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Should the presence of psoriatic arthritis change how we manage psoriasis?
Warren H. Chan, Rohan Singh & Steven R. Feldman
doi : 10.1080/09546634.2021.1980976
Volume 32, Issue 8, Pages: 863-865
Treatment of sebaceous gland hyperplasia: a review of the literature
Lama Hussein & Conal M Perrett
doi : 10.1080/09546634.2020.1720582
Volume 32, Issue 8, Pages: 866-877
Sebaceous gland hyperplasia (SGH) is a benign cutaneous proliferation of the sebaceous glands that primarily affects the elderly group and frequently appears in individuals receiving long-term ciclosporin therapy such as organ transplant recipients. In the latter group, SGHs are usually multiple in number and occur predominantly on the face. Patients may find their appearance cosmetically undesirable and, in some cases, may result in significant negative psychological impact. There is, therefore, a demand for safe and effective treatment for SGH particularly in this patient group. A variety of treatment modalities have been previously described including electrodessication,surgery, cryotherapy, oral isotretinoin, lasers, and topical photodynamic therapy (PDT).
Changing within the same class: efficacy of brodalumab in plaque psoriasis after treatment with an IL-17A blocker – a retrospective multicenter study
C. Kromer, D. Wilsmann-Theis, S. Gerdes, S. Krebs, A. Pinter, S. Philipp & R. Mössner
doi : 10.1080/09546634.2020.1716932
Volume 32, Issue 8, Pages: 878-882
Biologic switching is common in psoriasis patients with non-response to or adverse events under therapy with a biologic. However, evidence on efficacy of switching between newly approved biologics of similar mode of action is scarce. The objective was to assess the efficacy of treating psoriasis patients with an IL-17-receptor A antagonist after failure of any IL-17A antagonist and to identify predictors of treatment response.
Calcipotriol/betamethasone dipropionate aerosol foam for the treatment of psoriasis vulgaris: a review of real-world evidence (RWE)
Sascha Gerdes, Manuel Velasco, Jashin J. Wu, Mario Hubo & Karen A. Veverka
doi : 10.1080/09546634.2020.1717417
Volume 32, Issue 8, Pages: 883-893
Randomized controlled trials (RCTs) demonstrated the advantages of an aerosol foam formulation of calcipotriol/betamethasone dipropionate (Cal/BD) in patients with psoriasis. In this review, we investigated whether such benefits could also be obtained in real-world clinical practice.
In psoriasis treatment, greater improvement in skin severity predicts greater improvement in nail severity
Amanda M. Rusk & Alan B. Fleischer Jr.
doi : 10.1080/09546634.2020.1720578
Volume 32, Issue 8, Pages: 894-897
Nail are important for both function and esthetic appearance and although they represent a small body surface area, dermatologic disorders affecting the nails can have a detrimental effect to the patient. Deciding on the best systemic antipsoriatic drug to treat nail psoriasis can be difficult due to the lack of nail data on their Food and Drug Administration-approved labels, as well as the variety of scoring systems used for nail psoriasis.
Correct performance of subcutaneous injections in plaque psoriasis: comparison of trained and untrained patients with different application systems in routine clinical care
Franziska Stenger, Anke König, Falk Ochsendorf, Roland Kaufmann & Andreas Pinter
doi : 10.1080/09546634.2020.1720580
Volume 32, Issue 8, Pages: 898-906
Moderate-to-severe plaque psoriasis can be treated very successfully with systemic therapies. Often the therapeutics must be injected subcutaneously. This prospective observational study aimed to compare the correct preparation and performance of subcutaneous injections in trained and untrained patients with plaque psoriasis.
Characterization of insufficient responders to ustekinumab in patients with moderate-to-severe psoriasis in the US Corrona Psoriasis Registry
Abby S. Van Voorhees, Marc A. Mason, Leslie R. Harrold, Ning Guo, Adriana Guana, Haijun Tian, Vivian Herrera & Bruce E. Strober
doi : 10.1080/09546634.2020.1720586
Volume 32, Issue 8, Pages: 907-915
Biologic therapies have revolutionized the management of moderate-to-severe psoriasis; however, there are a limited number of US real-world studies characterizing patients based on response to these treatments. This study examined characteristics at enrollment and change in outcomes of US patients with moderate-to-severe psoriasis who achieved insufficient responses with ustekinumab.
