J. Ring
doi : 10.1111/jdv.17765
Volume 35, Issue 12 p. 2340-2341
R.S. Gibson,A.B. Kimball
doi : 10.1111/jdv.17741
Volume 35, Issue 12 p. 2342-2342
J.R. Stanley
doi : 10.1111/jdv.17739
Volume 35, Issue 12 p. 2343-2345
N. Kluger,A. Perciaccante,P. Charlier,P. Vabres
doi : 10.1111/jdv.17545
Volume 35, Issue 12 p. 2346-2348
C. Has,M. El Hachem,H. Bu?ková,P. Fischer,M. Friedová,C. Greco,P. Nevoránková,C. Salavastru,J.E. Mellerio,G. Zambruno,C. Bodemer
doi : 10.1111/jdv.17629
Volume 35, Issue 12 p. 2349-2360
Inherited epidermolysis bullosa (EB) comprises rare disorders that manifest with fragility and blistering of the skin and mucous membranes, with variable clinical severity. Management of EB is challenging due to disease rarity and complexity, the wide range of extracutaneous manifestations and a profound impact on daily life for the patient and family members. Although reference centres providing multidisciplinary care for EB exist in each European country, it is common for healthcare professionals that are not specialized in this rare disorder to treat EB patients. Here, experts of the European Reference Network for Rare and Undiagnosed Skin Diseases (ERN-Skin, https://ern-skin.eu) propose practical recommendations for the diagnosis and management of the commonest clinical issues, skin blisters and wounds, oral manifestations, pain and itch.
M. Iorizzo,M. Starace,A. Di Altobrando,A. Alessandrini,L. Veneziano,B.M. Piraccini
doi : 10.1111/jdv.17521
Volume 35, Issue 12 p. 2361-2366
The non-invasive examination of the nail unit using a dermoscope is known as onychoscopy. This technique has become increasingly appreciated to facilitate the clinical diagnosis of nail disorders, opening up a valuable second front with a potential to avoid invasive diagnostic procedures. During a nail consultation, the nail unit should always be examined with the aid of a dermatoscope in all its components. The aim of this paper was to provide practical information about onychoscopy of the nail plate free edge and hyponychium, two components of the nail unit difficult to evaluate at naked eye and often forgotten, but of paramount importance.
M. Augustin,M. Valencia López,K. Reich
doi : 10.1111/jdv.17650
Volume 35, Issue 12 p. 2367-2376
Network meta-analyses (NMAs) increasingly assist in treatment decisions in disease areas such as psoriasis, where data from multiple clinical trials (CTs) on a growing number of different drugs become available. This study aimed to characterize NMAs published in psoriasis. A systematic literature search in PubMed was conducted using a structured search protocol based on the PRISMA criteria. Twenty-seven NMAs were identified, including an average of 43 CTs per NMA. Only eight of 27 NMAs (29.6%) were documented in the PROSPERO registry and only 17 (63%) reported following the PRISMA criteria. The mean number of patients per NMA was 19?624 (range: 6113–51?749). Across all NMAs, the drugs most frequently included were ustekinumab (n?=?27 NMAs), followed by adalimumab (n?=?25), infliximab and etanercept (n?=?24 each). In all n?=?27 NMAs, placebo comparisons and in n?=?25, comparisons with active controls were used for bridging. Effect estimates were performed in all cases, SUCRA in 14. Most frequently used outcomes were Psoriasis Area and Severity Index (PASI) 75 (n?=?25) and PASI 90 (n?=?24), and Dermatology Life Quality Index (n?=?10). NMAs mostly measured induction efficacy (weeks 10–16, n?=?25) but rarely long-term outcomes (weeks 48–56, n?=?4). Sensitivity analyses were performed in n?=?17 (63%) of the studies. Main results varied considerably between studies and depended on the year of publication and thus the number of available drugs and studies. However, the concordance between NMA efficacy rankings based on PASI 75 was high. Although a large number of NMAs have been published on psoriasis showing highly comparable results on efficacy, no sufficient information on the quality criteria was reported, and PROSPERO registry criteria were not followed. This argues in favour of greater standardization of NMA methodology and reporting.
