JAMA Neurology

Rustam Al-Shahi Salman, PhD1,2; Martin S. Dennis, MD1; Peter A. G. Sandercock, DM1; Cathie L. M. Sudlow, DPhil1,2,3; Joanna M. Wardlaw, MD1,4,5; William N. Whiteley, PhD1; Gordon D. Murray, PhD2; Jacqueline Stephen, PhD2; Aryelly Rodriguez, MSc2; Steff Lewis, PhD2; David J. Werring, PhD6; Phil M. White, MD7,8; for the RESTART Collaboration

doi : 10.1001/jamaneurol.2021.2956

JAMA Neurol. 2021;78(10):1179-1186

The Restart or Stop Antithrombotics Randomized Trial (RESTART) found that antiplatelet therapy appeared to be safe up to 5 years after intracerebral hemorrhage (ICH) that had occurred during antithrombotic (antiplatelet or anticoagulant) therapy.

خرید پکیج و مشاهده آنلاین مقاله

Association of Short and Long Sleep Duration With Amyloid-? Burden and Cognition in Aging

Joseph R. Winer, PhD1; Kacie D. Deters, PhD1; Gabriel Kennedy, BSc1; Meghan Jin1; Andrea Goldstein-Piekarski, PhD2,3; Kathleen L. Poston, MD, MS1; Elizabeth C. Mormino, PhD1

doi : 10.1001/jamaneurol.2021.2876

JAMA Neurol. 2021;78(10):1187-1196

Disrupted sleep is common in aging and is associated with cognition. Age-related changes to sleep are associated with multiple causes, including early Alzheimer disease pathology (amyloid ? [A?]), depression, and cardiovascular disease.

خرید پکیج و مشاهده آنلاین مقاله

Treatment Escalation vs Immediate Initiation of Highly Effective Treatment for Patients With Relapsing-Remitting Multiple Sclerosis

Tim Spelman, PhD, MD1; Melinda Magyari, PhD, MD2,3,4; Fredrik Piehl, PhD, MD1; Anders Svenningsson, PhD, MD5; Peter Vestergaard Rasmussen, PhD, MD6; Matthias Kant, PhD, MD7,8; Finn Sellebjerg, PhD, MD3,4; Hanna Joensen, BScScientBibl, GradDipB2,4; Jan Hillert, PhD, MD1; Jan Lycke, PhD, MD9,10

doi : 10.1001/jamaneurol.2021.2738

JAMA Neurol. 2021;78(10):1197-1204

Treatment strategies for relapsing-remitting multiple sclerosis (RRMS) vary markedly between Denmark and Sweden. The difference in the association of these national strategies with clinical outcomes is unknown.

خرید پکیج و مشاهده آنلاین مقاله

Association of Tourette Syndrome and Chronic Tic Disorder With Cervical Spine Disorders and Related Neurological Complications

Josef Isung, MD, PhD1; Kayoko Isomura, MD, PhD1; Henrik Larsson, PhD2,3; Anna Sidorchuk, MD, PhD1; Lorena Fernández de la Cruz, PhD1; David Mataix-Cols, PhD1

doi : 10.1001/jamaneurol.2021.2798

JAMA Neurol. 2021;78(10):1205-1211

Severe forms of Tourette syndrome or chronic tic disorder (TS/CTD) may involve repeated head jerking. Isolated case reports have described a spectrum of severe neck disorders in individuals with TS/CTD. However, the nature and prevalence of cervical spine disorders in TS/CTD are unknown.

خرید پکیج و مشاهده آنلاین مقاله

General Anesthesia vs Local Anesthesia in Microelectrode Recording–Guided Deep-Brain Stimulation for Parkinson Disease

Rozemarije A. Holewijn, MD1; Dagmar Verbaan, PhD1; Pepijn M. van den Munckhof, MD, PhD1; Maarten Bot, MD, PhD1; Gert J. Geurtsen, PhD2; Joke M. Dijk, MD, PhD2; Vincent J. Odekerken, MD, PhD2; Martijn Beudel, MD, PhD2; Rob M. A. de Bie, MD, PhD2; P. Rick Schuurman, MD, PhD1

doi : 10.1001/jamaneurol.2021.2979

JAMA Neurol. 2021;78(10):1212-1219

It is unknown if there is a difference in outcome in asleep vs awake deep brain stimulation (DBS) of the subthalamic nucleus for advanced Parkinson disease.

