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Vaccination in patients with chronic kidney disease—Review of current recommendations and recent advances
Becky Mingyao Ma Desmond Yat Hin Yap Terence Pok Siu Yip Ivan Fan Ngai Hung Sydney Chi Wai Tang Tak Mao Chan
doi : 10.1111/nep.13741
Volume26, Issue1 January 2021 Pages 5-11
Hepatitis B virus (HBV), influenza, pneumococcus and herpes zoster are important infections which could result in significant morbidity and mortality in patients with chronic kidney disease (CKD). While seroconversion rates after vaccination are often lower in CKD patients compared with healthy adults due to impaired innate and adaptive immunity, vaccinations for HBV, influenza, pneumococcus and herpes zoster are generally effective in reducing the transmission and/or severity of these infections. Practical issues that have an impact on the efficacy of vaccination in the CKD population include the timing, dose, schedule of vaccination, the route of administration, and adjuncts applied at time of vaccination. This review discusses the vaccination regimens and the efficacy of HBV, influenza, pneumococcus and zoster vaccines in CKD patients, and highlights recent advances in enhancing vaccine seroconversion rates.
Acute interstitial nephritis and nephrogenic diabetes insipidus following treatment with sulfamethoxazole?trimethoprim and temozolomide
Akshay Athavale Jack Morris Meg Jardine Martin Gallagher Shaundeep Sen Angus Ritchie Amanda Y. Wang
doi : 10.1111/nep.13783
Volume26, Issue1 January 2021 Pages 12-14
We report a case of acute interstitial nephritis with associated nephrogenic diabetes insipidus in a patient treated with temozolomide and sulfamethoxazole?trimethoprim for glioblastoma multiforme. Kidney biopsy demonstrated focal tubulointerstitial change with tubular dilatation, epithelial change and interstitial inflammation. The patient's kidney function improved with cessation of sulfamethoxazole?trimethoprim and treatment with hydrochlorothiazide for nephrogenic diabetes insipidus. Recommencement of temozolomide did not result in further deterioration in kidney function. In this case report, we discuss the novel association between sulfamethoxazole?trimethoprim?induced acute interstitial nephritis and nephrogenic diabetes insipidus, and suggest possible mechanisms involved.
Renal supportive care, palliative care and end?of?life care: Perceptions of similarities, differences and challenges across Australia and New Zealand
Kathryn Ducharlet Jennifer Philip Katerina Kiburg Hilton Gock
doi : 10.1111/nep.13787
Volume26, Issue1 January 2021 Pages 15-22
Renal supportive care (RSC) is an approach integrating nephrology and palliative care to improve quality of life for people with chronic kidney disease (CKD). RSC practice varies across services; therefore, understanding clinicians' perspectives is important to the evolution and definition of RSC.
Performance of a pre?procedural Mehran score to predict acute kidney injury after percutaneous coronary intervention
Anamarys Blanco Faisal Rahim Michelle Nguyen Steven Quach Sai Guduru Shraddha Makadia Khalid Abusaada
doi : 10.1111/nep.13769
Volume26, Issue1 January 2021 Pages 23-29
Acute kidney injury (AKI) is a known complication of patients undergoing cardiac catheterization or percutaneous coronary interventions (PCI).The Mehran score was developed to identify patients at risk for AKI after cardiac catheterization or PCI, but its use of contrast volume as part of the score calculation limits its application prior to the procedure. In this study, we evaluated the utility of a modified Mehran score that utilizes only pre?procedural data by excluding contrast volume.
Systemic complement activation in anti?neutrophil cytoplasmic antibody?associated vasculitis and necrotizing glomerulonephritis
Kostas Bantis Maria Stangou Savvas Kalpakidis Maria Hatziadamou Dimitra?Vasilia Daikidou George Lioulios Zoi Mitsoglou Helen Chatzidrosou Christina Nikolaidou Asimina Fylaktou Aikaterini Papagianni …
doi : 10.1111/nep.13747
Volume26, Issue1 January 2021 Pages 30-37
Due to the accumulating evidence of complement activation in anti?neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV), we decided to investigate the possibility of systemic complement activation in patients with Necrotizing Glomerulonephritis secondary to AAV.