Topical treatment of psoriasis: questionnaire results on topical therapy as long-term continuous treatment and use on specific body sites
T. Hoegsberg, L. Iversen, M. M. Lange, R. Bissonette, A. V. E. Carvalho, P. C. van de Kerkhof, B. Kirby, C. E. Kleyn, J. M. van der Walt, J. J. Wu & C. W. Lynde
doi : 10.1080/09546634.2020.1724250
Volume 32, Issue 8, Pages: 916-921
Currently, no formalized international consensus guidelines exist to direct optimal topical treatment including long-term treatment.
Dermatologist attitudes toward ciclosporin use in atopic dermatitis
Kevin Phan, Olivia Charlton, Chris Baker, Peter Foley & Saxon D. Smith
doi : 10.1080/09546634.2020.1724251
Volume 32, Issue 8, Pages: 922-924
Ciclosporin (CsA) is a systemic immunosuppressive agent indicated for use in the treatment of patients with recalcitrant atopic dermatitis (AD). Studies demonstrate reasonable evidence of benefit compared with placebo. However as biologic agents are under development for use in AD, an assessment of the use, attitude to and safety of CsA is essential in understanding unmet needs in severe AD. We present the results of a survey asking questions relating to initial dose, duration of prescription, precautions and monitoring undertaken during treatment, adverse events seen, and hierarchy of use for systemic agents. This survey was distributed at the annual meeting of the Australasian College of Dermatologists. Twenty-two percent of respondents never prescribe CsA, and 50% prescribe it only 1–2 times per month. When prescribed, the most frequently recommended duration was 6–12 months (24%). Of prescribers, 56% start with a low dose of <3.5?mg/kg daily, and when stratified according to years of experience, a higher proportion of more junior dermatologists commenced with lower doses (p=.028). Regarding side effects, 95% of respondents expressed concern about nephrotoxicity, 37% about hypertension, and 17% infection. The results suggest that although most dermatologists consider CsA to be effective, there are concerns regarding the safety profile.
Efficacy and safety comparison of combination of 0.04% tretinoin microspheres plus 1% clindamycin versus their monotherapy in patients with acne vulgaris: a phase 3, randomized, double-blind study
S. Dogra, T. K. Sumathy, C. Nayak, G. Ravichandran, P. P. Vaidya, S. Mehta, R. Mittal, A. Mane & S. N. Charugulla
doi : 10.1080/09546634.2020.1720579
Volume 32, Issue 8, Pages: 925-933
There is an unmet need for topical treatments with good tolerability in management of acne vulgaris. The present study aimed to evaluate efficacy and safety of a novel tretinoin (microsphere, 0.04%) formulation in combination with clindamycin (1%) gel for treatment of acne vulgaris.
Impact of lifestyle and demographics on the gut microbiota of acne patients and the response to minocycline
B. M. Rainer, K. G. Thompson, C. Antonescu, L. Florea, E. F. Mongodin, S. Kang & A. L. Chien
doi : 10.1080/09546634.2020.1720583
Volume 32, Issue 8, Pages: 934-935
Effect of isotretinoin (13-cis-retinoic acid) on levels of soluble VEGF receptors (sVEGFR1, sVEGFR2, sVEGFR3) in patients with acne vulgaris
Erhan Ayhan, Özgür Aslan & E?ref Araç
doi : 10.1080/09546634.2020.1729331
Volume 32, Issue 8, Pages: 936-940
The effect of isotretinoin on soluble VEGFRs has not been previously investigated. This study evaluate the effects of isotretinoin (13-cis-retinoic acid) on soluble VEGFR1 (sVEGFR1), soluble VEGFR2 (sVEGFR2) and soluble VEGFR3 (sVEGFR3).
