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Reducing the risk of atrial fibrillation in ESKD: is the devil in the dialysis?
Mark Canney, Manish M Sood, Gregory L Hundemer
doi : 10.1093/ndt/gfab063
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1963–1964
Sex differences in the progression of kidney injury and risk of death in CKD patients: is different ambulatory blood pressure control the underlying cause?
Pantelis Sarafidis, Michel Burnier
doi : 10.1093/ndt/gfab115
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1965–1967
Regenerating tubular epithelial cells of the kidney
Eleni Stamellou, Katja Leuchtle, Marcus J Moeller
doi : 10.1093/ndt/gfaa103
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1968–1975
Acute tubular injury accounts for the most common intrinsic cause for acute kidney injury. Normally, the tubular epithelium is mitotically quiescent. However, upon injury, it can show a brisk capacity to regenerate and repair. The scattered tubular cell (STC) phenotype was discovered as a uniform reaction of tubule cells triggered by injury. The STC phenotype is characterized by a unique protein expression profile, increased robustness during tubular damage and increased proliferation. Nevertheless, the exact origin and identity of these cells have been unveiled only in part. Here, we discuss the classical concept of renal regeneration. According to this model, surviving cells dedifferentiate and divide to replace neighbouring lost tubular cells. However, this view has been challenged by the concept of a pre-existing and fixed population of intratubular progenitor cells. This review presents a significant body of previous work and animal studies using lineage-tracing methods that have investigated the regeneration of tubular cells. We review the experimental findings and discuss whether they support the progenitor hypothesis or the classical concept of renal tubular regeneration. We come to the conclusion that any proximal tubular cell may differentiate into the regenerative STC phenotype upon injury thus contributing to regeneration, and these cells differentiate back into tubular cells once regeneration is finished.
Iron deficiency after kidney transplantation
Joanna Sophia J Vinke, Marith I Francke, Michele F Eisenga, Dennis A Hesselink, Martin H de Borst
doi : 10.1093/ndt/gfaa123
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1976–1985
Iron deficiency (ID) is highly prevalent in kidney transplant recipients (KTRs) and has been independently associated with an excess mortality risk in this population. Several causes lead to ID in KTRs, including inflammation, medication and an increased iron need after transplantation. Although many studies in other populations indicate a pivotal role for iron as a regulator of the immune system, little is known about the impact of ID on the immune system in KTRs. Moreover, clinical trials in patients with chronic kidney disease or heart failure have shown that correction of ID, with or without anaemia, improves exercise capacity and quality of life, and may improve survival. ID could therefore be a modifiable risk factor to improve graft and patient outcomes in KTRs; prospective studies are warranted to substantiate this hypothesis.
Myostatin and muscle atrophy during chronic kidney disease
Stanislas Bataille, Philippe Chauveau, Denis Fouque, Michel Aparicio, Laetitia Koppe
doi : 10.1093/ndt/gfaa129
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1986–1993
Chronic kidney disease (CKD) patients often exhibit a low muscle mass and strength, leading to physical impairment and an increased mortality. Two major signalling pathways control protein synthesis, the insulin-like growth factor-1/Akt (IGF-1/Akt) pathway, acting as a positive regulator, and the myostatin (Mstn) pathway, acting as a negative regulator. Mstn, also known as the growth development factor-8 (GDF-8), is a member of the transforming growth factor-? superfamily, which is secreted by mature muscle cells. Mstn inhibits satellite muscle cell proliferation and differentiation and induces a proteolytic phenotype of muscle cells by activating the ubiquitin–proteasome system. Recent advances have been made in the comprehension of the Mstn pathway disturbance and its role in muscle wasting during CKD. Most studies report higher Mstn concentrations in CKD and dialysis patients than in healthy subjects. Several factors increase Mstn production in uraemic conditions: low physical activity, chronic or acute inflammation and oxidative stress, uraemic toxins, angiotensin II, metabolic acidosis and glucocorticoids. Mstn seems to be only scarcely removed during haemodialysis or peritoneal dialysis, maybe because of its large molecule size in plasma where it is linked to its prodomain. In dialysis patients, Mstn has been proposed as a biomarker of muscle mass, muscle strength or physical performances, but more studies are needed in this field. This review outlines the interconnection between Mstn activation, muscle dysfunction and CKD. We discuss mechanisms of action and efficacy of pharmacological Mstn pathway inhibition that represents a promising treatment approach of striated muscle dysfunction. Many approaches and molecules are in development but until now, no study has proved a benefit in CKD.
