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2019 Health Care & Education Presidential Address: It’s All About Access!
Gretchen A. Youssef
doi : 10.2337/dci20-0050
Diabetes Care 2021 Jan; 44 (1): 1-7.
This article is adapted from a speech Ms. Youssef delivered as President, Health Care & Education, of the American Diabetes Association at its 79th Scientific Sessions in San Francisco, CA, on 8 June 2019.
A Lesson From 2020: Public Health Matters for Both COVID-19 and Diabetes
Matthew C. Riddle, George Bakris, Lawrence Blonde, Andrew J.M. Boulton, David D’Alessio, Linda A. DiMeglio, Linda Gonder-Frederick, Korey K. Hood, Frank B. Hu, Steven E. Kahn, Sanjay Kaul, Lawrence A. Leiter, Robert G. Moses, Stephen S. Rich, Julio Rosenstock and Judith Wylie-Rosett
doi : 10.2337/dci20-0071
Diabetes Care 2021 Jan; 44 (1): 8-10.
Social Determinants of Health and Structural Inequities—Root Causes of Diabetes Disparities
S. Michelle Ogunwole and Sherita H. Golden
doi : 10.2337/dci20-0060
Diabetes Care 2021 Jan; 44 (1): 11-13.
Racial and Socioeconomic Disparities in Pediatric Type 1 Diabetes: Time for a Paradigm Shift in Approach
Terri H. Lipman and Colin P. Hawkes
doi : 10.2337/dci20-0048
Diabetes Care 2021 Jan; 44 (1): 14-16.
Is Being Physically Active Enough to Be Metabolically Healthy? The Key Role of Sedentary Behavior
Mary O. Whipple, Judith G. Regensteiner and Audrey Bergouignan
doi : 10.2337/dci20-0064
Diabetes Care 2021 Jan; 44 (1): 17-19.
Emotional Regulation and Diabetes Distress in Adults With Type 1 and Type 2 Diabetes
Emil F. Coccaro, Sophie Lazarus, Joshua Joseph, Kathline Wyne, Tina Drossos, Louis Phillipson and Mary de Groot
doi : 10.2337/dc20-1059
Diabetes Care 2021 Jan; 44 (1): 20-25.
OBJECTIVE To explore the correlates of diabetes-related distress (DD) with psychometrically valid assessments of emotional regulation in individuals with type 1 and type 2 diabetes.
Effects of a Tailored Text Messaging Intervention Among Diverse Adults With Type 2 Diabetes: Evidence From the 15-Month REACH Randomized Controlled Trial
Lyndsay A. Nelson, Robert A. Greevy, Andrew Spieker, Kenneth A. Wallston, Tom A. Elasy, Sunil Kripalani, Chad Gentry, Erin M. Bergner, Lauren M. LeStourgeon, Sarah E. Williamson and Lindsay S. Mayberry
doi : 10.2337/dc20-0961
Diabetes Care 2021 Jan; 44 (1): 26-34.
OBJECTIVE Text messaging interventions have high potential for scalability and for reductions in health disparities. However, more rigorous, long-term trials are needed. We examined the long-term efficacy and mechanisms of a tailored text messaging intervention.
Long-term Follow-up of Glycemic and Neurological Outcomes in an International Series of Patients With Sulfonylurea-Treated ABCC8 Permanent Neonatal Diabetes
Pamela Bowman, Frances Mathews, Fabrizio Barbetti, Maggie H. Shepherd, Janine Sanchez, Barbara Piccini, Jacques Beltrand, Lisa R. Letourneau-Freiberg, Michel Polak, Siri Atma W. Greeley, Eamon Rawlins, Tarig Babiker, Nicholas J. Thomas, Elisa De Franco, Sian Ellard, Sarah E. Flanagan and Andrew T. Hattersley, for the Neonatal Diabetes International Collaborative Group
doi : 10.2337/dc20-1520
Diabetes Care 2021 Jan; 44 (1): 35-42.
OBJECTIVE ABCC8 mutations cause neonatal diabetes mellitus that can be transient (TNDM) or, less commonly, permanent (PNDM); ?90% of individuals can be treated with oral sulfonylureas instead of insulin. Previous studies suggested that people with ABCC8-PNDM require lower sulfonylurea doses and have milder neurological features than those with KCNJ11-PNDM. However, these studies were short-term and included combinations of ABCC8-PNDM and ABCC8-TNDM. We aimed to assess the long-term glycemic and neurological outcomes in sulfonylurea-treated ABCC8-PNDM.