Combination of ultra-low-dose isotretinoin and antihistamines in treating Morbihan disease – a new long-term approach with excellent results and a minimum of side effects
Katharina Welsch & Martin Schaller
doi : 10.1080/09546634.2020.1721417
Volume 32, Issue 8, Pages: 941-944
Morbihan disease is characterized by erythema and solid edema in the two upper thirds of the face. Underlying factors are an imbalance in lymphatic drainage, chronic inflammation, and mast cells leading to fibrosis. Treatment options known thus far have led to unsatisfactory results and have often been associated with a greater risk of side effects; even invasive options have been applied. This study presents four patients treated with a combination of ultra-low-dose isotretinoin and antihistamines for a mean duration of 14 months. While no side effects other than dryness of the lips were noted, a significant reduction of the erythema and edema could be observed in all patients. Specialists evaluated the treatment’s success by photodocumentation and measured a 91.5% alleviation of erythema, and 85% reduction of edema, respectively. Based on these results, this new regimen in the therapeutic approach toward Morbihan disease is suggested due to its anti-inflammatory features and low risk of side effects.
Comparison of hair reduction by intensive pulsed light device and combined intense pulsed light with a bipolar radiofrequency
Anna Erkiert-Polguj, Barbara Algiert-Zielinska, Janusz Skubalski & Helena Rotsztejn
doi : 10.1080/09546634.2020.1722310
Volume 32, Issue 8, Pages: 945-949
Photoepilation has become a very popular epilation procedure in esthetic and cosmetic practice. There are some types of lasers and other light sources used for epilation.
Development of a combination therapy with silanols complexed with boron citrate and ablative-fractional laser for treatment of wrinkles and stretch marks
Klaudyna Wolak & Roksana Gruszkiewicz-Majczak
doi : 10.1080/09546634.2020.1729332
Volume 32, Issue 8, Pages: 950-956
The twenty first century’s progress in medicine and cosmetology triggered the search for effective and safe new cosmetics and procedures to fight with such problems as wrinkles or stretch marks. The study aimed to use the synergy of silanols with boron compounds and to develop treatment methods supported by a fractional-ablative laser.
Targeting of keloid with TRAIL and TRAIL-R2/DR5
Pengfei Sun, Zhensheng Hu, Bo Pan & Xiaosheng Lu
doi : 10.1080/09546634.2020.1714541
Volume 32, Issue 8, Pages: 957-964
Keloid is a common and frequently-occurring disease in plastic surgery, and its ugly appearance and itching symptoms bring mental and life pain to patients. However, the clinical treatment of keloid, such as drug injection treatment, surgical resection, cryotherapy, laser treatment and other therapeutic effects are poor. Since the discovery of tumor necrosis factor related apoptosis inducing ligand (TRAIL) in 1995, its selective apoptosis on tumor cells makes it have a great prospect in the targeted treatment of tumor. In recent years, it has been found that the formation of keloid is related to the imbalance of apoptosis of fibroblasts in scar and the binding of TRAI to its receptor mediates the apoptosis of fibroblasts. Therefore, the use of TRAIL and TRAIL-R2/death receptor 5 (DR5) in the treatment of keloid has become a hot research topic. In this paper, the present situation, mechanism and development prospect of TRAIL and TRAIL-R2/DR5 targeted treatment of keloid were reviewed, which provided a reference for promoting the development of keloid treatment.
Clinical and histopathological comparison of microneedling combined with platelets rich plasma versus fractional erbium-doped yttrium aluminum garnet (Er: YAG) laser 2940?nm in treatment of atrophic post traumatic scar: a randomized controlled study
N. F. Agamia, O. Sorror, M. Alrashidy, A. A. Tawfik & A. Badawi
doi : 10.1080/09546634.2020.1729334
Volume 32, Issue 8, Pages: 965-972
Different modalities have been tried for treating atrophic post traumatic scars.