R. Ottevanger,S. van Beugen,A.W.M. Evers,R. Willemze,M.H. Vermeer,K.D. Quint
doi : 10.1111/jdv.17570
Volume 35, Issue 12 p. 2377-2387
Cutaneous T-cell Lymphoma’s (CTCL) are a rare, heterogeneous group of T-cell lymphomas that primarily manifest in the skin. Mycosis fungoides (MF) and Sézary syndrome (SS) are considered the classic types of CTCL. The diverse manifestation of CTCL results in a wide range of symptoms with a possible mild to severe impact on Quality of Life (QoL) depending on the disease stage. Previous studies on QoL in CTCL patients report diverse patient populations and use many different QoL instruments. In the current literature, a clear overview on the influence of the different stages of disease (early MF, late-stage MF/SS or total group) on the QoL is lacking. Therefore, a systematic search of the literature was conducted using the PubMed, Embase, PsycINFO and Web of Science databases. Studies were included if they described QoL in patients with MF and SS retrieved by standardized instruments or qualitative interviews. In total, 24 studies were included using 18 different questionnaires to report on dermatology-specific, cancer-specific and generic QoL. The effect on QoL was found to be greater in patients with late-stage disease as compared to early stage disease, with significant impairments on functional, emotional and physical domains. Nonetheless, even in patients with limited disease, QoL was mildly to moderately affected. Overall, pruritus was the most frequent reported and most bothersome symptom. Significant influence of the disease on daily life activities were found, not only in patients but also on caregivers and family. This broad, structured overview on QoL in MF and SS patients underlines the influence of disease stage on QoL, and therefore, recommends future studies to distinguish between disease stages when reporting results. Furthermore, this overview can inform clinicians in clinical practice by creating awareness of QoL deficits according to disease stage.
C. Ruini,S. Schuh,C. Gust,B. Kendziora,L. Frommherz,L.E. French,D. Hartmann,J. Welzel,E.C. Sattler
doi : 10.1111/jdv.17603
Volume 35, Issue 12 p. 2388-2397
The treatment of keratinocyte cancers (KC) strictly depends on their differentiation and invasiveness. Non-invasive diagnostic techniques can support the diagnosis in real time, avoiding unnecessary biopsies. This study aimed to preliminarily define main imaging criteria and histological correlations of actinic keratosis (AK), Bowen’s disease (BD) and squamous cell carcinoma (SCC) using the novel device line-field confocal optical coherence tomography (LC-OCT).
R. B. Warren,M. Lebwohl,H. Sofen,V. Piguet,M. Augustin,F. Brock,C.?Arendt,F. Fierens,A. Blauvelt
doi : 10.1111/jdv.17486
Volume 35, Issue 12 p. 2398-2408
Certolizumab pegol (CZP) is an Fc-free, PEGylated anti-tumor necrosis factor biologic.
K. Reich,U. Mrowietz,A. Menter,C.E.M. Griffiths,J. Bagel,B. Strober,N. Nunez Gomez,R. Shi,B. Guerette,M. Lebwohl
doi : 10.1111/jdv.17520
Volume 35, Issue 12 p. 2409-2414
Treating to absolute treatment targets rather than relative measures such as Psoriasis Area and Severity Index (PASI)-75 is emerging as an important clinical concept included in psoriasis guidelines and clinical practice. Achieving treatment targets is associated with achievement of long-term outcomes.
B. Largeau,M.-S. Agier,F. Beau-Salinas,A. Pariente,A. Maruani,T. Vial,A.-P. Jonville-Béra
doi : 10.1111/jdv.17631
Volume 35, Issue 12 p. 2415-2420
Growing evidence indicates that amoxicillin induces herpesvirus replication in?vitro. As these play a central pathophysiological role in Drug Reaction with Eosinophilia and Systemic Symptoms syndrome (DRESS), amoxicillin could present with specific DRESS features.
M. Maurer,T. Caballero,W. Aberer,A. Zanichelli,L. Bouillet,A. Bygum,A.S. Grumach,J. Botha,I. Andresen,H.J. Longhurst,for the IOS Study Group
doi : 10.1111/jdv.17654
Volume 35, Issue 12 p. 2421-2430
Hereditary angioedema due to C1 inhibitor deficiency (HAE-1/2) is a chronic and debilitating disease. The unpredictable clinical course represents a significant patient burden.
W. Gulliver,A. Alavi,M.C. Wiseman,M.J. Gooderham,J. Rao,M.S. Alam,K.A. Papp,O. Desjardins,C. Jean
doi : 10.1111/jdv.17598
Volume 35, Issue 12 p. 2431-2439
Long-term, real-word data are needed to help manage patients with hidradenitis suppurativa (HS) through this recurrent, painful and debilitating disease.