The Impact of Physical Activity on the Prevention of Type 2 Diabetes: Evidence and Lessons Learned From the Diabetes Prevention Program, a Long-Standing Clinical Trial Incorporating Subjective and Objective Activity Measures
Andrea M. Kriska, Bonny Rockette-Wagner, Sharon L. Edelstein, George A. Bray, Linda M. Delahanty, Mary A. Hoskin, Edward S. Horton, Elizabeth M. Venditti, William C. Knowler and the DPP Research Group
doi : 10.2337/dc20-1129
Diabetes Care 2021 Jan; 44 (1): 43-49.
OBJECTIVE Across the Diabetes Prevention Program (DPP) follow-up, cumulative diabetes incidence remained lower in the lifestyle compared with the placebo and metformin randomized groups and could not be explained by weight. Collection of self-reported physical activity (PA) (yearly) with cross-sectional objective PA (in follow-up) allowed for examination of PA and its long-term impact on diabetes prevention.
Type 2 Diabetes and COVID-19–Related Mortality in the Critical Care Setting: A National Cohort Study in England, March–July 2020
John M. Dennis, Bilal A. Mateen, Raphael Sonabend, Nicholas J. Thomas, Kashyap A. Patel, Andrew T. Hattersley, Spiros Denaxas, Andrew P. McGovern and Sebastian J. Vollmer
doi : 10.2337/dc20-1444
Diabetes Care 2021 Jan; 44 (1): 50-57.
OBJECTIVE To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.
Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records
Gabrielle S. Davie, Kingshuk Pal, Elizabeth Orton, Edward G. Tyrrell and Irene Petersen
doi : 10.2337/dc20-1220
Diabetes Care 2021 Jan; 44 (1): 58-66.
OBJECTIVE To estimate risk of fracture in men and women with recent diagnosis of type 2 diabetes compared with individuals without diabetes.
Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study
Ping Zhang, Karen M. Atkinson, George A. Bray, Haiying Chen, Jeanne M. Clark, Mace Coday, Gareth R. Dutton, Caitlin Egan, Mark A. Espeland, Mary Evans, John P. Foreyt, Frank L. Greenway, Edward W. Gregg, Helen P. Hazuda, James O. Hill, Edward S. Horton, Van S. Hubbard, Peter J. Huckfeldt, Sharon D. Jackson, John M. Jakicic, Robert W. Jeffery, Karen C. Johnson, Steven E. Kahn, Tina Killean, William C. Knowler, Mary Korytkowski, Cora E. Lewis, Nisa M. Maruthur, Sara Michaels, Maria G. Montez, David M. Nathan, Jennifer Patricio, Anne Peters, Xavier Pi-Sunyer, Henry Pownall, Bruce Redmon, Julia T. Rushing, Helmut Steinburg, Thomas A. Wadden, Rena R. Wing, Holly Wyatt and Susan Z. Yanovski, on behalf of the Look AHEAD Research Group
doi : 10.2337/dc20-0358
Diabetes Care 2021 Jan; 44 (1): 67-74.
OBJECTIVE To assess the cost-effectiveness (CE) of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) in adults with overweight/obesity and type 2 diabetes, as implemented in the Action for Health in Diabetes study.
Postintervention Effects of Varying Treatment Arms on Glycemic Failure and ?-Cell Function in the TODAY Trial
The TODAY Study Group
doi : 10.2337/dc20-0622
Diabetes Care 2021 Jan; 44 (1): 75-80.
OBJECTIVE The Treatment Options for type 2 Diabetes in Adolescents and Youth (TODAY) trial demonstrated that glycemic failure rates were significantly lower in youth randomized to metformin plus rosiglitazone treatment than in youth randomized to metformin alone or metformin plus intensive lifestyle intervention. At the end of the study, rosiglitazone was permanently discontinued, and routine diabetes care resumed. Herein, we report postintervention glycemic failure rates in TODAY participants over an additional 36 months of follow-up for the three original treatment arms and describe insulin sensitivity and ?-cell function outcomes.
