comorbidities in OA and their temporal relationships in the UK.
Osteoarthritis and risk of hospitalization for ambulatory care-sensitive conditions: a general population-based cohort study
Ali Kiadaliri, Martin Englund
doi : 10.1093/rheumatology/keab161
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4340–4347
To determine the association between OA and risk of hospitalization for ambulatory care-sensitive conditions (HACSCs).
De novo lupus nephritis during treatment with belimumab
Ioannis Parodis, Edward M Vital, Sabih-Ul Hassan, Andreas Jönsen, Anders A Bengtsson, Per Eriksson, Dag Leonard, Iva Gunnarsson, Lars Rönnblom, Christopher Sjöwall
doi : 10.1093/rheumatology/keaa796
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4348–4354
In light of reports of de novo LN during belimumab (BLM) treatment, we sought to determine its frequency and contributing or protective factors in a real-life setting.
Significance of PR3-ANCA positivity in eosinophilic granulomatosis with polyangiitis (Churg-Strauss)
Matthias Papo, Renato A. Sinico, Vítor Teixeira, Nils Venhoff, Maria-Letizia Urban, Michele Iudici, Juliane Mahrhold, Francesco Locatelli, Giulia Cassone, Franco Schiavon, Benjamin Seeliger, Thomas Neumann, Claus Kroegel, Matthieu Groh, Chiara Marvisi, Maxime Samson, Thomas Barba, David Jayne, Arianna Troilo, Jens Thiel, Bernhard Hellmich, Sara Monti, Carlomaurizio Montecucco, Carlo Salvarani, Jean-Emmanuel Kahn, Bernard Bonnotte, Cécile-Audrey Durel, Xavier Puéchal, Luc Mouthon, Loïc Guillevin, Giacomo Emmi, Augusto Vaglio, Benjamin Terrier, the French Vasculitis Study Group and the EGPA European Study Group
doi : 10.1093/rheumatology/keaa805
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4355–4360
Only a third of patients with eosinophilic granulomatosis with polyangiitis (EGPA) are ANCA-positive, mainly directed against MPO. ANCA directed against PR3 are rarely found in EGPA. We aimed to examine the significance of PR3-ANCA in EGPA.
Ultrasonographic Halo Score in giant cell arteritis: association with intimal hyperplasia and ischaemic sight loss
Kornelis S. M. van der Geest, Konrad Wolfe, Frances Borg, Alwin Sebastian, Abdul Kayani, Alessandro Tomelleri, Prisca Gondo, Wolfgang A. Schmidt, Raashid Luqmani, Bhaskar Dasgupta
doi : 10.1093/rheumatology/keaa806
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4361–4366
We investigated the relationship between the ultrasonographic Halo Score and temporal artery biopsy (TAB) findings in GCA.
Improvement from ixekizumab treatment in patients with psoriatic arthritis who have had an inadequate response to one or two TNF inhibitors
Bruce Kirkham, Carlos Sesin, Amanda M. Gellett, Aubrey T. Sprabery, Chen-Yen Lin, Anthony Turkiewicz
doi : 10.1093/rheumatology/keaa824
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4367–4372
To evaluate the efficacy of ixekizumab (IXE), a monoclonal antibody selectively targeting interleukin-17A, in patients with inadequate response to one or two TNF inhibitors (TNFi).
Anti-tumour necrosis factor treatment for the prevention of ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2)
Samantha Cooray, Ebun Omyinmi, Ying Hong, Charalampia Papadopoulou, Lorraine Harper, Eslam Al-Abadi, Ruchika Goel, Shirish Dubey, Mark Wood, Stephen Jolles, Stefan Berg, Maria Ekelund, Kate Armon, Despina Eleftheriou, Paul A Brogan
doi : 10.1093/rheumatology/keaa837
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4373–4378
To evaluate the impact of anti-Tumour Necrosis Factor-? (anti-TNF) treatment on the occurrence of vasculitic ischaemic events in patients with deficiency of adenosine deaminase 2 (DADA2).
Salivary glands involvement: a new indicator of juvenile idiopathic oligoarticular arthritis (preliminary results)
Patrizia Defabianis, Franco Garofalo, Federica Romano
doi : 10.1093/rheumatology/keaa891
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4379–4383
Early diagnosis is critical to reduce long-term disability in patients with JIA by ensuring prompt treatment. The aim of this cross-sectional study was to evaluate the salivary gland function in JIA, addressing specifically oligoarticular (JIA1) and polyarticular (JIA2) subtypes, compared with healthy controls. This may contribute to the identification of salivary risk indicators of the disease that may help diagnosis at an early stage or even before the onset of other clinical evidence.