Management of post-transplant recurrent focal and segmental glomerulosclerosis
Gabriel Morin, Christophe Legendre, Guillaume Canaud
doi : 10.1093/ndt/gfaa021
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1994–1996
Pancreas transplantation
Andrew Sutherland, Lorna Marson
doi : 10.1093/ndt/gfaa046
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 1997–1999
Sex difference in ambulatory blood pressure control associates with risk of ESKD and death in CKD patients receiving stable nephrology care
Roberto Minutolo, Francis B Gabbai, Rajiv Agarwal, Carlo Garofalo, Silvio Borrelli, Paolo Chiodini, Simona Signoriello, Ernesto Paoletti, Maura Ravera, Vincenzo Bellizzi, Giuseppe Conte, Luca De Nicola
doi : 10.1093/ndt/gfab017
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2000–2007
It is unknown whether faster progression of chronic kidney disease (CKD) in men than in women relates to differences in ambulatory blood pressure (ABP) levels.
The impact of chronic kidney disease Stages 3–5 on pregnancy outcomes
Kate Wiles, Philip Webster, Paul T Seed, Katy Bennett-Richards, Kate Bramham, Nigel Brunskill, Sue Carr, Matt Hall, Rehan Khan, Catherine Nelson-Piercy, Louise M Webster, Lucy C Chappell, Liz Lightstone
doi : 10.1093/ndt/gfaa247
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2008–2017
Contemporaneous data are required for women with chronic kidney disease (CKD) Stages 3–5 to inform pre-pregnancy counselling and institute appropriate antenatal surveillance.
Laxative use in patients with advanced chronic kidney disease transitioning to dialysis
Keiichi Sumida, Ankur A Dashputre, Praveen K Potukuchi, Fridtjof Thomas, Yoshitsugu Obi, Miklos Z Molnar, Justin D Gatwood, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
doi : 10.1093/ndt/gfaa205
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2018–2026
Constipation is highly prevalent in patients with chronic kidney disease (CKD), particularly among those with end-stage renal disease (ESRD), partly due to their dietary restrictions, comorbidities and medications. Laxatives are typically used for constipation management; however, little is known about laxative use and its associated factors in patients with advanced CKD transitioning to ESRD.
DNA methylation profiling identifies epigenetic differences between early versus late stages of diabetic chronic kidney disease
Ashani Lecamwasam, Boris Novakovic, Braydon Meyer, Elif I Ekinci, Karen M Dwyer, Richard Saffery
doi : 10.1093/ndt/gfaa226
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2027–2038
We investigated a cross-sectional epigenome-wide association study of patients with early and late diabetes-associated chronic kidney disease (CKD) to identify possible epigenetic differences between the two groups as well as changes in methylation across all stages of diabetic CKD. We also evaluated the potential of using a panel of identified 5?-C-phosphate-G-3? (CpG) sites from this cohort to predict the progression of diabetic CKD.
Global Phase 3 programme of vadadustat for treatment of anaemia of chronic kidney disease: rationale, study design and baseline characteristics of dialysis-dependent patients in the INNO2VATE trials
Kai-Uwe Eckardt, Rajiv Agarwal, Youssef Mk Farag, Alan G Jardine, Zeeshan Khawaja, Mark J Koury, Wenli Luo, Kunihiro Matsushita, Peter A McCullough, Patrick Parfrey, Geoffrey Ross, Mark J Sarnak, Dennis Vargo, Wolfgang C Winkelmayer, Glenn M Chertow
doi : 10.1093/ndt/gfaa204
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2039–2048
Erythropoiesis-stimulating agents (ESAs) are currently the mainstay of treatment for anaemia of chronic kidney disease (CKD). Vadadustat is an investigational oral hypoxia-inducible factor prolyl-hydroxylase inhibitor that stimulates endogenous erythropoietin formation. The INNO2VATE programme comprises two studies designed to evaluate the safety and efficacy of vadadustat versus the ESA darbepoetin alfa in ameliorating anaemia in patients with dialysis-dependent CKD (DD-CKD). Here we describe the trial design along with patient demographics and baseline characteristics.
Does dietary potassium intake associate with hyperkalemia in patients with chronic kidney disease?