Regression to the Mean Contributes to the Apparent Improvement in Glycemia 3.8 Years After Screening: The ELSA-Brasil Study
Maria Inês Schmidt, Paula Bracco, Scheine Canhada, Joanna M.N. Guimar?es, Sandhi Maria Barreto, Dora Chor, Rosane Griep, John S. Yudkin and Bruce B. Duncan
doi : 10.2337/dc20-2030
Diabetes Care 2021 Jan; 44 (1): 81-88.
OBJECTIVE Glycemic regression is common in real-world settings, but the contribution of regression to the mean (RTM) has been little investigated. We aimed to estimate glycemic regression before and after adjusting for RTM in a free-living cohort of adults with newly ascertained diabetes and intermediate hyperglycemia (IH).
Worldwide Epidemiology of Diabetes-Related End-Stage Renal Disease, 2000–2015
Hui-Teng Cheng, Xiaoqi Xu, Paik Seong Lim and Kuan-Yu Hung
doi : 10.2337/dc20-1913
Diabetes Care 2021 Jan; 44 (1): 89-97.
OBJECTIVE The annual risk among patients with diabetes of reaching end-stage renal disease (ESRD) is largely unknown worldwide. This study aimed to compare the incidence of diabetes-related ESRD by creating a global atlas during 2000–2015.
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations
Ju-Sheng Zheng, Jian’an Luan, Eleni Sofianopoulou, Fumiaki Imamura, Isobel D. Stewart, Felix R. Day, Maik Pietzner, Eleanor Wheeler, Luca A. Lotta, Thomas E. Gundersen, Pilar Amiano, Eva Ardanaz, Mar?a-Dolores Chirlaque, Guy Fagherazzi, Paul W. Franks, Rudolf Kaaks, Nasser Laouali, Francesca Romana Mancini, Peter M. Nilsson, N. Charlotte Onland-Moret, Anja Olsen, Kim Overvad, Salvatore Panico, Domenico Palli, Fulvio Ricceri, Olov Rolandsson, Annemieke M.W. Spijkerman, Mar?a-José S?nchez, Matthias B. Schulze, N?ria Sala, Sabina Sieri, Anne Tj?nneland, Rosario Tumino, Yvonne T. van der Schouw, Elisabete Weiderpass, Elio Riboli, John Danesh, Adam S. Butterworth, Stephen J. Sharp, Claudia Langenberg, Nita G. Forouhi and Nicholas J. Wareham
doi : 10.2337/dc20-1328
Diabetes Care 2021 Jan; 44 (1): 98-106.
OBJECTIVE Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes.
Association Between Preoperative Blood Glucose Level and Hospital Length of Stay for Patients Undergoing Appendectomy or Laparoscopic Cholecystectomy
Hsiu-Yin Chiang, Kuan-Ting Robin Lin, Ya-Luan Hsiao, Han-Chun Huang, Shih-Ni Chang, Chien-Hui Hung, Ying Chang, Yu-Chun Wang and Chin-Chi Kuo
doi : 10.2337/dc19-0963
Diabetes Care 2021 Jan; 44 (1): 107-115.
OBJECTIVE To evaluate the effect of preoperative blood glucose (POBG) level on hospital length of stay (LOS) in patients undergoing appendectomy or laparoscopic cholecystectomy.
The Impact of Bariatric Surgery on Incident Microvascular Complications in Patients With Type 2 Diabetes: A Matched Controlled Population-Based Retrospective Cohort Study
Pushpa Singh, Nicola Adderley, Anuradhaa Subramanian, Krishna Gokhale, Rishi Singhal, Konstantinos A. Toulis, Srikanth Bellary, Krishnarajah Nirantharakumar and Abd A. Tahrani
doi : 10.2337/dc20-0571
Diabetes Care 2021 Jan; 44 (1): 116-124.
OBJECTIVE To assess the impact of bariatric surgery (BS) on incident microvascular complications of diabetes-related foot disease (DFD), sight-threatening diabetic retinopathy (STDR), and chronic kidney disease (CKD) in patients with type 2 diabetes and obesity.