Use of 18F-fluorodeoxyglucose positron emission tomography to monitor tocilizumab effect on vascular inflammation in giant cell arteritis
Kaitlin A. Quinn, Himanshu Dashora, Elaine Novakovich, Mark A. Ahlman, Peter C. Grayson
doi : 10.1093/rheumatology/keaa894
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4384–4389
To evaluate the time-dependent effects of tocilizumab on vascular inflammation as measured by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in GCA.
Evaluation of PR3- and MPO-ANCA line and dot immunoassays in ANCA-associated vasculitis
Nina Kempiners, Juliane Mahrhold, Bernhard Hellmich, Elena Csernok
doi : 10.1093/rheumatology/keaa776
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4390–4394
This study was performed to evaluate the diagnostic accuracy of novel line and dot immunoassays for detection of MPO and PR3 ANCA.
The intracellular chloride channel 4 (CLIC4) activates systemic sclerosis fibroblasts
Christopher W. Wasson, Rebecca. L. Ross, Ruth Morton, Jamel Mankouri, Francesco Del Galdo
doi : 10.1093/rheumatology/keaa797
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4395–4400
Tissue fibrosis in SSc is driven by active fibroblasts (myofibroblasts). Previous studies have shown the intracellular chloride channel 4 (CLIC4) mediates the activation of cancer-associated fibroblasts. In this study we investigated the role of CLIC4 in SSc fibroblast activation.
Decreased serum ACE2 levels in patients with connective tissue diseases
Xiaojun Tang, Linyu Geng, Xuebing Feng, Lingyun Sun
doi : 10.1093/rheumatology/keaa898
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4401–4406
To evaluate serum concentration and activity of angiotensin-converting enzyme 2 (ACE2) in patients with connective tissue diseases (CTDs).
Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus
Qin Song, Yao Lei, Li Shao, Weiyang Li, Qingsheng Kong, Zhiming Lin, Xiao Qin, Wei Wei, Fei Hou, Jian Li, Xianghua Guo, Yujing Mao, Yujie Cao, Zhongyi Liu, Lichuan Zheng, Rui Liang, Yuping Jiang, Yan Liu, Lili Zhang, Jing Yang, Yu Lung Lau, Yan Zhang, Bo Ban, Yong-Fei Wang, Wanling Yang
doi : 10.1093/rheumatology/keab016
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4407–4417
To identify novel genetic loci associated with systemic lupus erythematosus (SLE) and to evaluate potential genetic differences between ethnic Chinese and European populations in SLE susceptibility.
Solving the mystery of HBV-related mixed cryoglobulinemia: potential biomarkers of disease progression
Krizia Pocino, Cecilia Napodano, Laura Gragnani, Gabriele Ciasca, Stefania Colantuono, Silvia Marri, Lorenzo Vantaggio, Francesca Gulli, Serena Lorini, Antonella Barini, Annunziata Stefanile, Luca Miele, Milvia Casato, Anna Linda Zignego, Gian Ludovico Rapaccini, Mariapaola Marino, Marcella Visentini, Umberto Basile
doi : 10.1093/rheumatology/keab157
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4418–4427
The biomarkers of an immunological dysregulation due to a chronic HBV infection are indeed understudied. If untreated, this condition may evolve into liver impairment co-occurring with extrahepatic involvements. Here, we aim to identify a new panel of biomarkers [including immunoglobulin G (IgG) subclasses, RF, and Free Light Chains (FLCs)] that may be useful and reliable for clinical evaluation of HBV-related cryoglobulinemia.
Anti-MDA-5-positive dermatomyositis associated rapidly progressive interstitial lung disease, a virus-triggered autoimmune-like symptom?