خرید پکیج و مشاهده آنلاین مقاله

Prehospital Comprehensive Stroke Center vs Primary Stroke Center Triage in Patients With Suspected Large Vessel Occlusion Stroke

Tareq Kass-Hout, MD1; Jungwha Lee, PhD, MPH2; Katie Tataris, MD, MPH3,4; Christopher T. Richards, MD, MS5; Eddie Markul, MD4,6; Joseph Weber, MD4,7; Scott Mendelson, PhD, MD1; Kathleen O’Neill, MHA8; Renee M. Sednew, MPH8; Shyam Prabhakaran, MD, MS1

doi : 10.1001/jamaneurol.2021.2485

JAMA Neurol. 2021;78(10):1220-1227

Endovascular therapy (EVT) improves functional outcomes in acute ischemic stroke (AIS) with large vessel occlusion (LVO). Whether implementation of a regional prehospital transport policy for comprehensive stroke center triage increases use of EVT is uncertain.

خرید پکیج و مشاهده آنلاین مقاله

Risk of Rupture After Intracranial Aneurysm Growth

Laura T. van der Kamp, MD1; Gabriel J. E. Rinkel, MD1; Dagmar Verbaan, PhD2; René van den Berg, MD, PhD3; W. Peter Vandertop, MD, PhD2; Yuichi Murayama, MD4; Toshihiro Ishibashi, MD4; Antti Lindgren, MD, PhD5,6; Timo Koivisto, MD, PhD6,7; Mario Teo, MD8; Jerome St George, MD8; Ronit Agid, MD9; Ivan Radovanovic, MD, PhD9; Junta Moroi, MD10; Keiji Igase, MD, PhD11; Ido R. van den Wijngaard, MD, PhD12; Melissa Rahi, MD, PhD13,14; Jaakko Rinne, MD, PhD13,14; Johanna Kuhmonen, MD, PhD13,14; Hieronymus D. Boogaarts, MD, PhD15; George K. C. Wong, MD16; Jill M. Abrigo, MD17; Akio Morita, MD, PhD18; Yoshiaki Shiokawa, MD, PhD19; Katharina A. M. Hackenberg, MD20; Nima Etminan, MD20; Irene C. van der Schaaf, MD, PhD21; Nicolaas P. A. Zuithoff, PhD22; Mervyn D. I. Vergouwen, MD, PhD1

doi : 10.1001/jamaneurol.2021.2915

JAMA Neurol. 2021;78(10):1228-1235

Unruptured intracranial aneurysms not undergoing preventive endovascular or neurosurgical treatment are often monitored radiologically to detect aneurysm growth, which is associated with an increase in risk of rupture. However, the absolute risk of aneurysm rupture after detection of growth remains unclear.