Pharmacokinetic and Pharmacodynamic Head-to-Head Comparison of Clinical, Equivalent Doses of Insulin Glargine 300 units · mL?1 and Insulin Degludec 100 units · mL?1 in Type 1 Diabetes
Paola Lucidi, Paola Candeloro, Patrizia Cioli, Anna Marinelli Andreoli, Chiara Pascucci, Angela Gambelunghe, Geremia B. Bolli, Carmine G. Fanelli and Francesca Porcellati
doi : 10.2337/dc20-1033
Diabetes Care 2021 Jan; 44 (1): 125-132.
OBJECTIVE To prove equivalence of individual, clinically titrated basal insulin doses of glargine 300 units ? mL?1 (Gla-300) and degludec 100 units ? mL?1 (Deg-100) under steady state conditions in a single-blind, randomized, crossover study, on the glucose pharmacodynamics (PD) in people with type 1 diabetes (T1D).
A Decade of Disparities in Diabetes Technology Use and HbA1c in Pediatric Type 1 Diabetes: A Transatlantic Comparison
Ananta Addala, Marie Auzanneau, Kellee Miller, Werner Maier, Nicole Foster, Thomas Kapellen, Ashby Walker, Joachim Rosenbauer, David M. Maahs and Reinhard W. Holl
doi : 10.2337/dc20-0257
Diabetes Care 2021 Jan; 44 (1): 133-140.
OBJECTIVE As diabetes technology use in youth increases worldwide, inequalities in access may exacerbate disparities in hemoglobin A1c (HbA1c). We hypothesized that an increasing gap in diabetes technology use by socioeconomic status (SES) would be associated with increased HbA1c disparities.
Sustained Intensive Treatment and Long-term Effects on HbA1c Reduction (SILVER Study) by CGM in People With Type 1 Diabetes Treated With MDI
Marcus Lind, Arnd?s F. ?lafsd?ttir, Irl B. Hirsch, Jan Bolinder, Sofia Dahlqvist, Aldina Pivodic, Jarl Hellman, Magnus Wijkman, Erik Schwarcz, Henrik Albrektsson, Tim Heise and William Polonsky
doi : 10.2337/dc20-1468
Diabetes Care 2021 Jan; 44 (1): 141-149.
OBJECTIVE Continuous glucose monitoring (CGM) reduces HbA1c and time spent in hypoglycemia in people with type 1 diabetes (T1D) treated with multiple daily insulin injections (MDI) when evaluated over shorter time periods. It is unclear to what extent CGM improves and helps to maintain glucose control, treatment satisfaction, diabetes distress, hypoglycemic concerns, and overall well-being over longer periods of time.
Diagnosis of Neuropathy and Risk Factors for Corneal Nerve Loss in Type 1 and Type 2 Diabetes: A Corneal Confocal Microscopy Study
Maryam Ferdousi, Alise Kalteniece, Shazli Azmi, Ioannis N. Petropoulos, Georgios Ponirakis, Uazman Alam, Omar Asghar, Andrew Marshall, Catherine Fullwood, Maria Jeziorska, Caroline Abbott, Giuseppe Lauria, Catharina G. Faber, Handrean Soran, Nathan Efron, Andrew J.M. Boulton and Rayaz A. Malik
doi : 10.2337/dc20-1482
Diabetes Care 2021 Jan; 44 (1): 150-156.
OBJECTIVE To assess the diagnostic utility of corneal confocal microscopy (CCM) for diabetic peripheral neuropathy (DPN) and the risk factors for corneal nerve loss.
Plasma Methylglyoxal Levels Are Associated With Amputations and Mortality in Severe Limb Ischemia Patients With and Without Diabetes
Nordin M.J. Hanssen, Martin Teraa, Jean L.J.M. Scheijen, Marjo Van de Waarenburg, Hendrik Gremmels, Coen D.A. Stehouwer, Marianne C. Verhaar and Casper G. Schalkwijk
doi : 10.2337/dc20-0581
Diabetes Care 2021 Jan; 44 (1): 157-163.
OBJECTIVE Diabetes is a risk factor for severe limb ischemia (SLI), a condition associated with high mortality, morbidity, and limb loss. The reactive glucose-derived dicarbonyl methylglyoxal (MGO) is a major precursor for advanced glycation end products (AGEs) and a potential driver of cardiovascular disease. We investigated whether plasma MGO levels are associated with poor outcomes in SLI.