Lingxiao Xu, Lei Wang, Chengyin Lv, Wenfeng Tan
doi : 10.1093/rheumatology/keab224
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4428–4429
An X chromosome-wide meta-analysis based on Japanese cohorts revealed that non-autosomal variations are associated with serum urate
Masahiro Nakatochi, Yu Toyoda, Masahiro Kanai, Akiyoshi Nakayama, Yusuke Kawamura, Asahi Hishida, Haruo Mikami, Keitaro Matsuo, Toshiro Takezaki, Yukihide Momozawa, The Biobank Japan Project, Yoichiro Kamatani, Sahoko Ichihara, Nariyoshi Shinomiya, Mitsuhiro Yokota, Kenji Wakai, Yukinori Okada, Hirotaka Matsuo, the Japan Uric Acid Genomics Consortium (Japan Urate)
doi : 10.1093/rheumatology/keab404
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4430–4432
New prescribing recommendations bring an opportunity to focus on better reproductive health for women with rheumatic disease
Iona Thorne
doi : 10.1093/rheumatology/keab409
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4432–4434
Point-of-care ultrasound enables diagnosis of giant cell arteritis with a modern innovative handheld probe
Pantelis Karakostas, Christian Dejaco, Charlotte Behning, Florian Recker, Valentin Sebastian Schäfer
doi : 10.1093/rheumatology/keab424
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4434–4436
No added value of optimal spectral transmission imaging in persons at risk of rheumatoid arthritis
Laurette van Boheemen, Annelies Blanken, Aja Kuin, Dirkjan van Schaardenburg
doi : 10.1093/rheumatology/keab435
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4436–4438
Giant cell arteritis involving the posterior auricular artery
Kei Kobayashi, Shunichiro Hanai, Daiki Nakagomi
doi : 10.1093/rheumatology/keaa886
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4439–4440
Dense calcifications of giant coronary aneurysms in an 11-year-old girl with Kawasaki disease
Rakesh Kumar Pilania, Manphool Singhal, Surjit Singh
doi : 10.1093/rheumatology/keaa907
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4441–4442
A huge pancreatic cyst in eosinophilic granulomatosis with polyangitis
Maurizio Marvisi, Mario Uccelli
doi : 10.1093/rheumatology/keab008
Rheumatology, Volume 60, Issue 9, September 2021, Page 4443
Pulmonary apical fibrosis as the initial symptom of ankylosing spondylitis
Aydan Koken Avsar, Tuba Yuce Inel, Sinem Burcu Kocaer, Gercek Can
doi : 10.1093/rheumatology/keab012
Rheumatology, Volume 60, Issue 9, September 2021, Pages 4444–4445
Osteoporosis circumscripta cranii with a pathological fracture of the skull
Matthew Colquhoun, Henry Penn, Clare Batten
doi : 10.1093/rheumatology/keab013
Rheumatology, Volume 60, Issue 9, September 2021, Page 4446
Mycobacterium bovis infection under apremilast in Behçet's syndrome
Matheus Vieira, Mathieu Vautier, Frédéric Charlotte, David Saadoun
doi : 10.1093/rheumatology/keab199
Rheumatology, Volume 60, Issue 9, September 2021, Pages e301–e303
A case of VEXAS syndrome manifesting as Kikuchi-Fujimoto disease, relapsing polychondritis, venous thromboembolism and macrocytic anaemia
Shang Ming Samuel Lee, Bingwen Eugene Fan, Joel Hua-Liang Lim, Liuh Ling Goh, Joyce Siong See Lee, Li Wearn Koh
doi : 10.1093/rheumatology/keab200
Rheumatology, Volume 60, Issue 9, September 2021, Pages e304–e306
Severe hepatotoxicity as a rare side effect of anakinra in a patient with systemic JIA
G. M. Murray, S. Kheng Ng, D. Beasley, L. Johansen, A. V. Ramanan
doi : 10.1093/rheumatology/keab202
Rheumatology, Volume 60, Issue 9, September 2021, Pages e307–e308
JAK inhibition for treatment of psoriatic arthritis in Down syndrome
Andrew T. Pham, Angela L. Rachubinski, Belinda Enriquez-Estrada, Kayleigh Worek, Melissa Griffith, Joaquin M. Espinosa
doi : 10.1093/rheumatology/keab203
Rheumatology, Volume 60, Issue 9, September 2021, Pages e309–e311
Contrary immediate effect of abatacept on skin and joint manifestations in psoriatic arthritis
Larissa Valor-Méndez, Arnd Kleyer, Georg Schett, Bernhard Manger, Michael Sticherling
doi : 10.1093/rheumatology/keab206
Rheumatology, Volume 60, Issue 9, September 2021, Pages e312–e313
VEXAS syndrome in a patient with previous spondyloarthritis with a favourable response to intravenous immunoglobulin and anti-IL17 therapy
Marion Magnol, Loukianos Couvaras, Yannick Degboé, Eric Delabesse, Cristina Bulai-Livideanu, Adeline Ruyssen-Witrand, Arnaud Constantin
doi : 10.1093/rheumatology/keab211