خرید پکیج و مشاهده آنلاین مقاله

Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis

Janel O. Johnson, PhD1; Ruth Chia, PhD1; Danny E. Miller, MD, PhD2,3; Rachel Li, MD4; Ravindran Kumaran, PhD5; Yevgeniya Abramzon, BSc1,6; Nada Alahmady, PhD7,8; Alan E. Renton, PhD1,9,10,11; Simon D. Topp, PhD7,12; J. Raphael Gibbs, PhD13; Mark R. Cookson, PhD6; Marya S. Sabir, BSc14; Clifton L. Dalgard, PhD15,16; Claire Troakes, PhD7; Ashley R. Jones, PhD7; Aleksey Shatunov, PhD7; Alfredo Iacoangeli, PhD7; Ahmad Al Khleifat, PhD7; Nicola Ticozzi, MD, PhD17,18; Vincenzo Silani, MD17,18; Cinzia Gellera, PhD19; Ian P. Blair, PhD20; Carol Dobson-Stone, PhD21,22; John B. Kwok, PhD21,22; Emily S. Bonkowski, ScM3; Robin Palvadeau, MSc23; Pentti J. Tienari, MD24; Karen E. Morrison, MD25; Pamela J. Shaw, MD26; Ammar Al-Chalabi, PhD7,27; Robert H. Brown Jr, MD, PhD28; Andrea Calvo, PhD29; Gabriele Mora, PhD30; Hind Al-Saif, MD31; Marc Gotkine, MBBS32; Fawn Leigh, MD33; Irene J. Chang, MD2; Seth J. Perlman, MD33; Ian Glass, MB ChB, MD2,3; Anna I. Scott, PhD34,35; Christopher E. Shaw, MD7,12; A. Nazli Basak, PhD23; John E. Landers, PhD28; Adriano Chiò, PhD29,36; Thomas O. Crawford, PhD37,38; Bradley N. Smith, PhD7; Bryan J. Traynor, MD, PhD1,6,37,39; and the FALS Sequencing Consortium; American Genome Center; International ALS Genomics Consortium; and ITALSGEN Consortium

doi : 10.1001/jamaneurol.2021.2598

JAMA Neurol. 2021;78(10):1236-1248

Juvenile amyotrophic lateral sclerosis (ALS) is a rare form of ALS characterized by age of symptom onset less than 25 years and a variable presentation.

خرید پکیج و مشاهده آنلاین مقاله

Sex-Specific Association of the X Chromosome With Cognitive Change and Tau Pathology in Aging and Alzheimer Disease

Emily J. Davis, PhD1,2; Caroline W. Solsberg, BS1,3,4,5; Charles C. White, PhD6,7; Elena Miñones-Moyano, PhD1; Marina Sirota, PhD4,8; Lori Chibnik, PhD9,10; David A. Bennett, MD6; Philip L. De Jager, MD, PhD6,7; Jennifer S. Yokoyama, PhD1,5,11; Dena B. Dubal, MD, PhD1,2,12

doi : 10.1001/jamaneurol.2021.2806

JAMA Neurol. 2021;78(10):1249-1254

The X chromosome represents 5% of the human genome in women and men, and its influence on cognitive aging and Alzheimer disease (AD) is largely unknown.

خرید پکیج و مشاهده آنلاین مقاله

Characterizing Demographic, Racial, and Geographic Diversity in Dementia Research

Sanne S. Mooldijk, BSc1; Silvan Licher, MD1; Frank J. Wolters, MD, PhD1,2

doi : 10.1001/jamaneurol.2021.2943

JAMA Neurol. 2021;78(10):1255-1261

For informed decision making on diagnosis and treatment of dementia, physicians and their patients rely on the generalizability of evidence from published studies to clinical practice. However, it is uncertain whether everyday care of elderly patients with dementia is sufficiently captured in contemporary research.

خرید پکیج و مشاهده آنلاین مقاله

Emerging Neuroimaging Biomarkers Across Disease Stage in Parkinson Disease

Trina Mitchell, MSc1; Stéphane Lehéricy, MD, PhD2; Shannon Y. Chiu, MD, MSc3; Antonio P. Strafella, MD, PhD4,5,6; A. Jon Stoessl, MD7; David E. Vaillancourt, PhD1,3,8

doi : 10.1001/jamaneurol.2021.1312

JAMA Neurol. 2021;78(10):1262-1272

Imaging biomarkers in Parkinson disease (PD) are increasingly important for monitoring progression in clinical trials and also have the potential to improve clinical care and management. This Review addresses a critical need to make clear the temporal relevance for diagnostic and progression imaging biomarkers to be used by clinicians and researchers over the clinical course of PD. Magnetic resonance imaging (diffusion imaging, neuromelanin-sensitive imaging, iron-sensitive imaging, T1-weighted imaging), positron emission tomography/single-photon emission computed tomography dopaminergic, serotonergic, and cholinergic imaging as well as metabolic and cerebral blood flow network neuroimaging biomarkers in the preclinical, prodromal, early, and moderate to late stages are characterized.

خرید پکیج و مشاهده آنلاین مقاله