R. Jerjen,J. Pinczewski,R. Sinclair,B. Bhoyrul
doi : 10.1111/jdv.17604
Volume 35, Issue 12 p. 2440-2447
Fibrosing alopecia in a pattern distribution (FAPD) is a primary cicatricial alopecia considered a subtype of lichen planopilaris (LPP).
S.H. Ibbotson,D. Allan,R.S. Dawe,E. Eadie,P.M. Farr,H. Fassihi,F. Fedele,J. Ferguson,A. Fityan,P. Freeman,L. Fullerton,V. Goulden,S. Haque,T.C. Ling,A. Mackay,K. McKenna,N. Ralph,L.E. Rhodes,R. Sarkany,D. Turner,S. Ungureanu,S. Weatherhead
doi : 10.1111/jdv.17632
Volume 35, Issue 12 p. 2448-2455
Photodiagnostic investigations are essential for the accurate diagnosis of abnormal cutaneous photosensitivity and provide important information for the management of patients with photodermatoses (cutaneous photosensitivity disorders). Although photodiagnosis has been undertaken since the early 1970s, specialist services in the United Kingdom (UK) and Republic of Ireland are limited and there is no formal guidance on diagnostic approach. Indeed, there is a limited literature in this area of methodology and diagnostic practice.
M. Tihy,S. Menzinger,R. André,E. Laffitte,L. Toutous-Trellu,G. Kaya
doi : 10.1111/jdv.17633
Volume 35, Issue 12 p. 2456-2461
Cutaneous reactions, mostly on injection site after mRNA-based COVID-19 vaccines, have been reported but not with detailed histopathological characterization.
B.M. Berger,G.R. Giuffrida,Z.I. Zalaudek,E.E. Eber,H.R. Hofmann-Wellenhof
doi : 10.1111/jdv.17624
Volume 35, Issue 12 p. 2462-2462
Françoise Poot
doi : 10.1111/jdv.17717
Volume 35, Issue 12 p. 2463-2463
D. Jakhar,A. Das,S. Kaul,I. Kaur,B. Madke,A. Dalal
doi : 10.1111/jdv.17532
Volume 35, Issue 12 p. e832-e833
I. Lladó,B. Butrón,R. Sampedro-Ruiz,J. Fraga,D. de Argila
doi : 10.1111/jdv.17542
Volume 35, Issue 12 p. e833-e835
C. Dessinioti,C. Garbe,A.J. Stratigos
doi : 10.1111/jdv.17552
Volume 35, Issue 12 p. e836-e837
P. Ramezani Darmian,Z. Memarzadeh,R. Aryan,Y. Nahidi,Z. Mehri,A. Taghipour,N. Samimi,M. Amini,P. Layegh
doi : 10.1111/jdv.17557
Volume 35, Issue 12 p. e837-e839
M. Brito Caldeira,M. Pestana,A.L. João,C. Fernandes,A. João,N. Cunha
doi : 10.1111/jdv.17562
Volume 35, Issue 12 p. e839-e841
J.N. Yu,C.B. Angeles,H.G. Lim,C. Chavez,C. Roxas-Rosete
doi : 10.1111/jdv.17575
Volume 35, Issue 12 p. e841-e845
M. Vastarella,V. Picone,F. Martora,G. Fabbrocini
doi : 10.1111/jdv.17576
Volume 35, Issue 12 p. e845-e846
A.K. Özdemir,S. Kayhan,S.K. Çakmak
doi : 10.1111/jdv.17577
Volume 35, Issue 12 p. e846-e847
E. Annabi,N. Dupin,P. Sohier,B. Garel,N. Franck,S. Aractingi,S. Guégan,B. Oulès
doi : 10.1111/jdv.17578
Volume 35, Issue 12 p. e847-e850
V. Piccolo,C. Mazzatenta,T. Russo,F. Morandi,A. Bassi,G. Argenziano,E. Valerio,R. Grimalt,M. Cutrone