MiR-486-5p inhibits the hyperproliferation and production of collagen in hypertrophic scar fibroblasts via IGF1/PI3K/AKT pathway
Yifeng Xiao
doi : 10.1080/09546634.2020.1728210
Volume 32, Issue 8, Pages: 973-982
This study explored the function and mechanism of miR-486-5p in HSFBs.
Anthocyanins rich pomegranate cream as a topical formulation with anti-aging activity
Ahmed A. H. Abdellatif, Sulaiman Hamad Alawadh, Abdellatif Bouazzaoui, Ahmad H. Alhowail & Hamdoon A. Mohammed
doi : 10.1080/09546634.2020.1721418
Volume 32, Issue 8, Pages: 983-990
Anthocyanins are antioxidant compounds constitute the primary dyes of the pomegranate arils. Anthocyanins could protect the aged skin induced by oxidant exposure as a major role in aging processing and skin degeneration.
Four-weeks daily intake of oral collagen hydrolysate results in improved skin elasticity, especially in sun-exposed areas: a randomized, double-blind, placebo-controlled trial
Wich Sangsuwan & Pravit Asawanonda
doi : 10.1080/09546634.2020.1725412
Volume 32, Issue 8, Pages: 991-996
Topical as well as oral ‘collagen’ is widely popularized and claimed to possess anti-aging properties for the past several years. Few placebo-controlled trials exist.
Topical glycopyrrolate followed by microneedling: a novel treatment option for eccrine hidrocystomas
Amanda Hui Yu Kuan & Hong Liang Tey
doi : 10.1080/09546634.2020.1716929
Volume 32, Issue 8, Pages: 997-998
Eccrine hidrocystomas (EH) are benign cystic tumors of the eccrine glands with no established treatment yet. Eccrine glands are activated by acetylcholine released from innervating sympathetic nerve fibers. Use of oral anti-cholinergic agents is rare due to the possibility of systemic side effects while topical atropine and scopolamine have been found to be ineffective. In our patient, we tried using topical glycopyrrolate over the entire affected region followed by microneedling. Our aim was to create micro-channels through the epidermis and dermis, delivering the drug to EH lesions in the deeper dermis. We only performed microneedling over the left half of the chest to compare the difference made by microneedling. The effective percutaneous delivery of topical glycol was evident by our patient’s transient systemic side effects and reduction of the EH lesions. Specifically, the lesions were reduced more significantly over the left where microneedles were applied. Our treatment was effective for our patient and he was satisfied with the improvement in cosmesis. The method described may serve as a therapeutic option for patients with EH.
Combined microneedling with tacrolimus vs tacrolimus monotherapy for vitiligo treatment
Howyda M. Ebrahim, Reham Elkot & Waleed Albalate
doi : 10.1080/09546634.2020.1716930
Volume 32, Issue 8, Pages: 999-1004
Miconeedling has been used to augment the transdermal drug delivery. Combination modalities may accelerate and improve the repigmentation in vitiligo.
A new treatment protocol of microfocused ultrasound for lower eyelid fat bulging
Hye Chan Jeon, Do-Yeop Kim, Seon-Pil Jin & Dong Hun Lee
doi : 10.1080/09546634.2020.1720581
Volume 32, Issue 8, Pages: 1005-1009
Microfocused ultrasound (MFU) causes tissue tightening by producing thermal injury zones and is used to treat various age-related changes including lower eyelid fat bulging.
Intralesional measles–mumps–rubella is associated with a higher complete response in cutaneous warts: a systematic review and meta-analysis of randomized controlled trial including GRADE qualification
Rachel Vania, Raymond Pranata & Sukmawati Tansil Tan
doi : 10.1080/09546634.2020.1716931
Volume 32, Issue 8, Pages: 1010-1017
Warts can be difficult to treat and progressing to chronic and resistant disease. Several studies have reported the successful application of mumps–measles–rubella (MMR) vaccine resulting in clearance of warts via immunomodulation and induction of immune system.