Christiane I Ramos, Ailema González-Ortiz, Angeles Espinosa-Cuevas, Carla M Avesani, Juan Jesus Carrero, Lilian Cuppari
doi : 10.1093/ndt/gfaa232
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2049–2057
Dietary potassium restriction is a strategy to control hyperkalemia in chronic kidney disease (CKD). However, hyperkalemia may result from a combination of clinical conditions. This study aimed to investigate whether dietary potassium or the intake of certain food groups associate with serum potassium in the face of other risk factors.
Plasma total adiponectin and changes in renal function in a cohort from the community: the prospective Data from an Epidemiological Study on the Insulin Resistance Syndrome study
Frédéric Fumeron, Ray El Boustany, Jean-Philippe Bastard, Soraya Fellahi, Beverley Balkau, Michel Marre, Nicolas Venteclef, Gilberto Velho, Ronan Roussel
doi : 10.1093/ndt/gfaa228
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2058–2065
High adiponectin levels are associated with diabetic nephropathy. Nevertheless, it is not known whether plasma adiponectin is associated with renal function decline in the general population. We evaluated whether adiponectin concentrations were associated with changes in renal function in a community cohort, the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) study.
Impaired perfusion in the myocardial microcirculation in asymptomatic patients with Stages 1–4 chronic kidney disease with intrarenal arterial lesions
Fei Xiao, Weiwei Zhang, Ya-Ni He, Jie Yang, Xinghong Liu, Ling Wang, Jianguo Zhang, Huanzi Dai
doi : 10.1093/ndt/gfaa245
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2066–2075
Even mild renal disease is a powerful cardiovascular risk factor. However, the association between these pathophysiologic processes (especially in the early asymptomatic stage) is not known.
CYP24A1 and KL polymorphisms are associated with the extent of vascular calcification but do not improve prediction of cardiovascular events
Guillermo Solache-Berrocal, Valeria Rolle-Sóñora, Noelia Martín-Fernández, Serafí Cambray, José Manuel Valdivielso, Isabel Rodríguez on behalf of the NEFRONA investigators
doi : 10.1093/ndt/gfaa240
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2076–2083
Novel ways of determining cardiovascular risk are needed as a consequence of population ageing and the increased prevalence of chronic kidney disease (CKD), both of which favour vascular calcification. Since the formation of arterial calcium deposits has a genetic component, single nucleotide polymorphisms (SNPs) could predict cardiovascular events.
Ultrafiltration rate and incident atrial fibrillation among older individuals initiating hemodialysis
Jennifer E Flythe, Sai Liu, Maria E Montez-Rath, Wolfgang C Winkelmayer, Tara I Chang
doi : 10.1093/ndt/gfaa332
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2084–2093
Higher ultrafiltration (UF) rates are associated with numerous adverse cardiovascular outcomes among individuals receiving maintenance hemodialysis. We undertook this study to investigate the association of UF rate and incident atrial fibrillation in a large, nationally representative US cohort of incident, older hemodialysis patients.
COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study
Eric Goffin, Alexandre Candellier, Priya Vart, Marlies Noordzij, Miha Arnol, Adrian Covic, Paolo Lentini, Shafi Malik, Louis J Reichert, Mehmet S Sever, Bruno Watschinger, Kitty J Jager, Ron T Gansevoort, ERACODA Collaborators
doi : 10.1093/ndt/gfab200
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2094–2105
Coronavirus disease 2019 (COVID-19) has exposed haemodialysis (HD) patients and kidney transplant (KT) recipients to an unprecedented life-threatening infectious disease, raising concerns about kidney replacement therapy (KRT) strategy during the pandemic. This study investigated the association of the type of KRT with COVID-19 severity, adjusting for differences in individual characteristics.
Prevalence of mild cognitive impairment in automated peritoneal dialysis patients
Noé A Salazar-Félix, Fabiola Martin-del-Campo, Alfonso M Cueto-Manzano, María L Romo-Flores, Alma L Velázquez-Vidaurri, Artemio Sánchez-Soriano, Neri Ruvalcaba-Contreras, Alejandro Calderón-Fabian, Enrique Rojas-Campos, Laura Cortés-Sanabria
doi : 10.1093/ndt/gfab238
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2106–2111
Cognitive deterioration decreases quality of life, self-care and adherence to treatment, increasing mortality risk. There is scarce information of cognitive impairment in peritoneal dialysis (PD) and data are controversial. Our aim was to determine the frequency and associated factors of cognitive impairment in patients on automated PD (APD).