doi : 10.1111/jdv.17579
Volume 35, Issue 12 p. e850-e852
C. Huang,Q. Sun,D. Jiang,X. Zhang,C. Chen,D. Yan,X. Liu,Y. Zhou,C. Ding,L. Lan,J. Wu,L. Li,A. Li,X. Liu,S. Yang
doi : 10.1111/jdv.17580
Volume 35, Issue 12 p. e853-e855
L. Juay,N.S. Chandran
doi : 10.1111/jdv.17581
Volume 35, Issue 12 p. e855-e857
E. Sotiriou,A. Tsentemeidou,K. Bakirtzi,A. Lallas,D. Ioannides,E. Vakirlis
doi : 10.1111/jdv.17582
Volume 35, Issue 12 p. e857-e859
R. Castro Silva,G. Castro Silva,M.C. Castro Silva,O. Lupi
doi : 10.1111/jdv.17583
Volume 35, Issue 12 p. e859-e861
E. Akda?,B. Ö?üt,Ö. Erdem,M.O. Özta?,N. ?lter
doi : 10.1111/jdv.17592
Volume 35, Issue 12 p. e861-e864
A. D’Cruz,H. Parker,M. Saha
doi : 10.1111/jdv.17606
Volume 35, Issue 12 p. e864-e865
S. Recalcati,S. Tonolo,E. Meroni,F. Fantini
doi : 10.1111/jdv.17607
Volume 35, Issue 12 p. e865-e866
S. Gregoriou,I. A. Kleidona,A. Tsimpidakis,E. Nicolaidou,A. Stratigos,D. Rigopoulos
doi : 10.1111/jdv.17614
Volume 35, Issue 12 p. e867-e868
G. Ciccarese,F. Drago,A. Rebora,A. Parodi
doi : 10.1111/jdv.17615
Volume 35, Issue 12 p. e868-e870
T. So,S. Un,K.D. Lestari,L.C. Fuller,I. Elyazar,C. Bendick,M.L. Grijsen
doi : 10.1111/jdv.17458
Volume 35, Issue 12 p. e871-e873
D. Richardson,D. Trotman,J. Devlin,Z. Buss,R. Fortescue-Talwar,C. Fitzpatrick,D. Williams
doi : 10.1111/jdv.17503
Volume 35, Issue 12 p. e873-e875
S.B. Bowe,C.G. Gallagher,M.O.C. O'Connell,L.P. Paul
doi : 10.1111/jdv.17515
Volume 35, Issue 12 p. e875-e876
S.H. Yale,H. Tekiner,E.S. Yale
doi : 10.1111/jdv.17516
Volume 35, Issue 12 p. e876-e877
L. Steele,D. Velazquez-Pimentel,B.R. Thomas
doi : 10.1111/jdv.17517
Volume 35, Issue 12 p. e877-e879
N. Pflug,M. Vitus,J. Knuever,S. Hamacher,C. Mauch,M. Schlaak,S. Theurich
doi : 10.1111/jdv.17533
Volume 35, Issue 12 p. e879-e883
H. Svensson,J. Paoli
doi : 10.1111/jdv.17534
Volume 35, Issue 12 p. e883-e884
J.W. Frew,D. Grand,K. Navrazhina,S. Garcet,J.G. Krueger
doi : 10.1111/jdv.17536
Volume 35, Issue 12 p. e884-e887
R.M. Trüeb
doi : 10.1111/jdv.17537
Volume 35, Issue 12 p. e888-e889
R. Balestri,M. Magnano,S.D. Infusino,L. Rizzoli,C.R. Girardelli,G. Rech
doi : 10.1111/jdv.17538
Volume 35, Issue 12 p. e889-e891
J. Strobl,C. Sinz,P.M. Heil,G. Stary,W. Weninger
doi : 10.1111/jdv.17539
Volume 35, Issue 12 p. e891-e894
Z. Ridha,J. Guirguis,L. Ouchene,M. Chergui,I.V. Litvinov,E. Netchiporouk
doi : 10.1111/jdv.17540
Volume 35, Issue 12 p. e894-e896
E. Nettis,S. M. Ferrucci,G. Pellacani,E. Di Leo,G. Argenziano,C. Foti,F. Rongioletti,C. Patruno,M. Ortoncelli,L. Macchia,S. Tavecchio,L. Bonzano,D. Di Bona,G. Calabrese,G. Fabbrocini,STUDY GROUP
doi : 10.1111/jdv.17541