Rheumatology, Volume 60, Issue 9, September 2021, Pages e314–e315
Colitis expands the phenotype of PAAND patients: new case report and review of the literature
Juan L. Valdivieso Shephard, Chamaida Plasencia Rodríguez, Cristina Suárez Ferrer, Diana Peiteado López, Alejandro Balsa Criado, Eduardo López-Granados, María Bravo García-Morato
doi : 10.1093/rheumatology/keab215
Rheumatology, Volume 60, Issue 9, September 2021, Pages e316–e317
MRI negative myeloradiculoneuropathy unmasking systemic lupus erythematosus
Shambaditya Das, Biman Kanti Ray, Alak Pandit, Souvik Dubey
doi : 10.1093/rheumatology/keab216
Rheumatology, Volume 60, Issue 9, September 2021, Pages e318–e320
VEXAS syndrome: still expanding the clinical phenotype
Artem Oganesyan, Vincent Jachiet, Francois Chasset, Pierre Hirsch, Mehdi Hage-Sleiman, Bettina Fabiani, Paul Duriez, Sophie Georgin-Lavialle, Francois Delhommeau, Yervand Hakobyan, Olivier Fain, Arsène Mekinian, on behalf MINHEMON
doi : 10.1093/rheumatology/keab225
Rheumatology, Volume 60, Issue 9, September 2021, Pages e321–e323
PET-CT scan to diagnose and demonstrate resolution of lupus lymphadenitis with belimumab
S. Garcia-Cirera, J. Calvet, J. C. Martin-Marimon, R. B. García-Chamón, J. Gratacós
doi : 10.1093/rheumatology/keab226
Rheumatology, Volume 60, Issue 9, September 2021, Pages e324–e325
Severe thrombotic microangiopathy after autologous stem cell transplantation in systemic sclerosis: a case report
Maryam O. Sharif, Helen L. Leavis, Pieter van Paassen, Anna van Rhenen, Sjoerd A. M. E. G. Timmermans, Evelien Ton, Jacob M. van Laar, Julia Spierings
doi : 10.1093/rheumatology/keab239
Rheumatology, Volume 60, Issue 9, September 2021, Pages e326–e328
Anti-PD-1 associated retroperitoneal fibrosis
Dimitrios Daoussis, Pantelis Kraniotis, Foteini Kalofonou, Haralabos Kalofonos
doi : 10.1093/rheumatology/keab264
Rheumatology, Volume 60, Issue 9, September 2021, Pages e329–e330
A 72-year-old man with life-threatening dyspnoea due to a neck mass of unexpected origin
Nick M.A. Schubert, Nynke A. Jager, Jeroen Vister, Boudewijn E.C. Plaat
doi : 10.1093/rheumatology/keab295
Rheumatology, Volume 60, Issue 9, September 2021, Pages e331–e333
Comment on: Real-world single centre use of JAK inhibitors across the rheumatoid arthritis pathway
Francesca Romana Spinelli, Cristina Garufi, Silvia Mancuso, Fulvia Ceccarelli, Fabrizio Conti
doi : 10.1093/rheumatology/keab195
Rheumatology, Volume 60, Issue 9, September 2021, Pages e334–e336
Comment on: Risk factors associated with pneumocystis jirovecii pneumonia in juvenile myositis in North America
Tomohiro Yoshida, Daisuke Waki
doi : 10.1093/rheumatology/keab411
Rheumatology, Volume 60, Issue 9, September 2021, Pages e337–e338
Comment on: Beneficial effect of Mediterranean diet on disease activity and cardiovascular risk in systemic lupus erythematosus patients: a cross-sectional study
Yusuke Matsuo, Toshimasa Shimizu, Yoshie Gon, Motohiko Sato, Sho Matsushita, Takashi Yoshioka
doi : 10.1093/rheumatology/keab281
Rheumatology, Volume 60, Issue 9, September 2021, Pages e339–e340
Comment on: Association between environmental air pollution and rheumatoid arthritis flares: reply
Giovanni Adami, Maurizio Rossini
doi : 10.1093/rheumatology/keab282
Rheumatology, Volume 60, Issue 9, September 2021, Page e341
Comment on: Femoral vein wall thickness measurement: A new diagnostic tool for Behçet’s disease
Tetsuro Aita, Yusuke Matsuo, Yoshie Yamada, Jun Miyata, Takashi Yoshioka
doi : 10.1093/rheumatology/keab319
Rheumatology, Volume 60, Issue 9, September 2021, Pages e342–e343
Comment on: What is the meaning of ANCA positivity in IgG4-related disease?
Hakan Apaydin, Berkan Arma?an, Serdar C. Güven, Ahmet Omma, Orhan Kucuksahin, Abdulsamet Erden
doi : 10.1093/rheumatology/keab356
Rheumatology, Volume 60, Issue 9, September 2021, Pages e344–e345
Comment on ‘Axial And Peripheral spondyloarthritis: does Psoriasis influence the clinical expression and disease burden? Data from REGISPONSER registry’
Yen-Po Lin, Chih-Jung Yeh, James Cheng-Chung Wei
doi : 10.1093/rheumatology/keab390
Rheumatology, Volume 60, Issue 9, September 2021, Page e346
Comment on: Acquired low immunoglobulin levels and risk of clinically relevant infection in adult patients with systemic lupus erythematosus
Wen-Kang Yang, Chih-Jen Tseng, James Cheng-Chung Wei
doi : 10.1093/rheumatology/keab408
Rheumatology, Volume 60, Issue 9, September 2021, Page e347