‘Cryo-immuno-therapy’ is superior to intralesional Candida antigen monotherapy in the treatment of multiple common warts
Enayat Attwa, Rehab Elawady & Eman Salah
doi : 10.1080/09546634.2020.1720585
Volume 32, Issue 8, Pages: 1018-1025
The treatment of multiple common warts can be challenging. Cryotherapy is commonly used for eradicating common warts with variable success. Intralesional Candida antigen has showed promising results in treating different human papillomavirus infections.
Efficacy of topical epigallocatechin gallate (EGCG) 1% on the healing of chronic plantar ulcers in leprosy
C. R. S. Prakoeswa, R. N. Oktaviyanti, D. M. Indramaya, E. Hendradri, S. Sawitri, L. Astari, D. Damayanti & M. Y. Listiawan
doi : 10.1080/09546634.2020.1729333
Volume 32, Issue 8, Pages: 1026-1030
Chronic plantar ulcers in leprosy (CPUL) occur in areas that have a sensory and an autonomic nerve impairment where the wound healing takes longer. Framycetin gauze dressing (FGD) is best used in the wound healing process during the inflammatory phase because it contains antibiotics. Epigallocatechin gallate (EGCG) is the highest component in the extract of green tea that can accelerate blood vessel formation, has an anti-inflammatory effect, and reepithelialization.
Therapeutic outcomes of pemphigus in a referral service in Northern Brazil: a retrospective study of 32 patients
Carla Andréa Avelar Pires, Yandra Sherring Einecke, Nathalia Gabay Pereira, Caio César Chaves Costa, Alyne Condurú dos Santos Cunha, Amanda Gabay Moreira, Fernanda do Nascimento Rodrigues & Marília Brasil Xavier
doi : 10.1080/09546634.2020.1714540
Volume 32, Issue 8, Pages: 1031-1034
Pemphigus are rare chronic autoimmune blistering disorders with challenging therapeutic management.
Management of adolescents with hidradenitis suppurativa
Erin Collier, Vivian Y. Shi & Jennifer L. Hsiao
doi : 10.1080/09546634.2020.1716933
Volume 32, Issue 8, Pages: 1035-1038
Hidradenitis suppurativa (HS) can have devastating impacts on quality of life (QoL), especially during adolescence when patients face unique challenges related to self-esteem, body-image, and sexual maturation. Many teenage HS patients also experience social challenges related to school, relationships, and employment that may require physician intervention. Strategies for comprehensive management of this special group include addressing low medication adherence, screening for comorbidities, and recommending practical lifestyle modifications to reduce disease flares. Herein, we review the impact of HS on adolescent patients and provide practical recommendations to minimize effects on the adolescent life course.
Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats
Ohn Mar Lwin, Nelli Giribabu, Eswar Kumar Kilari & Naguib Salleh
doi : 10.1080/09546634.2020.1721419
Volume 32, Issue 8, Pages: 1039-1048
This study identifies the potential use of mangiferin gel to promote wound healing in diabetes mellitus (DM).
Ingenol mebutate treatment for actinic cheilitis: clinical, histopathological and p53 profile of 14 cases
Rita de Cassia Rossini, Gerson Dellatorre, Lismary Aparecida de Forville Mesquita & Roberto Gomes Tarlé
doi : 10.1080/09546634.2020.1724865
Volume 32, Issue 8, Pages: 1049-1052
Actinic cheilitis (AC) is part of a spectral disease of keratinocyte carcinomas considered by some authors an early stage of in situ squamous cell carcinoma. Treatment options for AC can be lesion and field-directed therapies. Ingenol mebutate (IM) induces rapid and direct cell death and immune responses being able to destruct dysplastic cells.
Fractional 2940-nm Er:YAG laser-assisted drug delivery of timolol maleate for the treatment of deep infantile hemangioma
Li Sun, Chenxia Wang, Yuting Cao, Xinxiang Lv, Limin Tian, Dandan Liu, Lizhong Li & Wenchao Zhao
doi : 10.1080/09546634.2020.1729330
Volume 32, Issue 8, Pages: 1053-1059
To study the efficacy and safety of fractional 2940?nm laser-assisted drug delivery of timolol maleate 0.5% solution for the treatment of deep IHs.