Intensive Risk Factor Management and Cardiovascular Autonomic Neuropathy in Type 2 Diabetes: The ACCORD Trial
Yaling Tang, Hetal Shah, Carlos Roberto Bueno Junior, Xiuqin Sun, Joanna Mitri, Maria Sambataro, Luisa Sambado, Hertzel C. Gerstein, Vivian Fonseca, Alessandro Doria and Rodica Pop-Busui
doi : 10.2337/dc20-1842
Diabetes Care 2021 Jan; 44 (1): 164-173.
OBJECTIVE The effects of preventive interventions on cardiovascular autonomic neuropathy (CAN) remain unclear. We examined the effect of intensively treating traditional risk factors for CAN, including hyperglycemia, hypertension, and dyslipidemia, in individuals with type 2 diabetes (T2D) and high cardiovascular risk participating in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial.
Depression Is Associated With Progression of Diabetic Nephropathy in Type 1 Diabetes
Aila J. Ahola, Valma Harjutsalo, Carol Forsblom, François Pouwer and Per-Henrik Groop, on behalf of the FinnDiane Study Group
doi : 10.2337/dc20-0493
Diabetes Care 2021 Jan; 44 (1): 174-180.
OBJECTIVE To investigate the relationship between depression and diabetic nephropathy progression in type 1 diabetes.
Progression of Diabetic Retinopathy and Predictors of Its Development and Progression During Pregnancy in Patients With Type 1 Diabetes: A Report of 499 Pregnancies
Julien Bourry, Hugues Courteville, Nassima Ramdane, Elodie Drumez, Alain Duhamel, Damien Subtil, Philippe Deruelle and Anne Vambergue
doi : 10.2337/dc20-0904
Diabetes Care 2021 Jan; 44 (1): 181-187.
OBJECTIVE Pregnancy has been associated with development and progression of diabetic retinopathy (DR), but incidence of DR remains unclear. We assessed DR progression rate and its predictors during pregnancies in patients with type 1 diabetes.
Metabolic Syndrome and COVID-19 Mortality Among Adult Black Patients in New Orleans
John Xie, Yuanhao Zu, Ala Alkhatib, Thaidan T. Pham, Frances Gill, Albert Jang, Stella Radosta, Gerard Chaaya, Leann Myers, Jerry S. Zifodya, Christine M. Bojanowski, Nassir F. Marrouche, Franck Mauvais-Jarvis and Joshua L. Denson
doi : 10.2337/dc20-1714
Diabetes Care 2021 Jan; 44 (1): 188-193.
OBJECTIVE Coronavirus disease 2019 (COVID-19) mortality is high in patients with hypertension, obesity, and diabetes. We examined the association between hypertension, obesity, and diabetes, individually and clustered as metabolic syndrome (MetS), and COVID-19 outcomes in patients hospitalized in New Orleans during the peak of the outbreak.
Sedentary Time and Metabolic Risk in Extremely Active Older Adults
Kenneth M. Madden, Boris Feldman and Jocelyn Chase
doi : 10.2337/dc20-0849
Diabetes Care 2021 Jan; 44 (1): 194-200.
OBJECTIVE Increasing evidence suggests that time spent sedentary predicts increasing cardiometabolic risk independent of other physical activity. We objectively measured activity levels in active older adults and examined the association between sedentary behavior and the continuous metabolic syndrome risk score (cMSy).
Improvements in Glycemic Control After Acute Moderate-Intensity Continuous or High-Intensity Interval Exercise Are Greater in South Asians Than White Europeans With Nondiabetic Hyperglycemia: A Randomized Crossover Study
Jack A. Sargeant, Charlotte Jelleyman, Nicole A. Coull, Charlotte L. Edwardson, Joseph Henson, James A. King, Kamlesh Khunti, Matthew McCarthy, Alex V. Rowlands, David J. Stensel, Helen L. Waller, David R. Webb, Melanie J. Davies and Thomas Yates
doi : 10.2337/dc20-1393
Diabetes Care 2021 Jan; 44 (1): 201-209.
OBJECTIVE To examine whether circulating metabolic responses to low-volume high-intensity interval exercise (LV-HIIE) or continuous moderate-intensity aerobic exercise (CME) differ between white Europeans and South Asians with nondiabetic hyperglycemia (NDH).