Shear wave elastography accurately detects chronic changes in renal histopathology
Sook Sam Leong Jeannie Hsiu Ding Wong Mohammad Nazri Md Shah Anushya Vijayananthan Maisarah Jalalonmuhali Tak Kuan Chow Nur H. M. Sharif Kwan Hoong Ng
doi : 10.1111/nep.13805
Volume26, Issue1 January 2021 Pages 38-45
Renal biopsy is the gold standard for the histological characterization of chronic kidney disease (CKD), of which renal fibrosis is a dominant component, affecting its stiffness. The aim of this study was to investigate the correlation between kidney stiffness obtained by shear wave elastography (SWE) and renal histological fibrosis.
Association of erythropoietin resistance and fibroblast growth factor 23 in dialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study
Tomoko Usui Junhui Zhao Douglas S. Fuller Norio Hanafusa Takeshi Hasegawa Hiroshi Fujino Takanobu Nomura Jarcy Zee Eric Young Bruce M. Robinson Masaomi Nangaku
doi : 10.1111/nep.13765
Volume26, Issue1 January 2021 Pages 46-53
Fibroblast growth factor 23 (FGF23) plays an important role in chronic kidney disease (CKD)?related mineral and bone disorders. High FGF23 levels are associated with increased risk of anaemia in non?haemodialysis CKD patients. FGF23 also negatively regulates erythropoiesis in mice. We hypothesized that higher FGF23 levels are associated with increased erythropoietin hyporesponsiveness among haemodialysis patients.
Associations of coenzyme Q10 with endothelial function in hemodialysis patients
Jian?jun Gao Yong?xing Xu Hua?ping Jia Li Zhang Xue?ying Cao Xiao?wen Zuo Guang?yan Cai Xiang?mei Chen
doi : 10.1111/nep.13766
Volume26, Issue1 January 2021 Pages 54-61
Endothelial dysfunction is common in patients undergoing hemodialysis (HD). However, little is known about the relationship between endothelial dysfunction and coenzyme Q10 (CoQ10) levels in HD patients.
Perspectives on blood pressure by patients on haemo? and peritoneal dialysis
Nicole Evangelidis Benedicte Sautenet Karine E. Manera Martin Howell Jonathan C. Craig Andrea K. Viecelli Emma O'Lone Nicole Scholes?Robertson David W. Johnson Yeoungjee Cho Charles Tomson David C. Wheeler Allison Tong for the SONG?HD and SONG?PD initiative …
doi : 10.1111/nep.13775
Volume26, Issue1 January 2021 Pages 62-69
The management of blood pressure in patients requiring dialysis remains challenging and controversial. This study aimed to describe the perspectives of patients treated with peritoneal or haemodialysis regarding blood pressure, to inform patient?centred management.
Impact of pre?transplant biopsy on 5?year outcomes of expanded criteria donor kidney transplantation
Yun Ting Yap Quan Yao Ho Terence Kee Chee Yong Ng Chang Yin Chionh
doi : 10.1111/nep.13788
Volume26, Issue1 January 2021 Pages 70-77
Compared to Standard Criteria Donors (SCD), Expanded Criteria Donor (ECD) kidneys are associated with poorer outcomes, although pre?transplant biopsy may mitigate risks. This study assessed 5?year outcomes of deceased?donor kidney transplant recipients, comparing recipients of ECD allografts evaluated histologically to recipients of SCD and ECD kidneys assessed clinically.
Nodakenin alleviates renal ischaemia?reperfusion injury via inhibiting reactive oxygen species?induced NLRP3 inflammasome activation
Yuan Liao Xiao Lin Jianchun Li Ruizhi Tan Xia Zhong Li Wang
doi : 10.1111/nep.13781
Volume26, Issue1 January 2021 Pages 78-87
Acute kidney injury (AKI) is a vital contributor to chronic kidney disease and limited therapeutic options are existed to preserve the renal injury. The research presented here investigated the protective effect of nodakenin against AKI and the underlying mechanism.
Acetazolamide toxicity and dosing in dialysis patients
Wai Lun Will Pak Ka Lok Chan Zi Chan Wai Ping Law Yick Hei Wong Chi Kwan Lam Sze Ho Sunny Wong
doi : 10.1111/nep.13654
Volume26, Issue1 January 2021 Pages 88-88
Immunotherapy?related acute kidney injury: Kidney biopsy or not?
Sophie Chatterton Sarah Williams Kazi Nahar Alexander M. Menzies Muh G. Wong
doi : 10.1111/nep.13687
Volume26, Issue1 January 2021 Pages 89-90