Dialysis withdrawal in The Netherlands between 2000 and 2019: time trends, risk factors and centre variation
Mathijs van Oevelen, Alferso C Abrahams, Willem Jan W Bos, Tiny Hoekstra, Marc H Hemmelder, Marc ten Dam, Marjolijn van Buren
doi : 10.1093/ndt/gfab244
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2112–2119
Dialysis withdrawal is a common cause of death in dialysis-dependent patients. This study aims to describe dialysis withdrawal practice in The Netherlands, focussing on time trends, risk factors and centre variation.
LIMS1 risk genotype and T cell–mediated rejection in kidney transplant recipients
Yasar Caliskan, Gonca Karahan, Sebahat Usta Akgul, Safak Mirioglu, Yasemin Ozluk, Halil Yazici, Erol Demir, Ahmet B Dirim, Aydin Turkmen, John Edwards, Fatma Oguz Savran, Mehmet S Sever, Krzysztof Kiryluk, Ali Gharavi, Krista L Lentine
doi : 10.1093/ndt/gfab168
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2120–2129
This study aims to examine the association of LIM zinc finger domain containing 1 (LIMS1) genotype with allograft rejection in an independent kidney transplant cohort.
Patterns of renal osteodystrophy 1?year after kidney transplantation
Hanne Skou Jørgensen, Geert Behets, Bert Bammens, Kathleen Claes, Bjorn Meijers, Maarten Naesens, Ben Sprangers, Dirk R J Kuypers, Patrick D’Haese, Pieter Evenepoel
doi : 10.1093/ndt/gfab239
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2130–2139
Renal osteodystrophy is considered common, but is not well characterized in contemporary kidney transplant recipients. This study reports extensively on bone phenotype by bone histomorphometry, bone densitometry and novel bone biomarkers 1?year after kidney transplantation.
Normalized protein catabolic rate and lymphopenia drive humoral response to the Pfizer BNT162b2 vaccine in haemodialysis patients
Amélie Jacq, Jean-Michel Rebibou, Emmanuelle Kohler, Charline Baudoin, Jean-Baptiste Bour, Alexis De Rougemont, Elise Marechal, Mathieu Legendre
doi : 10.1093/ndt/gfab241
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2140–2142
Renal markers for monitoring acute kidney injury transition to chronic kidney disease after COVID-19
Faeq Husain-Syed, Gianluca Villa, Jochen Wilhelm, Sara Samoni, Ulrich Matt, István Vadász, Khodr Tello, Birgit Jennert, Hartmut Dietrich, Janina Trauth, Shadi Kassoumeh, Borros Arneth, Harald Renz, Michael Sander, Susanne Herold, Werner Seeger, Stefan J Schunk, Thimoteus Speer, Horst-Walter Birk, Claudio Ronco
doi : 10.1093/ndt/gfab235
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2143–2147
Contribution of a histologic index to the prognostic information of C3 glomerulopathy
Fernando Caravaca-Fontán, Hernando Trujillo, Francisco Caravaca, Manuel Praga on behalf of the C3G study group of the Spanish Group for the Study of Glomerular Diseases (GLOSEN)
doi : 10.1093/ndt/gfab169
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2148–2150
Sodium zirconium cyclosilicate use in kidney transplant recipients
Kurtis J Swanson, Fahad Aziz, Sandesh Parajuli, Maha Mohamed, Didier A Mandelbrot, Arjang Djamali, Neetika Garg
doi : 10.1093/ndt/gfab172
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2151–2153
Erratum to: Results of the European EDITH Nephrologist survey on factors influencing treatment modality choice for end-stage kidney disease
Rianne W de Jong, Kitty J Jager, Raymond C Vanholder, Cécile Couchoud, Mark Murphy, Axel Rahmel, Ziad A Massy, Vianda S Stel
doi : 10.1093/ndt/gfab062
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Page 2154
Erratum to: Screening of Fabry disease in patients with chronic kidney disease in Japan
Akiko Nagata, Makoto Nasu, Yusuke Kaida, Yosuke Nakayama, Yuka Kurokawa, Nao Nakamura, Ryo Shibata, Takuma Hazama, Takahiro Tsukimura, Tadayasu Togawa, Seiji Saito, Hitoshi Sakuraba, Kei Fukami
doi : 10.1093/ndt/gfab234
Nephrology Dialysis Transplantation, Volume 36, Issue 11, November 2021, Pages 2155–2159