Insulin-Like Growth Factor Binding Protein 7 Predicts Renal and Cardiovascular Outcomes in the Canagliflozin Cardiovascular Assessment Study
James L. Januzzi, Javed Butler, Naveed Sattar, Jialin Xu, Wayne Shaw, Norman Rosenthal, Michael Pfeifer, Kenneth W. Mahaffey, Bruce Neal and Michael K. Hansen
doi : 10.2337/dc20-1889
Diabetes Care 2021 Jan; 44 (1): 210-216.
OBJECTIVE To analyze the association between concentrations of plasma insulin-like growth factor binding protein 7 (IGFBP7) with renal and cardiac outcomes among participants with type 2 diabetes and high cardiovascular risk.
Association of Maternal Folate and Vitamin B12 in Early Pregnancy With Gestational Diabetes Mellitus: A Prospective Cohort Study
Xiaotian Chen, Yi Zhang, Hongyan Chen, Yuan Jiang, Yin Wang, Dingmei Wang, Mengru Li, Yalan Dou, Xupeng Sun, Guoying Huang and Weili Yan
doi : 10.2337/dc20-1607
Diabetes Care 2021 Jan; 44 (1): 217-223.
OBJECTIVE To investigate the association of folate and vitamin B12 in early pregnancy with gestational diabetes mellitus (GDM) risk.
Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
Amra Juji?, Peter M. Nilsson, Naeimeh Atabaki-Pasdar, Anna Dieden, Tiinamaija Tuomi, Paul W. Franks, Jens Juul Holst, Signe S?rensen Torekov, Susana Ravassa, Javier D?ez, Margaretha Persson, Emma Ahlqvist, Olle Melander, Maria F. Gomez, Leif Groop and Martin Magnusson
doi : 10.2337/dc20-1318
Diabetes Care 2021 Jan; 44 (1): 224-230.
OBJECTIVE While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortality, and it was suggested that GIP plays a role in pathogenesis of coronary artery disease. We investigated the associations between fasting and postchallenge GIP and GLP-1 concentrations and subclinical atherosclerosis as measured by mean intima-media thickness in the common carotid artery (IMTmeanCCA) and maximal intima-media thickness in the carotid bifurcation (IMTmaxBulb).
Association of Cardiometabolic Multimorbidity and Depression With Cardiovascular Events in Early-Onset Adult Type 2 Diabetes: A Multiethnic Study in the U.S.
John Epoh Dibato, Olga Montvida, Francesco Zaccardi, Jack Alistair Sargeant, Melanie J. Davies, Kamlesh Khunti and Sanjoy K. Paul
doi : 10.2337/dc20-2045
Diabetes Care 2021 Jan; 44 (1): 231-239.
OBJECTIVE To evaluate the temporal patterns of cardiometabolic multimorbidity (CM) and depression in White Caucasians (WCs) and African Americans (AAs) with early-onset type 2 diabetes and their impact on long-term atherosclerotic cardiovascular disease (ASCVD).
Differences in Physiological Responses to Cardiopulmonary Exercise Testing in Adults With and Without Type 1 Diabetes: A Pooled Analysis
Max L. Eckstein, Juliano Boufleur Farinha, Olivia McCarthy, Daniel J. West, Jane E. Yardley, Lia Bally, Thomas Zueger, Christoph Stettler, Winston Boff, Alvaro Reischak-Oliveira, Michael C. Riddell, Dessi P. Zaharieva, Thomas R. Pieber, Alexander Müller, Philipp Birnbaumer, Faisal Aziz, Laura Brugnara, Hanne Haahr, Eric Zijlstra, Tim Heise, Harald Sourij, Michael Roden, Peter Hofmann, Richard M. Bracken, Dominik Pesta and Othmar Moser
doi : 10.2337/dc20-1496
Diabetes Care 2021 Jan; 44 (1): 240-247.
OBJECTIVE To investigate physiological responses to cardiopulmonary exercise (CPX) testing in adults with type 1 diabetes compared with age-, sex-, and BMI-matched control participants without type 1 diabetes.