Volume 35, Issue 12 p. e896-e898
Y. Zhang,X. Ding,Z. Meng,M. Chen,X. Zheng,M. Cai,J. Wu,Y. Chang,Q. Zhang,L. Jin,D. Qian,X. Li,M. Wu,K. Yan,Y. Lu,X. Zhang
doi : 10.1111/jdv.17544
Volume 35, Issue 12 p. e898-e900
C. Lenoir,E. Cinotti,L. Tognetti,C. Orte Cano,G. Diet,M. Miyamoto,L. Rocq,A.-L. Trépant,J. Perez-Anker,S. Puig,J. Malvehy,P. Rubegni,J.-L. Perrot,V. del Marmol,M. Suppa
doi : 10.1111/jdv.17548
Volume 35, Issue 12 p. e900-e902
E. Edigin,Z. El-Amir,F. Wani,A. Kichloo,P.O Eseaton
doi : 10.1111/jdv.17556
Volume 35, Issue 12 p. e903-e904
P. Jauker,J. Tittes,A. Tanew
doi : 10.1111/jdv.17559
Volume 35, Issue 12 p. e905-e906
S. Poortinga,G. Balakirski,C. Kromer,R. Mössner,M.P. Schön,T. Bieber,D. Wilsmann-Theis
doi : 10.1111/jdv.17560
Volume 35, Issue 12 p. e907-e911
M.M.B. Seyger,A. Reich,C. El Baou,C. Schuster,E. Riedl,A.S. Paller
doi : 10.1111/jdv.17564
Volume 35, Issue 12 p. e911-e913
J. Lavaud,S. Hüssler,G. Gricourt,N. de Prost,C. Rodriguez,S. Ingen-Housz-Oro,O. Chosidow,C. Bernigaud,P.L. Woerther
doi : 10.1111/jdv.17584
Volume 35, Issue 12 p. e914-e917
T. Narang,R. Ashraf,A. Kaushik,S. Dogra
doi : 10.1111/jdv.17585
Volume 35, Issue 12 p. e917-e919
X. Gu,Y. Xiao,S. Li,J. Su,J. Li,S. Shan,X. Wang,B. Wu,J. Tao,X. Kang,B. Zou,X. Chen,M. Shen
doi : 10.1111/jdv.17586
Volume 35, Issue 12 p. e920-e921
Z. Ali,K.M. Joergensen,C. Vestergaard,A.D. Andersen,M. Alexaki,A.L. Eiken,I. Manole,S.F. Thomsen,M. Deleuran,J.R. Zibert
doi : 10.1111/jdv.17587
Volume 35, Issue 12 p. e922-e923
M.C. Fargnoli,C. Pellegrini,A. Piccerillo,G. Spallone,T. Rocco,A. Ventura,S. Necozione,L. Bianchi,K. Peris,A. Cortellini
doi : 10.1111/jdv.17588
Volume 35, Issue 12 p. e923-e926
D. Richardson,K. Samarasekara,M. Ringshall,K. Parashar,K. Nichols,J. Devlin,Z. Buss,A. Pickering,C. Fitzpatrick,D. Williams
doi : 10.1111/jdv.17589
Volume 35, Issue 12 p. e926-e928
E. Edigin,M.M. Rivera Pavon,P.O. Eseaton,A. Manadan
doi : 10.1111/jdv.17590
Volume 35, Issue 12 p. e928-e930
N.S. Ali,V.N. Sahni,B.C. Ma,D.R. Sahni,C.M. Hull,D.L. Powell,A.M. Secrest
doi : 10.1111/jdv.17591
Volume 35, Issue 12 p. e930-e931
D. Rigopoulos,E. Lazaridou,E. Papadavid,S. Georgiou,V. Chasapi,K. Sfaelos,G. Cheliotis,D. Ioannides
doi : 10.1111/jdv.17593
Volume 35, Issue 12 p. e931-e934
A.E. Verzì,G. Micali,F. Lacarrubba
doi : 10.1111/jdv.17594
Volume 35, Issue 12 p. e934-e936
P. Puri,M. Wiggins,M. Yousif,B.D. Pollock,L.P. Fox,M. Rosenbach,M.R. Pittelkow,A.R. Mangold
doi : 10.1111/jdv.17595
Volume 35, Issue 12 p. e936-e938
F. Peccerillo,G. Odorici,S. Ciardo,M. Greco,S. Guida,F. Farnetani,G. Pellacani
doi : 10.1111/jdv.17596
Volume 35, Issue 12 p. e938-e942
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