Severe Hypoglycemia, Cardiac Structure and Function, and Risk of Cardiovascular Events Among Older Adults With Diabetes
Justin B. Echouffo-Tcheugui, Natalie Daya, Alexandra K. Lee, Olive Tang, Chiadi E. Ndumele, B. Gwen Windham, Amil M. Shah and Elizabeth Selvin
doi : 10.2337/dc20-0552
Diabetes Care 2021 Jan; 44 (1): 248-254.
OBJECTIVE To assess the association of severe hypoglycemia measured at baseline with cardiovascular disease (CVD) among community-dwelling older individuals with diabetes, a group particularly susceptible to hypoglycemia.
Racial and Ethnic Disparities in Rates of Continuous Glucose Monitor Initiation and Continued Use in Children With Type 1 Diabetes
Charlene W. Lai, Terri H. Lipman, Steven M. Willi and Colin P. Hawkes
doi : 10.2337/dc20-1663
Diabetes Care 2021 Jan; 44 (1): 255-257.
OBJECTIVE Racial/ethnic disparities in continuous glucose monitor (CGM) use exist among children with type 1 diabetes. It is not known whether differential rates of device initiation or sustained use are the cause of this disparity. Our objective was to compare CGM initiation rates and continued use among non-Hispanic White (NHW), non-Hispanic Black (NHB), and Hispanic children.
Social Determinants of Health and Diabetes: A Scientific Review
Felicia Hill-Briggs, Nancy E. Adler, Seth A. Berkowitz, Marshall H. Chin, Tiffany L. Gary-Webb, Ana Navas-Acien, Pamela L. Thornton and Debra Haire-Joshu
doi : 10.2337/dci20-0053
Diabetes Care 2021 Jan; 44 (1): 258-279.
Ketones in Pregnancy: Why Is It Considered Necessary to Avoid Them and What Is the Evidence Behind Their Perceived Risk?
Helen L. Tanner, Marloes Dekker Nitert, Leonie K. Callaway and Helen L. Barrett
doi : 10.2337/dc20-2008
Diabetes Care 2021 Jan; 44 (1): 280-289.
Current dietary advice for women with gestational diabetes mellitus is to avoid diets that result in elevated ketone levels. This guidance stems from a concern that maternal ketones are associated with poor fetal and childhood outcomes, including reduced childhood intelligence quota. The evidence behind these guidelines is conflicting and inconsistent. Given that dietary counseling is the initial treatment strategy for women with diabetes in pregnancy, it is important that clinicians understand the concern regarding maternal ketones. This review examines the physiology of ketogenesis in pregnancy, the prevalence of elevated maternal ketone levels, and the relationship between maternal ketones and fetal and childhood outcomes.
HbA1c Change and Diabetic Retinopathy During GLP-1 Receptor Agonist Cardiovascular Outcome Trials: A Meta-analysis and Meta-regression
M. Angelyn Bethel, Rafael Diaz, Noelia Castellana, Indranil Bhattacharya, Hertzel C. Gerstein and Mark C. Lakshmanan
doi : 10.2337/dc20-1815
Diabetes Care 2021 Jan; 44 (1): 290-296.
BACKGROUND Long-term glycemic control reduces retinopathy risk, but transient worsening can occur with glucose control intensification. Glucagon-like peptide 1 receptor agonists (GLP-1RA) lower glucose, but the long-term impact on retinopathy is unknown. GLP-1RA cardiovascular outcome trials (CVOTs) provide long-term follow-up, allowing examination of retinopathy outcomes.
Erratum. Effects of Sustained Treatment With Lixisenatide on Gastric Emptying and Postprandial Glucose Metabolism in Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care 2020;43:1813–1821
Christopher K. Rayner, Linda E. Watson, Liza K. Phillips, Kylie Lange, Michelle J. Bound, Jacqueline Grivell, Tongzhi Wu, Karen L. Jones, Michael Horowitz, Ele Ferrannini, Domenico Tric?, Silvia Frascerra, Andrea Mari and Andrea Natali
doi : 10.2337/dc21-er01
Diabetes Care 2021 Jan; 44 (1): 297.
Erratum. Risk of Severe Hypoglycemia in Type 1 Diabetes Over 30 Years of Follow-up in the DCCT/EDIC Study. Diabetes Care 2017;40:1010–1016
Rose A. Gubitosi-Klug, Barbara H. Braffett, Neil H. White, Robert S. Sherwin, F. John Service, John M. Lachin and William V. Tamborlane, and the Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications (EDIC) Research Group
doi : 10.2337/dc21-er01a
Diabetes Care 2021 Jan; 44 (1): 298.
Erratum. The Relationship Between CGM-Derived Metrics, A1C, and Risk of Hypoglycemia in Older Adults With Type 1 Diabetes. Diabetes Care 2020;43:2349–2354
Elena Toschi, Christine Slyne, Kayla Sifre, Rachel O’Donnell, Jordan Greenberg, Astrid Atakov-Castillo, Sam Carl and Medha Munshi
doi : 10.2337/dc21-er01b
Diabetes Care 2021 Jan; 44 (1): 299.
Identification and Characterization of Patients With Rapid Progression of Diabetic Retinopathy in the Danish National Screening Program
Jakob Grauslund, Anne S. Thykj?r, Ryo Kawasaki, Kurt H?jlund, Nis Andersen, Jens Andresen, Toke Bek, Morten la Cour, Steffen Heegaard, Line Kessel, Caroline S. Laugesen, Katja C. Schielke, Katrine H. Rubin and Lonny Stokholm
doi : 10.2337/dc20-1534
Diabetes Care 2021 Jan; 44 (1): e1-e3.
Variations in the Prevalence of Gestational Diabetes Mellitus With Remote Testing and a Pragmatic Solution to Improve Accuracy
Emma L. Jamieson, Erica P. Spry, Andrew B. Kirke, Carly Roxburgh, David N. Atkinson and Julia V. Marley
doi : 10.2337/dc20-2211
Diabetes Care 2021 Jan; 44 (1): e4-e5.
Adolescent Hypertension and Risk for Early-Onset Type 2 Diabetes: A Nationwide Study of 1.9 Million Israeli Adolescents
Boris Fishman, Ehud Grossman, Inbar Zucker, Omri Orr, Miri Lutski, Aya Bardugo, Cole D. Bendor, Yoav Leiba, Tali Cukierman-Yaffe, Estela Derazne, Ofri Mosenzon, Dorit Tzur, Zivan Beer, Orit Pinhas-Hamiel, Tamar Fishman, Arnon Afek, Amir Tirosh, Itamar Raz, Hertzel C. Gerstein and Gilad Twig
doi : 10.2337/dc20-1752
Diabetes Care 2021 Jan; 44 (1): e6-e8.
Sodium–Glucose Cotransporter 2 Inhibitors and the Short-term Risk of Breast Cancer Among Women With Type 2 Diabetes
Melanie Suissa, Hui Yin, Oriana H.Y. Yu, Stephanie M. Wong and Laurent Azoulay
doi : 10.2337/dc20-1073
Diabetes Care 2021 Jan; 44 (1): e9-e11.
Ocular and Systemic Risk Markers for Development of Macular Edema and Proliferative Retinopathy in Type 2 Diabetes: A 5-Year Longitudinal Study
Ant?nio C.-V. Martinho, Inês P. Marques, Ana L. Messias, Torcato Santos, Maria H. Madeira, David C. Sousa, Conceiç?o Lobo and José Cunha-Vaz
doi : 10.2337/dc20-1125
Diabetes Care 2021 Jan; 44 (1): e12-e14.
Racial and Geographic Disparities in Internet Use in the U.S. Among Patients With Hypertension or Diabetes: Implications for Telehealth in the Era of COVID-19
Vardhmaan Jain, Mahmoud Al Rifai, Michelle T. Lee, Ankur Kalra, Laura A. Petersen, Elizabeth M. Vaughan, Nathan D. Wong, Christie M. Ballantyne and Salim S. Virani
doi : 10.2337/dc20-2016
Diabetes Care 2021 Jan; 44 (1): e15-e17.
The Toll of Lockdown Against COVID-19 on Diabetes Outpatient Care: Analysis From an Outbreak Area in Northeast Italy
Benedetta Maria Bonora, Mario Luca Morieri, Angelo Avogaro and Gian Paolo Fadini
doi : 10.2337/dc20-1872
Diabetes Care 2021 Jan; 44 (1): e18-e21.
